NOP10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOP10_HUMAN
• UniProt AC: Q9NPE3
• Protein Name: H/ACA ribonucleoprotein complex subunit 3
• Gene Name: NOP10
• Organism: Homo sapiens (Human).
• Sequence Length: 64
• Subcellular Localization: Nucleus, nucleolus . Nucleus, Cajal body . Also localized to Cajal bodies (coiled bodies).
• Protein Description: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme..
• Protein Sequence: MFLQYYLNEQGDRVYTLKKFDPMGQQTCSAHPARFSPDDKYSRHRITIKKRFKVLMTQQPRPVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Methylation	YLNEQGDRVYTLKKF EECCCCCEEEEEEEE	30.11	115485395
19	Ubiquitination	DRVYTLKKFDPMGQQ CEEEEEEEECCCCCC	59.10	29967540
19	Acetylation	DRVYTLKKFDPMGQQ CEEEEEEEECCCCCC	59.10	25953088
27	Phosphorylation	FDPMGQQTCSAHPAR ECCCCCCCCCCCCCC	10.67	20068231
29	Phosphorylation	PMGQQTCSAHPARFS CCCCCCCCCCCCCCC	32.76	30576142
34	Methylation	TCSAHPARFSPDDKY CCCCCCCCCCCCCCC	36.71	115485389
36	Phosphorylation	SAHPARFSPDDKYSR CCCCCCCCCCCCCCC	23.13	25159151
40	Ubiquitination	ARFSPDDKYSRHRIT CCCCCCCCCCCCEEE	53.13	29967540
40	Acetylation	ARFSPDDKYSRHRIT CCCCCCCCCCCCEEE	53.13	25953088
40	2-Hydroxyisobutyrylation	ARFSPDDKYSRHRIT CCCCCCCCCCCCEEE	53.13	-
41	Phosphorylation	RFSPDDKYSRHRITI CCCCCCCCCCCEEEE	20.24	23186163
42	Phosphorylation	FSPDDKYSRHRITIK CCCCCCCCCCEEEEE	27.61	20068231
53	Acetylation	ITIKKRFKVLMTQQP EEEEHHHEEEECCCC	38.19	26051181
56	Sulfoxidation	KKRFKVLMTQQPRPV EHHHEEEECCCCCCC	3.39	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOP10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOP10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOP10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NHP2_HUMAN	NHP2	physical	25416956
NHP2_HUMAN	NHP2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 224230: Dyskeratosis congenita, autosomal recessive, 1 (DKCB1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.