| UniProt ID | WDR48_HUMAN | |
|---|---|---|
| UniProt AC | Q8TAF3 | |
| Protein Name | WD repeat-containing protein 48 | |
| Gene Name | WDR48 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 677 | |
| Subcellular Localization | Nucleus . Cytoplasm . Lysosome . Late endosome . Mainly in cytoplasmic compartments (PubMed:12196293, PubMed:18032488). In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11 (PubMed:18 | |
| Protein Description | Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. [PubMed: 18082604] | |
| Protein Sequence | MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVNPMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 (in isoform 2) | Ubiquitination | - | 1.94 | 21890473 | |
| 24 (in isoform 4) | Ubiquitination | - | 42.60 | 21890473 | |
| 28 | Phosphorylation | IRDEVEKYNRNGVNA EHHHHHHHCCCCCCH | 13.07 | - | |
| 39 | Acetylation | GVNALQLDPALNRLF CCCHHHCCHHHHHHH | 17.29 | 19608861 | |
| 52 | Phosphorylation | LFTAGRDSIIRIWSV HHHCCCCCEEEEEEC | 20.67 | 24719451 | |
| 63 | Ubiquitination | IWSVNQHKQDPYIAS EEECCCCCCCCCEEE | 46.78 | - | |
| 63 (in isoform 2) | Ubiquitination | - | 46.78 | 21890473 | |
| 97 (in isoform 3) | Ubiquitination | - | 35.12 | 21890473 | |
| 106 (in isoform 1) | Ubiquitination | - | 51.80 | 21890473 | |
| 106 | Acetylation | VKVWNAHKGFCMSTL EEEEECCCCCCHHHH | 51.80 | 26051181 | |
| 106 | Ubiquitination | VKVWNAHKGFCMSTL EEEEECCCCCCHHHH | 51.80 | 21890473 | |
| 112 | Acetylation | HKGFCMSTLRTHKDY CCCCCHHHHHHCHHH | 8.06 | 19608861 | |
| 121 | Acetylation | RTHKDYVKALAYAKD HHCHHHHHHHHHHCC | 31.30 | 19608861 | |
| 129 | Ubiquitination | ALAYAKDKELVASAG HHHHHCCHHHHHHCC | 52.84 | - | |
| 132 | Acetylation | YAKDKELVASAGLDR HHCCHHHHHHCCCCC | 4.08 | 19608861 | |
| 172 | Phosphorylation | SGNKDSIYSLAMNQL CCCHHHHHHHHHHCC | 11.11 | 28857561 | |
| 173 | Phosphorylation | GNKDSIYSLAMNQLG CCHHHHHHHHHHCCC | 14.16 | 28857561 | |
| 185 | Phosphorylation | QLGTIIVSGSTEKVL CCCEEEEECCCCCEE | 19.33 | 28857561 | |
| 187 | Phosphorylation | GTIIVSGSTEKVLRV CEEEEECCCCCEEEE | 26.36 | 28857561 | |
| 188 | Phosphorylation | TIIVSGSTEKVLRVW EEEEECCCCCEEEEE | 43.27 | 28857561 | |
| 205 | Acetylation | RTCAKLMKLKGHTDN HHHHHHHHHCCCCCC | 58.44 | 19608861 | |
| 207 | Ubiquitination | CAKLMKLKGHTDNVK HHHHHHHCCCCCCCE | 43.03 | - | |
| 214 | Acetylation | KGHTDNVKALLLNRD CCCCCCCEEEEECCC | 39.30 | 19608861 | |
| 214 | Ubiquitination | KGHTDNVKALLLNRD CCCCCCCEEEEECCC | 39.30 | - | |
| 223 | Phosphorylation | LLLNRDGTQCLSGSS EEECCCCCCCCCCCC | 22.01 | 30257219 | |
| 227 | Phosphorylation | RDGTQCLSGSSDGTI CCCCCCCCCCCCCEE | 44.23 | 24732914 | |
| 229 | Phosphorylation | GTQCLSGSSDGTIRL CCCCCCCCCCCEEEE | 23.14 | 24732914 | |
| 230 | Phosphorylation | TQCLSGSSDGTIRLW CCCCCCCCCCEEEEE | 43.51 | 24732914 | |
| 233 | Phosphorylation | LSGSSDGTIRLWSLG CCCCCCCEEEEEEEC | 14.12 | 24732914 | |
| 245 (in isoform 4) | Ubiquitination | - | 3.32 | 21890473 | |
| 275 | Ubiquitination | YSGGRDRKIYCTDLR EECCCCCEEEEECCC | 42.17 | - | |
| 277 | Phosphorylation | GGRDRKIYCTDLRNP CCCCCEEEEECCCCC | 7.73 | 29496907 | |
| 294 | Acetylation | RVLICEEKAPVLKME EEEEECCCCCEEEEE | 35.38 | 26051181 | |
| 294 | Ubiquitination | RVLICEEKAPVLKME EEEEECCCCCEEEEE | 35.38 | - | |
| 299 | Ubiquitination | EEKAPVLKMELDRSA CCCCCEEEEECCCCC | 30.48 | - | |
| 305 | Phosphorylation | LKMELDRSADPPPAI EEEECCCCCCCCCEE | 36.37 | - | |
| 308 (in isoform 5) | Ubiquitination | - | 36.17 | 21890473 | |
| 318 (in isoform 3) | Ubiquitination | - | 39.51 | 21890473 | |
| 318 | Ubiquitination | AIWVATTKSTVNKWT EEEEEECCHHHCCEE | 39.51 | - | |
| 323 | Acetylation | TTKSTVNKWTLKGIH ECCHHHCCEECCEEE | 36.90 | 25953088 | |
| 325 | Phosphorylation | KSTVNKWTLKGIHNF CHHHCCEECCEEECC | 21.87 | 28961369 | |
| 327 (in isoform 1) | Ubiquitination | - | 48.74 | 21890473 | |
| 327 | Ubiquitination | TVNKWTLKGIHNFRA HHCCEECCEEECCCC | 48.74 | 21890473 | |
| 335 | Phosphorylation | GIHNFRASGDYDNDC EEECCCCCCCCCCCC | 28.13 | 23401153 | |
| 338 | Phosphorylation | NFRASGDYDNDCTNP CCCCCCCCCCCCCCC | 21.85 | 30278072 | |
| 343 | Phosphorylation | GDYDNDCTNPITPLC CCCCCCCCCCCCCCC | 47.06 | 30278072 | |
| 347 | Phosphorylation | NDCTNPITPLCTQPD CCCCCCCCCCCCCCC | 16.09 | 23927012 | |
| 351 | Phosphorylation | NPITPLCTQPDQVIK CCCCCCCCCCCCEEE | 51.31 | 23927012 | |
| 358 | Ubiquitination | TQPDQVIKGGASIIQ CCCCCEEECCCCEEE | 53.05 | - | |
| 372 | Ubiquitination | QCHILNDKRHILTKD EEEECCCCCCEEEEC | 44.81 | - | |
| 377 | Phosphorylation | NDKRHILTKDTNNNV CCCCCEEEECCCCCE | 26.69 | - | |
| 378 | Ubiquitination | DKRHILTKDTNNNVA CCCCEEEECCCCCEE | 60.14 | - | |
| 386 | Phosphorylation | DTNNNVAYWDVLKAC CCCCCEEHHHHHHHC | 9.62 | 25147952 | |
| 391 | Ubiquitination | VAYWDVLKACKVEDL EEHHHHHHHCCCHHH | 52.14 | - | |
| 400 | Ubiquitination | CKVEDLGKVDFEDEI CCCHHHCCCCCHHHH | 46.02 | - | |
| 408 | Ubiquitination | VDFEDEIKKRFKMVY CCCHHHHHHHCEEEE | 35.53 | - | |
| 451 | Phosphorylation | SAKDAGFSSPDGSDP EHHHCCCCCCCCCCC | 39.79 | - | |
| 452 | Phosphorylation | AKDAGFSSPDGSDPK HHHCCCCCCCCCCCC | 25.42 | - | |
| 456 | Phosphorylation | GFSSPDGSDPKLNLG CCCCCCCCCCCCCHH | 59.11 | - | |
| 496 (in isoform 4) | Ubiquitination | - | 55.45 | 21890473 | |
| 496 | Acetylation | VNHVNGEQENRVQKG CCCCCHHHCCCEECC | 55.45 | 19608861 | |
| 564 | Acetylation | KNMPKFNKIPFYLQP CCCCCCCCCCEEECC | 55.69 | 25953088 | |
| 568 | Phosphorylation | KFNKIPFYLQPHASS CCCCCCEEECCCCCC | 10.08 | 28152594 | |
| 569 (in isoform 3) | Ubiquitination | - | 6.99 | 21890473 | |
| 569 | Acetylation | FNKIPFYLQPHASSG CCCCCEEECCCCCCC | 6.99 | 19608861 | |
| 574 | Phosphorylation | FYLQPHASSGAKTLK EEECCCCCCCCCCCC | 26.69 | 25627689 | |
| 575 | Phosphorylation | YLQPHASSGAKTLKK EECCCCCCCCCCCCC | 43.48 | 25159151 | |
| 578 | Ubiquitination | PHASSGAKTLKKDRL CCCCCCCCCCCCCCC | 58.89 | 21890473 | |
| 578 (in isoform 1) | Ubiquitination | - | 58.89 | 21890473 | |
| 578 | Acetylation | PHASSGAKTLKKDRL CCCCCCCCCCCCCCC | 58.89 | 23954790 | |
| 586 | Phosphorylation | TLKKDRLSASDMLQV CCCCCCCCHHHHHHH | 26.98 | 30108239 | |
| 588 | Phosphorylation | KKDRLSASDMLQVRK CCCCCCHHHHHHHHH | 21.85 | 20860994 | |
| 611 | Phosphorylation | IINLDNESQTTSSSN HHCCCCCCCCCCCCC | 38.80 | 25159151 | |
| 613 | Phosphorylation | NLDNESQTTSSSNNE CCCCCCCCCCCCCCC | 37.61 | 27373336 | |
| 614 | Phosphorylation | LDNESQTTSSSNNEK CCCCCCCCCCCCCCC | 20.97 | 25850435 | |
| 615 | Phosphorylation | DNESQTTSSSNNEKP CCCCCCCCCCCCCCC | 34.85 | 25850435 | |
| 616 | Phosphorylation | NESQTTSSSNNEKPG CCCCCCCCCCCCCCC | 34.69 | 29514088 | |
| 617 | Phosphorylation | ESQTTSSSNNEKPGE CCCCCCCCCCCCCCC | 43.36 | 27050516 | |
| 621 (in isoform 1) | Ubiquitination | - | 61.52 | 21890473 | |
| 621 | Ubiquitination | TSSSNNEKPGEQEKE CCCCCCCCCCCHHHH | 61.52 | 2190698 | |
| 663 | Acetylation | TVKHFIWKSGGDLTL HHEEEHHHCCCCEEE | 34.11 | 26051181 | |
| 664 | Phosphorylation | VKHFIWKSGGDLTLH HEEEHHHCCCCEEEE | 32.77 | 24719451 | |
| 672 | Phosphorylation | GGDLTLHYRQKST-- CCCEEEEEEECCC-- | 20.18 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WDR48_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WDR48_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WDR48_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-121; LYS-214 AND LYS-578,AND MASS SPECTROMETRY. | |
