MET13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MET13_HUMAN
• UniProt AC: Q8N6R0
• Protein Name: Methyltransferase-like protein 13
• Gene Name: METTL13
• Organism: Homo sapiens (Human).
• Sequence Length: 699
• Protein Sequence: MNLLPKSSREFGSVDYWEKFFQQRGKKAFEWYGTYLELCGVLHKYIKPREKVLVIGCGNSELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFQVVLDKGTLDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLCISLAQAHILKKAVGHFSREGWMVRVHQVANSQDQVLEAEPQFSLPVFAFIMTKFRPVPGSALQIFELCAQEQRKPVRLESAERLAEAVQERQQYAWLCSQLRRKARLGSVSLDLCDGDTGEPRYTLHVVDSPTVKPSRDNHFAIFIIPQGRETEWLFGMDEGRKQLAASAGFRRLITVALHRGQQYESMDHIQAELSARVMELAPAGMPTQQQVPFLSVGGDIGVRTVQHQDCSPLSGDYVIEDVQGDDKRYFRRLIFLSNRNVVQSEARLLKDVSHKAQKKRKKDRKKQRPADAEDLPAAPGQSIDKSYLCCEHHKAMIAGLALLRNPELLLEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHPEQKLATPELLETAQALERTLRKPGRGWDDTYVLSDMLKTVKIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19 (in isoform 1)	Ubiquitination	-	37.01	22053931
19 (in isoform 4)	Ubiquitination	-	37.01	21890473
19 (in isoform 5)	Ubiquitination	-	37.01	21890473
48 (in isoform 2)	Ubiquitination	-	39.85	21906983
48 (in isoform 3)	Ubiquitination	-	39.85	21890473
134 (in isoform 1)	Ubiquitination	-	58.79	22053931
134 (in isoform 4)	Ubiquitination	-	58.79	21890473
134 (in isoform 5)	Ubiquitination	-	58.79	21890473
166 (in isoform 1)	Ubiquitination	-	7.27	22053931
181 (in isoform 3)	Phosphorylation	-	4.69	-
207 (in isoform 3)	Ubiquitination	-	2.39	21890473
293 (in isoform 4)	Ubiquitination	-	39.49	21890473
293 (in isoform 5)	Ubiquitination	-	39.49	21890473
320 (in isoform 2)	Ubiquitination	-	37.51	21906983
467 (in isoform 1)	Ubiquitination	-	21.42	22053931
537 (in isoform 3)	Ubiquitination	-	5.21	21890473
623 (in isoform 4)	Ubiquitination	-	46.27	21890473
623 (in isoform 5)	Ubiquitination	-	46.27	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MET13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MET13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MET13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANKY2_HUMAN	ANKMY2	physical	26344197
BUB3_HUMAN	BUB3	physical	26344197
DNJC8_HUMAN	DNAJC8	physical	26344197
PFKAP_HUMAN	PFKP	physical	26344197
PIN4_HUMAN	PIN4	physical	26344197
PTN2_HUMAN	PTPN2	physical	26344197
SK2L2_HUMAN	SKIV2L2	physical	26344197
SMRC1_HUMAN	SMARCC1	physical	26344197
HNRPQ_HUMAN	SYNCRIP	physical	26344197
THAP1_HUMAN	THAP1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, AND MASSSPECTROMETRY.
PubMed: 18669648