GCYB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCYB1_HUMAN
• UniProt AC: Q02153
• Protein Name: Guanylate cyclase soluble subunit beta-1 {ECO:0000305}
• Gene Name: GUCY1B1 {ECO:0000312|HGNC:HGNC:4687}
• Organism: Homo sapiens (Human).
• Sequence Length: 619
• Subcellular Localization: Cytoplasm .
• Protein Description: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP..
• Protein Sequence: MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Ubiquitination	PEVWEDIKKEAQLDE HHHHHHHHHHHCCCC	57.81	-
145	Ubiquitination	EREGLQDIVIGIIKT CCCCCHHHHHHHHHH	1.24	-
165	Ubiquitination	HGTEIDMKVIQQRNE HCCCCCHHHHHHHHH	32.22	-
192	Phosphorylation	ESKEEDFYEDLDRFE HHCCCCHHHCHHHHH	22.36	28796482
395	Phosphorylation	KKTDTLLYSVLPPSV HCCCEEEECCCCHHH	10.39	27067055
396	Phosphorylation	KTDTLLYSVLPPSVA CCCEEEECCCCHHHH	19.69	27067055
401	Phosphorylation	LYSVLPPSVANELRH EECCCCHHHHHHHHC	31.74	27067055
471	Ubiquitination	RKNPFVYKVETVGDK CCCCCEEEEEEECCC	28.44	-
540	Phosphorylation	IGQRMPRYCLFGNTV CCCCCCEEEEECCEE	6.40	-
541	Ubiquitination	GQRMPRYCLFGNTVN CCCCCEEEEECCEEE	2.40	-
561	Ubiquitination	ETTGEKGKINVSEYT EECCCCCEEEEHHEE	42.02	-
567	Phosphorylation	GKINVSEYTYRCLMS CEEEEHHEEEEEECC	11.10	-
574	Phosphorylation	YTYRCLMSPENSDPQ EEEEEECCCCCCCCC	19.00	29978859
578	Phosphorylation	CLMSPENSDPQFHLE EECCCCCCCCCCCCC	49.35	29978859
591	Phosphorylation	LEHRGPVSMKGKKEP CCCCCCCCCCCCCCC	20.22	29978859
609	Phosphorylation	WFLSRKNTGTEETKQ EEEEECCCCCCCCCC	48.82	28152594
611	Phosphorylation	LSRKNTGTEETKQDD EEECCCCCCCCCCCC	28.71	28152594
614	Phosphorylation	KNTGTEETKQDDD-- CCCCCCCCCCCCC--	27.98	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
192	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCYB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCYB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOS3_HUMAN	NOS3	physical	12676772
HS90A_HUMAN	HSP90AA1	physical	12676772
A4_HUMAN	APP	physical	21832049
GCYA2_HUMAN	GUCY1A2	physical	28514442
GCYA3_HUMAN	GUCY1A3	physical	28514442
MXRA7_HUMAN	MXRA7	physical	28514442
UACA_HUMAN	UACA	physical	28514442
MTFR2_HUMAN	MTFR2	physical	28514442
MYCB2_HUMAN	MYCBP2	physical	28514442
BBS2_HUMAN	BBS2	physical	28514442
MUL1_HUMAN	MUL1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.