TEP1_HUMAN - dbPTM
TEP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TEP1_HUMAN
UniProt AC Q99973
Protein Name Telomerase protein component 1
Gene Name TEP1
Organism Homo sapiens (Human).
Sequence Length 2627
Subcellular Localization Nucleus . Chromosome, telomere.
Protein Description Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity)..
Protein Sequence MEKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLKTMEKPHGYVSAHPDILSLENQCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLSSLKSTVSASPLFQSLQISHMTQADLYRVNNSNCLLSEPPSWRAQHFSKGLDLSTCPIALKSISATETAQEATLGRWFDSEEKKGAETQMPSYSLSLGEEEEVEDLAVKLTSGDSESHPEPTDHVLQEKKMALLSLLCSTLVSEVNMNNTSDPTLAAIFEICRELALLEPEFILKASLYARQQLNVRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDKNKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPGMEPPFSHRCFPRYIGFLREEQRKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYPSNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPSNITLMRRILTRNEKNRPRRRFLCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGEMLNRYRQALETAVNLSVKHSLPLLPGRTVLVYLTDANADRLCPKSNPQGPPLNYALLLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEFDENDGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLNPNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHGIDLRWGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVMQFLNRNQRLQPSAQALIYFRDSSFLSSVPDAWKSDFVSESEEAARRISELKSYLSRQKGITCRRYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDLVQATFQQLQKPPSPARPRLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVASLVFFHFSGARPDQGLALTLLRRLCTYLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTLPATVPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVWRTLPKGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGEGPLERPGARLCLPDGPLRTAAKRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFRTFLRQQASILSQYPRLLPQQAANQPLDSPLCHQASLLSRRWHLQHTLRWLNKPRTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMILSTHKEYGIFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENPSRTLISITQAKPESESSFLCASSDGILWNLAKCSPEGEWTTGNMWQKKANTPETQTPGTDPSTCRESDASMDSDASMDSEPTPHLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationSTHSDILSLKNQCLA
CCHHHHHHHHHHHHH		37.3224719451
48UbiquitinationHSDILSLKNQCLATL
HHHHHHHHHHHHHCC		41.41-
67PhosphorylationTMEKPHGYVSAHPDI
CCCCCCCCCCCCHHH		6.54-
89UbiquitinationLATLSDLKTMEKPHG
HHHHHHHCCCCCCCC		51.30-
116PhosphorylationNRCLATLSSLKSTVS
HHHHHHHHHHHHCCC		29.3026699800
117PhosphorylationRCLATLSSLKSTVSA
HHHHHHHHHHHCCCC		42.8226699800
134PhosphorylationLFQSLQISHMTQADL
HHHHHCCCCCCHHHE		8.3428787133
137PhosphorylationSLQISHMTQADLYRV
HHCCCCCCHHHEEEE		18.3828787133
143MethylationMTQADLYRVNNSNCL
CCHHHEEEECCCCCC		31.8030761351
156PhosphorylationCLLSEPPSWRAQHFS
CCCCCCCCHHHHHHC		39.6526091039
176UbiquitinationSTCPIALKSISATET
CCCCEEEEECCCCCC		36.40-
292PhosphorylationPEFILKASLYARQQL
HHHHHHHHHHHHHHC		21.9624719451
368UbiquitinationLRTAMTDKFAQFDEY
HHHHCCHHCCCCCHH		33.17-
379UbiquitinationFDEYQLAKYNPRKHR
CCHHHHHHHCCCCCC		54.90-
379MalonylationFDEYQLAKYNPRKHR
CCHHHHHHHCCCCCC		54.9026320211
397PhosphorylationHPRRPPRSPGMEPPF
CCCCCCCCCCCCCCC		31.4230266825
405PhosphorylationPGMEPPFSHRCFPRY
CCCCCCCCCCHHHHH		18.7827080861
425UbiquitinationEEQRKFEKAGDTVSE
HHHHHHHHCCCCCCC		61.88-
429PhosphorylationKFEKAGDTVSEKKNP
HHHHCCCCCCCCCCC		25.6428985074
434UbiquitinationGDTVSEKKNPPRFTL
CCCCCCCCCCCCCCH		71.31-
465PhosphorylationQALLGYRYPSNLQLF
HHHHCCCCCCCCEEE		11.5224114839
503PhosphorylationETWERELSLRGNKAS
CHHHHHHHHCCCCHH		15.9724719451
508AcetylationELSLRGNKASVWEEL
HHHHCCCCHHHHHHH		44.8811794981
633UbiquitinationPVLYEQLKREKLRVH
HHHHHHHHHHCCHHH		59.20-
695PhosphorylationADRLCPKSNPQGPPL
HHHCCCCCCCCCCCH		38.5918491316
714PhosphorylationLLIGMMITRAEQVDV
HHHHHHHHCHHHCCE		13.1118491316
728PhosphorylationVVLCGGDTLKTAVLK
EEEECCCHHHHHHHH		33.1724732914
731PhosphorylationCGGDTLKTAVLKAEE
ECCCHHHHHHHHHHH		25.7224732914
735UbiquitinationTLKTAVLKAEEGILK
HHHHHHHHHHHCHHH		47.34-
742UbiquitinationKAEEGILKTAIKLQA
HHHHCHHHHHHHHHH		33.71-
798AcetylationDGMINVAKQLYWQRV
CCHHHHHHHHHHHHH		36.2319827687
808AcetylationYWQRVNSKCLFVGIL
HHHHHCCHHHHHHHH		29.7419827697
864UbiquitinationGQMDKIFKIPPPPGK
CCCCCCEECCCCCCC		58.75-
898PhosphorylationVSQQGWRSIRLFISS
CCHHCHHHEEEEHHH		12.9322210691
904PhosphorylationRSIRLFISSTFRDMH
HHEEEEHHHHCHHHC		18.9122210691
1058PhosphorylationEEAARRISELKSYLS
HHHHHHHHHHHHHHH		34.76-
1061UbiquitinationARRISELKSYLSRQK
HHHHHHHHHHHHHCC		32.76-
1062PhosphorylationRRISELKSYLSRQKG
HHHHHHHHHHHHCCC		43.8830576142
1065PhosphorylationSELKSYLSRQKGITC
HHHHHHHHHCCCCCC		25.1630576142
1175PhosphorylationGQSGQGKTAFLASLV
CCCCCCHHHHHHHHH		29.4822210691
1180PhosphorylationGKTAFLASLVSALQA
CHHHHHHHHHHHHHC		31.3022210691
1227UbiquitinationTYLRGQLKEPGALPS
HHHHHCCCCCCCCCH		54.71-
1339UbiquitinationEELALYGKRLEESPF
HHHHHHCCCCCCCCC		40.01-
1344PhosphorylationYGKRLEESPFNNQMR
HCCCCCCCCCCCCEE		25.9725159151
1382PhosphorylationFTLYEQVSERLRTLP
HHHHHHHHHHHHCCC		19.3823532336
1401PhosphorylationLLLQHILSTLEKEHG
HHHHHHHHHHHHHHC		30.28-
1402PhosphorylationLLQHILSTLEKEHGP
HHHHHHHHHHHHHCC		35.18-
1559PhosphorylationSGNRGLLSKFLTNLH
CCCHHHHHHHHHHHH		26.8024719451
1642PhosphorylationSPLCHQASLLSRRWH
CHHHHHHHHHHHHHH		24.2327080861
1645PhosphorylationCHQASLLSRRWHLQH
HHHHHHHHHHHHHHH		25.7024719451
1844PhosphorylationDLGAPGASIRTLAFN
CCCCCCCEEEEEEEE		20.6528188228
1847PhosphorylationAPGASIRTLAFNVPG
CCCCEEEEEEEECCC		22.29-
1960PhosphorylationIYKISSGSQGAQGQA
EEEECCCCCCCCHHH		27.65-
2353PhosphorylationQVKLRKGSAPGNLSL
EEEECCCCCCCCHHH		34.0328857561
2508UbiquitinationTGNMWQKKANTPETQ
CCCCCCCCCCCCCCC		31.59-
2511PhosphorylationMWQKKANTPETQTPG
CCCCCCCCCCCCCCC		27.6228857561
2514PhosphorylationKKANTPETQTPGTDP
CCCCCCCCCCCCCCH		38.6627794612
2516PhosphorylationANTPETQTPGTDPST
CCCCCCCCCCCCHHH		30.9828857561
2519PhosphorylationPETQTPGTDPSTCRE
CCCCCCCCCHHHHCC		46.0427794612
2527PhosphorylationDPSTCRESDASMDSD
CHHHHCCCCCCCCCC		21.0828985074
2533PhosphorylationESDASMDSDASMDSE
CCCCCCCCCCCCCCC		26.8328348404
2536PhosphorylationASMDSDASMDSEPTP
CCCCCCCCCCCCCCC		28.2827251275
2539PhosphorylationDSDASMDSEPTPHLK
CCCCCCCCCCCCCCC		36.5128348404
2547PhosphorylationEPTPHLKTRQRRKIH
CCCCCCCCCCCCCCC		38.0928985074
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TEP1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TEP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TEP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TERT_HUMANTERTphysical
11029039
P53_HUMANTP53physical
10597287
BLM_HUMANBLMphysical
19329795
TERF2_HUMANTERF2physical
19329795
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TEP1_HUMAN

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Related Literatures of Post-Translational Modification

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