DNJB5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNJB5_HUMAN
• UniProt AC: O75953
• Protein Name: DnaJ homolog subfamily B member 5
• Gene Name: DNAJB5
• Organism: Homo sapiens (Human).
• Sequence Length: 348
• Protein Sequence: MGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRGLYDQYGEEGLKTGGGTSGGSSGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSTRPFSGFDPDDMDVDEDEDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Ubiquitination	EIKKAYRKMALKYHP HHHHHHHHHHHHHCC	18.82	23000965
30	Ubiquitination	AYRKMALKYHPDKNK HHHHHHHHHCCCCCC	31.79	23000965
35	Ubiquitination	ALKYHPDKNKEPNAE HHHHCCCCCCCCCHH	74.50	23000965
59	Ubiquitination	YDVLSDPKKRGLYDQ HHHHCCHHHCCCHHH	61.16	29967540
64	Phosphorylation	DPKKRGLYDQYGEEG CHHHCCCHHHCCCCC	12.11	29496907
67	Phosphorylation	KRGLYDQYGEEGLKT HCCCHHHCCCCCCCC	24.49	29496907
79	Ubiquitination	LKTGGGTSGGSSGSF CCCCCCCCCCCCCCE	44.42	29967540
98	Ubiquitination	HGDPHATFASFFGGS CCCCCCCHHHHHCCC	5.79	23000965
102	Ubiquitination	HATFASFFGGSNPFD CCCHHHHHCCCCCCE	11.38	23000965
107	Ubiquitination	SFFGGSNPFDIFFAS HHHCCCCCCEEEEEE	29.95	23000965
121	Ubiquitination	SSRSTRPFSGFDPDD ECCCCCCCCCCCCCC	11.41	29967540
131	Ubiquitination	FDPDDMDVDEDEDPF CCCCCCCCCCCCCCC	7.53	29967540
140	Ubiquitination	EDEDPFGAFGRFGFN CCCCCCCCCCCCCCC	12.23	23000965
144	Ubiquitination	PFGAFGRFGFNGLSR CCCCCCCCCCCCCCC	15.58	23000965
149	Ubiquitination	GRFGFNGLSRGPRRA CCCCCCCCCCCCCCC	3.11	23000965
161	Phosphorylation	RRAPEPLYPRRKVQD CCCCCCCCCCCCCCC	12.86	22461510
173	Ubiquitination	VQDPPVVHELRVSLE CCCCCCEEEEEECHH	28.71	29967540
183	Phosphorylation	RVSLEEIYHGSTKRM EECHHHHHCCCCCCC	11.92	29496907
259	Phosphorylation	AHFRRDGTNVLYSAL CCCCCCCCHHHHHHH	26.83	21406692
263	Phosphorylation	RDGTNVLYSALISLK CCCCHHHHHHHHHHH	6.39	25884760
264	Phosphorylation	DGTNVLYSALISLKE CCCHHHHHHHHHHHH	16.67	21406692
268	Phosphorylation	VLYSALISLKEALCG HHHHHHHHHHHHHCC	33.95	24719451
275	Phosphorylation	SLKEALCGCTVNIPT HHHHHHCCCEEECCC	15.81	-
302	Ubiquitination	VIKPGTVKRLRGEGL CCCCCCCEECCCCCC	45.62	29967540
313	Ubiquitination	GEGLPFPKVPTQRGD CCCCCCCCCCCCCCC	62.31	23000965
334	Phosphorylation	VRFPDRLTPQTRQIL EECCCCCCHHHHHHH	17.78	28555341
338	Ubiquitination	DRLTPQTRQILKQHL CCCCHHHHHHHHHHC	19.12	-
374	Ubiquitination	--------------------------------- ---------------------------------		29967540
377	Phosphorylation	------------------------------------ ------------------------------------		-
385	Ubiquitination	-------------------------------------------- --------------------------------------------		23000965
416	Ubiquitination	--------------------------------------------------------------------------- ---------------------------------------------------------------------------		29967540
427	Ubiquitination	-------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------		23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNJB5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNJB5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNJB5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBPL2_HUMAN	TBPL2	physical	18555775
HYOU1_HUMAN	HYOU1	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.