| UniProt ID | MINY1_HUMAN | |
|---|---|---|
| UniProt AC | Q8N5J2 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase MINDY-1 {ECO:0000303|PubMed:27292798} | |
| Gene Name | MINDY1 {ECO:0000312|HGNC:HGNC:25648} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 469 | |
| Subcellular Localization | ||
| Protein Description | Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.. | |
| Protein Sequence | MEYHQPEDPAPGKAGTAEAVIPENHEVLAGPDEHPQDTDARDADGEAREREPADQALLPSQCGDNLESPLPEASSAPPGPTLGTLPEVETIRACSMPQELPQSPRTRQPEPDFYCVKWIPWKGEQTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGSGSPETQLQVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQQEEYQQQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MEYHQPEDPA -----CCCCCCCCCC | 25106551 | ||
| 8 (in isoform 4) | Phosphorylation | - | 27762562 | ||
| 60 | Phosphorylation | ADQALLPSQCGDNLE HHHHCCHHHCCCCCC | 27251275 | ||
| 68 | Phosphorylation | QCGDNLESPLPEASS HCCCCCCCCCCCHHC | 28857561 | ||
| 74 | Phosphorylation | ESPLPEASSAPPGPT CCCCCCHHCCCCCCC | 27251275 | ||
| 75 | Phosphorylation | SPLPEASSAPPGPTL CCCCCHHCCCCCCCC | 27251275 | ||
| 95 | Phosphorylation | VETIRACSMPQELPQ HHHHEECCCCCCCCC | 26552605 | ||
| 103 | Phosphorylation | MPQELPQSPRTRQPE CCCCCCCCCCCCCCC | 30278072 | ||
| 105 | Methylation | QELPQSPRTRQPEPD CCCCCCCCCCCCCCC | - | ||
| 107 | Methylation | LPQSPRTRQPEPDFY CCCCCCCCCCCCCEE | - | ||
| 113 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 116 | Phosphorylation | PEPDFYCVKWIPWKG CCCCEEEEEECCCCC | 27251275 | ||
| 117 | Methylation | EPDFYCVKWIPWKGE CCCEEEEEECCCCCC | - | ||
| 143 | Phosphorylation | PCPLLAIMNILFLQW CCHHHHHHHHHHHHH | 27251275 | ||
| 151 | Phosphorylation | NILFLQWKVKLPPQK HHHHHHHCCCCCCCC | 24719451 | ||
| 160 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 176 | Phosphorylation | HLGNCLLSIKPQEKS HHHCCEEECCCCCCC | 24719451 | ||
| 178 | Ubiquitination | GNCLLSIKPQEKSEG HCCEEECCCCCCCCC | - | ||
| 182 | Ubiquitination | LSIKPQEKSEGLQLN EECCCCCCCCCCCCE | - | ||
| 183 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 226 (in isoform 3) | Ubiquitination | - | - | ||
| 230 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 243 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 255 | Ubiquitination | EAVRAVGKLSYNQLV HHHHHHHHCCHHHHH | 21890473 | ||
| 255 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 290 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 325 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 325 | Ubiquitination | NHFSTMTKHKSHLYL CCCCCCCCCCCEEEE | 2190698 | ||
| 373 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 385 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 411 | Phosphorylation | PRGPLGLTDLELAQQ CCCCCCCCHHHHHHH | 26552605 | ||
| 424 | Phosphorylation | QQLQQEEYQQQQAAQ HHHHHHHHHHHHCHH | 23532336 | ||
| 430 | Phosphorylation | EYQQQQAAQPVRMRT HHHHHHCHHHHHHHH | 24719451 | ||
| 433 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 437 | Phosphorylation | AQPVRMRTRVLSLQG HHHHHHHHHHHEECC | 26437602 | ||
| 441 | Phosphorylation | RMRTRVLSLQGRGAT HHHHHHHEECCCCCC | 23401153 | ||
| 445 | Methylation | RVLSLQGRGATSGRP HHHEECCCCCCCCCC | - | ||
| 448 | Phosphorylation | SLQGRGATSGRPAGE EECCCCCCCCCCCCC | - | ||
| 449 | Phosphorylation | LQGRGATSGRPAGER ECCCCCCCCCCCCCC | - | ||
| 489 | Phosphorylation | --------------------------- --------------------------- | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MINY1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MINY1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MINY1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GMCL1_HUMAN | GMCL1 | physical | 25416956 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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