| UniProt ID | NECT3_MOUSE | |
|---|---|---|
| UniProt AC | Q9JLB9 | |
| Protein Name | Nectin-3 | |
| Gene Name | Nectin3 {ECO:0000250|UniProtKB:Q9NQS3} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 549 | |
| Subcellular Localization |
Cell membrane Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane . |
|
| Protein Description | Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.. | |
| Protein Sequence | MARTPGPAPLCPGGGKAQLSSAFPPAAGLLLPAPTPPPLLLLLIPLLLFSRLCGALAGSIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSTQTVAVHHPQYGFSVQGDYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAVCVAATGKPVAQIDWEGDLGEMESSTTSFPNETATIVSQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTVNYSGVYVCKVSNSLGQRSDQKVIYISDPPTTTTLQPTVQWHSSPADVQDIATEHKKLPFPLSTLATLKDDTIGTIIASVVGGALFLVLVSILAGVFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLHQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLTRFERPMDYYEDLKMGMKFVSDERYNESEDGLVSHVDGSVISRREWYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 73 | N-linked_Glycosylation | VTAVWGKNVSLKCLI EEEEECCCCEEEEEE | - | ||
| 83 | N-linked_Glycosylation | LKCLIEVNETITQIS EEEEEEECCCEEEEE | - | ||
| 125 | N-linked_Glycosylation | QGRVLFKNYSLNDAT CCEEEEEEEECCCCE | - | ||
| 186 | N-linked_Glycosylation | DSLIDGGNETVAAVC CCCCCCCCCEEEEEE | - | ||
| 222 | N-linked_Glycosylation | SSTTSFPNETATIVS CCCCCCCCCCCEEEE | - | ||
| 318 | Phosphorylation | WPDGLLASDNTLHFV CCCCEEECCCEEEEE | - | ||
| 331 | N-linked_Glycosylation | FVHPLTVNYSGVYVC EECEEEECCCEEEEE | - | ||
| 332 | Phosphorylation | VHPLTVNYSGVYVCK ECEEEECCCEEEEEE | - | ||
| 398 (in isoform 3) | Phosphorylation | - | 25177544 | ||
| 398 (in isoform 2) | Phosphorylation | - | 25177544 | ||
| 399 (in isoform 3) | Phosphorylation | - | 25177544 | ||
| 399 (in isoform 2) | Phosphorylation | - | 25177544 | ||
| 438 | Phosphorylation | RRTFRGDYFAKNYIP CCCCCCCHHHHCCCC | 29514104 | ||
| 443 | Phosphorylation | GDYFAKNYIPPSDMQ CCHHHHCCCCHHHCC | 25293948 | ||
| 447 | Phosphorylation | AKNYIPPSDMQKESQ HHCCCCHHHCCCHHH | 25293948 | ||
| 451 | Ubiquitination | IPPSDMQKESQIDVL CCHHHCCCHHHCCEE | 22790023 | ||
| 453 | Phosphorylation | PSDMQKESQIDVLHQ HHHCCCHHHCCEECH | 23984901 | ||
| 465 | Phosphorylation | LHQDELDSYPDSVKK ECHHHHHHCCHHHCC | 26824392 | ||
| 466 | Phosphorylation | HQDELDSYPDSVKKE CHHHHHHCCHHHCCC | 19060867 | ||
| 469 | Phosphorylation | ELDSYPDSVKKENKN HHHHCCHHHCCCCCC | 21743459 | ||
| 471 | Ubiquitination | DSYPDSVKKENKNPV HHCCHHHCCCCCCCC | 22790023 | ||
| 475 | Ubiquitination | DSVKKENKNPVNNLI HHHCCCCCCCCHHCC | 22790023 | ||
| 484 | Ubiquitination | PVNNLIRKDYLEEPE CCHHCCCHHHCCCCC | 22790023 | ||
| 492 | Ubiquitination | DYLEEPEKTQWNNVE HHCCCCCHHCCCCHH | 22790023 | ||
| 510 | Phosphorylation | RFERPMDYYEDLKMG HCCCCCCHHHHHHHH | 22499769 | ||
| 511 | Phosphorylation | FERPMDYYEDLKMGM CCCCCCHHHHHHHHC | 22499769 | ||
| 515 | Ubiquitination | MDYYEDLKMGMKFVS CCHHHHHHHHCCCCC | 22790023 | ||
| 526 | Phosphorylation | KFVSDERYNESEDGL CCCCCCCCCCCCCCE | 21183079 | ||
| 529 | Phosphorylation | SDERYNESEDGLVSH CCCCCCCCCCCEEEE | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NECT3_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NECT3_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NECT3_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NECT3_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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