ADCY3_HUMAN - dbPTM
ADCY3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADCY3_HUMAN
UniProt AC O60266
Protein Name Adenylate cyclase type 3
Gene Name ADCY3
Organism Homo sapiens (Human).
Sequence Length 1144
Subcellular Localization Cell membrane
Multi-pass membrane protein . Cytoplasm . Cell projection, cilium . Golgi apparatus . Also detected in the cytoplasm, close to lipid droplets.
Protein Description Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet..
Protein Sequence MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationQGFSEPEYSAEYSAE
CCCCCCCCCCEEEEE		24.7222817900
13PhosphorylationGFSEPEYSAEYSAEY
CCCCCCCCCEEEEEE		16.9868997691
16PhosphorylationEPEYSAEYSAEYSVS
CCCCCCEEEEEEEEE		16.9468997697
17PhosphorylationPEYSAEYSAEYSVSL
CCCCCEEEEEEEEEC		13.2168997703
20PhosphorylationSAEYSAEYSVSLPSD
CCEEEEEEEEECCCC		17.6827642862
21PhosphorylationAEYSAEYSVSLPSDP
CEEEEEEEEECCCCC		9.2027642862
23PhosphorylationYSAEYSVSLPSDPDR
EEEEEEEECCCCCCC		28.7327642862
39PhosphorylationVGRTHEISVRNSGSC
CCCEEEEEEECCCCE		16.4323911959
39UbiquitinationVGRTHEISVRNSGSC
CCCEEEEEEECCCCE		16.4321890473
61PhosphorylationRLTFVPESLENLYQT
HEEECHHHHHHHHHH		34.6168732283
272PhosphorylationKMNLEEQSQQQENLM
HCCHHHHHHHHHHHH		32.9827067055
281PhosphorylationQQENLMLSILPKHVA
HHHHHHHHHHHHHHH		14.2327067055
293UbiquitinationHVADEMLKDMKKDES
HHHHHHHHHHCCCCH		55.24-
309PhosphorylationKDQQQFNTMYMYRHE
HHHHHHHHHHHHHCC		15.8029083192
357UbiquitinationRFDKLAAKYHQLRIK
HHHHHHHHHHHHHEE		37.34-
406UbiquitinationSYVREKTKTGVDMRV
HHHHHHCCCCCCEEE		55.11-
407PhosphorylationYVREKTKTGVDMRVG
HHHHHCCCCCCEEEE		47.909891273
417PhosphorylationDMRVGVHTGTVLGGV
CEEEEEECCCCHHCH		31.949891285
419PhosphorylationRVGVHTGTVLGGVLG
EEEEECCCCHHCHHC		17.4546159581
428UbiquitinationLGGVLGQKRWQYDVW
HHCHHCCCCCEEEEE		54.5321890473
465UbiquitinationQSTMDCLKGEFDVEP
HHHHHHHCCCCCCCC		63.83-
485UbiquitinationRCDYLEEKGIETYLI
CCHHHHHCCCEEEEE		56.67-
523PhosphorylationGAPASSKSSSPALIE
CCCCCCCCCCCCEEE		37.6930266825
524PhosphorylationAPASSKSSSPALIET
CCCCCCCCCCCEEEE		44.0430266825
525PhosphorylationPASSKSSSPALIETK
CCCCCCCCCCEEEEC		22.6830266825
531PhosphorylationSSPALIETKEPNGSA
CCCCEEEECCCCCCC		33.4430266825
537PhosphorylationETKEPNGSAHSSGST
EECCCCCCCCCCCCC		29.4626471730
540PhosphorylationEPNGSAHSSGSTSEK
CCCCCCCCCCCCCCC		35.7926471730
541PhosphorylationPNGSAHSSGSTSEKP
CCCCCCCCCCCCCCH		27.2226471730
543PhosphorylationGSAHSSGSTSEKPEE
CCCCCCCCCCCCHHH		30.6126471730
544PhosphorylationSAHSSGSTSEKPEEQ
CCCCCCCCCCCHHHC		44.4226471730
545PhosphorylationAHSSGSTSEKPEEQD
CCCCCCCCCCHHHCC		45.3726471730
547UbiquitinationSSGSTSEKPEEQDAQ
CCCCCCCCHHHCCCC		58.45-
559PhosphorylationDAQADNPSFPNPRRR
CCCCCCCCCCCHHHH		60.6426471730
580PhosphorylationADRVVDASEDEHELN
HHHHCCCCCCHHHHH		40.9127422710
588UbiquitinationEDEHELNQLLNEALL
CCHHHHHHHHHHHHH		61.01-
591UbiquitinationHELNQLLNEALLERE
HHHHHHHHHHHHHHH		40.88-
633UbiquitinationVEKEKQSGAAFSCSC
CCHHHHCCCCHHHHH		20.5921890473
695PhosphorylationPKKLVAFSTWIDRTR
CHHHEEEECCCCHHH		17.0726270265
696PhosphorylationKKLVAFSTWIDRTRW
HHHEEEECCCCHHHH		21.7126270265
698UbiquitinationLVAFSTWIDRTRWAR
HEEEECCCCHHHHHH		2.3221890473
701PhosphorylationFSTWIDRTRWARNTW
EECCCCHHHHHHHHH		27.1526270265
707UbiquitinationRTRWARNTWAMLAIF
HHHHHHHHHHHHHHH		14.7321890473
736N-linked_GlycosylationQYYTGPSNATAGMET
HHHHCCCCCCCCCCC		44.43UniProtKB CARBOHYD
854PhosphorylationFLMMLSFYYFSRHVE
HHHHHHHHHHHHHHH		10.5424370023
857PhosphorylationMLSFYYFSRHVEKLA
HHHHHHHHHHHHHHH		12.8346159575
878UbiquitinationKIEVHDQKERVYEMR
EEEECCHHHHHHHHH		54.2521906983
879UbiquitinationIEVHDQKERVYEMRR
EEECCHHHHHHHHHH		41.5721890473
972PhosphorylationNPKFRVITKIKTIGS
CCCEEEEEEEEECCC		24.7024275569
979PhosphorylationTKIKTIGSTYMAASG
EEEEECCCCHHCCCC		16.7124275569
981PhosphorylationIKTIGSTYMAASGVT
EEECCCCHHCCCCCC		6.1030576142
985PhosphorylationGSTYMAASGVTPDVN
CCCHHCCCCCCCCCC		25.0230576142
998PhosphorylationVNTNGFASSNKEDKS
CCCCCCCCCCCCCHH		31.9830576142
1001UbiquitinationNGFASSNKEDKSERE
CCCCCCCCCCHHHHH		70.0521906983
1002UbiquitinationGFASSNKEDKSERER
CCCCCCCCCHHHHHH		74.9521890473
1005PhosphorylationSSNKEDKSERERWQH
CCCCCCHHHHHHHHH		54.9626437602
1046UbiquitinationMLRIGMNKGGVLAGV
HHEECCCCCCCEEEE		48.4221890473
1047UbiquitinationLRIGMNKGGVLAGVI
HEECCCCCCCEEEEE		26.8321890473
1076PhosphorylationNVASRMESTGVMGNI
EHHHHHHHCCCCCCE		22.558798667
1077PhosphorylationVASRMESTGVMGNIQ
HHHHHHHCCCCCCEE		22.0824043423
1089PhosphorylationNIQVVEETQVILREY
CEEEEEEEEHHHHHH		18.0324043423
1111UbiquitinationGPIFVKGKGELLTFF
CCEEEECCCEEEEEE		43.4221890473
1112UbiquitinationPIFVKGKGELLTFFL
CEEEECCCEEEEEEE		39.1821890473
1120UbiquitinationELLTFFLKGRDKLAT
EEEEEEEECCCCCCC		46.9021890473
1121UbiquitinationLLTFFLKGRDKLATF
EEEEEEECCCCCCCC		45.2021890473
1124UbiquitinationFFLKGRDKLATFPNG
EEEECCCCCCCCCCC		38.36-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1076SPhosphorylationKinaseCAMK2-FAMILY-GPS
1076SPhosphorylationKinaseCAMK2-Uniprot
1076SPhosphorylationKinaseCAM-KII_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
1076SPhosphorylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADCY3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ADCY3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D01697 Colforsin daropate hydrochloride (JAN); Nkh 477; Adehl (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADCY3_HUMAN

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Related Literatures of Post-Translational Modification

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