ANDR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANDR_HUMAN
• UniProt AC: P10275
• Protein Name: Androgen receptor
• Gene Name: AR
• Organism: Homo sapiens (Human).
• Sequence Length: 920
• Subcellular Localization: Nucleus . Cytoplasm . Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence o
• Protein Description: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.; Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones..
• Protein Sequence: MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	QLGLGRVYPRPPSKT EECCCCCCCCCCCCC	7.68	25002506
16	Phosphorylation	RVYPRPPSKTYRGAF CCCCCCCCCCHHHHH	40.07	12015328
18	Phosphorylation	YPRPPSKTYRGAFQN CCCCCCCCHHHHHHH	23.84	25002506
19	Phosphorylation	PRPPSKTYRGAFQNL CCCCCCCHHHHHHHH	15.70	25002506
29	Phosphorylation	AFQNLFQSVREVIQN HHHHHHHHHHHHHHC	18.79	27499020
81	Phosphorylation	QQQQQQQETSPRQQQ HHHHHHHHCCHHHHH	19.82	12015328
83	Phosphorylation	QQQQQETSPRQQQQQ HHHHHHCCHHHHHHH	46.86	12015328
94	Phosphorylation	QQQQQGEDGSPQAHR HHHHHCCCCCCCHHH	26.59	20363803
96	Phosphorylation	QQQGEDGSPQAHRRG HHHCCCCCCCHHHCC	52.04	30278072
119	Phosphorylation	EEQQPSQPQSALECH CCCCCCCCCHHHHHC	41.31	12015328
121	Phosphorylation	QQPSQPQSALECHPE CCCCCCCHHHHHCCC	9.75	12015328
142	Phosphorylation	PGAAVAASKGLPQQL CCHHHHHHCCCCCCC	39.84	26546556
206	Phosphorylation	QEAVSEGSSSGRARE HHHHHHCCCCHHHHC	33.71	11404460
208	Phosphorylation	AVSEGSSSGRAREAS HHHHCCCCHHHHCCC	32.21	11404460
213	Phosphorylation	SSSGRAREASGAPTS CCCHHHHCCCCCCCC	30.63	22155408
215	Phosphorylation	SGRAREASGAPTSSK CHHHHCCCCCCCCCC	11.16	11404460
217	Phosphorylation	RAREASGAPTSSKDN HHHCCCCCCCCCCCC	45.13	-
219	Phosphorylation	REASGAPTSSKDNYL HCCCCCCCCCCCCCC	46.65	-
223	Phosphorylation	GAPTSSKDNYLGGTS CCCCCCCCCCCCCCC	19.50	19060867
225	Phosphorylation	PTSSKDNYLGGTSTI CCCCCCCCCCCCCCC	27.29	19060867
231	Phosphorylation	NYLGGTSTISDNAKE CCCCCCCCCCHHHHH	25.54	-
233	Phosphorylation	LGGTSTISDNAKELC CCCCCCCCHHHHHHH	46.23	-
242	Phosphorylation	NAKELCKAVSVSMGL HHHHHHHHHHHHCCC	17.21	-
244	Phosphorylation	KELCKAVSVSMGLGV HHHHHHHHHHCCCCH	10.30	-
246	Phosphorylation	LCKAVSVSMGLGVEA HHHHHHHHCCCCHHH	16.27	-
256	Phosphorylation	LGVEALEHLSPGEQL CCHHHHHHCCCCCCC	32.54	12015328
258	Phosphorylation	VEALEHLSPGEQLRG HHHHHHCCCCCCCCC	31.72	12015328
267	Phosphorylation	GEQLRGDCMYAPLLG CCCCCCCCCCHHHCC	16.05	20623637
269	Phosphorylation	QLRGDCMYAPLLGVP CCCCCCCCHHHCCCC	15.61	20623637
280	Phosphorylation	LGVPPAVRPTPCAPL CCCCCCCCCCCCCCH	22.04	20713353
282	Phosphorylation	VPPAVRPTPCAPLAE CCCCCCCCCCCCHHH	7.20	20713353
291	Phosphorylation	CAPLAECKGSLLDDS CCCHHHCCCCCCCCC	15.97	20713353
293	Phosphorylation	PLAECKGSLLDDSAG CHHHCCCCCCCCCCC	8.02	20713353
298	Phosphorylation	KGSLLDDSAGKSTED CCCCCCCCCCCCCCC	28.53	27251275
300	Phosphorylation	SLLDDSAGKSTEDTA CCCCCCCCCCCCCCH	35.79	12015328
301	Phosphorylation	LLDDSAGKSTEDTAE CCCCCCCCCCCCCHH	41.17	19369195
302	Phosphorylation	LDDSAGKSTEDTAEY CCCCCCCCCCCCHHC	61.53	12015328
303	Phosphorylation	DDSAGKSTEDTAEYS CCCCCCCCCCCHHCC	51.83	19369195
307	Phosphorylation	GKSTEDTAEYSPFKG CCCCCCCHHCCCCCC	21.12	19369195
308	Phosphorylation	KSTEDTAEYSPFKGG CCCCCCHHCCCCCCC	18.50	12015328
309	Phosphorylation	STEDTAEYSPFKGGY CCCCCHHCCCCCCCC	33.78	19369195
310	Phosphorylation	TEDTAEYSPFKGGYT CCCCHHCCCCCCCCC	10.64	12015328
328	Phosphorylation	EGESLGCSGSAAAGS CCCCCCCCCCCCCCC	9.84	27251275
330	Phosphorylation	ESLGCSGSAAAGSSG CCCCCCCCCCCCCCC	17.66	27251275
335	Phosphorylation	SGSAAAGSSGTLELP CCCCCCCCCCCEECC	35.70	27251275
336	Phosphorylation	GSAAAGSSGTLELPS CCCCCCCCCCEECCC	21.00	22210691
338	Phosphorylation	AAAGSSGTLELPSTL CCCCCCCCEECCCHH	59.48	27251275
346	Phosphorylation	LELPSTLSLYKSGAL EECCCHHHHHHCCCC	10.34	17045208
348	Phosphorylation	LPSTLSLYKSGALDE CCCHHHHHHCCCCCH	18.75	17045208
357	Phosphorylation	SGALDEAAAYQSRDY CCCCCHHHHHCCCCC	11.42	17045208
359	Phosphorylation	ALDEAAAYQSRDYYN CCCHHHHHCCCCCCC	17.91	17045208
362	Phosphorylation	EAAAYQSRDYYNFPL HHHHHCCCCCCCCCH	10.13	17045208
363	Phosphorylation	AAAYQSRDYYNFPLA HHHHCCCCCCCCCHH	18.02	17494760
364	Phosphorylation	AAYQSRDYYNFPLAL HHHCCCCCCCCCHHH	26.32	27642862
365	Phosphorylation	AYQSRDYYNFPLALA HHCCCCCCCCCHHHC	2.79	17494760
386	Sumoylation	PPPHPHARIKLENPL CCCCCCCCCCCCCCC	44.16	-
386	Sumoylation	PPPHPHARIKLENPL CCCCCCCCCCCCCCC	44.16	-
388	Sumoylation	PHPHARIKLENPLDY CCCCCCCCCCCCCCH	52.37	-
388	Sumoylation	PHPHARIKLENPLDY CCCCCCCCCCCCCCH	52.37	11121022
393	Phosphorylation	RIKLENPLDYGSAWA CCCCCCCCCHHHHHH	22.21	17045208
395	Phosphorylation	KLENPLDYGSAWAAA CCCCCCCHHHHHHHH	17.89	17045208
405	Phosphorylation	AWAAAAAQCRYGDLA HHHHHHHHCHHCCHH	26.79	-
407	Phosphorylation	AAAAAQCRYGDLASL HHHHHHCHHCCHHHH	12.24	-
422	Phosphorylation	HGAGAAGPGSGSPSA CCCCCCCCCCCCCCH	38.95	12015328
424	Phosphorylation	AGAAGPGSGSPSAAA CCCCCCCCCCCCHHH	19.85	12015328
426	Phosphorylation	AAGPGSGSPSAAASS CCCCCCCCCCHHHCC	32.03	12015328
503	Phosphorylation	DFTAPDVWYPGGMVS CCCCCCCCCCCCCCC	7.58	19369195
504	Phosphorylation	FTAPDVWYPGGMVSR CCCCCCCCCCCCCCC	19.70	19369195
515	Phosphorylation	MVSRVPYPSPTCVKS CCCCCCCCCCCCCCC	27.31	18511414
516	Phosphorylation	VSRVPYPSPTCVKSE CCCCCCCCCCCCCCC	25.88	22985185
518	Phosphorylation	RVPYPSPTCVKSEMG CCCCCCCCCCCCCCC	4.05	28348404
520	Sumoylation	PYPSPTCVKSEMGPW CCCCCCCCCCCCCCC	42.73	-
520	Sumoylation	PYPSPTCVKSEMGPW CCCCCCCCCCCCCCC	42.73	-
521	Sumoylation	YPSPTCVKSEMGPWM CCCCCCCCCCCCCCC	16.65	-
521	Sumoylation	YPSPTCVKSEMGPWM CCCCCCCCCCCCCCC	16.65	11121022
534	Phosphorylation	WMDSYSGPYGDMRLE CCCCCCCCCCCCCHH	29.32	20383201
535	Phosphorylation	MDSYSGPYGDMRLET CCCCCCCCCCCCHHH	25.93	20383201
551	Phosphorylation	RDHVLPIDYYFPPQK HHCCCCCCEECCCCC	14.02	17045208
552	Phosphorylation	DHVLPIDYYFPPQKT HCCCCCCEECCCCCE	13.08	17045208
578	Phosphorylation	HYGALTCGSCKVFFK CCCEECCCCCCEEEH	16.95	18511414
579	Phosphorylation	YGALTCGSCKVFFKR CCEECCCCCCEEEHH	2.36	18511414
606	Acetylation	RNDCTIDKFRRKNCP CCCCCHHHHHHHCCC	8.95	118298201
619	Acetylation	CPSCRLRKCYEAGMT CCCCCHHHHHHHCCH	2.76	118298199
630	Acetylation	AGMTLGARKLKKLGN HCCHHHHHHHHHHCC	65.21	-
630	Methylation	AGMTLGARKLKKLGN HCCHHHHHHHHHHCC	65.21	-
631	Acetylation	GMTLGARKLKKLGNL CCHHHHHHHHHHCCC	5.01	11971970
631	Methylation	GMTLGARKLKKLGNL CCHHHHHHHHHHCCC	5.01	21273441
632	Acetylation	MTLGARKLKKLGNLK CHHHHHHHHHHCCCC	49.33	-
632	Methylation	MTLGARKLKKLGNLK CHHHHHHHHHHCCCC	49.33	-
633	Acetylation	TLGARKLKKLGNLKL HHHHHHHHHHCCCCC	72.55	11994312
633	Methylation	TLGARKLKKLGNLKL HHHHHHHHHHCCCCC	72.55	20959290
634	Acetylation	LGARKLKKLGNLKLQ HHHHHHHHHCCCCCC	5.41	11971970
647	Phosphorylation	LQEEGEASSTTSPTE CCCCCCCCCCCCCCH	42.63	28450419
648	Phosphorylation	QEEGEASSTTSPTEE CCCCCCCCCCCCCHH	28.88	24719451
649	Phosphorylation	EEGEASSTTSPTEET CCCCCCCCCCCCHHH	34.36	24719451
650	Phosphorylation	EGEASSTTSPTEETT CCCCCCCCCCCHHHH	29.88	25849741
651	Phosphorylation	GEASSTTSPTEETTQ CCCCCCCCCCHHHHC	41.56	25849741
653	Phosphorylation	ASSTTSPTEETTQKL CCCCCCCCHHHHCEE	57.65	25072903
656	Phosphorylation	TTSPTEETTQKLTVS CCCCCHHHHCEEEHH	27.30	25072903
657	Phosphorylation	TSPTEETTQKLTVSH CCCCHHHHCEEEHHH	46.29	25072903
761	Methylation	SFTNVNSRMLYFAPD HCCCCCCCEEECCCH	3.41	-
791	Phosphorylation	QCVRMRHLSQEFGWL HHHHHHHHHHHHCCC	22.87	11404460
792	Phosphorylation	CVRMRHLSQEFGWLQ HHHHHHHHHHHCCCC	57.29	11404460
826	Ubiquitination	VDGLKNQKFFDELRM CCCCCCCHHHHHHHH	7.22	-
837	Acetylation	ELRMNYIKELDRIIA HHHHHHHHHHHHHHC	46.47	7367661
845	Ubiquitination	ELDRIIACKRKNPTS HHHHHHCCCCCCCCC	58.34	19345326
846	Ubiquitination	LDRIIACKRKNPTSC HHHHHCCCCCCCCCH	43.82	PubMed
847	Ubiquitination	DRIIACKRKNPTSCS HHHHCCCCCCCCCHH	53.42	19345326
848	Ubiquitination	RIIACKRKNPTSCSR HHHCCCCCCCCCHHH	49.46	PubMed
850	Phosphorylation	IACKRKNPTSCSRRF HCCCCCCCCCHHHHH	52.32	22584579
851	Phosphorylation	ACKRKNPTSCSRRFY CCCCCCCCCHHHHHH	16.02	22584579
857	Phosphorylation	PTSCSRRFYQLTKLL CCCHHHHHHHHHHHH	10.78	-
858	Phosphorylation	TSCSRRFYQLTKLLD CCHHHHHHHHHHHHH	39.69	-
915	Phosphorylation	LSGKVKPIYFHTQ-- HCCCCEEEEEECC--	9.61	17045208
916	Phosphorylation	SGKVKPIYFHTQ--- CCCCEEEEEECC---	5.35	10221692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
81	S	Phosphorylation	Kinase	CDK9	P50750	GPS
83	S	Phosphorylation	Kinase	CDK1	P06493	PSP
83	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
83	S	Phosphorylation	Kinase	CDK9	P50750	Uniprot
96	S	Phosphorylation	Kinase	CDK2	P24941	PSP
213	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
213	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
215	S	Phosphorylation	Kinase	AKT1	P31749	PSP
215	S	Phosphorylation	Kinase	PIM1	P11309	PSP
223	Y	Phosphorylation	Kinase	CSK	P41240	GPS
225	Y	Phosphorylation	Kinase	FER	P16591	PSP
225	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
267	Y	Phosphorylation	Kinase	CSK	P41240	GPS
269	Y	Phosphorylation	Kinase	ACK	Q07912	PSP
269	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
282	T	Phosphorylation	Kinase	AURKA	O14965	GPS
293	S	Phosphorylation	Kinase	AURKA	O14965	GPS
307	Y	Phosphorylation	Kinase	CSK	P41240	GPS
309	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
310	S	Phosphorylation	Kinase	CDK1	P06493	PSP
310	S	Phosphorylation	Kinase	CDK11B	P21127	PSP
310	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
346	Y	Phosphorylation	Kinase	CSK	P41240	GPS
348	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
357	Y	Phosphorylation	Kinase	CSK	P41240	GPS
359	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
362	Y	Phosphorylation	Kinase	CSK	P41240	GPS
363	Y	Phosphorylation	Kinase	CSK	P41240	GPS
364	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
365	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
365	Y	Phosphorylation	Kinase	ACK	Q07912	PSP
393	Y	Phosphorylation	Kinase	CSK	P41240	GPS
395	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
516	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
516	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
516	S	Phosphorylation	Kinase	CDK7	P50613	PSP
516	S	Phosphorylation	Kinase	CDK1	P06493	PSP
534	Y	Phosphorylation	Kinase	CSK	P41240	GPS
535	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
535	Y	Phosphorylation	Kinase	SRC	P12931	PSP
551	Y	Phosphorylation	Kinase	CSK	P41240	GPS
552	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
579	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
579	S	Phosphorylation	Kinase	PAK6	Q9NQU5	PSP
650	S	Phosphorylation	Kinase	STK4	Q13043	GPS
651	S	Phosphorylation	Kinase	MST1	P26927	Uniprot
651	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
651	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
651	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
791	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
791	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
792	S	Phosphorylation	Kinase	AKT1	P31749	PSP
851	T	Phosphorylation	Kinase	PIM1	P11309	PSP
915	Y	Phosphorylation	Kinase	CSK	P41240	GPS
916	Y	Phosphorylation	Kinase	CSK	P41240	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:12559985
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	RNF6	Q9Y252	PMID:14559117
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:18703514
-	K	Ubiquitination	E3 ubiquitin ligase	SPOP	O43791	PMID:24508459:25274033
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH2	O43255	PMID:23518348

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
6	K	ubiquitylation	'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity.	1424203
83	S	Phosphorylation	Phosphorylation at Ser-83 by CDK9 regulates AR promoter selectivity and cell growth.	20980437
388	K	Sumoylation	Sumoylated on Lys-388 (major) and Lys-521.	11121022
521	K	Sumoylation	Sumoylated on Lys-388 (major) and Lys-521.	11121022

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANDR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RACK1_HUMAN	GNB2L1	physical	12958311
FLNA_HUMAN	FLNA	physical	12682292
RAN_HUMAN	RAN	physical	10400640
NR2C2_HUMAN	NR2C2	physical	10611280
NCOA3_HUMAN	NCOA3	physical	10965917
RNF4_HUMAN	RNF4	physical	9710597
RNF4_HUMAN	RNF4	physical	10617653
NCOA4_HUMAN	NCOA4	physical	9892017
NCOA4_HUMAN	NCOA4	physical	8643607
PAK6_HUMAN	PAK6	physical	11278661
ZN363_HUMAN	RCHY1	physical	12200228
PIAS2_HUMAN	PIAS2	physical	11117529
PIAS2_HUMAN	PIAS2	physical	9920921
HNF4A_HUMAN	HNF4A	physical	12944908
IL6RB_HUMAN	IL6ST	physical	15129430
SMAD3_HUMAN	SMAD3	physical	11707452
CCNH_HUMAN	CCNH	physical	10734072
CDK7_HUMAN	CDK7	physical	10734072
ANDR_HUMAN	AR	physical	15525515
STAT3_HUMAN	STAT3	physical	11322786
STAT3_HUMAN	STAT3	physical	11751884
ANDR_HUMAN	AR	physical	15062556
JUN_HUMAN	JUN	physical	9211894
XRCC5_HUMAN	XRCC5	physical	15640154
XRCC6_HUMAN	XRCC6	physical	15640154
CTNB1_HUMAN	CTNNB1	physical	15256534
CTNB1_HUMAN	CTNNB1	physical	14593076
NCOA1_HUMAN	NCOA1	physical	15256534
NCOR1_HUMAN	NCOR1	physical	15256534
NCOR1_HUMAN	NCOR1	physical	14593076
NCOR1_HUMAN	NCOR1	physical	12089345
SMAD3_HUMAN	SMAD3	physical	11280774
NCOR2_HUMAN	NCOR2	physical	12441355
NCOR2_HUMAN	NCOR2	physical	14593076
NCOR2_HUMAN	NCOR2	physical	11923464
NCOA2_HUMAN	NCOA2	physical	14593076
FOXO1_HUMAN	FOXO1	physical	12482965
ANDR_HUMAN	AR	physical	15256534
ANDR_HUMAN	AR	physical	11504717
MAGAB_HUMAN	MAGEA11	physical	15684378
CTNB1_HUMAN	CTNNB1	physical	12799378
P53_HUMAN	TP53	genetic	11504717
TGFI1_HUMAN	TGFB1I1	physical	11856738
NCOA6_HUMAN	NCOA6	physical	14645241
CBP_HUMAN	CREBBP	physical	9822653
EGFR_HUMAN	EGFR	physical	15305378
EGFR_HUMAN	EGFR	physical	15288768
GRIP1_HUMAN	GRIP1	physical	10607837
PELP1_HUMAN	PELP1	physical	15466214
SRC_HUMAN	SRC	physical	15027889
SART3_HUMAN	SART3	physical	15031286
ZMIZ1_HUMAN	ZMIZ1	physical	14609956
HDAC3_HUMAN	HDAC3	physical	12943985
HDAC4_HUMAN	HDAC4	physical	12943985
GELS_HUMAN	GSN	physical	12941811
PSPC1_HUMAN	PSPC1	physical	12810069
NONO_HUMAN	NONO	physical	12810069
NCOA2_HUMAN	NCOA2	physical	12810069
CBP_HUMAN	CREBBP	physical	12810069
ANDR_HUMAN	AR	physical	12682292
EFCB6_HUMAN	EFCAB6	physical	12612053
HDAC1_HUMAN	HDAC1	physical	11994312
CDK9_HUMAN	CDK9	physical	11266437
NSD1_HUMAN	NSD1	physical	11509567
CBP_HUMAN	CREBBP	genetic	9482849
TS101_HUMAN	TSG101	physical	10508170
COX5B_HUMAN	COX5B	physical	11719263
RAF1_HUMAN	RAF1	physical	8349631
SVIL_HUMAN	SVIL	physical	11792840
FHL2_HUMAN	FHL2	physical	10654935
PAK6_HUMAN	PAK6	physical	11773441
PIAS4_HUMAN	PIAS4	physical	11439351
NCOA4_HUMAN	NCOA4	physical	11818501
NR0B1_HUMAN	NR0B1	physical	11875111
TMF1_HUMAN	TMF1	physical	10428808
SRY_HUMAN	SRY	physical	11585838
CTNB1_HUMAN	CTNNB1	physical	11916967
UBC9_HUMAN	UBE2I	physical	10383460
UBC9_HUMAN	UBE2I	genetic	10383460
SMAD3_HUMAN	SMAD3	physical	12226080
SMAD4_HUMAN	SMAD4	physical	12226080
CALR_HUMAN	CALR	physical	8107809
NCOA4_HUMAN	NCOA4	physical	11779876
RNF14_HUMAN	RNF14	physical	11779876
TGFI1_HUMAN	TGFB1I1	physical	11779876
SPDEF_HUMAN	SPDEF	physical	10625666
NCOA3_HUMAN	NCOA3	physical	11747336
RNF4_HUMAN	RNF4	physical	11719514
PATZ1_HUMAN	PATZ1	physical	11719514
ETV5_HUMAN	ETV5	physical	8798622
BAG1_HUMAN	BAG1	physical	9565586
PIAS1_HUMAN	PIAS1	physical	11117529
PIAS3_HUMAN	PIAS3	physical	11117529
HMGB1_HUMAN	HMGB1	physical	9671457
HMGB2_HUMAN	HMGB2	physical	9671457
PRP6_HUMAN	PRPF6	physical	12039962
RNF14_HUMAN	RNF14	physical	10085091
T2FA_HUMAN	GTF2F1	physical	9238003
T2FB_HUMAN	GTF2F2	physical	9238003
TBP_HUMAN	TBP	physical	9238003
TF2H1_HUMAN	GTF2H1	physical	10734072
MED1_HUMAN	MED1	physical	12218053
HS90A_HUMAN	HSP90AA1	physical	1525041
PMEPA_HUMAN	PMEPA1	physical	18703514
RAD9A_HUMAN	RAD9A	physical	14966297
SMCA4_HUMAN	SMARCA4	physical	14966121
SMRC1_HUMAN	SMARCC1	physical	14966121
NCOA2_HUMAN	NCOA2	physical	14966121
NCOA3_HUMAN	NCOA3	physical	14966121
RNF14_HUMAN	RNF14	physical	12612084
NCOA4_HUMAN	NCOA4	physical	12612084
NCOA2_HUMAN	NCOA2	physical	12612084
NCOA2_HUMAN	NCOA2	physical	15684378
TRI68_HUMAN	TRIM68	physical	18451177
HSPB2_HUMAN	HSPB2	physical	17974989
MDM2_HUMAN	MDM2	physical	17974989
HS90A_HUMAN	HSP90AA1	physical	17974989
NSD2_HUMAN	WHSC1	physical	19481544
ZN363_HUMAN	RCHY1	physical	17721809
MDN1_HUMAN	MDN1	physical	19762545
NAL10_HUMAN	NLRP10	physical	19762545
SMCA2_HUMAN	SMARCA2	physical	19762545
SMCA4_HUMAN	SMARCA4	physical	19762545
ZBT16_HUMAN	ZBTB16	physical	19762545
MED24_HUMAN	MED24	physical	19762545
DEN5A_HUMAN	DENND5A	physical	19762545
ZBTB1_HUMAN	ZBTB1	physical	19762545
MD12L_HUMAN	MED12L	physical	19762545
SMRD1_HUMAN	SMARCD1	physical	19762545
SPOP_HUMAN	SPOP	physical	19762545
MLH3_HUMAN	MLH3	physical	19762545
KIFA3_HUMAN	KIFAP3	physical	19762545
HDAC1_HUMAN	HDAC1	physical	15640443
MDM2_HUMAN	MDM2	physical	15640443
SIR1_HUMAN	SIRT1	physical	16923962
NCOR1_HUMAN	NCOR1	physical	16914745
ZN363_HUMAN	RCHY1	physical	16914734
ZN318_HUMAN	ZNF318	physical	16469430
SMCE1_HUMAN	SMARCE1	physical	18559499
EP300_HUMAN	EP300	physical	18487222
SMCA2_HUMAN	SMARCA2	physical	18487222
SMCA4_HUMAN	SMARCA4	physical	18487222
CTNB1_HUMAN	CTNNB1	physical	12944908
HDAC1_HUMAN	HDAC1	physical	15835920
TGIF1_HUMAN	TGIF1	physical	11682623
KAT5_HUMAN	KAT5	physical	10364196
NCOR2_HUMAN	NCOR2	physical	15062576
SRC_HUMAN	SRC	physical	15062576
SFPQ_HUMAN	SFPQ	physical	17452459
NONO_HUMAN	NONO	physical	17452459
G45IP_HUMAN	GADD45GIP1	physical	17885209
HDAC4_HUMAN	HDAC4	physical	21242980
UBP26_HUMAN	USP26	physical	20501646
RNF6_HUMAN	RNF6	physical	19345326
NELFD_HUMAN	NELFCD	physical	20069563
HS90A_HUMAN	HSP90AA1	physical	19706771
CHIP_HUMAN	STUB1	physical	19706771
GELS_HUMAN	GSN	physical	15604093
RNF14_HUMAN	RNF14	physical	15604093
REPS2_HUMAN	REPS2	physical	15604093
NCOA4_HUMAN	NCOA4	physical	15604093
KIF1A_HUMAN	KIF1A	physical	15604093
ERCC3_HUMAN	ERCC3	physical	21157430
ERCC2_HUMAN	ERCC2	physical	21157430
TF2H2_HUMAN	GTF2H2	physical	21157430
CDK7_HUMAN	CDK7	physical	21157430
MDM2_HUMAN	MDM2	physical	21157430
CHIP_HUMAN	STUB1	physical	21157430
HS90A_HUMAN	HSP90AA1	physical	21157430
TIF1A_HUMAN	TRIM24	physical	19909775
ZBT7A_HUMAN	ZBTB7A	physical	20812024
NCOR1_HUMAN	NCOR1	physical	15598662
E2F1_HUMAN	E2F1	physical	22508987
E2F4_HUMAN	E2F4	physical	22508987
NCOR2_HUMAN	NCOR2	physical	22508987
PRS6A_HUMAN	PSMC3	physical	19325002
CHIP_HUMAN	STUB1	physical	15107424
LATS2_HUMAN	LATS2	physical	15131260
CSN2_HUMAN	COPS2	physical	17356171
NCOR2_HUMAN	NCOR2	physical	17356171
UBP10_HUMAN	USP10	physical	16368182
TAF1_HUMAN	TAF1	physical	20181722
ACK1_HUMAN	TNK2	physical	17494760
DDB2_HUMAN	DDB2	physical	22846800
PAX6_HUMAN	PAX6	physical	19790232
RNF14_HUMAN	RNF14	physical	17110431
ARI5A_HUMAN	ARID5A	physical	15941852
NCOA1_HUMAN	NCOA1	physical	12163482
PAX6_HUMAN	PAX6	physical	21935435
TCF20_HUMAN	TCF20	physical	21935435
DCAF6_HUMAN	DCAF6	physical	15784617
CHIP_HUMAN	STUB1	physical	20661446
FKBP5_HUMAN	FKBP5	physical	20661446
FKBP4_HUMAN	FKBP4	physical	20661446
PPP5_HUMAN	PPP5C	physical	20661446
DNJC7_HUMAN	DNAJC7	physical	20661446
PPID_HUMAN	PPID	physical	20661446
MAGAB_HUMAN	MAGEA11	physical	19828458
TAB2_HUMAN	TAB2	physical	16469706
NCOR1_HUMAN	NCOR1	physical	16469706
HDAC3_HUMAN	HDAC3	physical	16469706
TBL1R_HUMAN	TBL1XR1	physical	16469706
SIN3A_HUMAN	SIN3A	physical	16469706
SIN3B_HUMAN	SIN3B	physical	16469706
PARK7_HUMAN	PARK7	physical	17510388
HS90A_HUMAN	HSP90AA1	physical	19805354
STAT3_HUMAN	STAT3	physical	12804609
MDM2_HUMAN	MDM2	physical	23132866
AKT1_HUMAN	AKT1	physical	18332867
MDM2_HUMAN	MDM2	physical	18332867
SIAH2_HUMAN	SIAH2	physical	23518348
NCOR1_HUMAN	NCOR1	physical	23518348
ACTB_HUMAN	ACTB	physical	17353003
HS90A_HUMAN	HSP90AA1	physical	17353003
NCOA1_HUMAN	NCOA1	physical	17353003
JHD2C_HUMAN	JMJD1C	physical	17353003
SMAD1_HUMAN	SMAD1	physical	17183365
VHL_HUMAN	VHL	physical	23961993
NCOA4_HUMAN	NCOA4	physical	10347167
TEBP_HUMAN	PTGES3	physical	22899854
RBL1_HUMAN	RBL1	physical	23853093
UBP12_HUMAN	USP12	physical	24056413
SPOP_HUMAN	SPOP	physical	24508459
VHL_HUMAN	VHL	physical	24422631
RNF14_HUMAN	RNF14	physical	24422631
ANDR_HUMAN	AR	physical	23172223
MAGAB_HUMAN	MAGEA11	physical	23172223
EP300_HUMAN	EP300	physical	23172223
NCOA1_HUMAN	NCOA1	physical	23975195
MAGAB_HUMAN	MAGEA11	physical	24722188
UBP12_HUMAN	USP12	physical	25216524
SPOP_HUMAN	SPOP	physical	25274033
DAPK3_HUMAN	DAPK3	physical	23146908
TS101_HUMAN	TSG101	physical	23146908
AATF_HUMAN	AATF	physical	23146908
KAT2B_HUMAN	KAT2B	physical	10779504
TF65_HUMAN	RELA	genetic	9482849
TRI18_HUMAN	MID1	physical	24913494
TF7L2_HUMAN	TCF7L2	physical	12799378
ELF3_HUMAN	ELF3	physical	23435425
UBP7_HUMAN	USP7	physical	26175158
HS90A_HUMAN	HSP90AA1	physical	26342197
PP1A_HUMAN	PPP1CA	physical	26636645
AHR_HUMAN	AHR	physical	25908644
ANDR_HUMAN	AR	physical	25908644
WDR20_HUMAN	WDR20	physical	26462181
WDR48_HUMAN	WDR48	physical	26462181
UBP12_HUMAN	USP12	physical	26462181
PRP8_HUMAN	PRPF8	physical	26371515
UBP26_HUMAN	USP26	physical	27089915
HS90A_HUMAN	HSP90AA1	physical	20048054
FKBP5_HUMAN	FKBP5	physical	20048054
TEBP_HUMAN	PTGES3	physical	20048054
PP2AA_HUMAN	PPP2CA	physical	20048054
EP300_HUMAN	EP300	physical	27903893
HS90A_HUMAN	HSP90AA1	physical	27903893
CACL1_HUMAN	CACUL1	physical	27085459
KDM1A_HUMAN	KDM1A	physical	27085459
UBP14_HUMAN	USP14	physical	28151478
SMRC2_HUMAN	SMARCC2	physical	28611094
TLE3_HUMAN	TLE3	physical	28611094
TCF20_HUMAN	TCF20	physical	28611094
GSE1_HUMAN	GSE1	physical	28611094
ARI1A_HUMAN	ARID1A	physical	28611094
JHD2C_HUMAN	JMJD1C	physical	28611094
ARI1B_HUMAN	ARID1B	physical	28611094
SMRC1_HUMAN	SMARCC1	physical	28611094
KDM1A_HUMAN	KDM1A	physical	28611094
BCOR_HUMAN	BCOR	physical	28611094
SMCE1_HUMAN	SMARCE1	physical	28611094
SMCA4_HUMAN	SMARCA4	physical	28611094
SNF5_HUMAN	SMARCB1	physical	28611094
NCOR2_HUMAN	NCOR2	physical	28611094
KMT2D_HUMAN	KMT2D	physical	28611094
SMCA2_HUMAN	SMARCA2	physical	28611094
CHD7_HUMAN	CHD7	physical	28611094
RCOR1_HUMAN	RCOR1	physical	28611094
DPF1_HUMAN	DPF1	physical	28611094
RAI1_HUMAN	RAI1	physical	28611094
AP2A_HUMAN	TFAP2A	physical	28611094
2ABA_HUMAN	PPP2R2A	physical	28611094
REQU_HUMAN	DPF2	physical	28611094
ARI3B_HUMAN	ARID3B	physical	28611094
CNBP_HUMAN	CNBP	physical	28611094
NCOR1_HUMAN	NCOR1	physical	28611094
ARI5B_HUMAN	ARID5B	physical	28611094
NFL_HUMAN	NEFL	physical	28611094
RS21_HUMAN	RPS21	physical	28611094
SPS2L_HUMAN	SPATS2L	physical	28611094
SMRD1_HUMAN	SMARCD1	physical	28611094
RCC2_HUMAN	RCC2	physical	28611094
DD19A_HUMAN	DDX19A	physical	28611094
SYK_HUMAN	KARS	physical	28611094
SIAH2_HUMAN	SIAH2	physical	28549433
NCOR1_HUMAN	NCOR1	physical	28549433
EP300_HUMAN	EP300	physical	28549433
MDM2_HUMAN	MDM2	physical	28708672
SUV92_HUMAN	SUV39H2	physical	28042025
AKT1_HUMAN	AKT1	physical	28708672
DCAF6_HUMAN	DCAF6	physical	28212551
DDB2_HUMAN	DDB2	physical	28212551
BRD2_HUMAN	BRD2	physical	28805820
BRD3_HUMAN	BRD3	physical	28805820
BRD4_HUMAN	BRD4	physical	28805820
CHIP_HUMAN	STUB1	physical	27835608
KDM6A_HUMAN	KDM6A	physical	22722839
ASXL1_HUMAN	ASXL1	physical	22722839
KMT2A_HUMAN	KMT2A	physical	22722839
KMT2D_HUMAN	KMT2D	physical	22722839
ASH2L_HUMAN	ASH2L	physical	22722839
FOXA1_HUMAN	FOXA1	physical	22722839
ERG_HUMAN	ERG	physical	22722839

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300068: Androgen insensitivity syndrome (AIS)
• 313200: Spinal and bulbar muscular atrophy X-linked 1 (SMAX1)
• : Note=Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.
• 312300:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01128: Bicalutamide
• DB04839: Cyproterone acetate
• DB01406: Danazol
• DB01395: Drospirenone
• DB00858: Drostanolone
• DB08899: Enzalutamide
• DB00687: Fludrocortisone
• DB01185: Fluoxymesterone
• DB00499: Flutamide
• DB01026: Ketoconazole
• DB00367: Levonorgestrel
• DB06710: Methyltestosterone
• DB08804: Nandrolone decanoate
• DB00984: Nandrolone phenpropionate
• DB00665: Nilutamide
• DB00621: Oxandrolone
• DB00421: Spironolactone
• DB00624: Testosterone
• DB01420: Testosterone Propionate

Related Literatures of Post-Translational Modification

Phosphorylation

"MST1 is a multifunctional caspase-independent inhibitor of androgenicsignaling.";
Cinar B., Collak F.K., Lopez D., Akgul S., Mukhopadhyay N.K.,Kilicarslan M., Gioeli D.G., Freeman M.R.;
Cancer Res. 71:4303-4313(2011).
Cited for: PHOSPHORYLATION AT SER-650, AND INTERACTION WITH STK4/MST1.
PubMed: 21512132

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300; THR-301 ANDTYR-307, AND MASS SPECTROMETRY.
PubMed: 19369195

"CDK9 regulates AR promoter selectivity and cell growth through serine81 phosphorylation.";
Gordon V., Bhadel S., Wunderlich W., Zhang J., Ficarro S.B.,Mollah S.A., Shabanowitz J., Hunt D.F., Xenarios I., Hahn W.C.,Conaway M., Carey M.F., Gioeli D.;
Mol. Endocrinol. 24:2267-2280(2010).
Cited for: FUNCTION IN AR KINASE, PHOSPHORYLATION AT SER-81 BY CDK9, MUTAGENESISOF SER-81, AND INTERACTION WITH CDK9.
PubMed: 20980437

"Effect of Ack1 tyrosine kinase inhibitor on ligand-independentandrogen receptor activity.";
Mahajan K., Challa S., Coppola D., Lawrence H., Luo Y., Gevariya H.,Zhu W., Chen Y.A., Lawrence N.J., Mahajan N.P.;
Prostate 70:1274-1285(2010).
Cited for: PHOSPHORYLATION AT TYR-267, AND ENZYME REGULATION.
PubMed: 20623637

"Activated Cdc42-associated kinase Ack1 promotes prostate cancerprogression via androgen receptor tyrosine phosphorylation.";
Mahajan N.P., Liu Y., Majumder S., Warren M.R., Parker C.E.,Mohler J.L., Earp H.S., Whang Y.E.;
Proc. Natl. Acad. Sci. U.S.A. 104:8438-8443(2007).
Cited for: INTERACTION WITH TNK2, PHOSPHORYLATION AT TYR-267 AND TYR-363 BY TNK2,AND MUTAGENESIS OF TYR-267 AND TYR-363.
PubMed: 17494760

"Regulation of androgen receptor activity by tyrosinephosphorylation.";
Guo Z., Dai B., Jiang T., Xu K., Xie Y., Kim O., Nesheiwat I.,Kong X., Melamed J., Handratta V.D., Njar V.C., Brodie A.M., Yu L.-R.,Veenstra T.D., Chen H., Qiu Y.;
Cancer Cell 10:309-319(2006).
Cited for: PHOSPHORYLATION AT TYR-223; TYR-267; TYR-307; TYR-346; TYR-357;TYR-362; TYR-363; TYR-393; TYR-534; TYR-551 AND TYR-915, MUTAGENESISOF TYR-223; TYR-267; TYR-307; TYR-346; TYR-357; TYR-362; TYR-363;TYR-393; TYR-534; TYR-551 AND TYR-915, AND MASS SPECTROMETRY.
PubMed: 17045208

Sumoylation

"Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1).";
Poukka H., Karvonen U., Jaenne O.A., Palvimo J.J.;
Proc. Natl. Acad. Sci. U.S.A. 97:14145-14150(2000).
Cited for: SUMOYLATION AT LYS-386 AND LYS-520.
PubMed: 11121022

Ubiquitylation

"Regulation of androgen receptor transcriptional activity andspecificity by RNF6-induced ubiquitination.";
Xu K., Shimelis H., Linn D.E., Jiang R., Yang X., Sun F., Guo Z.,Chen H., Li W., Chen H., Kong X., Melamed J., Fang S., Xiao Z.,Veenstra T.D., Qiu Y.;
Cancer Cell 15:270-282(2009).
Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, POLYUBIQUITINATION ATLYS-845 AND LYS-847 BY RNF6, MUTAGENESIS OF LYS-845 AND LYS-847,INTERACTION WITH RNF14 AND RNF6, AND SUBCELLULAR LOCATION.
PubMed: 19345326