dbPTM

NEST_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NEST_HUMAN
UniProt AC	P48681
Protein Name	Nestin
Gene Name	NES
Organism	Homo sapiens (Human).
Sequence Length	1621
Subcellular Localization
Protein Description	Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity)..
Protein Sequence	MEGCMGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEEESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVGQGMPLVSEGDRGSPFQEEEGSALKTSWAGAPVHLGQGQFLKFTQREGDRESWSSGED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGCMGEE -------CCCCCCHH	43.29	22223895
22	Phosphorylation	LNRRLEAYLARVKAL HHHHHHHHHHHHHHH	7.48	-
27	Ubiquitination	EAYLARVKALEEQNE HHHHHHHHHHHHHHH	41.52	-
37	Phosphorylation	EEQNELLSAELGGLR HHHHHHHHHHHCCHH	32.11	20860994
50	Phosphorylation	LRAQSADTSWRAHAD HHCCCCCCCHHHCCC	29.88	24732914
51	Phosphorylation	RAQSADTSWRAHADD HCCCCCCCHHHCCCH	18.34	24732914
74	Ubiquitination	VDQRWREKHAAEVAR HHHHHHHHHHHHHHH	29.94	21906983
120	Ubiquitination	RRAVEAEKCARAWLS HHHHHHHHHHHHHHH	40.00	21906983
202	Phosphorylation	ERVAHMETSLGQARE HHHHHHHHHHHHHHH	22.98	28555341
203	Phosphorylation	RVAHMETSLGQARER HHHHHHHHHHHHHHH	19.73	28555341
259	Ubiquitination	ERLRATEKFQLAVEA HHHHHHHHHHHHHHH	33.77	-
271	Ubiquitination	VEALEQEKQGLQSQI HHHHHHHHHHHHHHH	49.73	21906983
276	Phosphorylation	QEKQGLQSQIAQVLE HHHHHHHHHHHHHHH	28.70	23403867
294	Phosphorylation	QLAHLKMSLSLEVAT HHHHHHHHHHHHHHH	17.14	30266825
296	Phosphorylation	AHLKMSLSLEVATYR HHHHHHHHHHHHHHH	18.38	30266825
301	Phosphorylation	SLSLEVATYRTLLEA HHHHHHHHHHHHHHH	20.79	24043423
302	Phosphorylation	LSLEVATYRTLLEAE HHHHHHHHHHHHHHH	7.58	24043423
304	Phosphorylation	LEVATYRTLLEAENS HHHHHHHHHHHHHHC	25.86	23403867
311	Phosphorylation	TLLEAENSRLQTPGG HHHHHHHCCCCCCCC	26.35	30266825
315	Phosphorylation	AENSRLQTPGGGSKT HHHCCCCCCCCCCCC	28.61	30266825
320	Phosphorylation	LQTPGGGSKTSLSFQ CCCCCCCCCCCCCCC	35.71	30266825
321	Ubiquitination	QTPGGGSKTSLSFQD CCCCCCCCCCCCCCC	45.46	-
322	Phosphorylation	TPGGGSKTSLSFQDP CCCCCCCCCCCCCCC	36.28	21712546
323	Phosphorylation	PGGGSKTSLSFQDPK CCCCCCCCCCCCCCC	26.25	21712546
325	Phosphorylation	GGSKTSLSFQDPKLE CCCCCCCCCCCCCCE	22.19	19664994
330	Ubiquitination	SLSFQDPKLELQFPR CCCCCCCCCEEECCC	63.98	-
338	Phosphorylation	LELQFPRTPEGRRLG CEEECCCCCCCCCHH	26.40	30266825
346	Phosphorylation	PEGRRLGSLLPVLSP CCCCCHHHCCCCCCC	31.18	22617229
352	Phosphorylation	GSLLPVLSPTSLPSP HHCCCCCCCCCCCCC	26.77	25159151
354	Phosphorylation	LLPVLSPTSLPSPLP CCCCCCCCCCCCCCC	39.25	25159151
355	Phosphorylation	LPVLSPTSLPSPLPA CCCCCCCCCCCCCCC	41.49	25159151
358	Phosphorylation	LSPTSLPSPLPATLE CCCCCCCCCCCCCCC	44.34	25159151
363	Phosphorylation	LPSPLPATLETPVPA CCCCCCCCCCCCCCH	24.16	24043423
366	Phosphorylation	PLPATLETPVPAFLK CCCCCCCCCCCHHHC	32.47	23403867
382	Phosphorylation	QEFLQARTPTLASTP HHHHHCCCCCCCCCC	24.52	22617229
384	Phosphorylation	FLQARTPTLASTPIP HHHCCCCCCCCCCCC	34.05	25159151
387	Phosphorylation	ARTPTLASTPIPPTP CCCCCCCCCCCCCCC	37.52	21712546
388	Phosphorylation	RTPTLASTPIPPTPQ CCCCCCCCCCCCCCC	21.45	21712546
393	Phosphorylation	ASTPIPPTPQAPSPA CCCCCCCCCCCCCCC	23.76	30266825
398	Phosphorylation	PPTPQAPSPAVDAEI CCCCCCCCCCCCHHH	28.62	30266825
413	Phosphorylation	RAQDAPLSLLQTQGG HHCCCCHHHEECCCC	26.44	29255136
417	Phosphorylation	APLSLLQTQGGRKQA CCHHHEECCCCCCCC	29.20	29255136
439	Phosphorylation	ARVAIPASVLPGPEE EEEEEEHHHCCCCCC	20.87	27174698
455	Phosphorylation	GGQRQEASTGQSPED CCCCCCCCCCCCHHH	32.11	30266825
456	Phosphorylation	GQRQEASTGQSPEDH CCCCCCCCCCCHHHH	46.41	30266825
459	Phosphorylation	QEASTGQSPEDHASL CCCCCCCCHHHHHHC	31.44	30266825
465	Phosphorylation	QSPEDHASLAPPLSP CCHHHHHHCCCCCCC	22.96	30266825
471	Phosphorylation	ASLAPPLSPDHSSLE HHCCCCCCCCCCCCE	33.77	29255136
475	Phosphorylation	PPLSPDHSSLEAKDG CCCCCCCCCCEECCC	43.96	30266825
476	Phosphorylation	PLSPDHSSLEAKDGE CCCCCCCCCEECCCC	27.15	30266825
484	Phosphorylation	LEAKDGESGGSRVFS CEECCCCCCCCEEEE	54.72	24732914
487	Phosphorylation	KDGESGGSRVFSICR CCCCCCCCEEEEEEE	28.88	24732914
491	Phosphorylation	SGGSRVFSICRGEGE CCCCEEEEEEECCCC	20.23	24732914
507	Ubiquitination	QIWGLVEKETAIEGK CEEEEEECCCCCCCC	53.54	-
514	Ubiquitination	KETAIEGKVVSSLQQ CCCCCCCCHHHHHHH	27.03	-
517	Phosphorylation	AIEGKVVSSLQQEIW CCCCCHHHHHHHHHH	28.46	23403867
518	Phosphorylation	IEGKVVSSLQQEIWE CCCCHHHHHHHHHHH	20.70	23403867
532	Ubiquitination	EEEDLNRKEIQDSQV HHHHCCHHHHCCCCC	59.08	-
537	Phosphorylation	NRKEIQDSQVPLEKE CHHHHCCCCCCCCHH	19.39	24732914
545	Phosphorylation	QVPLEKETLKSLGEE CCCCCHHHHHHHHHH	51.02	26657352
548	Phosphorylation	LEKETLKSLGEEIQE CCHHHHHHHHHHHHH	44.73	19664994
556	Phosphorylation	LGEEIQESLKTLENQ HHHHHHHHHHHHHHC	20.84	27499020
559	Phosphorylation	EIQESLKTLENQSHE HHHHHHHHHHHCHHH	44.60	24732914
564	Phosphorylation	LKTLENQSHETLERE HHHHHHCHHHHHHHH	34.57	30266825
567	Phosphorylation	LENQSHETLERENQE HHHCHHHHHHHHHCC	28.61	30266825
578	Phosphorylation	ENQECPRSLEEDLET HHCCCCCCHHHHHHH	25.85	19664994
585	Phosphorylation	SLEEDLETLKSLEKE CHHHHHHHHHHHHHH	46.94	26657352
587	Ubiquitination	EEDLETLKSLEKENK HHHHHHHHHHHHHHH	61.49	-
588	Phosphorylation	EDLETLKSLEKENKE HHHHHHHHHHHHHHH	44.89	30266825
617	Phosphorylation	AVGQLKPTGKEDTQT HCCCCCCCCCHHHHH	60.34	28555341
622	Phosphorylation	KPTGKEDTQTLQSLQ CCCCCHHHHHHHHHH	25.25	24173317
624	Phosphorylation	TGKEDTQTLQSLQKE CCCHHHHHHHHHHHH	28.93	24173317
627	Phosphorylation	EDTQTLQSLQKENQE HHHHHHHHHHHHHHH	35.56	28555341
638	Phosphorylation	ENQELMKSLEGNLET HHHHHHHHHCCCCHH	20.07	27251275
658	Phosphorylation	TENQELVSSLQENLE CCCHHHHHHHHHHHH	37.65	27251275
659	Phosphorylation	ENQELVSSLQENLES CCHHHHHHHHHHHHH	26.96	27251275
666	Phosphorylation	SLQENLESLTALEKE HHHHHHHHHHHHHHH	33.90	27251275
668	Phosphorylation	QENLESLTALEKENQ HHHHHHHHHHHHHCC	38.18	27251275
680	Phosphorylation	ENQEPLRSPEVGDEE HCCCCCCCCCCCCHH	32.85	29255136
693	Phosphorylation	EEALRPLTKENQEPL HHHHHHCCCCCCCCH	38.71	23403867
702	Phosphorylation	ENQEPLRSLEDENKE CCCCCHHCCHHHCHH	43.74	30266825
708	Ubiquitination	RSLEDENKEAFRSLE HCCHHHCHHHHHHHH	48.66	-
713	Phosphorylation	ENKEAFRSLEKENQE HCHHHHHHHHHHCCC	34.13	25159151
716	Ubiquitination	EAFRSLEKENQEPLK HHHHHHHHHCCCCCC	68.22	-
724	Phosphorylation	ENQEPLKTLEEEDQS HCCCCCCCHHHHHHC	47.27	26074081
731	Phosphorylation	TLEEEDQSIVRPLET CHHHHHHCCCCCCCC	35.06	26074081
738	Phosphorylation	SIVRPLETENHKSLR CCCCCCCCCCHHHHH	50.17	26074081
743	Phosphorylation	LETENHKSLRSLEEQ CCCCCHHHHHHHHHH	22.82	23403867
746	Phosphorylation	ENHKSLRSLEEQDQE CCHHHHHHHHHHHHH	45.48	29255136
754	Phosphorylation	LEEQDQETLRTLEKE HHHHHHHHHHHHHHH	18.86	23403867
757	Phosphorylation	QDQETLRTLEKETQQ HHHHHHHHHHHHHHH	42.24	21712546
768	Phosphorylation	ETQQRRRSLGEQDQM HHHHHHHHCCCCCCC	38.63	29255136
776	Phosphorylation	LGEQDQMTLRPPEKV CCCCCCCCCCCCCCC	17.62	30266825
790	Phosphorylation	VDLEPLKSLDQEIAR CCCHHHCCCCHHHHH	44.88	21406692
808	Ubiquitination	NENQEFLKSLKEESV CCCHHHHHHHHHHHH	60.09	-
809	Phosphorylation	ENQEFLKSLKEESVE CCHHHHHHHHHHHHH	46.98	30266825
811	Sumoylation	QEFLKSLKEESVEAV HHHHHHHHHHHHHHH	67.53	25114211
814	Phosphorylation	LKSLKEESVEAVKSL HHHHHHHHHHHHHHH	26.75	30266825
819	Ubiquitination	EESVEAVKSLETEIL HHHHHHHHHHHHHHH	57.27	2190698
820	Phosphorylation	ESVEAVKSLETEILE HHHHHHHHHHHHHHH	25.49	22617229
823	Phosphorylation	EAVKSLETEILESLK HHHHHHHHHHHHHHH	33.35	23403867
828	Phosphorylation	LETEILESLKSAGQE HHHHHHHHHHHCCHH	37.34	30266825
830	Ubiquitination	TEILESLKSAGQENL HHHHHHHHHCCHHHH	47.76	-
831	Phosphorylation	EILESLKSAGQENLE HHHHHHHHCCHHHHH	42.81	22617229
839	Phosphorylation	AGQENLETLKSPETQ CCHHHHHHCCCCCCC	42.52	21712546
842	Phosphorylation	ENLETLKSPETQAPL HHHHHCCCCCCCCCC	30.95	30266825
845	Phosphorylation	ETLKSPETQAPLWTP HHCCCCCCCCCCCCH	33.15	30266825
851	Phosphorylation	ETQAPLWTPEEINQG CCCCCCCCHHHHCCC	28.62	30266825
860	Sulfoxidation	EEINQGAMNPLEKEI HHHCCCCCCHHHHHH	7.30	30846556
873	Phosphorylation	EIQEPLESVEVNQET HHHHCHHHCCCCHHH	31.12	23403867
880	Phosphorylation	SVEVNQETFRLLEEE HCCCCHHHHHHHHHH	12.32	28555341
891	Phosphorylation	LEEENQESLRSLGAW HHHHCHHHHHHCCCC	21.22	29255136
894	Phosphorylation	ENQESLRSLGAWNLE HCHHHHHHCCCCCHH	36.13	30266825
905	Phosphorylation	WNLENLRSPEEVDKE CCHHHCCCHHHHCHH	39.57	30266825
911	Ubiquitination	RSPEEVDKESQRNLE CCHHHHCHHHHHCHH	65.52	-
913	Phosphorylation	PEEVDKESQRNLEEE HHHHCHHHHHCHHHH	39.93	24732914
925	Ubiquitination	EEEENLGKGEYQESL HHHHHCCCHHHHHHH	52.30	-
928	Phosphorylation	ENLGKGEYQESLRSL HHCCCHHHHHHHHHH	26.67	30266825
931	Phosphorylation	GKGEYQESLRSLEEE CCHHHHHHHHHHHHH	17.35	30266825
934	Phosphorylation	EYQESLRSLEEEGQE HHHHHHHHHHHHHCC	45.48	19664994
945	Phosphorylation	EGQELPQSADVQRWE HHCCCCCCCCHHHHH	25.21	30266825
954	Phosphorylation	DVQRWEDTVEKDQEL CHHHHHHHHHHHHHH	21.03	21815630
965	Phosphorylation	DQELAQESPPGMAGV HHHHHHHCCCCCCCC	25.06	19664994
1003	Phosphorylation	EQGELNATEEVWIPG HHCCCCCEEEEECCC	31.44	30266825
1016	Phosphorylation	PGEGHPESPEPKEQR CCCCCCCCCCCHHHC	38.73	19664994
1030	Phosphorylation	RGLVEGASVKGGAEG CCCCCCCCCCCCCCC	34.91	28857561
1128	Phosphorylation	EPPLEEESLEAKRVQ CCCCCHHHHHHHHHC	34.49	23403867
1152	Phosphorylation	EEAGGLGTEFSELPG HHCCCCCCCHHCCCC	38.61	29083192
1155	Phosphorylation	GGLGTEFSELPGKSR CCCCCCHHCCCCCCC	31.80	29083192
1175	Phosphorylation	PREGREESEAEAPRG CCCCCCCCCCCCCCC	37.04	29255136
1222	Phosphorylation	PPVLVSPSPTYTPIL CCEEECCCCCCCCCC	23.51	24275569
1225	Phosphorylation	LVSPSPTYTPILEDA EECCCCCCCCCCCCC	17.57	24275569
1261	Phosphorylation	EALGKVESEQEELGS HHHCCCCHHHHHHCC	47.79	21406692
1282	Phosphorylation	PQEEGEESREESEED CHHCCCHHHHHHHHC	40.46	29255136
1286	Phosphorylation	GEESREESEEDELGE CCHHHHHHHHCHHHC	41.34	30266825
1294	Phosphorylation	EEDELGETLPDSTPL HHCHHHCCCCCCCCC	41.62	30266825
1299	Phosphorylation	GETLPDSTPLGFYLR HCCCCCCCCCCEEEC	29.88	12832492
1307	Phosphorylation	PLGFYLRSPTSPRWD CCCEEECCCCCCCCC	29.90	23403867
1309	Phosphorylation	GFYLRSPTSPRWDPT CEEECCCCCCCCCCC	53.24	21406692
1310	Phosphorylation	FYLRSPTSPRWDPTG EEECCCCCCCCCCCC	18.82	23403867
1316	Phosphorylation	TSPRWDPTGEQRPPP CCCCCCCCCCCCCCC	51.37	21406692
1327	Phosphorylation	RPPPQGETGKEGWDP CCCCCCCCCCCCCCH	61.45	30177828
1339	Phosphorylation	WDPAVLASEGLEAPP CCHHHHHHCCCCCCC	28.21	28102081
1347	Phosphorylation	EGLEAPPSEKEEGEE CCCCCCCCHHHCCCC	61.31	19664994
1363	Phosphorylation	EEECGRDSDLSEEFE CHHCCCCCCCHHHHH	38.81	21406692
1366	Phosphorylation	CGRDSDLSEEFEDLG CCCCCCCHHHHHHHC	39.82	21406692
1374	Phosphorylation	EEFEDLGTEAPFLPG HHHHHHCCCCCCCCC	35.95	21406692
1409	Phosphorylation	AWDRDGESDGFADEE HCCCCCCCCCCCCHH	48.87	22167270
1418	Phosphorylation	GFADEEESGEEGEED CCCCHHHCCCCCCHH	55.58	23459991
1441	Phosphorylation	AGRWGPGSSVGSLQA CCCCCCCCCHHHHHH	25.61	30266825
1442	Phosphorylation	GRWGPGSSVGSLQAL CCCCCCCCHHHHHHC	36.09	30266825
1445	Phosphorylation	GPGSSVGSLQALSSS CCCCCHHHHHHCCCC	18.36	30266825
1450	Phosphorylation	VGSLQALSSSQRGEF HHHHHHCCCCCCCCC	30.84	28348404
1451	Phosphorylation	GSLQALSSSQRGEFL HHHHHCCCCCCCCCC	31.19	25850435
1452	Phosphorylation	SLQALSSSQRGEFLE HHHHCCCCCCCCCCC	22.11	25850435
1460	Phosphorylation	QRGEFLESDSVSVSV CCCCCCCCCCEEEEC	37.01	28348404
1462	Phosphorylation	GEFLESDSVSVSVPW CCCCCCCCEEEECCC	26.10	28348404
1464	Phosphorylation	FLESDSVSVSVPWDD CCCCCCEEEECCCCH	16.78	24173317
1472	Phosphorylation	VSVPWDDSLRGAVAG EECCCCHHHCHHHCC	19.93	27251275
1483	Phosphorylation	AVAGAPKTALETESQ HHCCCCCCHHHCCCC	35.10	25850435
1487	Phosphorylation	APKTALETESQDSAE CCCCHHHCCCCCCCC	41.61	27251789
1489	Phosphorylation	KTALETESQDSAEPS CCHHHCCCCCCCCCC	46.86	21712546
1492	Phosphorylation	LETESQDSAEPSGSE HHCCCCCCCCCCCCC	27.22	30631047
1496	Phosphorylation	SQDSAEPSGSEEESD CCCCCCCCCCCCCCC	46.59	22617229
1498	Phosphorylation	DSAEPSGSEEESDPV CCCCCCCCCCCCCCC	46.29	22617229
1502	Phosphorylation	PSGSEEESDPVSLER CCCCCCCCCCCCCCC	50.96	21712546
1506	Phosphorylation	EEESDPVSLEREDKV CCCCCCCCCCCCCCC	29.87	25850435
1521	Phosphorylation	PGPLEIPSGMEDAGP CCCCCCCCCCCCCCC	57.33	28857561
1546	Phosphorylation	GPNLEGKSQHVNGGV CCCCCCCCCCCCCCC	36.05	21406692
1560	Phosphorylation	VMNGLEQSEEVGQGM CCCCCCCCCHHCCCC	26.75	21406692
1571	Phosphorylation	GQGMPLVSEGDRGSP CCCCCCCCCCCCCCC	43.47	23898821
1577	Phosphorylation	VSEGDRGSPFQEEEG CCCCCCCCCCCHHCC	24.36	19664994
1585	Phosphorylation	PFQEEEGSALKTSWA CCCHHCCCCCCCCCC	33.44	21082442
1589	Phosphorylation	EEGSALKTSWAGAPV HCCCCCCCCCCCCCE	30.28	26657352
1590	Phosphorylation	EGSALKTSWAGAPVH CCCCCCCCCCCCCEE	17.22	25159151
1605	Ubiquitination	LGQGQFLKFTQREGD ECCCCEEEEECCCCC	47.88	-
1615	Phosphorylation	QREGDRESWSSGED- CCCCCHHHCCCCCC-	32.90	25159151
1617	Phosphorylation	EGDRESWSSGED--- CCCHHHCCCCCC---	37.43	21712546
1618	Phosphorylation	GDRESWSSGED---- CCHHHCCCCCC----	39.69	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
315	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
315	T	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
1299	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
1299	T	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NEST_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NEST_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDK5_HUMAN	CDK5	physical	12832492
ADDA_HUMAN	ADD1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
FLII_HUMAN	FLII	physical	26496610
PUR2_HUMAN	GART	physical	26496610
GOGA2_HUMAN	GOLGA2	physical	26496610
ECHB_HUMAN	HADHB	physical	26496610
HS90A_HUMAN	HSP90AA1	physical	26496610
IDE_HUMAN	IDE	physical	26496610
IMDH2_HUMAN	IMPDH2	physical	26496610
K2C7_HUMAN	KRT7	physical	26496610
LMNB1_HUMAN	LMNB1	physical	26496610
RPOM_HUMAN	POLRMT	physical	26496610
RL10_HUMAN	RPL10	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
PRDX2_HUMAN	PRDX2	physical	26496610
VIME_HUMAN	VIM	physical	26496610
PKP4_HUMAN	PKP4	physical	26496610
EIF3I_HUMAN	EIF3I	physical	26496610
U3IP2_HUMAN	RRP9	physical	26496610
ATP9A_HUMAN	ATP9A	physical	26496610
RNF13_HUMAN	RNF13	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
UBR2_HUMAN	UBR2	physical	26496610
CNDD3_HUMAN	NCAPD3	physical	26496610
SF3B1_HUMAN	SF3B1	physical	26496610
UBR5_HUMAN	UBR5	physical	26496610
S35F6_HUMAN	SLC35F6	physical	26496610
AMRA1_HUMAN	AMBRA1	physical	26496610
CHD7_HUMAN	CHD7	physical	26496610
GHC1_HUMAN	SLC25A22	physical	26496610
GRTP1_HUMAN	GRTP1	physical	26496610
MILK2_HUMAN	MICALL2	physical	26496610
MRM1_HUMAN	MRM1	physical	26496610
GKAP1_HUMAN	GKAP1	physical	26496610
LAS1L_HUMAN	LAS1L	physical	26496610
CMS1_HUMAN	CMSS1	physical	26496610
UBR1_HUMAN	UBR1	physical	26496610
LAMA1_HUMAN	LAMA1	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NEST_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1347, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1418, AND MASSSPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311; THR-315; SER-320;SER-325; THR-338; THR-384; THR-388; SER-398; SER-471; SER-548;SER-564; SER-578; SER-588; SER-746; SER-768; SER-842; THR-851;SER-905; SER-1418; SER-1585; SER-1615; SER-1617 AND SER-1618, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-354; SER-680; SER-768;SER-1409; SER-1418; SER-1617 AND SER-1618, AND MASS SPECTROMETRY.	17081983 [Abstract]