NEB1_HUMAN - dbPTM
NEB1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NEB1_HUMAN
UniProt AC Q9ULJ8
Protein Name Neurabin-1
Gene Name PPP1R9A
Organism Homo sapiens (Human).
Sequence Length 1098
Subcellular Localization Cytoplasm, cytoskeleton. Cell junction, synapse, synaptosome.
Protein Description Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity)..
Protein Sequence MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPKKEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHLKDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQLLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSYYQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMTSTTAEGAGEQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MLKTESSGERT
----CCCCCCCCCCC		54.4520068231
6Phosphorylation--MLKTESSGERTTL
--CCCCCCCCCCCCC		49.2020068231
7Phosphorylation-MLKTESSGERTTLR
-CCCCCCCCCCCCCC		38.1420068231
17PhosphorylationRTTLRSASPHRNAYR
CCCCCCCCCCCCCCH		23.6126329039
19 (in isoform 2)Phosphorylation-32.88-
21 (in isoform 2)Phosphorylation-37.99-
39PhosphorylationSTFDKPKSDGEQKTK
HHCCCCCCCCCCCCC		60.4128985074
70 (in isoform 2)Phosphorylation-4.4625159151
94PhosphorylationTRGKGGHSSPQRRMK
CCCCCCCCCCCCCCC		47.1626329039
95PhosphorylationRGKGGHSSPQRRMKP
CCCCCCCCCCCCCCH		21.2726329039
100 (in isoform 2)Phosphorylation-10.7020068231
104 (in isoform 2)Phosphorylation-65.0820068231
105 (in isoform 2)Phosphorylation-15.4922210691
106 (in isoform 2)Phosphorylation-7.4722210691
119PhosphorylationSVVKLESSVSERISR
CEEEEECCHHHHHHC		21.9322817900
129PhosphorylationERISRFDTMYDGPSY
HHHHCCCCCCCCCCC		18.2128857561
129 (in isoform 2)Phosphorylation-18.2128985074
130 (in isoform 2)Phosphorylation-2.8627273156
131PhosphorylationISRFDTMYDGPSYSK
HHCCCCCCCCCCCHH		21.6025159151
135PhosphorylationDTMYDGPSYSKFTET
CCCCCCCCCHHHHHH		47.79-
136PhosphorylationTMYDGPSYSKFTETR
CCCCCCCCHHHHHHH		21.00-
137PhosphorylationMYDGPSYSKFTETRK
CCCCCCCHHHHHHHH		26.15-
146 (in isoform 2)Phosphorylation-8.7227251275
149PhosphorylationTRKMFERSVHESGQN
HHHHHHHHHHHCCCC		22.1923312004
149 (in isoform 2)Phosphorylation-22.19-
153PhosphorylationFERSVHESGQNNRYS
HHHHHHHCCCCCCCC		30.7025159151
159PhosphorylationESGQNNRYSPKKEKA
HCCCCCCCCCCCCCC		31.3028985074
160PhosphorylationSGQNNRYSPKKEKAG
CCCCCCCCCCCCCCC		27.3125159151
160 (in isoform 2)Phosphorylation-27.3125690035
160 (in isoform 5)Phosphorylation-27.3124719451
162AcetylationQNNRYSPKKEKAGGS
CCCCCCCCCCCCCCC		68.5711790971
169PhosphorylationKKEKAGGSEPQDEWG
CCCCCCCCCCCCCCC		45.2327251275
170 (in isoform 2)Phosphorylation-50.70-
171 (in isoform 2)Phosphorylation-48.93-
179AcetylationQDEWGGSKSNRGSTD
CCCCCCCCCCCCCCC		55.8311790983
180PhosphorylationDEWGGSKSNRGSTDS
CCCCCCCCCCCCCCC		33.1925159151
184PhosphorylationGSKSNRGSTDSLDSL
CCCCCCCCCCCHHHH		26.2923663014
184 (in isoform 5)Phosphorylation-26.2924719451
185PhosphorylationSKSNRGSTDSLDSLS
CCCCCCCCCCHHHHH		32.2225850435
187PhosphorylationSNRGSTDSLDSLSSR
CCCCCCCCHHHHHHC		33.8828355574
187 (in isoform 5)Phosphorylation-33.8824719451
188 (in isoform 2)Phosphorylation-6.0424719451
190PhosphorylationGSTDSLDSLSSRTEA
CCCCCHHHHHHCHHC		35.1328355574
190 (in isoform 2)Phosphorylation-35.1324719451
190 (in isoform 5)Phosphorylation-35.1324719451
192PhosphorylationTDSLDSLSSRTEAVS
CCCHHHHHHCHHCCC		23.0223663014
193PhosphorylationDSLDSLSSRTEAVSP
CCHHHHHHCHHCCCC		48.8121815630
195PhosphorylationLDSLSSRTEAVSPTV
HHHHHHCHHCCCCCH		30.1930206219
199PhosphorylationSSRTEAVSPTVSQLS
HHCHHCCCCCHHHHH		23.1530278072
199 (in isoform 2)Phosphorylation-23.1527251275
200 (in isoform 2)Phosphorylation-30.1627251275
201PhosphorylationRTEAVSPTVSQLSAV
CHHCCCCCHHHHHHH		25.8630278072
201 (in isoform 5)Phosphorylation-25.8624719451
203PhosphorylationEAVSPTVSQLSAVFE
HCCCCCHHHHHHHHC		28.0730206219
204 (in isoform 2)Phosphorylation-34.7925850435
206PhosphorylationSPTVSQLSAVFENTD
CCCHHHHHHHHCCCC		18.1030206219
207 (in isoform 2)Phosphorylation-20.7127251275
212PhosphorylationLSAVFENTDSPSAII
HHHHHCCCCCCCEEE		30.5618669648
214PhosphorylationAVFENTDSPSAIISE
HHHCCCCCCCEEEEE		20.7920068231
216PhosphorylationFENTDSPSAIISEKA
HCCCCCCCEEEEEEC		35.7320068231
220PhosphorylationDSPSAIISEKAENNE
CCCCEEEEEECCCCC		27.2520068231
229PhosphorylationKAENNEYSVTGHYPL
ECCCCCEEEECCCCC		13.6625159151
243 (in isoform 2)Phosphorylation-2.9024719451
253 (in isoform 2)Phosphorylation-54.1330266825
254 (in isoform 2)Phosphorylation-60.4530266825
263 (in isoform 2)Phosphorylation-55.6630266825
267 (in isoform 2)Phosphorylation-47.4027174698
277PhosphorylationDAHKSNATPVPEVAS
HHHHHCCCCCCHHHC		29.1228857561
284PhosphorylationTPVPEVASKSTSLAS
CCCCHHHCCCCCCCC		32.1120860994
284 (in isoform 5)Phosphorylation-32.1124719451
286PhosphorylationVPEVASKSTSLASIP
CCHHHCCCCCCCCCC		22.2625159151
287PhosphorylationPEVASKSTSLASIPG
CHHHCCCCCCCCCCH		31.3425159151
288PhosphorylationEVASKSTSLASIPGE
HHHCCCCCCCCCCHH		29.0925159151
291PhosphorylationSKSTSLASIPGEEIQ
CCCCCCCCCCHHHHH		34.3125159151
312PhosphorylationDSTSNQQTPDSIDKD
CCCCCCCCCCCCCCC		21.21-
334PhosphorylationESKAMPKSEIPSPQS
HCCCCCHHHCCCCHH		34.5830266825
338PhosphorylationMPKSEIPSPQSQLLE
CCHHHCCCCHHHHHH		41.0330266825
338 (in isoform 5)Phosphorylation-41.0324719451
341PhosphorylationSEIPSPQSQLLEDAE
HHCCCCHHHHHHHHH		26.6130266825
370PhosphorylationELAGGDFTSPDASAS
HHCCCCCCCCCCCHH		44.0520068231
370 (in isoform 5)Phosphorylation-44.0524719451
371PhosphorylationLAGGDFTSPDASASS
HCCCCCCCCCCCHHH		22.3021815630
375PhosphorylationDFTSPDASASSCGKE
CCCCCCCCHHHCCCC		35.7420068231
377PhosphorylationTSPDASASSCGKEVP
CCCCCCHHHCCCCCC		24.5427251275
378PhosphorylationSPDASASSCGKEVPE
CCCCCHHHCCCCCCC		26.9720068231
460PhosphorylationANRKIKFSSAPIKVF
CCCCCCCCCCCEEEE		22.1622817900
461PhosphorylationNRKIKFSSAPIKVFN
CCCCCCCCCCEEEEE		40.9928102081
681UbiquitinationSKLSHKFKELQIKHA
HHHHHHHHHHHHHHC		63.42-
696UbiquitinationVTEAEIQKLKTKLQA
CCHHHHHHHHHHHHH		58.58-
726UbiquitinationQQNIEENKERMLKLE
HHHHHHHHHHHHHHH		50.40-
753PhosphorylationVNEHLKETQSQYQAL
HHHHHHHHHHHHHHH		31.7528331001
755PhosphorylationEHLKETQSQYQALEK
HHHHHHHHHHHHHHH		37.9728331001
757PhosphorylationLKETQSQYQALEKKY
HHHHHHHHHHHHHHH		10.8628331001
777UbiquitinationLIKDFQQKELDFIKR
HHHHHHHHHHHHHHH		49.8421890473
777UbiquitinationLIKDFQQKELDFIKR
HHHHHHHHHHHHHHH		49.84-
777UbiquitinationLIKDFQQKELDFIKR
HHHHHHHHHHHHHHH		49.842189047
777 (in isoform 1)Ubiquitination-49.8421890473
777 (in isoform 2)Ubiquitination-49.8421890473
799UbiquitinationIEDLEKAHLVEVQGL
HHHHHHHHEEEECCE		41.2821890473
839PhosphorylationNNIFERRTSLGEVSK
CCCEECCCCCCCCCC		34.2330266825
840PhosphorylationNIFERRTSLGEVSKG
CCEECCCCCCCCCCC		32.3430266825
840 (in isoform 5)Phosphorylation-32.3424719451
845PhosphorylationRTSLGEVSKGDTMEN
CCCCCCCCCCCCCCC		26.9823927012
849PhosphorylationGEVSKGDTMENLDGK
CCCCCCCCCCCCCCC		34.7423927012
865PhosphorylationTSCQDGLSQDLNEAV
CCCCCCCCCHHHHHC		27.4624719451
865 (in isoform 5)Phosphorylation-27.4624719451
885PhosphorylationLDSKALKTRAQLSVK
HCHHHHHHHHHHHHC		31.8920068231
890PhosphorylationLKTRAQLSVKNRRQR
HHHHHHHHHCCCCCC		20.9725159151
890 (in isoform 5)Phosphorylation-20.9724719451
901PhosphorylationRRQRPSRTRLYDSVS
CCCCCCCCCCCCCCC		29.3923312004
904PhosphorylationRPSRTRLYDSVSSTD
CCCCCCCCCCCCCCC		11.6829978859
906PhosphorylationSRTRLYDSVSSTDGE
CCCCCCCCCCCCCCC		15.4423663014
908PhosphorylationTRLYDSVSSTDGEDS
CCCCCCCCCCCCCCC		31.3223663014
908 (in isoform 5)Phosphorylation-31.3224719451
909PhosphorylationRLYDSVSSTDGEDSL
CCCCCCCCCCCCCCH		28.5023663014
910PhosphorylationLYDSVSSTDGEDSLE
CCCCCCCCCCCCCHH		40.2823663014
915PhosphorylationSSTDGEDSLERKNFT
CCCCCCCCHHHCCEE		28.0319691289
928PhosphorylationFTFNDDFSPSSTSSA
EECCCCCCCCCCCCC		30.7624076635
928 (in isoform 5)Phosphorylation-30.76-
930PhosphorylationFNDDFSPSSTSSADL
CCCCCCCCCCCCCCC		45.0828348404
930 (in isoform 5)Phosphorylation-45.08-
931PhosphorylationNDDFSPSSTSSADLS
CCCCCCCCCCCCCCC		35.3729802988
932PhosphorylationDDFSPSSTSSADLSG
CCCCCCCCCCCCCCC		30.9124076635
933PhosphorylationDFSPSSTSSADLSGL
CCCCCCCCCCCCCCC		26.0224719451
934PhosphorylationFSPSSTSSADLSGLG
CCCCCCCCCCCCCCC		26.3728857561
946PhosphorylationGLGAEPKTPGLSQSL
CCCCCCCCCCCCHHH		33.0528985074
946 (in isoform 4)Phosphorylation-33.05-
948 (in isoform 4)Phosphorylation-43.10-
950PhosphorylationEPKTPGLSQSLALSS
CCCCCCCCHHHCCCC		24.5228985074
956PhosphorylationLSQSLALSSDESLDM
CCHHHCCCCCCCCCC		30.09-
957PhosphorylationSQSLALSSDESLDMI
CHHHCCCCCCCCCCC		46.37-
960PhosphorylationLALSSDESLDMIDDE
HCCCCCCCCCCCCHH		34.36-
968 (in isoform 3)Phosphorylation-7.04-
970 (in isoform 3)Phosphorylation-64.75-
974PhosphorylationEILDDGQSPKHSQCQ
HHCCCCCCCCCHHHH		41.2528985074
979 (in isoform 5)Phosphorylation-32.3225159151
997 (in isoform 4)Phosphorylation-1.0825159151
1009 (in isoform 5)Phosphorylation-5.9720068231
1013 (in isoform 5)Phosphorylation-33.2420068231
1014 (in isoform 5)Phosphorylation-3.3022210691
1015 (in isoform 5)Phosphorylation-42.0622210691
1019 (in isoform 3)Phosphorylation-2.6125159151
1026UbiquitinationLLQLDGNKLKALGMT
HEEECCCHHHHHCCC		57.82-
1026 (in isoform 2)Ubiquitination-57.8221890473
1027 (in isoform 4)Phosphorylation-4.5620068231
1028AcetylationQLDGNKLKALGMTAS
EECCCHHHHHCCCCC		43.088258271
1031 (in isoform 4)Phosphorylation-19.0920068231
1032 (in isoform 4)Phosphorylation-2.6922210691
1033 (in isoform 4)Phosphorylation-22.7422210691
1035PhosphorylationKALGMTASQDRAVVK
HHHCCCCCCCHHHHH		24.3721815630
1038 (in isoform 5)Phosphorylation-22.9628985074
1039 (in isoform 5)Phosphorylation-20.8127273156
1044UbiquitinationDRAVVKKKLKEMKMS
CHHHHHHHHHHHHHH		60.1021890473
1049 (in isoform 3)Phosphorylation-26.8220068231
1053 (in isoform 3)Phosphorylation-37.0520068231
1054 (in isoform 3)Phosphorylation-59.8022210691
1055 (in isoform 3)Phosphorylation-14.6122210691
1055 (in isoform 5)Phosphorylation-14.6127251275
1056 (in isoform 4)Phosphorylation-46.0028985074
1057 (in isoform 4)Phosphorylation-60.3227273156
1058 (in isoform 5)Phosphorylation-19.74-
1066UbiquitinationQEKMEKQREKLRRKE
HHHHHHHHHHHHHHH		54.8321890473
1069 (in isoform 5)Phosphorylation-5.6925690035
1073 (in isoform 4)Phosphorylation-58.5027251275
1076 (in isoform 4)Phosphorylation-32.76-
1078 (in isoform 3)Phosphorylation-49.7128985074
1079 (in isoform 3)Phosphorylation-39.6127273156
1079 (in isoform 5)Phosphorylation-39.61-
1080 (in isoform 5)Phosphorylation-50.14-
1081PhosphorylationQEQMQRKSKKTEKMT
HHHHHHHCHHHHHHH		41.3928258704
1084PhosphorylationMQRKSKKTEKMTSTT
HHHHCHHHHHHHCCC		44.5728258704
1087 (in isoform 4)Phosphorylation-2.6625690035
1088PhosphorylationSKKTEKMTSTTAEGA
CHHHHHHHCCCCCCC		33.7130576142
1095 (in isoform 3)Phosphorylation-15.1727251275
1097 (in isoform 4)Phosphorylation-53.21-
1097 (in isoform 5)Phosphorylation-53.2124719451
1098 (in isoform 3)Phosphorylation-58.66-
1098 (in isoform 4)Phosphorylation-58.66-
1099 (in isoform 5)Phosphorylation-24719451
1108 (in isoform 5)Phosphorylation-27251275
1109 (in isoform 3)Phosphorylation-25690035
1109 (in isoform 5)Phosphorylation-27251275
1113 (in isoform 5)Phosphorylation-25850435
1115 (in isoform 4)Phosphorylation-24719451
1116 (in isoform 5)Phosphorylation-27251275
1117 (in isoform 4)Phosphorylation-24719451
1119 (in isoform 3)Phosphorylation--
1120 (in isoform 3)Phosphorylation--
1126 (in isoform 4)Phosphorylation-27251275
1127 (in isoform 4)Phosphorylation-27251275
1131 (in isoform 4)Phosphorylation-25850435
1134 (in isoform 4)Phosphorylation-27251275
1137 (in isoform 3)Phosphorylation-24719451
1139 (in isoform 3)Phosphorylation-24719451
1139 (in isoform 5)Phosphorylation-24719451
1140 (in isoform 5)Phosphorylation-27251275
1148 (in isoform 3)Phosphorylation-27251275
1149 (in isoform 3)Phosphorylation-27251275
1152 (in isoform 5)Phosphorylation-24719451
1153 (in isoform 3)Phosphorylation-25850435
1156 (in isoform 3)Phosphorylation-27251275
1162 (in isoform 5)Phosphorylation-30266825
1163 (in isoform 5)Phosphorylation-30266825
1172 (in isoform 5)Phosphorylation-30266825
1174 (in isoform 4)Phosphorylation-25954137
1176 (in isoform 5)Phosphorylation-27174698
1182 (in isoform 3)Phosphorylation-27174698
1183 (in isoform 3)Phosphorylation-27174698
1184 (in isoform 3)Phosphorylation-27174698
1185 (in isoform 3)Phosphorylation-27174698
1230 (in isoform 3)Phosphorylation-24719451
1240 (in isoform 3)Phosphorylation-30266825
1241 (in isoform 3)Phosphorylation-30266825
1250 (in isoform 3)Phosphorylation-30266825
1254 (in isoform 3)Phosphorylation-27174698
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
460SPhosphorylationKinasePRKACAP17612
GPS
460SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NEB1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NEB1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NEB1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NEB1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338, AND MASSSPECTROMETRY.

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