dbPTM

ZN318_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN318_HUMAN
UniProt AC	Q5VUA4
Protein Name	Zinc finger protein 318
Gene Name	ZNF318
Organism	Homo sapiens (Human).
Sequence Length	2279
Subcellular Localization	Nucleus .
Protein Description	Isoform 2: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.; Isoform 1: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division..
Protein Sequence	MYRSSARSSVSSHRPKDDGGGGPRSGRSSGSSSGPARRSSPPPPPSGSSSRTPARRPRSPSGHRGRRASPSPPRGRRVSPSPPRARRGSPSPPRGRRLFPPGPAGFRGSSRGESRADYARDGRGDHPGDSGSRRRSPGLCSDSLEKSLRITVGNDHFCVSTPERRRLSDRLGSPVDNLEDMDRDDLTDDSVFTRSSQCSRGLERYISQEEGPLSPFLGQLDEDYRTKETFLHRSDYSPHISCHDELLRGTERNREKLKGYSIRSEERSREAKRPRYDDTVKINSMGGDHPSFTSGTRNYRQRRRSPSPRFLDPEFRELDLARRKREEEEERSRSLSQELVGVDGGGTGCSIPGLSGVLTASEPGYSLHRPEEVSVMPKKSILKKRIEVDIMEPSMQLESFSSSTSSSQDHPLYSGHPSLPLSGAIAAFASEIENKGTMVETALKEPQGNLYQWGPLPGIPKDNSPLREKFGSFLCHKDNLDLKAEGPERHTDFLLPHERASQDGSGFSRILSMLADSTSTQEKRRRSFPDIEDEEKFLYGDEEEDLKAESVPKPLGSSESEVMRQKASSLPSSAPAVKLESLEETNPEYAKIHDLLKTIGLDIGVAEISQLAARTQERLHGKKPSLRSSADRRSSVDRYFSADHCSSVDHRFSADRCSSVDHCFSADRRSSDPHRLESREAHHSNTHSPEVSHPHPPSPVDPYLLTKNSPPFLKSDHPVGHISGPEVVGSGFQSSVAVRCMLPSAPSAPIRLPHTAALSQFHMPRASQFAAARIPPNYQGPAIPPASFDAYRHYMAYAASRWPMYPTSQPSNHPVPEPHRIMPITKQATRSRPNLRVIPTVTPDKPKQKESLRGSIPAAQVPVQVSIPSLIRYNPEKISDEKNRASQKQKVIEEREKLKNDREARQKKMYYLRTELERLHKQQGEMLRKKRREKDGHKDPLLVEVSRLQDNIMKDIAELRQEAEEAEKKQSELDKVAQILGINIFDKSQKSLSDSREPTEKPGKAEKSKSPEKVSSFSNSSSNKESKVNNEKFRTKSPKPAESPQSATKQLDQPTAAYEYYDAGNHWCKDCNTICGTMFDFFTHMHNKKHTQTLDPYNRPWASKTQSEAKQDAIKRTDKITVPAKGSEFLVPISGFYCQLCEEFLGDPISGEQHVKGHQHNEKYKKYVDENPLYEERRNLDRQAGLAVVLETERRRQSELKRKLSEKPKEEKKEKKAKAVKEVKEDDKVSEKLEDQLSEGRNSPEKAENKRNTGIKLQLKEEVKKESPTSSSFGKFSWKKPEKEEEKSSLVTPSISKEEILESSKDKEDGKTEAGKAKPIKIKLSGKTVVAHTSPWMPVVTTSTQTKIRPNLPIPSTVLRKSCSATMSKPAPLNTFLSIKSSGTTAKPLPVVKESSADLLLPPDIISKAFGGEEVILKGSPEEKVVLAEKSEPSHLPEQILPPPPPPPPPPPPPPPVIPHPAAPSAAQANAILAPVKSNPVVSQTLSPGFVGPNILNPVLPVAIMASAQPAAIPSDETAPGVSESDRDQTLFSVLVRPPPPLSSVFSEQAKKLEKRNSCLATANAKDLYDIFYSSGGKGAPETKGAPETKLSGGPLANGENSNLSRTKSSDTSSTSPLNSSASQEELHQDEGLVAAPIVSNSEKPIAKTLVALGKWSVVEHVGPKSTGSTYGFLQPLTRLCQSRPYETITPKTDTLAIWTSSSFQSDTSRDISPEKSELDLGEPGPPGVEPPPQLLDIQCKESQKLVEIHLRESVNQDKESQELRKSEDCRESEIETNTELKERVKELSEGIVDEGVSTSIGPHSIDDSNLNHGNRYMWEGEVKQPNLLMIDKEAEQSNKLMTGSETPSKVVIKLSPQACSFTKAKLDSFLSEARSLLNPQDTPVKISAPELLLHSPARSAMCLTGSPQEQGVSVVSEEGLENSAPESASRTSRYRSLKLKRERSKDFQVKKIYELAVWDENKKRPETWESPEKPKTEALELQDVHPELTVTIESKALEDFEATDLKVEELTALGNLGDMPVDFCTTRVSPAHRSPTVLCQKVCEENSVSPIGCNSSDPADFEPIPSFSGFPLDSPKTLVLDFETEGERNSPNPRSVRIPSPNILKTGLTENVDRGLGGLEGTHQALDLLAGGMMPEEVKESSQLDKQESLGLELKTINSAGLGPSPCLPDLVDFVTRTSGVQKDKLCSPLSEPGDPSKCSSLELGPLQLEISNASTTEVAILQVDDDSGDPLNLVKAPVSRSPPREQVIEDNMVPQGMPEQETTVGAIQDHTESSVHN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MYRSSARSSVS ----CCCCCCCCHHC	27.71	30631047
8	Phosphorylation	MYRSSARSSVSSHRP CCCCCCCCHHCCCCC	34.50	26074081
9	Phosphorylation	YRSSARSSVSSHRPK CCCCCCCHHCCCCCC	22.06	26074081
25	Phosphorylation	DGGGGPRSGRSSGSS CCCCCCCCCCCCCCC	41.51	18669648
34	Phosphorylation	RSSGSSSGPARRSSP CCCCCCCCCCCCCCC	23.10	18669648
39	Phosphorylation	SSGPARRSSPPPPPS CCCCCCCCCCCCCCC	41.46	23401153
40	Phosphorylation	SGPARRSSPPPPPSG CCCCCCCCCCCCCCC	39.35	23927012
40 (in isoform 2)	Phosphorylation	-	39.35	21406692
46	Phosphorylation	SSPPPPPSGSSSRTP CCCCCCCCCCCCCCC	58.02	23927012
48	Phosphorylation	PPPPPSGSSSRTPAR CCCCCCCCCCCCCCC	29.49	30278072
48 (in isoform 2)	Phosphorylation	-	29.49	21406692
49	Phosphorylation	PPPPSGSSSRTPARR CCCCCCCCCCCCCCC	27.62	30278072
49 (in isoform 2)	Phosphorylation	-	27.62	21406692
50	Phosphorylation	PPPSGSSSRTPARRP CCCCCCCCCCCCCCC	41.70	23927012
52	Phosphorylation	PSGSSSRTPARRPRS CCCCCCCCCCCCCCC	24.21	30576142
59	Phosphorylation	TPARRPRSPSGHRGR CCCCCCCCCCCCCCC	26.54	30576142
61	Phosphorylation	ARRPRSPSGHRGRRA CCCCCCCCCCCCCCC	48.77	30576142
69	Phosphorylation	GHRGRRASPSPPRGR CCCCCCCCCCCCCCC	24.89	20164059
71	Phosphorylation	RGRRASPSPPRGRRV CCCCCCCCCCCCCCC	45.07	20164059
79	Phosphorylation	PPRGRRVSPSPPRAR CCCCCCCCCCCCCCC	20.18	29255136
79 (in isoform 2)	Phosphorylation	-	20.18	21406692
81	Phosphorylation	RGRRVSPSPPRARRG CCCCCCCCCCCCCCC	39.78	29255136
81 (in isoform 2)	Phosphorylation	-	39.78	21406692
89	Phosphorylation	PPRARRGSPSPPRGR CCCCCCCCCCCCCCC	22.01	22167270
89 (in isoform 2)	Phosphorylation	-	22.01	21406692
91	Phosphorylation	RARRGSPSPPRGRRL CCCCCCCCCCCCCCC	49.59	22167270
91 (in isoform 2)	Phosphorylation	-	49.59	21406692
107	Methylation	PPGPAGFRGSSRGES CCCCCCCCCCCCCCC	43.07	54560835
109	Phosphorylation	GPAGFRGSSRGESRA CCCCCCCCCCCCCHH	16.77	20068231
110	Phosphorylation	PAGFRGSSRGESRAD CCCCCCCCCCCCHHH	47.32	23186163
136	Phosphorylation	DSGSRRRSPGLCSDS CCCCCCCCCCCCCCC	22.85	19664994
136 (in isoform 2)	Phosphorylation	-	22.85	21406692
141	Phosphorylation	RRSPGLCSDSLEKSL CCCCCCCCCCHHHHC	34.96	22167270
141 (in isoform 2)	Phosphorylation	-	34.96	21406692
143	Phosphorylation	SPGLCSDSLEKSLRI CCCCCCCCHHHHCCE	23.33	22167270
151	Phosphorylation	LEKSLRITVGNDHFC HHHHCCEEECCCCEE	18.87	23403867
160	Phosphorylation	GNDHFCVSTPERRRL CCCCEECCCHHHHHH	39.15	23401153
161	Phosphorylation	NDHFCVSTPERRRLS CCCEECCCHHHHHHH	14.58	23401153
168	Phosphorylation	TPERRRLSDRLGSPV CHHHHHHHHHHCCCC	20.90	20363803
168 (in isoform 2)	Phosphorylation	-	20.90	21406692
173	Phosphorylation	RLSDRLGSPVDNLED HHHHHHCCCCCCHHH	26.75	29255136
173 (in isoform 2)	Phosphorylation	-	26.75	21406692
187	Phosphorylation	DMDRDDLTDDSVFTR HCCCCCCCCCCHHHC	44.76	30266825
190	Phosphorylation	RDDLTDDSVFTRSSQ CCCCCCCCHHHCHHH	23.18	30266825
193	Phosphorylation	LTDDSVFTRSSQCSR CCCCCHHHCHHHHHH	27.73	20873877
199	Phosphorylation	FTRSSQCSRGLERYI HHCHHHHHHHHHHHH	23.03	22798277
205	Phosphorylation	CSRGLERYISQEEGP HHHHHHHHHCCCCCC	8.78	28102081
207	Phosphorylation	RGLERYISQEEGPLS HHHHHHHCCCCCCCC	23.70	25159151
214	Phosphorylation	SQEEGPLSPFLGQLD CCCCCCCCHHHCCCC	19.42	25159151
234	Phosphorylation	KETFLHRSDYSPHIS CCHHCCCCCCCCCCC	30.10	23927012
236	Phosphorylation	TFLHRSDYSPHISCH HHCCCCCCCCCCCHH	25.91	23927012
237	Phosphorylation	FLHRSDYSPHISCHD HCCCCCCCCCCCHHH	18.26	23401153
241	Phosphorylation	SDYSPHISCHDELLR CCCCCCCCHHHHHHH	11.45	23403867
261	Phosphorylation	REKLKGYSIRSEERS HHHHCCCCCCCHHHH	21.86	24719451
264	Phosphorylation	LKGYSIRSEERSREA HCCCCCCCHHHHHHC	41.98	25159151
268	Phosphorylation	SIRSEERSREAKRPR CCCCHHHHHHCCCCC	37.44	28258704
276	Phosphorylation	REAKRPRYDDTVKIN HHCCCCCCCCCEECC	22.36	28258704
279	Phosphorylation	KRPRYDDTVKINSMG CCCCCCCCEECCCCC	22.32	28258704
281	Sumoylation	PRYDDTVKINSMGGD CCCCCCEECCCCCCC	37.96	-
281	Sumoylation	PRYDDTVKINSMGGD CCCCCCEECCCCCCC	37.96	-
284	Phosphorylation	DDTVKINSMGGDHPS CCCEECCCCCCCCCC	23.44	17081983
291	Phosphorylation	SMGGDHPSFTSGTRN CCCCCCCCCCCCCCC	37.42	25332170
293	Phosphorylation	GGDHPSFTSGTRNYR CCCCCCCCCCCCCHH	30.50	28555341
294	Phosphorylation	GDHPSFTSGTRNYRQ CCCCCCCCCCCCHHH	35.84	-
296	Phosphorylation	HPSFTSGTRNYRQRR CCCCCCCCCCHHHHC	18.60	-
305	Phosphorylation	NYRQRRRSPSPRFLD CHHHHCCCCCCCCCC	28.11	27273156
307	Phosphorylation	RQRRRSPSPRFLDPE HHHCCCCCCCCCCHH	29.92	27273156
332	Phosphorylation	REEEEERSRSLSQEL HHHHHHHHHHHHHHH	29.51	28348404
334	Phosphorylation	EEEERSRSLSQELVG HHHHHHHHHHHHHHC	33.35	22210691
336	Phosphorylation	EERSRSLSQELVGVD HHHHHHHHHHHHCCC	23.90	22210691
380	Phosphorylation	VSVMPKKSILKKRIE CCCCCCHHHHHHHEE	39.00	24719451
444	Ubiquitination	TMVETALKEPQGNLY CCCHHHHCCCCCCCC	65.96	29967540
451	Phosphorylation	KEPQGNLYQWGPLPG CCCCCCCCCCCCCCC	13.25	21945579
461	Ubiquitination	GPLPGIPKDNSPLRE CCCCCCCCCCCHHHH	68.56	29967540
464	Phosphorylation	PGIPKDNSPLREKFG CCCCCCCCHHHHHHH	35.13	28355574
464 (in isoform 2)	Phosphorylation	-	35.13	21406692
472	Phosphorylation	PLREKFGSFLCHKDN HHHHHHHHCCCCCCC	20.41	23917254
477	Ubiquitination	FGSFLCHKDNLDLKA HHHCCCCCCCCCCCC	47.52	32015554
483	Sumoylation	HKDNLDLKAEGPERH CCCCCCCCCCCCCCC	44.02	-
483	Sumoylation	HKDNLDLKAEGPERH CCCCCCCCCCCCCCC	44.02	-
483	Ubiquitination	HKDNLDLKAEGPERH CCCCCCCCCCCCCCC	44.02	29967540
491	Phosphorylation	AEGPERHTDFLLPHE CCCCCCCCCCCCCCC	34.37	20068231
501	Phosphorylation	LLPHERASQDGSGFS CCCCCHHCCCCCHHH	34.72	23401153
501 (in isoform 2)	Phosphorylation	-	34.72	21406692
505	Phosphorylation	ERASQDGSGFSRILS CHHCCCCCHHHHHHH	44.98	23927012
508	Phosphorylation	SQDGSGFSRILSMLA CCCCCHHHHHHHHHH	23.18	28450419
512	Phosphorylation	SGFSRILSMLADSTS CHHHHHHHHHHCCCC	14.91	28857561
523	Ubiquitination	DSTSTQEKRRRSFPD CCCCHHHHHHHCCCC	41.19	29967540
527	Phosphorylation	TQEKRRRSFPDIEDE HHHHHHHCCCCCCCH	39.04	29255136
527 (in isoform 2)	Phosphorylation	-	39.04	21406692
536	Ubiquitination	PDIEDEEKFLYGDEE CCCCCHHHHCCCCHH	38.32	29967540
547	Sumoylation	GDEEEDLKAESVPKP CCHHHHHCCCCCCCC	63.53	28112733
547	Ubiquitination	GDEEEDLKAESVPKP CCHHHHHCCCCCCCC	63.53	29967540
553	Sumoylation	LKAESVPKPLGSSES HCCCCCCCCCCCCHH	51.20	28112733
566	Sumoylation	ESEVMRQKASSLPSS HHHHHHHHHHCCCCC	39.61	28112733
566	Ubiquitination	ESEVMRQKASSLPSS HHHHHHHHHHCCCCC	39.61	29967540
573	Phosphorylation	KASSLPSSAPAVKLE HHHCCCCCCCCCCHH	36.01	25627689
578	Sumoylation	PSSAPAVKLESLEET CCCCCCCCHHHHHHH	48.95	-
578	Sumoylation	PSSAPAVKLESLEET CCCCCCCCHHHHHHH	48.95	28112733
578	Ubiquitination	PSSAPAVKLESLEET CCCCCCCCHHHHHHH	48.95	32015554
591	Ubiquitination	ETNPEYAKIHDLLKT HHCHHHHHHHHHHHH	39.41	32015554
634	Phosphorylation	RSSADRRSSVDRYFS CCCCHHHHHHHHHHC	35.29	29214152
635	Phosphorylation	SSADRRSSVDRYFSA CCCHHHHHHHHHHCC	26.65	30576142
639	Phosphorylation	RRSSVDRYFSADHCS HHHHHHHHHCCCCCC	9.45	23312004
641	Phosphorylation	SSVDRYFSADHCSSV HHHHHHHCCCCCCCC	24.69	23312004
646	Phosphorylation	YFSADHCSSVDHRFS HHCCCCCCCCCCCCC	29.94	30576142
647	Phosphorylation	FSADHCSSVDHRFSA HCCCCCCCCCCCCCC	36.64	30576142
653	Phosphorylation	SSVDHRFSADRCSSV CCCCCCCCCCCCCCC	29.26	23917254
658	Phosphorylation	RFSADRCSSVDHCFS CCCCCCCCCCHHCCC	34.00	24719451
659	Phosphorylation	FSADRCSSVDHCFSA CCCCCCCCCHHCCCC	34.88	24961811
670	Phosphorylation	CFSADRRSSDPHRLE CCCCCCCCCCCCHHH	39.73	28102081
671	Phosphorylation	FSADRRSSDPHRLES CCCCCCCCCCCHHHH	54.04	28102081
684	Phosphorylation	ESREAHHSNTHSPEV HHHHHCCCCCCCCCC	33.29	26055452
684 (in isoform 2)	Phosphorylation	-	33.29	21406692
686	Phosphorylation	REAHHSNTHSPEVSH HHHCCCCCCCCCCCC	27.09	26055452
688	Phosphorylation	AHHSNTHSPEVSHPH HCCCCCCCCCCCCCC	22.25	27794612
692	Phosphorylation	NTHSPEVSHPHPPSP CCCCCCCCCCCCCCC	29.64	27794612
698	Phosphorylation	VSHPHPPSPVDPYLL CCCCCCCCCCCHHHC	41.84	26055452
703	Phosphorylation	PPSPVDPYLLTKNSP CCCCCCHHHCCCCCC	15.18	23663014
706	Phosphorylation	PVDPYLLTKNSPPFL CCCHHHCCCCCCCCC	26.11	23663014
709	Phosphorylation	PYLLTKNSPPFLKSD HHHCCCCCCCCCCCC	35.19	23401153
709 (in isoform 2)	Phosphorylation	-	35.19	21406692
739	Methylation	FQSSVAVRCMLPSAP CCCCEEEECCCCCCC	7.15	115387031
759	Phosphorylation	LPHTAALSQFHMPRA CCCHHHHHHCCCCCH	26.52	-
778	Phosphorylation	AARIPPNYQGPAIPP HCCCCCCCCCCCCCC	22.18	24043423
787	Phosphorylation	GPAIPPASFDAYRHY CCCCCCCCHHHHHHH	29.45	24043423
791	Phosphorylation	PPASFDAYRHYMAYA CCCCHHHHHHHHHHH	10.36	24043423
794	Phosphorylation	SFDAYRHYMAYAASR CHHHHHHHHHHHHHC	3.72	24043423
797	Phosphorylation	AYRHYMAYAASRWPM HHHHHHHHHHHCCCC	6.03	24043423
800	Phosphorylation	HYMAYAASRWPMYPT HHHHHHHHCCCCCCC	27.06	24043423
801	Methylation	YMAYAASRWPMYPTS HHHHHHHCCCCCCCC	36.47	115920449
825	Phosphorylation	PHRIMPITKQATRSR CCCCCCCCCCCCCCC	15.95	24719451
826	Ubiquitination	HRIMPITKQATRSRP CCCCCCCCCCCCCCC	38.36	32015554
829	Phosphorylation	MPITKQATRSRPNLR CCCCCCCCCCCCCCE	27.04	24719451
831	Phosphorylation	ITKQATRSRPNLRVI CCCCCCCCCCCCEEE	47.97	24719451
840	Phosphorylation	PNLRVIPTVTPDKPK CCCEEECCCCCCCCC	26.36	30266825
842	Phosphorylation	LRVIPTVTPDKPKQK CEEECCCCCCCCCHH	28.40	30266825
845	Acetylation	IPTVTPDKPKQKESL ECCCCCCCCCHHHHH	56.15	23954790
853	Methylation	PKQKESLRGSIPAAQ CCHHHHHCCCCCHHH	46.20	115920453
855	Phosphorylation	QKESLRGSIPAAQVP HHHHHCCCCCHHHCC	20.97	30622161
866	O-linked_Glycosylation	AQVPVQVSIPSLIRY HHCCEEEECHHHHCC	16.22	30059200
866	Phosphorylation	AQVPVQVSIPSLIRY HHCCEEEECHHHHCC	16.22	30622161
869	Phosphorylation	PVQVSIPSLIRYNPE CEEEECHHHHCCCHH	34.46	30622161
873	Phosphorylation	SIPSLIRYNPEKISD ECHHHHCCCHHHCCC	28.24	30622161
921	Ubiquitination	TELERLHKQQGEMLR HHHHHHHHHHHHHHH	49.24	29967540
938	Ubiquitination	RREKDGHKDPLLVEV HHHHCCCCCCCHHHH	67.58	29967540
991	Phosphorylation	IFDKSQKSLSDSREP CCCCCCCCCCCCCCC	26.01	30108239
993	Phosphorylation	DKSQKSLSDSREPTE CCCCCCCCCCCCCCC	40.40	25394399
995	Phosphorylation	SQKSLSDSREPTEKP CCCCCCCCCCCCCCC	34.86	30108239
1001	Acetylation	DSREPTEKPGKAEKS CCCCCCCCCCCCCCC	62.64	18584497
1008	Phosphorylation	KPGKAEKSKSPEKVS CCCCCCCCCCHHHHH	29.85	30108239
1010	Phosphorylation	GKAEKSKSPEKVSSF CCCCCCCCHHHHHHC	45.44	23401153
1015	Phosphorylation	SKSPEKVSSFSNSSS CCCHHHHHHCCCCCC	36.41	23927012
1016	Phosphorylation	KSPEKVSSFSNSSSN CCHHHHHHCCCCCCC	35.36	23927012
1018	Phosphorylation	PEKVSSFSNSSSNKE HHHHHHCCCCCCCCC	37.44	29083192
1020	Phosphorylation	KVSSFSNSSSNKESK HHHHCCCCCCCCCHH	33.67	29083192
1021	Phosphorylation	VSSFSNSSSNKESKV HHHCCCCCCCCCHHC	42.03	29083192
1022	Phosphorylation	SSFSNSSSNKESKVN HHCCCCCCCCCHHCC	52.31	29083192
1026	Phosphorylation	NSSSNKESKVNNEKF CCCCCCCHHCCHHHH	43.44	29083192
1035	Phosphorylation	VNNEKFRTKSPKPAE CCHHHHCCCCCCCCC	38.72	23927012
1036	Ubiquitination	NNEKFRTKSPKPAES CHHHHCCCCCCCCCC	61.58	-
1037	Phosphorylation	NEKFRTKSPKPAESP HHHHCCCCCCCCCCC	37.23	25159151
1037 (in isoform 2)	Phosphorylation	-	37.23	21406692
1043	Phosphorylation	KSPKPAESPQSATKQ CCCCCCCCCCHHHHH	30.28	30266825
1043 (in isoform 2)	Phosphorylation	-	30.28	21406692
1046	Phosphorylation	KPAESPQSATKQLDQ CCCCCCCHHHHHCCC	41.09	23927012
1048	Phosphorylation	AESPQSATKQLDQPT CCCCCHHHHHCCCCC	25.27	23927012
1055	Phosphorylation	TKQLDQPTAAYEYYD HHHCCCCCHHHHEEE	20.49	26074081
1058	Phosphorylation	LDQPTAAYEYYDAGN CCCCCHHHHEEECCC	11.29	26074081
1063	Phosphorylation	AAYEYYDAGNHWCKD HHHHEEECCCCCCCC	12.45	17081983
1089	Ubiquitination	FTHMHNKKHTQTLDP HHHHCCCCCCCCCCC	58.14	29967540
1091	Phosphorylation	HMHNKKHTQTLDPYN HHCCCCCCCCCCCCC	31.93	-
1097	Phosphorylation	HTQTLDPYNRPWASK CCCCCCCCCCCCHHC	24.38	-
1166	Ubiquitination	QHNEKYKKYVDENPL CCCHHHHHHHCCCHH	47.63	29967540
1205	Phosphorylation	SELKRKLSEKPKEEK HHHHHHHHHCCHHHH	46.76	-
1228	Acetylation	KEVKEDDKVSEKLED HHHHHCHHHHHHHHH	61.04	7934497
1232	Acetylation	EDDKVSEKLEDQLSE HCHHHHHHHHHHHHC	50.06	7934569
1238	Phosphorylation	EKLEDQLSEGRNSPE HHHHHHHHCCCCCHH	32.16	23401153
1240	Phosphorylation	LEDQLSEGRNSPEKA HHHHHHCCCCCHHHH	30.60	18669648
1243	Phosphorylation	QLSEGRNSPEKAENK HHHCCCCCHHHHHHH	32.83	29255136
1256	Acetylation	NKRNTGIKLQLKEEV HHHCCCCEEEEHHHH	31.37	25953088
1267	Phosphorylation	KEEVKKESPTSSSFG HHHHHHCCCCCCCCC	42.21	23401153
1269	Phosphorylation	EVKKESPTSSSFGKF HHHHCCCCCCCCCCC	50.98	30266825
1270	Phosphorylation	VKKESPTSSSFGKFS HHHCCCCCCCCCCCC	27.63	30266825
1271	Phosphorylation	KKESPTSSSFGKFSW HHCCCCCCCCCCCCC	31.97	23403867
1272	Phosphorylation	KESPTSSSFGKFSWK HCCCCCCCCCCCCCC	37.47	23927012
1275	Acetylation	PTSSSFGKFSWKKPE CCCCCCCCCCCCCCC	33.93	19608861
1277	Phosphorylation	SSSFGKFSWKKPEKE CCCCCCCCCCCCCCH	41.28	-
1288	Phosphorylation	PEKEEEKSSLVTPSI CCCHHHHCCCCCCCC	31.98	20068231
1289	Phosphorylation	EKEEEKSSLVTPSIS CCHHHHCCCCCCCCC	37.62	20068231
1292	Phosphorylation	EEKSSLVTPSISKEE HHHCCCCCCCCCHHH	19.33	20068231
1294	Phosphorylation	KSSLVTPSISKEEIL HCCCCCCCCCHHHHH	30.08	20068231
1296	Phosphorylation	SLVTPSISKEEILES CCCCCCCCHHHHHHH	38.05	20068231
1297	Ubiquitination	LVTPSISKEEILESS CCCCCCCHHHHHHHH	58.66	29967540
1303	Phosphorylation	SKEEILESSKDKEDG CHHHHHHHHCCCCCC	38.96	20068231
1304	Phosphorylation	KEEILESSKDKEDGK HHHHHHHHCCCCCCC	35.18	20068231
1305	Acetylation	EEILESSKDKEDGKT HHHHHHHCCCCCCCC	80.32	7684937
1311	Acetylation	SKDKEDGKTEAGKAK HCCCCCCCCCCCCCC	56.36	7684947
1312	O-linked_Glycosylation	KDKEDGKTEAGKAKP CCCCCCCCCCCCCCC	36.28	OGP
1316	Acetylation	DGKTEAGKAKPIKIK CCCCCCCCCCCEEEE	61.35	7684957
1325	Phosphorylation	KPIKIKLSGKTVVAH CCEEEEECCCEEEEE	32.99	29391485
1341	O-linked_Glycosylation	SPWMPVVTTSTQTKI CCCCCEEECCCCCCC	18.44	30059200
1342	O-linked_Glycosylation	PWMPVVTTSTQTKIR CCCCEEECCCCCCCC	20.40	30059200
1357	Phosphorylation	PNLPIPSTVLRKSCS CCCCCCHHHHHHCCC	20.43	24719451
1387	Acetylation	KSSGTTAKPLPVVKE ECCCCCCCCCCCCCC	45.02	26051181
1395	Phosphorylation	PLPVVKESSADLLLP CCCCCCCCCCCCCCC	25.71	28348404
1396	Phosphorylation	LPVVKESSADLLLPP CCCCCCCCCCCCCCH	27.22	28348404
1408	Ubiquitination	LPPDIISKAFGGEEV CCHHHHHHHHCCCEE	37.01	29967540
1420	Phosphorylation	EEVILKGSPEEKVVL CEEEECCCHHHCEEE	27.79	30266825
1443	Phosphorylation	LPEQILPPPPPPPPP CCCCCCCCCCCCCCC	51.05	17525332
1533	Phosphorylation	DRDQTLFSVLVRPPP HCCCEEEEEEECCCC	20.04	15302935
1558	Phosphorylation	KKLEKRNSCLATANA HHHHHHHCCHHCCCH	17.97	20363803
1569	Phosphorylation	TANAKDLYDIFYSSG CCCHHHHHHHHHCCC	19.68	29978859
1575	Phosphorylation	LYDIFYSSGGKGAPE HHHHHHCCCCCCCCC	39.94	21712546
1578	Acetylation	IFYSSGGKGAPETKG HHHCCCCCCCCCCCC	56.26	26051181
1578	Ubiquitination	IFYSSGGKGAPETKG HHHCCCCCCCCCCCC	56.26	29967540
1602	Phosphorylation	PLANGENSNLSRTKS CCCCCCCCCCCCCCC	34.54	28555341
1605	Phosphorylation	NGENSNLSRTKSSDT CCCCCCCCCCCCCCC	42.00	28555341
1607	Phosphorylation	ENSNLSRTKSSDTSS CCCCCCCCCCCCCCC	31.72	29978859
1609	Phosphorylation	SNLSRTKSSDTSSTS CCCCCCCCCCCCCCC	32.60	23927012
1610	Phosphorylation	NLSRTKSSDTSSTSP CCCCCCCCCCCCCCC	46.60	30108239
1612	Phosphorylation	SRTKSSDTSSTSPLN CCCCCCCCCCCCCCC	26.90	30108239
1613	Phosphorylation	RTKSSDTSSTSPLNS CCCCCCCCCCCCCCC	36.29	30108239
1614	Phosphorylation	TKSSDTSSTSPLNSS CCCCCCCCCCCCCCC	34.69	25159151
1615	Phosphorylation	KSSDTSSTSPLNSSA CCCCCCCCCCCCCCC	33.84	30278072
1616	Phosphorylation	SSDTSSTSPLNSSAS CCCCCCCCCCCCCCC	29.36	23401153
1620	Phosphorylation	SSTSPLNSSASQEEL CCCCCCCCCCCHHHH	34.66	25159151
1621	Phosphorylation	STSPLNSSASQEELH CCCCCCCCCCHHHHH	30.76	30108239
1623	Phosphorylation	SPLNSSASQEELHQD CCCCCCCCHHHHHCC	39.82	17525332
1640	Phosphorylation	LVAAPIVSNSEKPIA CCCCCCCCCCCCCHH	35.04	30108239
1642	Phosphorylation	AAPIVSNSEKPIAKT CCCCCCCCCCCHHHH	39.22	30108239
1657	Phosphorylation	LVALGKWSVVEHVGP HHHHCCCEEEEEECC	21.55	24732914
1667	Phosphorylation	EHVGPKSTGSTYGFL EEECCCCCCCCCCHH	41.08	28555341
1669	Phosphorylation	VGPKSTGSTYGFLQP ECCCCCCCCCCHHHH	20.67	28555341
1671	Phosphorylation	PKSTGSTYGFLQPLT CCCCCCCCCHHHHHH	13.94	-
1679	Methylation	GFLQPLTRLCQSRPY CHHHHHHHHHHCCCC	40.94	115920445
1684	Ubiquitination	LTRLCQSRPYETITP HHHHHHCCCCCCCCC	16.37	22817900
1686	Phosphorylation	RLCQSRPYETITPKT HHHHCCCCCCCCCCC	25.29	27642862
1686	Ubiquitination	RLCQSRPYETITPKT HHHHCCCCCCCCCCC	25.29	21890473
1688	Phosphorylation	CQSRPYETITPKTDT HHCCCCCCCCCCCCC	25.06	-
1700	Phosphorylation	TDTLAIWTSSSFQSD CCCEEEEECCCCCCC	16.77	28102081
1701	Phosphorylation	DTLAIWTSSSFQSDT CCEEEEECCCCCCCC	14.69	28102081
1702	Phosphorylation	TLAIWTSSSFQSDTS CEEEEECCCCCCCCC	28.00	28102081
1703	Phosphorylation	LAIWTSSSFQSDTSR EEEEECCCCCCCCCC	27.37	18669648
1706	Phosphorylation	WTSSSFQSDTSRDIS EECCCCCCCCCCCCC	40.62	28102081
1708	Phosphorylation	SSSFQSDTSRDISPE CCCCCCCCCCCCCCC	30.79	28102081
1709	Phosphorylation	SSFQSDTSRDISPEK CCCCCCCCCCCCCCH	32.71	28102081
1713	Phosphorylation	SDTSRDISPEKSELD CCCCCCCCCCHHCCC	31.15	30266825
1716	Phosphorylation	SRDISPEKSELDLGE CCCCCCCHHCCCCCC	53.25	18669648
1717	Phosphorylation	RDISPEKSELDLGEP CCCCCCHHCCCCCCC	41.55	30266825
1754	Phosphorylation	VEIHLRESVNQDKES EEHHHHHHCCCCHHH	21.67	30108239
1761	Phosphorylation	SVNQDKESQELRKSE HCCCCHHHHHHHCCH	34.39	24719451
1773	Phosphorylation	KSEDCRESEIETNTE CCHHHHHHHHHHHHH	25.23	23312004
1777	Phosphorylation	CRESEIETNTELKER HHHHHHHHHHHHHHH	53.77	20446291
1843	Phosphorylation	EQSNKLMTGSETPSK HHHCCCCCCCCCCCE	48.25	22199227
1845	Phosphorylation	SNKLMTGSETPSKVV HCCCCCCCCCCCEEE	29.18	29255136
1847	Phosphorylation	KLMTGSETPSKVVIK CCCCCCCCCCEEEEE	34.26	29255136
1849	Phosphorylation	MTGSETPSKVVIKLS CCCCCCCCEEEEEEC	45.56	29255136
1856	Phosphorylation	SKVVIKLSPQACSFT CEEEEEECHHHCCCC	15.23	30266825
1861	Phosphorylation	KLSPQACSFTKAKLD EECHHHCCCCHHHHH	38.68	23927012
1863	Phosphorylation	SPQACSFTKAKLDSF CHHHCCCCHHHHHHH	17.50	23927012
1864	Methylation	PQACSFTKAKLDSFL HHHCCCCHHHHHHHH	41.32	115978245
1864	Ubiquitination	PQACSFTKAKLDSFL HHHCCCCHHHHHHHH	41.32	22817900
1866	Acetylation	ACSFTKAKLDSFLSE HCCCCHHHHHHHHHH	55.15	23954790
1866	Ubiquitination	ACSFTKAKLDSFLSE HCCCCHHHHHHHHHH	55.15	22817900
1866 (in isoform 1)	Ubiquitination	-	55.15	21890473
1869	Phosphorylation	FTKAKLDSFLSEARS CCHHHHHHHHHHHHH	38.22	25159151
1883	Phosphorylation	SLLNPQDTPVKISAP HHCCCCCCCCEECCC	25.41	29255136
1886	Ubiquitination	NPQDTPVKISAPELL CCCCCCCEECCCHHH	31.95	32015554
1888	Phosphorylation	QDTPVKISAPELLLH CCCCCEECCCHHHHC	31.86	23927012
1896	Phosphorylation	APELLLHSPARSAMC CCHHHHCCCCCCCHH	21.89	29255136
1900	Phosphorylation	LLHSPARSAMCLTGS HHCCCCCCCHHHCCC	23.59	30108239
1905	Phosphorylation	ARSAMCLTGSPQEQG CCCCHHHCCCCHHHC	30.59	30108239
1907	Phosphorylation	SAMCLTGSPQEQGVS CCHHHCCCCHHHCEE	20.41	30108239
1914	Phosphorylation	SPQEQGVSVVSEEGL CCHHHCEEEECCCCC	24.51	30108239
1917	Phosphorylation	EQGVSVVSEEGLENS HHCEEEECCCCCCCC	27.98	30108239
1921	Phosphorylation	SVVSEEGLENSAPES EEECCCCCCCCCCCC	6.78	18669648
1924	Phosphorylation	SEEGLENSAPESASR CCCCCCCCCCCCCCC	35.51	27174698
1928	Phosphorylation	LENSAPESASRTSRY CCCCCCCCCCCHHHH	30.41	25159151
1937	Phosphorylation	SRTSRYRSLKLKRER CCHHHHHHHHCHHHH	22.41	-
1945	Phosphorylation	LKLKRERSKDFQVKK HHCHHHHCCCCCHHH	31.65	29496963
1954	Phosphorylation	DFQVKKIYELAVWDE CCCHHHHHEEEECCC	17.48	23403867
1968	Phosphorylation	ENKKRPETWESPEKP CCCCCCCCCCCCCCC	36.90	30266825
1971	Phosphorylation	KRPETWESPEKPKTE CCCCCCCCCCCCCCH	29.89	30266825
2009	Phosphorylation	EATDLKVEELTALGN HCCCCCHHHHHHHCC	45.78	18669648
2012	Phosphorylation	DLKVEELTALGNLGD CCCHHHHHHHCCCCC	24.10	26074081
2026	Phosphorylation	DMPVDFCTTRVSPAH CCCCCEECCCCCCCC	20.03	25159151
2027	Phosphorylation	MPVDFCTTRVSPAHR CCCCEECCCCCCCCC	30.19	25159151
2030	Phosphorylation	DFCTTRVSPAHRSPT CEECCCCCCCCCCCC	17.06	23401153
2035	Phosphorylation	RVSPAHRSPTVLCQK CCCCCCCCCCCHHHH	18.30	29255136
2037	Phosphorylation	SPAHRSPTVLCQKVC CCCCCCCCCHHHHHH	27.62	23401153
2048	Phosphorylation	QKVCEENSVSPIGCN HHHHHCCCCCCCCCC	27.53	29978859
2050	Phosphorylation	VCEENSVSPIGCNSS HHHCCCCCCCCCCCC	15.60	29978859
2056	Phosphorylation	VSPIGCNSSDPADFE CCCCCCCCCCCCCCC	39.95	29978859
2057	Phosphorylation	SPIGCNSSDPADFEP CCCCCCCCCCCCCCC	33.35	29978859
2063	Phosphorylation	SSDPADFEPIPSFSG CCCCCCCCCCCCCCC	42.75	18669648
2067	Phosphorylation	ADFEPIPSFSGFPLD CCCCCCCCCCCCCCC	32.53	29978859
2069	Phosphorylation	FEPIPSFSGFPLDSP CCCCCCCCCCCCCCC	43.81	29978859
2075	Phosphorylation	FSGFPLDSPKTLVLD CCCCCCCCCCEEEEE	35.66	29978859
2078	Phosphorylation	FPLDSPKTLVLDFET CCCCCCCEEEEECCC	26.03	29523821
2085	Phosphorylation	TLVLDFETEGERNSP EEEEECCCCCCCCCC	49.65	29255136
2091	Phosphorylation	ETEGERNSPNPRSVR CCCCCCCCCCCCCCC	32.07	29255136
2096	Phosphorylation	RNSPNPRSVRIPSPN CCCCCCCCCCCCCCC	19.60	23403867
2101	Phosphorylation	PRSVRIPSPNILKTG CCCCCCCCCCCCCCC	28.36	22167270
2107	Phosphorylation	PSPNILKTGLTENVD CCCCCCCCCCCCCCC	33.70	26074081
2110	Phosphorylation	NILKTGLTENVDRGL CCCCCCCCCCCCCCC	27.19	26074081
2123	Phosphorylation	GLGGLEGTHQALDLL CCCCCCHHHHHHHHH	11.05	-
2142	Phosphorylation	MPEEVKESSQLDKQE CHHHHHHHHHCCHHH	20.05	-
2147	Ubiquitination	KESSQLDKQESLGLE HHHHHCCHHHHHCCE	65.64	29967540
2150	Phosphorylation	SQLDKQESLGLELKT HHCCHHHHHCCEEEE	25.83	21815630
2157	Phosphorylation	SLGLELKTINSAGLG HHCCEEEEHHHCCCC	37.71	28857561
2160	Phosphorylation	LELKTINSAGLGPSP CEEEEHHHCCCCCCC	21.62	28857561
2166	Phosphorylation	NSAGLGPSPCLPDLV HHCCCCCCCCCHHHH	26.84	27251275
2168	Glutathionylation	AGLGPSPCLPDLVDF CCCCCCCCCHHHHHH	11.48	22555962
2179	Phosphorylation	LVDFVTRTSGVQKDK HHHHHHHCCCCCCCC	22.07	23312004
2180	Phosphorylation	VDFVTRTSGVQKDKL HHHHHHCCCCCCCCC	33.41	23312004
2186	Acetylation	TSGVQKDKLCSPLSE CCCCCCCCCCCCCCC	59.43	26051181
2189	Phosphorylation	VQKDKLCSPLSEPGD CCCCCCCCCCCCCCC	39.03	19664994
2192	Phosphorylation	DKLCSPLSEPGDPSK CCCCCCCCCCCCHHH	45.16	30266825
2198	Phosphorylation	LSEPGDPSKCSSLEL CCCCCCHHHCCCCEE	51.54	30266825
2229	Phosphorylation	ILQVDDDSGDPLNLV EEEECCCCCCCCCEE	52.68	26074081
2241	Phosphorylation	NLVKAPVSRSPPREQ CEEECCCCCCCCHHH	26.44	27174698
2243	Phosphorylation	VKAPVSRSPPREQVI EECCCCCCCCHHHHC	31.58	23401153
2264	Phosphorylation	QGMPEQETTVGAIQD CCCCCCCCCCCHHCC	26.86	23186163
2265	Phosphorylation	GMPEQETTVGAIQDH CCCCCCCCCCHHCCC	19.05	23186163
2275	Phosphorylation	AIQDHTESSVHN--- HHCCCCCCCCCC---	38.52	23186163
2276	Phosphorylation	IQDHTESSVHN---- HCCCCCCCCCC----	22.59	23186163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZN318_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN318_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN318_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ANDR_HUMAN	AR	physical	16469430
HDAC2_HUMAN	HDAC2	physical	16469430

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN318_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1275, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173; SER-214; SER-1037;SER-1713 AND SER-2101, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-709; SER-2101AND SER-2189, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79; SER-81; SER-136;SER-173; SER-214; SER-1420; SER-1896; SER-2101; SER-2189; SER-2192 ANDSER-2243, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1623, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305; SER-307; SER-464AND SER-1243, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1713 AND SER-2101, ANDMASS SPECTROMETRY.	15302935 [Abstract]