TIRAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIRAP_HUMAN
• UniProt AC: P58753
• Protein Name: Toll/interleukin-1 receptor domain-containing adapter protein
• Gene Name: TIRAP
• Organism: Homo sapiens (Human).
• Sequence Length: 221
• Subcellular Localization: Cytoplasm . Cell membrane . Membrane . Colocalizes with DAB2IP at the plasma membrane.
• Protein Description: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6..
• Protein Sequence: MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTSSDASQPTSQDSPLPPSLSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQDLVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQMLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQTLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASSTSLPAP -----CCCCCCCCCC	32.61	-
12	Phosphorylation	TSLPAPGSRPKKPLG CCCCCCCCCCCCCHH	44.33	24719451
28	Phosphorylation	MADWFRQTLLKKPKK HHHHHHHHHHHCCCC	29.78	-
39	Phosphorylation	KPKKRPNSPESTSSD CCCCCCCCCCCCCCC	32.50	27080861
42	Phosphorylation	KRPNSPESTSSDASQ CCCCCCCCCCCCCCC	36.65	27080861
43	Phosphorylation	RPNSPESTSSDASQP CCCCCCCCCCCCCCC	30.50	27080861
44	Phosphorylation	PNSPESTSSDASQPT CCCCCCCCCCCCCCC	35.18	27080861
45	Phosphorylation	NSPESTSSDASQPTS CCCCCCCCCCCCCCC	36.97	27080861
86	Phosphorylation	SSRWSKDYDVCVCHS CCCCCCCCCEEEECC	17.63	16439361
106	Phosphorylation	AAQDLVSYLEGSTAS HHHHHHHHHHCCHHH	10.99	16439361
124	Phosphorylation	FLQLRDATPGGAIVS HHHCCCCCCCCHHHH	27.10	21712546
180	Phosphorylation	GCTIPLLSGLSRAAY CCCHHHCCCCCCCCC	45.42	22210691
183	Phosphorylation	IPLLSGLSRAAYPPE HHHCCCCCCCCCCCC	24.33	22210691
187	Phosphorylation	SGLSRAAYPPELRFM CCCCCCCCCCCCEEE	20.52	16439361
216	Phosphorylation	VKEAVMRYLQTLS-- HHHHHHHHHHHCC--	5.76	-
219	Phosphorylation	AVMRYLQTLS----- HHHHHHHHCC-----	26.77	-
221	Phosphorylation	MRYLQTLS------- HHHHHHCC-------	41.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
86	Y	Phosphorylation	Kinase	BTK	Q06187	PSP
106	Y	Phosphorylation	Kinase	BTK	Q06187	PSP
106	Y	Phosphorylation	Kinase	PKCD	Q05655	PSP
187	Y	Phosphorylation	Kinase	BTK	Q06187	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIRAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIRAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TLR4_HUMAN	TLR4	physical	11526399
MYD88_HUMAN	MYD88	genetic	11544529
TIRAP_HUMAN	TIRAP	physical	11544529
MYD88_HUMAN	MYD88	physical	11544529
IRAK2_HUMAN	IRAK2	genetic	11544529
TRAF6_HUMAN	TRAF6	genetic	11544529
M3K7_HUMAN	MAP3K7	genetic	11544529
IRAK2_HUMAN	IRAK2	physical	11544529
TLR4_HUMAN	TLR4	physical	11544529
MYD88_HUMAN	MYD88	physical	17258210
MYD88_HUMAN	MYD88	physical	18221795
MYD88_HUMAN	MYD88	physical	20048342
IRAK1_HUMAN	IRAK1	physical	21903422
IRAK2_HUMAN	IRAK2	physical	21903422
IRAK4_HUMAN	IRAK4	physical	21903422
TLR4_HUMAN	TLR4	physical	21903422
NF1_HUMAN	NF1	physical	21903422
ARAF_HUMAN	ARAF	physical	21903422
CCD47_HUMAN	CCDC47	physical	21903422
JAK1_HUMAN	JAK1	physical	21903422
PDS5A_HUMAN	PDS5A	physical	21903422
LTN1_HUMAN	LTN1	physical	21903422
RPTOR_HUMAN	RPTOR	physical	21903422
SAMH1_HUMAN	SAMHD1	physical	21903422
U520_HUMAN	SNRNP200	physical	21903422
STAT3_HUMAN	STAT3	physical	21903422
TAB2_HUMAN	TAB2	physical	21903422
UBR1_HUMAN	UBR1	physical	21903422
UBR2_HUMAN	UBR2	physical	21903422
BTK_HUMAN	BTK	physical	12724322
TCAM2_HUMAN	TICAM2	physical	12721283
TRAF6_HUMAN	TRAF6	physical	19592497
TRAF6_HUMAN	TRAF6	physical	24084649
M3K7_HUMAN	MAP3K7	physical	24084649
TAB1_HUMAN	TAB1	physical	24084649
TNFL9_HUMAN	TNFSF9	physical	24084649
KCC2D_HUMAN	CAMK2D	physical	26186194
KCC2G_HUMAN	CAMK2G	physical	26186194
DHYS_HUMAN	DHPS	physical	26186194
NTM1A_HUMAN	NTMT1	physical	26186194
BTBD9_HUMAN	BTBD9	physical	26186194
KLH24_HUMAN	KLHL24	physical	26186194
TEP1_HUMAN	TEP1	physical	26186194
NTM1A_HUMAN	NTMT1	physical	28514442
DHYS_HUMAN	DHPS	physical	28514442
TEP1_HUMAN	TEP1	physical	28514442
KCC2G_HUMAN	CAMK2G	physical	28514442
KCC2D_HUMAN	CAMK2D	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.