dbPTM

ARHGA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARHGA_HUMAN
UniProt AC	O15013
Protein Name	Rho guanine nucleotide exchange factor 10
Gene Name	ARHGEF10
Organism	Homo sapiens (Human).
Sequence Length	1369
Subcellular Localization
Protein Description	May play a role in developmental myelination of peripheral nerves..
Protein Sequence	MRPPGFLSRAPSLNRAERGIWSCSMDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADRQAPSAPETGGAGASEAPAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVIDITPFQEDQPPTPVPSAEEENVGLHVPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATSLDEEAETPEVTEDRQPNSLSSEEPPTSEDQVGREDSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDEGGNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDLMASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDHRSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWIGSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGAPPDPETPAVRASDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVASYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVTSLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKDKDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSSGSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHRKARQPHQEELAPTVMVWQIPLLNI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	REPLPPAPAENEMKY CCCCCCCCCCCCCCC	45.97	32142685
35 (in isoform 5)	Phosphorylation	-	45.97	24719451
44	Phosphorylation	ENEMKYDTNNNEEEE CCCCCCCCCCCCCHH	36.43	29214152
59	Phosphorylation	GEQFDFDSGDEIPEA CCCCCCCCCCCCCHH	48.41	21955146
75 (in isoform 5)	Phosphorylation	-	60.86	27251275
88	Phosphorylation	ASEAPAPTGGEDGAG CCCCCCCCCCCCCCC	60.98	28985074
98	Phosphorylation	EDGAGAETTPVAEPT CCCCCCCCCCCCCCC	35.55	25159151
99	Phosphorylation	DGAGAETTPVAEPTK CCCCCCCCCCCCCCE	13.79	26657352
180	Phosphorylation	PVIICATSLDEEAET CEEEECCCCCCCCCC	18.46	-
198	Phosphorylation	TEDRQPNSLSSEEPP CCCCCCCCCCCCCCC	35.99	23663014
200	Phosphorylation	DRQPNSLSSEEPPTS CCCCCCCCCCCCCCC	35.21	23663014
201	Phosphorylation	RQPNSLSSEEPPTSE CCCCCCCCCCCCCCC	51.80	23663014
206	Phosphorylation	LSSEEPPTSEDQVGR CCCCCCCCCCCCCCC	56.30	27732954
216	Phosphorylation	DQVGREDSALARWAA CCCCCCCHHHHHHHC	22.04	21815630
239	Phosphorylation	ENPEEAIYDDVPREN CCHHHHCCCCCCCCC	17.09	29978859
283 (in isoform 5)	Phosphorylation	-	59.86	24719451
297	Phosphorylation	CKNGIPRSFLRSNHK CCCCCCHHHHHHHHH	24.23	28555341
308	Phosphorylation	SNHKKQLSHDLTRLK HHHHHHHHHHHHHHH	16.68	27251275
328	Phosphorylation	KMRDLMASTVGVVEI HHHHHHHHHHHHHHH	15.06	27762562
329	Phosphorylation	MRDLMASTVGVVEIQ HHHHHHHHHHHHHHH	16.25	27762562
353	Ubiquitination	MQKLVKAAKDGTKDG HHHHHHHHHCCCHHH	12.54	33845483
354 (in isoform 5)	Phosphorylation	-	62.64	24719451
362 (in isoform 5)	Phosphorylation	-	58.50	27251275
363 (in isoform 5)	Phosphorylation	-	34.26	27251275
373	Phosphorylation	AAVKRGRSFIRTKSL HHHHHCCHHHHHHHH	28.05	25106551
377	Phosphorylation	RGRSFIRTKSLIAQD HCCHHHHHHHHHHHC	21.84	23927012
379	Phosphorylation	RSFIRTKSLIAQDHR CHHHHHHHHHHHCHH	25.13	23927012
387	Phosphorylation	LIAQDHRSSLEEEQN HHHHCHHCCHHHHHC	35.54	27251275
388	Phosphorylation	IAQDHRSSLEEEQNL HHHCHHCCHHHHHCE	39.49	27251275
409	Phosphorylation	KHPEAILTPMPEGLS CCCHHEECCCCCCCC	16.07	27050516
416	Ubiquitination	TPMPEGLSQQQVVRR CCCCCCCCHHHHHHH	36.48	29967540
424	Phosphorylation	QQQVVRRYILGSVVD HHHHHHHHHHHHHHC	7.02	29514088
427 (in isoform 5)	Phosphorylation	-	14.61	24719451
428	Phosphorylation	VRRYILGSVVDSEKN HHHHHHHHHHCCCCH	18.60	29514088
432	Phosphorylation	ILGSVVDSEKNYVDA HHHHHHCCCCHHHHH	38.57	29514088
435 (in isoform 5)	Phosphorylation	-	37.70	24719451
441	Sumoylation	KNYVDALKRILEQYE CHHHHHHHHHHHHHH	38.83	-
452	Phosphorylation	EQYEKPLSEMEPKVL HHHHCCHHHCCCHHC	43.34	24719451
460	Phosphorylation	EMEPKVLSERKLKTV HCCCHHCCHHHHHHH	38.04	24719451
505	Phosphorylation	IGDVFVASFSKSMVL ECCCHHHCCCHHHHH	25.42	24719451
509	Phosphorylation	FVASFSKSMVLDAYS HHHCCCHHHHHHHHH	16.96	24905233
515	Phosphorylation	KSMVLDAYSEYVNNF HHHHHHHHHHHHHHH	11.16	24905233
516	Phosphorylation	SMVLDAYSEYVNNFS HHHHHHHHHHHHHHH	24.95	24905233
518	Phosphorylation	VLDAYSEYVNNFSTA HHHHHHHHHHHHHHH	11.53	24905233
523	Phosphorylation	SEYVNNFSTAVAVLK HHHHHHHHHHHHHHH	19.99	24905233
524	Phosphorylation	EYVNNFSTAVAVLKK HHHHHHHHHHHHHHH	22.48	24905233
557	Phosphorylation	SPDRTTLYSLMMKPI CCCHHHHHHHHCHHH	9.54	24114839
607	Ubiquitination	TLAEKLNERKRDADQ HHHHHHHHHHCCHHH	70.75	29967540
629	Phosphorylation	AKAINERYLNKLLSS HHHHHHHHHHHHHHC	14.40	-
636	Phosphorylation	YLNKLLSSGSRYLIR HHHHHHHCCCCEEEC	40.53	-
640	Phosphorylation	LLSSGSRYLIRSDDM HHHCCCCEEECCCCC	14.26	-
652 (in isoform 5)	Phosphorylation	-	20.83	-
676	Phosphorylation	LNDVLMCATVSSRPS ECCEEEEECCCCCCC	9.32	18669648
677	Phosphorylation	NDVLMCATVSSRPSH CCEEEEECCCCCCCC	18.92	18669648
683	Phosphorylation	ATVSSRPSHDSRVMS ECCCCCCCCCCCCCC	38.52	21406692
686	Phosphorylation	SSRPSHDSRVMSSQR CCCCCCCCCCCCCCC	22.73	21406692
690	Phosphorylation	SHDSRVMSSQRYLLK CCCCCCCCCCCCHHE	22.06	21406692
691	Phosphorylation	HDSRVMSSQRYLLKW CCCCCCCCCCCHHEE	10.69	21406692
694	Phosphorylation	RVMSSQRYLLKWSVP CCCCCCCCHHEECCC	14.56	23403867
710	Phosphorylation	GHVDAIEYGSSAGTG CCCEEEECCCCCCCC	19.05	-
720	Phosphorylation	SAGTGEHSRHLAVHP CCCCCCCCCCEEECC	19.66	-
777	Phosphorylation	IGNLKGNYQNLNQSV HHHHHCCHHHCCHHH	13.88	27642862
783	Phosphorylation	NYQNLNQSVAHDWTS CHHHCCHHHHCHHCH	21.87	20873877
789	Phosphorylation	QSVAHDWTSGLQRLI HHHHCHHCHHHHHHH	20.97	20873877
790	Phosphorylation	SVAHDWTSGLQRLIL HHHCHHCHHHHHHHH	33.00	20873877
822	Phosphorylation	LPGKQDKSGRPTFFT CCCCCCCCCCCCEEE	48.61	30576142
846	Phosphorylation	IKESWVNSLQMAKLA HHHHHHHHHHHHHHH	15.45	30576142
874	Ubiquitination	DDGNHIKKEKHPLLV CCCCCCCCCCCCEEE	71.97	-
876	Ubiquitination	GNHIKKEKHPLLVGH CCCCCCCCCCEEECC	60.44	-
980	Phosphorylation	GAPPDPETPAVRASD CCCCCCCCCCCCHHH	23.18	21815630
986	Phosphorylation	ETPAVRASDVPTICV CCCCCCHHHCCEEEE	28.69	25072903
990	Phosphorylation	VRASDVPTICVGTEE CCHHHCCEEEEECCC	27.19	25072903
995	Phosphorylation	VPTICVGTEEGSISI CCEEEEECCCCEEEE	15.51	25072903
999	Phosphorylation	CVGTEEGSISIYKSS EEECCCCEEEEEECC	19.22	25072903
1001	Phosphorylation	GTEEGSISIYKSSQG ECCCCEEEEEECCCC	22.89	25072903
1003	Phosphorylation	EEGSISIYKSSQGSK CCCEEEEEECCCCCC	9.68	25072903
1005	Phosphorylation	GSISIYKSSQGSKKV CEEEEEECCCCCCEE	15.77	25072903
1006	Phosphorylation	SISIYKSSQGSKKVR EEEEEECCCCCCEEE	34.11	25072903
1009	Phosphorylation	IYKSSQGSKKVRLQH EEECCCCCCEEEEEE	22.97	25072903
1023	Phosphorylation	HFFTPEKSTVMSLAC EEECCCHHHHHHHHH	25.27	30576142
1032	Phosphorylation	VMSLACTSQSLYAGL HHHHHHCCCHHHHHH	20.04	30576142
1034	Phosphorylation	SLACTSQSLYAGLVN HHHHCCCHHHHHHHC	24.10	30576142
1036	Phosphorylation	ACTSQSLYAGLVNGA HHCCCHHHHHHHCCH	12.13	-
1204	Phosphorylation	VTGRGMVSYHAHNSP CCCCCCEEEECCCCC	11.43	29083192
1204 (in isoform 5)	Phosphorylation	-	11.43	27251275
1205	Phosphorylation	TGRGMVSYHAHNSPV CCCCCEEEECCCCCC	7.51	29083192
1210	Phosphorylation	VSYHAHNSPVKFIVL EEEECCCCCCEEEEE	22.62	28555341
1229	Phosphorylation	HEKDKDKSRDSLAPG HHHCCCCCCCCCCCC	51.99	25849741
1232	Phosphorylation	DKDKSRDSLAPGPEP CCCCCCCCCCCCCCC	25.89	25159151
1233 (in isoform 5)	Phosphorylation	-	8.58	27251275
1250	Phosphorylation	DQKDALPSGGAGSSL CHHCCCCCCCCCCCC	51.19	21406692
1255	Phosphorylation	LPSGGAGSSLSQGDP CCCCCCCCCCCCCCC	27.80	21406692
1256	Phosphorylation	PSGGAGSSLSQGDPD CCCCCCCCCCCCCCC	30.99	22199227
1257 (in isoform 5)	Phosphorylation	-	4.79	-
1258	Phosphorylation	GGAGSSLSQGDPDAA CCCCCCCCCCCCCCH	33.78	22199227
1258 (in isoform 5)	Phosphorylation	-	33.78	27251275
1259 (in isoform 5)	Phosphorylation	-	66.65	-
1260 (in isoform 5)	Phosphorylation	-	45.07	-
1262 (in isoform 5)	Phosphorylation	-	39.71	24719451
1269 (in isoform 5)	Phosphorylation	-	13.89	27251275
1271	Phosphorylation	AAIWLGDSLGSMTQK CHHCCCCCCCCCCCH	32.60	18669648
1271 (in isoform 5)	Phosphorylation	-	32.60	-
1274	Phosphorylation	WLGDSLGSMTQKSDL CCCCCCCCCCCHHHC	24.77	21406692
1276	Phosphorylation	GDSLGSMTQKSDLSS CCCCCCCCCHHHCCC	34.24	21406692
1279	Phosphorylation	LGSMTQKSDLSSSSG CCCCCCHHHCCCCCC	33.69	23927012
1281	Phosphorylation	SMTQKSDLSSSSGSL CCCCHHHCCCCCCCE	7.45	17081983
1282	Phosphorylation	MTQKSDLSSSSGSLS CCCHHHCCCCCCCEE	32.91	22167270
1282 (in isoform 5)	Phosphorylation	-	32.91	-
1283	Phosphorylation	TQKSDLSSSSGSLSL CCHHHCCCCCCCEEE	35.50	22167270
1284	Phosphorylation	QKSDLSSSSGSLSLS CHHHCCCCCCCEEEC	35.03	22167270
1285	Phosphorylation	KSDLSSSSGSLSLSH HHHCCCCCCCEEECC	34.06	23401153
1286	Phosphorylation	SDLSSSSGSLSLSHG HHCCCCCCCEEECCC	34.26	17081983
1286	Ubiquitination	SDLSSSSGSLSLSHG HHCCCCCCCEEECCC	34.26	29967540
1287	Phosphorylation	DLSSSSGSLSLSHGS HCCCCCCCEEECCCC	19.41	22167270
1289	Phosphorylation	SSSSGSLSLSHGSSS CCCCCCEEECCCCCC	29.53	23927012
1291	Phosphorylation	SSGSLSLSHGSSSLE CCCCEEECCCCCCCC	23.56	25159151
1294	Phosphorylation	SLSLSHGSSSLEHRS CEEECCCCCCCCCCC	16.01	23927012
1295	Phosphorylation	LSLSHGSSSLEHRSE EEECCCCCCCCCCCC	43.46	23927012
1296	Phosphorylation	SLSHGSSSLEHRSED EECCCCCCCCCCCCC	39.20	23927012
1301	Phosphorylation	SSSLEHRSEDSTIYD CCCCCCCCCCCCHHH	47.89	21945579
1304	Phosphorylation	LEHRSEDSTIYDLLK CCCCCCCCCHHHHHH	16.80	21945579
1305	Phosphorylation	EHRSEDSTIYDLLKD CCCCCCCCHHHHHHC	35.56	28442448
1306	Phosphorylation	HRSEDSTIYDLLKDP CCCCCCCHHHHHHCH	2.67	18707149
1307	Phosphorylation	RSEDSTIYDLLKDPV CCCCCCHHHHHHCHH	10.71	21945579
1315	Phosphorylation	DLLKDPVSLRSKARR HHHHCHHHHHHHHHH	24.37	21712546
1318	Phosphorylation	KDPVSLRSKARRAKK HCHHHHHHHHHHHHH	35.64	23532336
1338	Methylation	ALVVCGGQGHRRVHR EEEECCCCHHHHHHH	29.78	26797129

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARHGA_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1338	Q	Methylation		26797129
Methylated at Gln-1338 by N6AMT1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARHGA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COPG1_HUMAN	COPG1	physical	22863883
PSME4_HUMAN	PSME4	physical	22863883
SART3_HUMAN	SART3	physical	22863883
PTH2_HUMAN	PTRH2	physical	26186194
DNJB5_HUMAN	DNAJB5	physical	26186194
SETD2_HUMAN	SETD2	physical	26186194
RSPRY_HUMAN	RSPRY1	physical	26186194
RNF31_HUMAN	RNF31	physical	26186194
GRDN_HUMAN	CCDC88A	physical	26186194
DNJB5_HUMAN	DNAJB5	physical	28514442
SETD2_HUMAN	SETD2	physical	28514442
RNF31_HUMAN	RNF31	physical	28514442
RSPRY_HUMAN	RSPRY1	physical	28514442
PTH2_HUMAN	PTRH2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
608236	Slowed nerve conduction velocity (SNCV)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARHGA_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1284 AND SER-1287, ANDMASS SPECTROMETRY.	18669648 [Abstract]

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