ANKY2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANKY2_HUMAN
• UniProt AC: Q8IV38
• Protein Name: Ankyrin repeat and MYND domain-containing protein 2
• Gene Name: ANKMY2
• Organism: Homo sapiens (Human).
• Sequence Length: 441
• Subcellular Localization: Cell projection, cilium.
• Protein Description: May be involved in the trafficking of signaling proteins to the cilia..
• Protein Sequence: MVHIKKGELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINNFFPRERLDYYTKPQGLDKEPKLPPKLAGPLHKIITTTNLHPVKIVMLVNENPLLTEEAALNKCYRVMDLICEKCMKQRDMNEVLAMKMHYISCIFQKCINFLKDGENKLDTLIKSLLKGRASDGFPVYQEKIIRESIRKFPYCEATLLQQLVRSIAPVEIGSDPTAFSVLTQAITGQVGFVDVEFCTTCGEKGASKRCSVCKMVIYCDQTCQKTHWFTHKKICKNLKDIYEKQQLEAAKEKRQEENHGKLDVNSNCVNEEQPEAEVGISQKDSNPEDSGEGKKESLESEAELEGLQDAPAGPQVSEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	HIKKGELTQEEKELL CCCCCCCCHHHHHHH	29.63	46163695
14	Ubiquitination	GELTQEEKELLEVIG CCCCHHHHHHHHHHC	53.56	-
35	Ubiquitination	AGTLLSSKNVRVNCL HHHHHHCCCEEEEEE	56.96	-
159	Ubiquitination	KEPKLPPKLAGPLHK CCCCCCHHHCCCCEE	49.37	-
170	Phosphorylation	PLHKIITTTNLHPVK CCEEEEECCCCCCEE	11.86	46163701
189	Phosphorylation	VNENPLLTEEAALNK ECCCCCCCHHHHHHH	39.19	46163707
207	Ubiquitination	VMDLICEKCMKQRDM HHHHHHHHHHHCCCH	34.91	-
242	Ubiquitination	FLKDGENKLDTLIKS HHHCCCCHHHHHHHH	43.36	-
245	Phosphorylation	DGENKLDTLIKSLLK CCCCHHHHHHHHHHC	40.60	28555341
248	Ubiquitination	NKLDTLIKSLLKGRA CHHHHHHHHHHCCCC	37.86	-
249	Phosphorylation	KLDTLIKSLLKGRAS HHHHHHHHHHCCCCC	31.75	24719451
265	Ubiquitination	GFPVYQEKIIRESIR CCCHHHHHHHHHHHH	28.10	-
333	Phosphorylation	KGASKRCSVCKMVIY CCCCCCCCCCEEEEE	34.28	50565263
340	Phosphorylation	SVCKMVIYCDQTCQK CCCEEEEEECCHHHH	4.41	50565269
344	Phosphorylation	MVIYCDQTCQKTHWF EEEEECCHHHHCCCH	12.03	50565275
366	Ubiquitination	NLKDIYEKQQLEAAK HHHHHHHHHHHHHHH	26.77	21906983
403	Phosphorylation	PEAEVGISQKDSNPE CHHHCCCCCCCCCCC	25.83	72243969
407	Phosphorylation	VGISQKDSNPEDSGE CCCCCCCCCCCCCCC	62.41	23186163
412	Phosphorylation	KDSNPEDSGEGKKES CCCCCCCCCCCHHHH	36.76	23186163
416	Ubiquitination	PEDSGEGKKESLESE CCCCCCCHHHHHHCH	49.41	21906983
417	Ubiquitination	EDSGEGKKESLESEA CCCCCCHHHHHHCHH	64.49	21906983
419	Phosphorylation	SGEGKKESLESEAEL CCCCHHHHHHCHHHH	46.44	25159151
422	Phosphorylation	GKKESLESEAELEGL CHHHHHHCHHHHCCC	47.61	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANKY2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANKY2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANKY2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYAC_HUMAN	AARS	physical	22863883
ARI1_HUMAN	ARIH1	physical	22863883
HSF1_HUMAN	HSF1	physical	22863883
BIG2_HUMAN	ARFGEF2	physical	26344197
HNRPF_HUMAN	HNRNPF	physical	26344197
KIF5C_HUMAN	KIF5C	physical	26344197
PBDC1_HUMAN	PBDC1	physical	26344197
GCYB1_HUMAN	GUCY1B3	physical	28514442
KANL3_HUMAN	KANSL3	physical	28514442
ADCY3_HUMAN	ADCY3	physical	28514442
AGO4_HUMAN	AGO4	physical	28514442
TEBP_HUMAN	PTGES3	physical	28514442
ADCY6_HUMAN	ADCY6	physical	28514442
FKBP8_HUMAN	FKBP8	physical	28514442
KLH26_HUMAN	KLHL26	physical	28514442
GCYA3_HUMAN	GUCY1A3	physical	28514442
HS90A_HUMAN	HSP90AA1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.