dbPTM

KANL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KANL3_HUMAN
UniProt AC	Q9P2N6
Protein Name	KAT8 regulatory NSL complex subunit 3
Gene Name	KANSL3
Organism	Homo sapiens (Human).
Sequence Length	904
Subcellular Localization	Nucleus .
Protein Description	As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription..
Protein Sequence	MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQHESTIESDVPIDVETVTSTPMPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTMAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIASSGPSSSVFPTSRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHMGSEPRDQDAEKKKKPRDVARRDLAFEVPERGSRPASPAAKLPASPSGSEDLSSVSSSPTSSPKTKVTTVTSAQKSSQIGSSQLLKRHVQRTEAVLTHKQAQAQFAAFLKQNMLVRKALPPGTSSCLFVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSLISQGDTAGGPCAPSQGSAPEAAGGKPITMTLGQASAGAKELTGLLTTAKSSSSEGGVSASPVPSVVSSSTAPSALHTLQSRLVATSPGSSLPGATSASSLLQGLSFSLQDISSKTSGLPANPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAPSEESSSQVLPSSSQRLPPAP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MAHRGGERDFQ ----CCCCCCCCCHH	45.32	115480803
26	Phosphorylation	TSLLFQLSVHERELD CCHHHHEEECCCCCE	15.62	20068231
63	Phosphorylation	PTRMLFVTPRRQHES CCEEEEEECCCCCCC	12.07	21815630
74	Phosphorylation	QHESTIESDVPIDVE CCCCCCCCCCCCCEE	39.80	22468782
91	Phosphorylation	TSTPMPLYDNQKARS CCCCCCCCCCHHHHH	13.64	22468782
95	Ubiquitination	MPLYDNQKARSVMNE CCCCCCHHHHHHHHH	52.61	-
98	Phosphorylation	YDNQKARSVMNECER CCCHHHHHHHHHHHH	30.49	22468782
138	Ubiquitination	GWTMAQNKLFNKILK CHHHHHHHHHHHHHH	42.23	29967540
145	Ubiquitination	KLFNKILKALQSDRL HHHHHHHHHHHHHHH	50.99	29967540
151	Methylation	LKALQSDRLARLANE HHHHHHHHHHHHHHC	35.18	115480811
202	Phosphorylation	LHTTLVETLSLPMLA HHHHHHHHCCHHHHH	17.73	22210691
217	Phosphorylation	AYLDALQTLKGKIPT HHHHHHHHHCCCCCH	31.15	22210691
221	Ubiquitination	ALQTLKGKIPTLIDR HHHHHCCCCCHHHHH	43.88	33845483
232	Phosphorylation	LIDRMLVSSNTKTGA HHHHHHCCCCCCCCH	17.57	20068231
233	Phosphorylation	IDRMLVSSNTKTGAA HHHHHCCCCCCCCHH	40.83	20068231
235	Phosphorylation	RMLVSSNTKTGAAGA HHHCCCCCCCCHHHH	31.75	20068231
236	Ubiquitination	MLVSSNTKTGAAGAE HHCCCCCCCCHHHHH	49.57	-
237	Phosphorylation	LVSSNTKTGAAGAEA HCCCCCCCCHHHHHH	29.98	20068231
246	Phosphorylation	AAGAEALSLLLKRPW HHHHHHHHHHHCCCC	24.82	20068231
271	Phosphorylation	KPSKLPGSPLILIAS CCCCCCCCCEEEEEC	18.00	27050516
278	Phosphorylation	SPLILIASSGPSSSV CCEEEEECCCCCCCC	28.91	28122231
279	Phosphorylation	PLILIASSGPSSSVF CEEEEECCCCCCCCC	45.78	28122231
448	Phosphorylation	ISKAKKKSEGLTQSM CCCCHHHCCCCCHHH	45.86	19413330
452	Phosphorylation	KKKSEGLTQSMVDRC HHHCCCCCHHHHHHH	29.47	18669648
454	Phosphorylation	KSEGLTQSMVDRCIQ HCCCCCHHHHHHHHH	18.62	-
511	Phosphorylation	FEVPERGSRPASPAA CCCCCCCCCCCCCCC	41.11	23401153
515	Phosphorylation	ERGSRPASPAAKLPA CCCCCCCCCCCCCCC	20.11	23401153
519	Acetylation	RPASPAAKLPASPSG CCCCCCCCCCCCCCC	58.05	25953088
523	O-linked_Glycosylation	PAAKLPASPSGSEDL CCCCCCCCCCCCCCH	20.05	20068230
523	Phosphorylation	PAAKLPASPSGSEDL CCCCCCCCCCCCCCH	20.05	29255136
525	Phosphorylation	AKLPASPSGSEDLSS CCCCCCCCCCCCHHH	53.08	30266825
527	Phosphorylation	LPASPSGSEDLSSVS CCCCCCCCCCHHHCC	32.07	30266825
531	Phosphorylation	PSGSEDLSSVSSSPT CCCCCCHHHCCCCCC	40.80	30266825
532	O-linked_Glycosylation	SGSEDLSSVSSSPTS CCCCCHHHCCCCCCC	33.06	20068230
532	Phosphorylation	SGSEDLSSVSSSPTS CCCCCHHHCCCCCCC	33.06	30266825
534	O-linked_Glycosylation	SEDLSSVSSSPTSSP CCCHHHCCCCCCCCC	27.35	20068230
534	Phosphorylation	SEDLSSVSSSPTSSP CCCHHHCCCCCCCCC	27.35	30266825
535	Phosphorylation	EDLSSVSSSPTSSPK CCHHHCCCCCCCCCC	37.88	30266825
536	Phosphorylation	DLSSVSSSPTSSPKT CHHHCCCCCCCCCCC	25.37	25159151
538	Phosphorylation	SSVSSSPTSSPKTKV HHCCCCCCCCCCCEE	43.73	30266825
539	Phosphorylation	SVSSSPTSSPKTKVT HCCCCCCCCCCCEEE	48.29	30266825
540	Phosphorylation	VSSSPTSSPKTKVTT CCCCCCCCCCCEEEE	32.66	30266825
543	Phosphorylation	SPTSSPKTKVTTVTS CCCCCCCCEEEEEEC	33.85	28450419
547	Phosphorylation	SPKTKVTTVTSAQKS CCCCEEEEEECCHHH	25.44	29396449
549	Phosphorylation	KTKVTTVTSAQKSSQ CCEEEEEECCHHHCC	19.09	28348404
550	Phosphorylation	TKVTTVTSAQKSSQI CEEEEEECCHHHCCC	25.11	25159151
559	Phosphorylation	QKSSQIGSSQLLKRH HHHCCCCCHHHHHHH	19.28	22199227
560	Phosphorylation	KSSQIGSSQLLKRHV HHCCCCCHHHHHHHH	21.45	22199227
632	Phosphorylation	QLKRHHPSSPLPGSK HHHHHCCCCCCCCCC	39.98	27794612
633	Phosphorylation	LKRHHPSSPLPGSKT HHHHCCCCCCCCCCC	34.60	23401153
638	Phosphorylation	PSSPLPGSKTSKRPK CCCCCCCCCCCCCCC	30.71	26074081
639	Acetylation	SSPLPGSKTSKRPKI CCCCCCCCCCCCCCE	63.83	25953088
647	Acetylation	TSKRPKIKVSLISQG CCCCCCEEEEEEECC	31.71	26051181
649	Phosphorylation	KRPKIKVSLISQGDT CCCCEEEEEEECCCC	18.25	-
652	Phosphorylation	KIKVSLISQGDTAGG CEEEEEEECCCCCCC	33.14	-
675	Acetylation	APEAAGGKPITMTLG CCCHHCCCCEEEEEE	32.12	23749302
689	Acetylation	GQASAGAKELTGLLT ECHHCCHHHHHHHHH	52.95	11922899
700	Phosphorylation	GLLTTAKSSSSEGGV HHHHCCCCCCCCCCC	32.75	26074081
701	Phosphorylation	LLTTAKSSSSEGGVS HHHCCCCCCCCCCCC	36.86	26074081
702	Phosphorylation	LTTAKSSSSEGGVSA HHCCCCCCCCCCCCC	39.23	26074081
703	Phosphorylation	TTAKSSSSEGGVSAS HCCCCCCCCCCCCCC	42.06	26074081
708	Phosphorylation	SSSEGGVSASPVPSV CCCCCCCCCCCCCCC	26.72	26074081
710	Phosphorylation	SEGGVSASPVPSVVS CCCCCCCCCCCCCCC	20.94	20068231
714	Phosphorylation	VSASPVPSVVSSSTA CCCCCCCCCCCCCCC	35.07	26074081
717	Phosphorylation	SPVPSVVSSSTAPSA CCCCCCCCCCCCCHH	19.20	26074081
718	Phosphorylation	PVPSVVSSSTAPSAL CCCCCCCCCCCCHHH	21.79	20068231
719	Phosphorylation	VPSVVSSSTAPSALH CCCCCCCCCCCHHHH	22.53	26074081
720	Phosphorylation	PSVVSSSTAPSALHT CCCCCCCCCCHHHHH	44.53	26074081
723	Phosphorylation	VSSSTAPSALHTLQS CCCCCCCHHHHHHHH	40.78	26074081
727	Phosphorylation	TAPSALHTLQSRLVA CCCHHHHHHHHHHEE	27.61	26074081
730	Phosphorylation	SALHTLQSRLVATSP HHHHHHHHHHEECCC	30.60	26074081
735	Phosphorylation	LQSRLVATSPGSSLP HHHHHEECCCCCCCC	28.16	19690332
736	Phosphorylation	QSRLVATSPGSSLPG HHHHEECCCCCCCCC	19.95	28464451
739	Phosphorylation	LVATSPGSSLPGATS HEECCCCCCCCCCCC	31.89	19690332
740	Phosphorylation	VATSPGSSLPGATSA EECCCCCCCCCCCCH	44.49	19690332
745	Phosphorylation	GSSLPGATSASSLLQ CCCCCCCCCHHHHHH	30.64	27251275
746	Phosphorylation	SSLPGATSASSLLQG CCCCCCCCHHHHHHH	26.14	27251275
748	Phosphorylation	LPGATSASSLLQGLS CCCCCCHHHHHHHHC	22.68	27251275
749	Phosphorylation	PGATSASSLLQGLSF CCCCCHHHHHHHHCC	32.58	28464451
763	Phosphorylation	FSLQDISSKTSGLPA CCHHHHHHCCCCCCC	40.04	28634120
765	Phosphorylation	LQDISSKTSGLPANP HHHHHHCCCCCCCCC	29.94	28985074
773	Phosphorylation	SGLPANPSPGPAPQA CCCCCCCCCCCCCCC	42.15	25159151
781	Phosphorylation	PGPAPQATSVKLPTP CCCCCCCCCCCCCCC	28.89	29978859
782	Phosphorylation	GPAPQATSVKLPTPM CCCCCCCCCCCCCCC	21.92	29978859
796	O-linked_Glycosylation	MQSLGAITTGTSTIV CHHCCCEECCCCCEE	20.74	20068230
796	Phosphorylation	MQSLGAITTGTSTIV CHHCCCEECCCCCEE	20.74	28787133
797	O-linked_Glycosylation	QSLGAITTGTSTIVR HHCCCEECCCCCEEE	32.14	20068230
797	Phosphorylation	QSLGAITTGTSTIVR HHCCCEECCCCCEEE	32.14	28787133
801	Phosphorylation	AITTGTSTIVRTIPV CEECCCCCEEECCCC	24.27	28787133
805	O-linked_Glycosylation	GTSTIVRTIPVATTL CCCCEEECCCCCCCH	20.81	20068230
810	O-linked_Glycosylation	VRTIPVATTLSSLGA EECCCCCCCHHHCCC	28.62	20068230
811	O-linked_Glycosylation	RTIPVATTLSSLGAT ECCCCCCCHHHCCCC	18.20	20068230
822	Acetylation	LGATPGGKPTAIHQL CCCCCCCCCCHHHHH	45.14	26051181
824	O-linked_Glycosylation	ATPGGKPTAIHQLLT CCCCCCCCHHHHHHH	41.55	20068230
859	O-linked_Glycosylation	ASGLKVPTTITLTLR CCCCCCCEEEEEEEC	33.54	20068230
860	O-linked_Glycosylation	SGLKVPTTITLTLRG CCCCCCEEEEEEECC	13.09	20068230
862	Phosphorylation	LKVPTTITLTLRGQP CCCCEEEEEEECCCC	16.17	24961811
864	O-linked_Glycosylation	VPTTITLTLRGQPSR CCEEEEEEECCCCCE	13.03	20068230
864	Phosphorylation	VPTTITLTLRGQPSR CCEEEEEEECCCCCE	13.03	24961811
870	Phosphorylation	LTLRGQPSRITTLSP EEECCCCCEEEEEEC	28.55	22210691
873	Phosphorylation	RGQPSRITTLSPMGS CCCCCEEEEEECCCC	22.15	28450419
874	Phosphorylation	GQPSRITTLSPMGSG CCCCEEEEEECCCCC	23.90	28450419
876	Phosphorylation	PSRITTLSPMGSGAA CCEEEEEECCCCCCC	15.68	28450419
880	Phosphorylation	TTLSPMGSGAAPSEE EEEECCCCCCCCCCC	21.00	21815630
885	Phosphorylation	MGSGAAPSEESSSQV CCCCCCCCCCCCCCC	49.63	28450419
888	Phosphorylation	GAAPSEESSSQVLPS CCCCCCCCCCCCCCC	31.10	28450419
889	Phosphorylation	AAPSEESSSQVLPSS CCCCCCCCCCCCCCH	28.24	28450419
890	Phosphorylation	APSEESSSQVLPSSS CCCCCCCCCCCCCHH	33.32	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KANL3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KANL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KANL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KANL3_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KANL3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535; SER-536; THR-538;SER-539 AND SER-773, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523; SER-536 ANDSER-540, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, AND MASSSPECTROMETRY.	15302935 [Abstract]