RSPRY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RSPRY_HUMAN
• UniProt AC: Q96DX4
• Protein Name: RING finger and SPRY domain-containing protein 1
• Gene Name: RSPRY1
• Organism: Homo sapiens (Human).
• Sequence Length: 576
• Subcellular Localization: Secreted .
• Protein Sequence: MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQQQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQEPPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPLCRKEIVSRIRQISHIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LGQGLLLTLEEHIAH CCCCHHHHHHHHHHH	31.90	22210691
33	Phosphorylation	HIAHFLGTGGAATTM HHHHHHCCCCCCCCC	34.29	22210691
43	Phosphorylation	AATTMGNSCICRDDS CCCCCCCCEEEECCC	10.10	22210691
50	Phosphorylation	SCICRDDSGTDDSVD CEEEECCCCCCCCCH	48.13	21712546
52	Phosphorylation	ICRDDSGTDDSVDTQ EEECCCCCCCCCHHH	40.35	21712546
55	Phosphorylation	DDSGTDDSVDTQQQQ CCCCCCCCCHHHHHH	25.38	29116813
58	Phosphorylation	GTDDSVDTQQQQAEN CCCCCCHHHHHHHHH	26.56	30278072
97	Ubiquitination	PHEPRRKKQNVDGLV CCCCCCCCCCCCHHH	45.34	-
144	Phosphorylation	GWLDVVQSLIRVIPL CHHHHHHHHHHCCCC	17.72	24719451
144	O-linked_Glycosylation	GWLDVVQSLIRVIPL CHHHHHHHHHHCCCC	17.72	29351928
177	Ubiquitination	PTKDALQKLTEILNL CCHHHHHHHHHHHCC	59.22	-
256	Phosphorylation	ALEKFAQTSENKLTI HHHHHHHCCCCCCEE	34.28	20068231
260	Ubiquitination	FAQTSENKLTISESS HHHCCCCCCEECHHH	42.85	-
286 (in isoform 1)	Ubiquitination	-	34.26	21890473
286	Ubiquitination	ANDPDYLKRQVGFCA HCCHHHHHHHHHHHH	34.26	21906983
312	Ubiquitination	GRQLTYEKVNLSSIR CCCCEEEEECHHHHH	26.47	-
314	N-linked_Glycosylation	QLTYEKVNLSSIRAM CCEEEEECHHHHHHH	45.32	UniProtKB CARBOHYD
316	Phosphorylation	TYEKVNLSSIRAMLN EEEEECHHHHHHHHH	20.65	24043423
317	Phosphorylation	YEKVNLSSIRAMLNS EEEECHHHHHHHHHC	21.18	25954137
330	Phosphorylation	NSNDVSEYLKISPHG HCCCHHHHHCCCCCC	13.04	-
397	Phosphorylation	YGIGDDEYSCAYDGC CCCCCCCCCCCHHCH	18.95	-
415	Ubiquitination	IWYNARSKPHIHPCW EEEECCCCCCCCCCC	34.75	-
460	Phosphorylation	QVFSSTVSGFFAAAS HHCHHHHHHHHHHHH	29.94	-
485	Phosphorylation	FGAKPFKYPPSMKFS CCCCCCCCCCCCCCE	22.28	23663014
488	Phosphorylation	KPFKYPPSMKFSTFN CCCCCCCCCCCEECC	30.05	23663014
492	Phosphorylation	YPPSMKFSTFNDYAF CCCCCCCEECCCCCC	26.94	23663014
493	Phosphorylation	PPSMKFSTFNDYAFL CCCCCCEECCCCCCE	29.59	23663014
497	Phosphorylation	KFSTFNDYAFLTAEE CCEECCCCCCEEHHH	10.60	23663014
501	Phosphorylation	FNDYAFLTAEEKIIL CCCCCCEEHHHEEEC	26.10	23663014
518	Ubiquitination	HRRLALLKQVSIREN HHHHHHHHHCCHHCC	49.88	21890473
518 (in isoform 1)	Ubiquitination	-	49.88	21890473
521	Phosphorylation	LALLKQVSIRENCCS HHHHHHCCHHCCHHH	17.27	28102081
528	Phosphorylation	SIRENCCSLCCDEVA CHHCCHHHHCCHHHH	27.00	25627689
545	Phosphorylation	QLKPCGHSDLCMDCA CCCCCCCCHHHHHHH	19.98	24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RSPRY_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RSPRY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RSPRY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
INF2_HUMAN	INF2	physical	28514442
CE030_HUMAN	C5orf30	physical	28514442
NEST_HUMAN	NES	physical	28514442
AINX_HUMAN	INA	physical	28514442
NFM_HUMAN	NEFM	physical	28514442
NFL_HUMAN	NEFL	physical	28514442
RM17_HUMAN	MRPL17	physical	28514442
GFAP_HUMAN	GFAP	physical	28514442
GALT3_HUMAN	GALNT3	physical	28514442
AGK_HUMAN	AGK	physical	28514442
GLPK_HUMAN	GK	physical	28514442
PDE9A_HUMAN	PDE9A	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.