GRTP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRTP1_HUMAN
• UniProt AC: Q5TC63
• Protein Name: Growth hormone-regulated TBC protein 1
• Gene Name: GRTP1
• Organism: Homo sapiens (Human).
• Sequence Length: 336
• Protein Description: May act as a GTPase-activating protein for Rab family protein(s)..
• Protein Sequence: MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTFMQKIFSEPGSLSMATVAKLRESCRARLLAQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	AAYEKFFSSYLVTLT HHHHHHHHHHHHHHH	22.62	-
34	Phosphorylation	AYEKFFSSYLVTLTR HHHHHHHHHHHHHHH	19.82	-
35	Phosphorylation	YEKFFSSYLVTLTRR HHHHHHHHHHHHHHH	12.18	22461510
38	Phosphorylation	FFSSYLVTLTRRAIK HHHHHHHHHHHHHHH	21.59	-
40	Phosphorylation	SSYLVTLTRRAIKWS HHHHHHHHHHHHHHH	14.56	22461510
113	Phosphorylation	RLEDAIRTDLNRTFP HHHHHHHHCHHHHCC	38.43	26270265
124	Ubiquitination	RTFPDNVKFRKTTDP HHCCCCCCCCCCCCH	45.78	21890473
124	Ubiquitination	RTFPDNVKFRKTTDP HHCCCCCCCCCCCCH	45.78	-
124 (in isoform 1)	Ubiquitination	-	45.78	21890473
231	Phosphorylation	VLWTLLVSRWFICLF HHHHHHHHHHHHHHH	24.62	24719451
323	Ubiquitination	LSMATVAKLRESCRA CCHHHHHHHHHHHHH	43.68	21890473
323 (in isoform 1)	Ubiquitination	-	43.68	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRTP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRTP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRTP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MINY1_HUMAN	FAM63A	physical	28514442
UBB_HUMAN	UBB	physical	28514442
AT2A1_HUMAN	ATP2A1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.