NTM1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NTM1A_HUMAN
• UniProt AC: Q9BV86
• Protein Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1
• Gene Name: NTMT1
• Organism: Homo sapiens (Human).
• Sequence Length: 223
• Subcellular Localization: Nucleus . Predominantly nuclear (PubMed:24090352).
• Protein Description: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. [PubMed: 24090352 Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1 Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.]
• Protein Sequence: MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTSEVIED -------CCHHHHHH	9.32	19413330
2	Acetylation	------MTSEVIEDE ------CCHHHHHHH	33.33	20068231
2	Phosphorylation	------MTSEVIEDE ------CCHHHHHHH	33.33	20068231
3	Phosphorylation	-----MTSEVIEDEK -----CCHHHHHHHH	28.68	20068231
10	Sumoylation	SEVIEDEKQFYSKAK HHHHHHHHHHHHHHH	59.01	-
10	Ubiquitination	SEVIEDEKQFYSKAK HHHHHHHHHHHHHHH	59.01	21890473
10	Ubiquitination	SEVIEDEKQFYSKAK HHHHHHHHHHHHHHH	59.01	21890473
10	Ubiquitination	SEVIEDEKQFYSKAK HHHHHHHHHHHHHHH	59.01	21890473
10	Ubiquitination	SEVIEDEKQFYSKAK HHHHHHHHHHHHHHH	59.01	21890473
10	Sumoylation	SEVIEDEKQFYSKAK HHHHHHHHHHHHHHH	59.01	-
13	Phosphorylation	IEDEKQFYSKAKTYW HHHHHHHHHHHHHHH	13.53	27642862
14	Phosphorylation	EDEKQFYSKAKTYWK HHHHHHHHHHHHHHH	27.68	25693802
17	Ubiquitination	KQFYSKAKTYWKQIP HHHHHHHHHHHHHCC	45.98	-
26	Phosphorylation	YWKQIPPTVDGMLGG HHHHCCCCCCCCCCC	26.35	21406692
34	Phosphorylation	VDGMLGGYGHISSID CCCCCCCCCCCEEEE	12.06	21406692
38	Phosphorylation	LGGYGHISSIDINSS CCCCCCCEEEECHHH	18.63	21406692
39	Phosphorylation	GGYGHISSIDINSSR CCCCCCEEEECHHHH	24.55	21406692
44	Phosphorylation	ISSIDINSSRKFLQR CEEEECHHHHHHHHH	31.67	21406692
45	Phosphorylation	SSIDINSSRKFLQRF EEEECHHHHHHHHHH	34.69	21406692
59	Ubiquitination	FLREGPNKTGTSCAL HHHHCCCCCCCCCHH	52.01	-
60	Phosphorylation	LREGPNKTGTSCALD HHHCCCCCCCCCHHC	52.94	20068231
60	Ubiquitination	LREGPNKTGTSCALD HHHCCCCCCCCCHHC	52.94	21890473
62	Phosphorylation	EGPNKTGTSCALDCG HCCCCCCCCCHHCCC	26.34	20068231
63	Phosphorylation	GPNKTGTSCALDCGA CCCCCCCCCHHCCCC	9.95	20068231
89	Sulfoxidation	PLFREVDMVDITEDF HHHCCCCEEECCHHH	3.35	30846556
93	Phosphorylation	EVDMVDITEDFLVQA CCCEEECCHHHHHHH	25.66	22210691
102	Phosphorylation	DFLVQAKTYLGEEGK HHHHHHHHHCCCCCC	27.30	28152594
103	Phosphorylation	FLVQAKTYLGEEGKR HHHHHHHHCCCCCCE	16.41	28152594
109	Ubiquitination	TYLGEEGKRVRNYFC HHCCCCCCEECCEEE	51.50	-
109 (in isoform 2)	Ubiquitination	-	51.50	-
110	Ubiquitination	YLGEEGKRVRNYFCC HCCCCCCEECCEEEC	43.41	21890473
169	Sulfoxidation	IIVIKDNMAQEGVIL EEEEECCCCCCCCEE	6.13	30846556
223	Methylation	HVYSFALR------- HHHHHHCC-------	40.85	115483165

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NTM1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NTM1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NTM1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RCC1_HUMAN	RCC1	physical	20668449
A4_HUMAN	APP	physical	21832049
PLCG1_HUMAN	PLCG1	physical	22939629
MET13_HUMAN	METTL13	physical	22939629
QORL1_HUMAN	CRYZL1	physical	22939629
MK01_HUMAN	MAPK1	physical	22939629
MK03_HUMAN	MAPK3	physical	22939629
DDB2_HUMAN	DDB2	physical	24753253

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.