dbPTM

KLH26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KLH26_HUMAN
UniProt AC	Q53HC5
Protein Name	Kelch-like protein 26
Gene Name	KLHL26
Organism	Homo sapiens (Human).
Sequence Length	615
Subcellular Localization
Protein Description
Protein Sequence	MAESGGSSGGAGGGGAFGAGPGPERPNSTADKNGALKCTFSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRAGTRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAESGGSSG ------CCCCCCCCC	21.47	19413330
28	Phosphorylation	PGPERPNSTADKNGA CCCCCCCCCCCCCCC	27.88	22210691
29	Phosphorylation	GPERPNSTADKNGAL CCCCCCCCCCCCCCE	45.58	22210691
32	Ubiquitination	RPNSTADKNGALKCT CCCCCCCCCCCEEEE	55.61	-
37	Ubiquitination	ADKNGALKCTFSAPS CCCCCCEEEEEECCC	30.60	-
44	Phosphorylation	KCTFSAPSHSTSLLQ EEEEECCCCCHHHHH	29.77	-
48	Phosphorylation	SAPSHSTSLLQGLAT ECCCCCHHHHHHHHH	30.05	-
68	Phosphorylation	QLLDVVLTINREAFP CEEEEEEEECHHHCC	12.47	-
78	Ubiquitination	REAFPAHKVVLAACS HHHCCHHHHHHHHCH	35.82	-
107	Ubiquitination	SQDVIELKGVSARGL CCHHHHHHCCCHHHH	44.47	21906983
164	Phosphorylation	KAAMSVETCLNIGQM HHHHCHHHHHHHHHH	21.82	28857561
173	Phosphorylation	LNIGQMATTFSLASL HHHHHHHHHHHHHHH	24.03	28857561
174	Phosphorylation	NIGQMATTFSLASLR HHHHHHHHHHHHHHH	11.16	28857561
179	Phosphorylation	ATTFSLASLRESVDA HHHHHHHHHHHHHHH	33.00	24719451
287	Phosphorylation	YLLEAFNYQVLPFRQ HHHHHHCCCCCCCCC	8.11	27642862
302	Phosphorylation	HEMQSPRTAVRSDVP CCCCCCCCCCCCCCC	32.65	22468782
306	Phosphorylation	SPRTAVRSDVPSLVT CCCCCCCCCCCCEEE	36.04	22468782
310	Phosphorylation	AVRSDVPSLVTFGGT CCCCCCCCEEEECCC	35.01	22468782
319	Phosphorylation	VTFGGTPYTDSDRSV EEECCCCCCCCCCCC	24.02	22468782
320	Phosphorylation	TFGGTPYTDSDRSVS EECCCCCCCCCCCCC	30.17	22468782
322	Phosphorylation	GGTPYTDSDRSVSSK CCCCCCCCCCCCCCC	27.42	22468782
327	Phosphorylation	TDSDRSVSSKVYQLP CCCCCCCCCCEEECC	26.20	22468782
328	Phosphorylation	DSDRSVSSKVYQLPE CCCCCCCCCEEECCC	24.80	22468782
329	Ubiquitination	SDRSVSSKVYQLPEP CCCCCCCCEEECCCC	37.14	21906983
331	Phosphorylation	RSVSSKVYQLPEPGA CCCCCCEEECCCCCH	14.20	28796482
402	Phosphorylation	RLQAMQESRIQFQLN HHHHHHHHCHHHHHH	20.14	24719451
416	Phosphorylation	NVLCGMVYATGGRNR HHHHCCEEECCCCCC	6.91	28176443
418	Phosphorylation	LCGMVYATGGRNRAG HHCCEEECCCCCCCC	23.60	24719451
426	Phosphorylation	GGRNRAGSLASVERY CCCCCCCCHHHHHHH	21.56	28857561
429	Phosphorylation	NRAGSLASVERYCPR CCCCCHHHHHHHCCC	29.79	22210691
442	Phosphorylation	PRRNEWGYACSLKRR CCCCCCCCEEECCCC	12.90	30206219
445	Phosphorylation	NEWGYACSLKRRTWG CCCCCEEECCCCCCC	28.84	30206219
447	Ubiquitination	WGYACSLKRRTWGHA CCCEEECCCCCCCCC	24.44	-
475	Ubiquitination	YGISVEDKKALHCYD CCEECCCCCCCCEEC	26.83	-
476	Ubiquitination	GISVEDKKALHCYDP CEECCCCCCCCEECC	69.38	-
491	Ubiquitination	VADQWEFKAPMSEPR CCCCEEEECCCCCCC	39.81	-
560	Ubiquitination	GCCLLERKIYIVGGY CEEEEEEEEEEEECC	30.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KLH26_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KLH26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KLH26_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KLH26_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KLH26_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]