TAP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAP1_HUMAN
• UniProt AC: Q03518
• Protein Name: Antigen peptide transporter 1
• Gene Name: TAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 808
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. The transmembrane segments seem to form a pore in the membrane.
• Protein Description: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules..
• Protein Sequence: MAELLASAGSACSWDFPRAPPSFPPPAASRGGLGGTRSFRPHRGAESPRPGRDRDGVRVPMASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Methylation	FPPPAASRGGLGGTR CCCCCHHCCCCCCCC	38.17	54559851
37	Methylation	RGGLGGTRSFRPHRG CCCCCCCCCCCCCCC	36.75	54559855
47	Phosphorylation	RPHRGAESPRPGRDR CCCCCCCCCCCCCCC	26.19	20860994
63	O-linked_Glycosylation	GVRVPMASSRCPAPR CCCCCCCCCCCCCCC	16.44	30379171
63	Phosphorylation	GVRVPMASSRCPAPR CCCCCCCCCCCCCCC	16.44	28102081
64	Phosphorylation	VRVPMASSRCPAPRG CCCCCCCCCCCCCCC	28.50	28102081
229	Phosphorylation	VPGGQGGSGNPVRRL CCCCCCCCCCHHHHH	42.07	22210691
422	Ubiquitination	QVRESLAKSSQVAIE HHHHHHHHHCHHHHH	56.80	-
423	Phosphorylation	VRESLAKSSQVAIEA HHHHHHHHCHHHHHH	22.01	28857561
424	Phosphorylation	RESLAKSSQVAIEAL HHHHHHHCHHHHHHH	28.15	30108239
434	Sulfoxidation	AIEALSAMPTVRSFA HHHHHHCCHHHHHHC	2.28	21406390
436	Phosphorylation	EALSAMPTVRSFANE HHHHCCHHHHHHCCC	18.57	24719451
439	Phosphorylation	SAMPTVRSFANEEGE HCCHHHHHHCCCCHH	25.11	30108239
449	2-Hydroxyisobutyrylation	NEEGEAQKFREKLQE CCCHHHHHHHHHHHH	54.13	-
449	Ubiquitination	NEEGEAQKFREKLQE CCCHHHHHHHHHHHH	54.13	21890473
453	Ubiquitination	EAQKFREKLQEIKTL HHHHHHHHHHHHHCC	51.74	-
458	Ubiquitination	REKLQEIKTLNQKEA HHHHHHHHCCCHHHH	46.32	21890473
458	2-Hydroxyisobutyrylation	REKLQEIKTLNQKEA HHHHHHHHCCCHHHH	46.32	-
530	2-Hydroxyisobutyrylation	SIYPRVQKAVGSSEK HHHHHHHHHHCCHHH	42.03	-
537	Ubiquitination	KAVGSSEKIFEYLDR HHHCCHHHHHHHHHC	55.43	21890473
541	Phosphorylation	SSEKIFEYLDRTPRC CHHHHHHHHHCCCCC	11.80	23403867
545	Phosphorylation	IFEYLDRTPRCPPSG HHHHHHCCCCCCCCC	18.10	22617229
587	Phosphorylation	VLQGLTFTLRPGEVT EEECEEEEECCCEEE	19.34	24719451
627	Ubiquitination	GQLLLDGKPLPQYEH CEEEECCEECCCCCH	42.94	-
666	Ubiquitination	IAYGLTQKPTMEEIT HHCCCCCCCCHHHHH	36.90	21890473
668	Phosphorylation	YGLTQKPTMEEITAA CCCCCCCCHHHHHHH	44.22	28348404
679	Phosphorylation	ITAAAVKSGAHSFIS HHHHHHHCCCCHHHC	34.31	27080861
683	Phosphorylation	AVKSGAHSFISGLPQ HHHCCCCHHHCCCCC	24.60	27080861
694	Phosphorylation	GLPQGYDTEVDEAGS CCCCCCCCCCCHHHH	29.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR412_HUMAN	KRTAP4-12	physical	16189514
HLAG_HUMAN	HLA-G	physical	9103419
PDIA3_HUMAN	PDIA3	physical	9545232
TAP2_HUMAN	TAP2	physical	11381133
COPB_HUMAN	COPB1	physical	11884415
COPG1_HUMAN	COPG1	physical	11884415
TPSN_HUMAN	TAPBP	physical	11884415
1A02_HUMAN	HLA-A	physical	11884415
1A03_HUMAN	HLA-A	physical	11884415
1A01_HUMAN	HLA-A	physical	11884415
1A26_HUMAN	HLA-A	physical	11884415
TAP2_HUMAN	TAP2	physical	17055437
CALR_HUMAN	CALR	physical	17055437
PDIA3_HUMAN	PDIA3	physical	17055437
PDIA2_HUMAN	PDIA2	physical	17055437
TPSN_HUMAN	TAPBP	physical	17055437
B2MG_HUMAN	B2M	physical	17055437
1A02_HUMAN	HLA-A	physical	17055437
1A03_HUMAN	HLA-A	physical	17055437
1A01_HUMAN	HLA-A	physical	17055437
1A26_HUMAN	HLA-A	physical	17055437
PSB8_HUMAN	PSMB8	physical	15488952
TYDP2_HUMAN	TDP2	physical	21988832
CALR_HUMAN	CALR	physical	11823531
PDIA3_HUMAN	PDIA3	physical	11823531
1B07_HUMAN	HLA-B	physical	11823531
1B18_HUMAN	HLA-B	physical	11823531
TPSN_HUMAN	TAPBP	physical	11823531
CALX_HUMAN	CANX	physical	11823531

Drug and Disease Associations

• Kegg Disease
• H00093: Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndro
• H00984: Bare lymphocyte syndrome (BLS) type1
• OMIM Disease
• 604571: Bare lymphocyte syndrome 1 (BLS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01259: Lapatinib