MUL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MUL1_HUMAN
• UniProt AC: Q969V5
• Protein Name: Mitochondrial ubiquitin ligase activator of NFKB 1
• Gene Name: MUL1
• Organism: Homo sapiens (Human).
• Sequence Length: 352
• Subcellular Localization: Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.
• Protein Description: Exhibits weak E3 ubiquitin-protein ligase activity. [PubMed: 18591963]
• Protein Sequence: MESGGRPSLCQFILLGTTSVVTAALYSVYRQKARVSQELKGAKKVHLGEDLKSILSEAPGKCVPYAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQRTNTVPFDLVPHEDGVDVAVRVLKPLDSVDLGLETVYEKFHPSIQSFTDVIGHYISGERPKGIQETEEMLKVGATLTGVGELVLDNNSVRLQPPKQGMQYYLSSQDFDSLLQRQESSVRLWKVLALVFGFATCATLFFILRKQYLQRQERLRLKQMQEEFQEHEAQLLSRAKPEDRESLKSACVVCLSSFKSCVFLECGHVCSCTECYRALPEPKKCPICRQAITRVIPLYNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESGGRPSLC -----CCCCCCCCHH	45.29	-
44	Ubiquitination	QELKGAKKVHLGEDL HHHCCCCEEECCHHH	34.06	-
52	Ubiquitination	VHLGEDLKSILSEAP EECCHHHHHHHHCCC	48.01	25621951
56	Phosphorylation	EDLKSILSEAPGKCV HHHHHHHHCCCCCCC	30.00	29449344
76	Ubiquitination	EGAVRSVKETLNSQF HHHHHHHHHHHHHHH	46.35	-
88	Ubiquitination	SQFVENCKGVIQRLT HHHHHHCHHHHHHHH	68.73	-
115	Ubiquitination	HLWNDCSKIIHQRTN HHHHHHHHHHHHCCC	52.60	-
143	Ubiquitination	DVAVRVLKPLDSVDL CEEEEEECCCCCCCC	40.45	21890473
154	Phosphorylation	SVDLGLETVYEKFHP CCCCCHHHHHHHHCH	33.17	20071362
156	Phosphorylation	DLGLETVYEKFHPSI CCCHHHHHHHHCHHH	22.33	20071362
214	Ubiquitination	SVRLQPPKQGMQYYL CEEECCCCCCHHHHH	67.19	21890473
273	Ubiquitination	RQERLRLKQMQEEFQ HHHHHHHHHHHHHHH	36.97	21890473
291	Ubiquitination	AQLLSRAKPEDRESL HHHHHHCCHHHHHHH	48.07	-
297	Phosphorylation	AKPEDRESLKSACVV CCHHHHHHHHHHHHH	41.83	26437602
299	Ubiquitination	PEDRESLKSACVVCL HHHHHHHHHHHHHHH	45.33	25621951
308	Phosphorylation	ACVVCLSSFKSCVFL HHHHHHHCCCCCEEE	24.60	26546556
311	Phosphorylation	VCLSSFKSCVFLECG HHHHCCCCCEEEECC	17.32	-
350	Phosphorylation	ITRVIPLYNS----- HHHHHHCCCC-----	14.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MUL1	Q969V5	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MUL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MUL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS35_HUMAN	VPS35	physical	20619655
VP26A_HUMAN	VPS26A	physical	20619655
UBC_HUMAN	UBC	physical	19407830
SUMO1_HUMAN	SUMO1	physical	19407830
UBC9_HUMAN	UBE2I	physical	19407830
DNM1L_HUMAN	DNM1L	physical	19407830
AKT1_HUMAN	AKT1	physical	22410793
P53_HUMAN	TP53	physical	21597459
UB2D2_HUMAN	UBE2D2	physical	19407830
UB2D1_HUMAN	UBE2D1	physical	21597459
UB2D3_HUMAN	UBE2D3	physical	21597459
APBP2_HUMAN	APPBP2	physical	19060904
TAP1_HUMAN	TAP1	physical	21988832
MUL1_HUMAN	MUL1	physical	18213395
UB2D2_HUMAN	UBE2D2	physical	18213395
UB2E2_HUMAN	UBE2E2	physical	25224329
UB2E3_HUMAN	UBE2E3	physical	25224329
UB2G2_HUMAN	UBE2G2	physical	25224329
UB2L3_HUMAN	UBE2L3	physical	25224329
TRIM9_HUMAN	TRIM9	physical	25416956
ULK1_HUMAN	ULK1	physical	26018823
UB2D1_HUMAN	UBE2D1	physical	26018823
P73_HUMAN	TP73	physical	26435500
M3K7_HUMAN	MAP3K7	physical	27082251
STING_HUMAN	TMEM173	physical	28763789
UB2D1_HUMAN	UBE2D1	physical	28763789
UB2D2_HUMAN	UBE2D2	physical	28763789
UB2D3_HUMAN	UBE2D3	physical	28763789
UB2D4_HUMAN	UBE2D4	physical	28763789
UB2E1_HUMAN	UBE2E1	physical	28763789
UBE2N_HUMAN	UBE2N	physical	28763789
UB2R1_HUMAN	CDC34	physical	28763789
UB2R2_HUMAN	UBE2R2	physical	28763789
UB2V2_HUMAN	UBE2V2	physical	28763789

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.