| UniProt ID | PDIA2_HUMAN | |
|---|---|---|
| UniProt AC | Q13087 | |
| Protein Name | Protein disulfide-isomerase A2 | |
| Gene Name | PDIA2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 525 | |
| Subcellular Localization | Endoplasmic reticulum lumen . | |
| Protein Description | Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.. | |
| Protein Sequence | MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEELGLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 48 | Phosphorylation | EDGILVLSRHTLGLA CCCEEEECCHHHHHH | 17.97 | 24719451 | |
| 127 | N-linked_Glycosylation | LKFFRNGNRTHPEEY EECCCCCCCCCHHHH | 49.58 | 23167757 | |
| 260 | Phosphorylation | THSMRLVTEFNSQTS HCHHHHHHHCCHHHH | 39.18 | 29083192 | |
| 264 | Phosphorylation | RLVTEFNSQTSAKIF HHHHHCCHHHHHHHH | 39.91 | 29083192 | |
| 266 | Phosphorylation | VTEFNSQTSAKIFAA HHHCCHHHHHHHHHH | 30.39 | 29083192 | |
| 267 | Phosphorylation | TEFNSQTSAKIFAAR HHCCHHHHHHHHHHH | 21.67 | 29083192 | |
| 284 | N-linked_Glycosylation | NHLLLFVNQTLAAHR HHHHHHHHHHHHHHH | 23.06 | 23167757 | |
| 286 | Phosphorylation | LLLFVNQTLAAHREL HHHHHHHHHHHHHHH | 17.11 | - | |
| 478 | Phosphorylation | PGRKVIEYKSTRDLE CCCEEEEECCCCCHH | 10.10 | 30576142 | |
| 479 | Acetylation | GRKVIEYKSTRDLET CCEEEEECCCCCHHH | 32.34 | 20167786 | |
| 481 | Phosphorylation | KVIEYKSTRDLETFS EEEEECCCCCHHHHH | 24.85 | 30576142 | |
| 516 | N-linked_Glycosylation | PFPEPPANSTMGSKE CCCCCCCCCCCCCCC | 43.73 | 23167757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PDIA2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PDIA2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PDIA2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| P4HA3_HUMAN | P4HA3 | physical | 14500733 | |
| HM13_HUMAN | HM13 | physical | 19942855 | |
| ERO1A_HUMAN | ERO1L | physical | 10970843 | |
| P4HTM_HUMAN | P4HTM | physical | 12485997 | |
| CO2A1_HUMAN | COL2A1 | physical | 12485997 | |
| SMS_HUMAN | SST | physical | 15590633 | |
| ENV_HV1H2 | env | physical | 20458450 | |
| ERO1A_HUMAN | ERO1L | physical | 25258311 | |
| MTP_HUMAN | MTTP | physical | 25108285 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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