SOCS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOCS1_HUMAN
• UniProt AC: O15524
• Protein Name: Suppressor of cytokine signaling 1
• Gene Name: SOCS1
• Organism: Homo sapiens (Human).
• Sequence Length: 211
• Subcellular Localization: Nucleus . Cytoplasmic vesicle . Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
• Protein Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway..
• Protein Sequence: MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	LLDACGFYWGPLSVH HHHHCCCCCCCCCCC	8.50	-
185	Phosphorylation	CRQRIVATVGRENLA HHHHHHHHHCCHHHH	16.76	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
80	Y	Phosphorylation	Kinase	BLK	P51451	PSP
80	Y	Phosphorylation	Kinase	LYN	P07948	PSP
80	Y	Phosphorylation	Kinase	SRC	P12931	PSP
80	Y	Phosphorylation	Kinase	YES	P07947	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	SOCS2	O14508	PMID:17898043
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM8	Q9BZR9	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOCS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOCS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IGF1R_HUMAN	IGF1R	physical	9727029
IRS2_HUMAN	IRS2	physical	12228220
JAK2_HUMAN	JAK2	physical	11713228
KIT_HUMAN	KIT	physical	10022833
FLT3_HUMAN	FLT3	physical	10022833
VAV_HUMAN	VAV1	physical	10022833
VAV2_HUMAN	VAV2	physical	10022833
JAK2_HUMAN	JAK2	physical	9202126
ELOC_HUMAN	TCEB1	physical	10051596
ELOA1_HUMAN	TCEB3	physical	10051596
JAK2_HUMAN	JAK2	physical	10064597
JAK2_HUMAN	JAK2	physical	10455112
COMD1_HUMAN	COMMD1	physical	17183367
TF65_HUMAN	RELA	physical	17183367
M3K5_HUMAN	MAP3K5	physical	16407264
GAG_HV1H2	gag	physical	19327355
IRF3_HUMAN	IRF3	physical	21079688
TF65_HUMAN	RELA	physical	21084693
PTN11_HUMAN	PTPN11	physical	14522994
CLC7A_HUMAN	CLEC7A	physical	21899704
M3K5_HUMAN	MAP3K5	physical	18776134
TBG1_HUMAN	TUBG1	physical	15456882
VAV_HUMAN	VAV1	physical	10747851
VHL_HUMAN	VHL	physical	21685897
TF65_HUMAN	RELA	physical	14690596
TIRAP_HUMAN	TIRAP	physical	16415872
IRS1_HUMAN	IRS1	physical	17276034
DAB1_HUMAN	DAB1	physical	17974915
ETV6_HUMAN	ETV6	physical	11314018
JAK2_HUMAN	JAK2	physical	11314018
JAK2_HUMAN	JAK2	physical	18508766
RASA1_HUMAN	RASA1	physical	18556463
FGFR3_HUMAN	FGFR3	physical	16410555
LCK_HUMAN	LCK	physical	21234523
P53_HUMAN	TP53	physical	20005840
GAG_HV1H2	gag	physical	18172216
ERBB2_HUMAN	ERBB2	physical	16273093
ELOC_HUMAN	TCEB1	physical	22787435
ABL1_HUMAN	ABL1	physical	22787435
P85A_HUMAN	PIK3R1	physical	25814554
MET_HUMAN	MET	physical	25728680
IRS2_HUMAN	IRS2	physical	27507812
NECT4_MOUSE	Pvrl4	physical	28258213
NECT3_MOUSE	Pvrl3	physical	28258213
NECT1_HUMAN	PVRL1	physical	28258213
JAK2_HUMAN	JAK2	physical	28258213

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.