P4HA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P4HA3_HUMAN
• UniProt AC: Q7Z4N8
• Protein Name: Prolyl 4-hydroxylase subunit alpha-3
• Gene Name: P4HA3
• Organism: Homo sapiens (Human).
• Sequence Length: 544
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins..
• Protein Sequence: MGPGARLAALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYDKVLSLHEDSTTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEKVEQDLPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLYSPDNKRMARNVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIALYHDFVSDSEAQKIRELAEPWLQRSVVASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMKSGNRVATFMIYLSSVEAGGATAFIYANLSVPVVRNAALFWWNLHRSGEGDSDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPCSSSPED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Phosphorylation	IRALKDGYEKVEQDL HHHHHHHHHHHHHCC	23.78	22210691
147	Phosphorylation	LMRLQDVYMLNVKGL HHHHHHEEEECHHHH	12.27	-
171	Phosphorylation	GSAITDLYSPKRLFS CCHHHHCCCCHHHHC	26.24	18083107
172	Phosphorylation	SAITDLYSPKRLFSL CHHHHCCCCHHHHCC	31.10	24719451
192	Phosphorylation	FQVGKVAYDMGDYYH CCCCCEEEECCCHHH	14.95	24043423
197	Phosphorylation	VAYDMGDYYHAIPWL EEEECCCHHHHHHHH	7.45	24043423
198	Phosphorylation	AYDMGDYYHAIPWLE EEECCCHHHHHHHHH	6.90	24043423
209	Phosphorylation	PWLEEAVSLFRGSYG HHHHHHHHHHCCCCC	28.92	24043423
242	N-linked_Glycosylation	FAYFRAGNVSCALSL HHHHHCCCHHHEEEE	22.88	UniProtKB CARBOHYD
248	Phosphorylation	GNVSCALSLSREFLL CCHHHEEEECHHHHH	13.03	24719451
250	Phosphorylation	VSCALSLSREFLLYS HHHEEEECHHHHHCC	26.79	17081983
482	N-linked_Glycosylation	ATAFIYANLSVPVVR CEEEEEECCCCCCCC	18.84	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P4HA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P4HA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P4HA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDIA2_HUMAN	PDIA2	physical	14500733
WDR62_HUMAN	WDR62	physical	25416956
ZBT7B_HUMAN	ZBTB7B	physical	28514442
KI21A_HUMAN	KIF21A	physical	28514442
PKCB1_HUMAN	ZMYND8	physical	28514442
KMT2B_HUMAN	KMT2B	physical	28514442
ZN687_HUMAN	ZNF687	physical	28514442
AGAP1_HUMAN	AGAP1	physical	28514442
SATB1_HUMAN	SATB1	physical	28514442
PWP2A_HUMAN	PWWP2A	physical	28514442
SLBP_HUMAN	SLBP	physical	28514442
F120C_HUMAN	FAM120C	physical	28514442
PPHLN_HUMAN	PPHLN1	physical	28514442
ZN787_HUMAN	ZNF787	physical	28514442
F1712_HUMAN	FAM171A2	physical	28514442
PATZ1_HUMAN	PATZ1	physical	28514442
RSRC2_HUMAN	RSRC2	physical	28514442
HASP_HUMAN	GSG2	physical	28514442
SRCAP_HUMAN	SRCAP	physical	28514442
FBRS_HUMAN	FBRS	physical	28514442
RB15B_HUMAN	RBM15B	physical	28514442
CSKI2_HUMAN	CASKIN2	physical	28514442
NF2IP_HUMAN	NFATC2IP	physical	28514442
YLPM1_HUMAN	YLPM1	physical	28514442
ZN592_HUMAN	ZNF592	physical	28514442
ZNHI1_HUMAN	ZNHIT1	physical	28514442
ZN579_HUMAN	ZNF579	physical	28514442
WDR33_HUMAN	WDR33	physical	28514442
ARP6_HUMAN	ACTR6	physical	28514442
NF1_HUMAN	NF1	physical	28514442
CAF1A_HUMAN	CHAF1A	physical	28514442
FXR2_HUMAN	FXR2	physical	28514442
DMAP1_HUMAN	DMAP1	physical	28514442
TIGD5_HUMAN	TIGD5	physical	28514442
VPS72_HUMAN	VPS72	physical	28514442
MTCL1_HUMAN	MTCL1	physical	28514442
TRPS1_HUMAN	TRPS1	physical	28514442
SESD1_HUMAN	SESTD1	physical	28514442
ASPP2_HUMAN	TP53BP2	physical	28514442
PWP2B_HUMAN	PWWP2B	physical	28514442
ZN444_HUMAN	ZNF444	physical	28514442
SF01_HUMAN	SF1	physical	28514442
SRRM1_HUMAN	SRRM1	physical	28514442
DISC1_HUMAN	DISC1	physical	28514442
PDIA1_HUMAN	P4HB	physical	28514442
UBR5_HUMAN	UBR5	physical	28514442
DEFM_HUMAN	PDF	physical	28514442
TSC2_HUMAN	TSC2	physical	28514442
PEX14_HUMAN	PEX14	physical	28514442
ZN318_HUMAN	ZNF318	physical	28514442
B2L11_HUMAN	BCL2L11	physical	28514442
YETS4_HUMAN	YEATS4	physical	28514442
SCRIB_HUMAN	SCRIB	physical	28514442
SIX1_HUMAN	SIX1	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.