| UniProt ID | GMCL1_HUMAN | |
|---|---|---|
| UniProt AC | Q96IK5 | |
| Protein Name | Germ cell-less protein-like 1 | |
| Gene Name | GMCL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 515 | |
| Subcellular Localization | Nucleus matrix. | |
| Protein Description | Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).. | |
| Protein Sequence | MGSLSSRVLRQPRPALAQQAQGARAGGSARRPDTGDDAAGHGFCYCAGSHKRKRSSGSFCYCHPDSETDEDEEEGDEQQRLLNTPRRKKLKSTSKYIYQTLFLNGENSDIKICALGEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDVEALQVAFGSLYRDDVLIKPSRVVAILAAACLLQLDGLIQQCGETMKETVNVKTVCGYYTSAGTYGLDSVKKKCLEWLLNNLMTHQNVELFKELSINVMKQLIGSSNLFVMQVEMDIYTALKKWMFLQLVPSWNGSLKQLLTETDVWFSKQRKDFEGMAFLETEQGKPFVSVFRHLRLQYIISDLASARIIEQDAVVPSEWLSSVYKQQWFAMLRAEQDSEVGPQEINKEELEGNSMRCGRKLAKDGEYCWRWTGFNFGFDLLVTYTNRYIIFKRNTLNQPCSGSVSLQPRRSIAFRLRLASFDSSGKLICSRTTGYQILTLEKDQEQVVMNLDSRLLIFPLYICCNFLYISPEKKN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MGSLSSRVLR -----CCCHHHHHHC | 24.63 | 24043423 | |
| 5 | Phosphorylation | ---MGSLSSRVLRQP ---CCCHHHHHHCCC | 20.14 | 24043423 | |
| 6 | Phosphorylation | --MGSLSSRVLRQPR --CCCHHHHHHCCCC | 31.53 | 24043423 | |
| 34 | Phosphorylation | GSARRPDTGDDAAGH CCCCCCCCCCCCCCC | 45.23 | - | |
| 49 | Phosphorylation | GFCYCAGSHKRKRSS CEEEECCCCCCCCCC | 13.81 | 28555341 | |
| 55 | Phosphorylation | GSHKRKRSSGSFCYC CCCCCCCCCCCCEEE | 41.93 | 28450419 | |
| 56 | Phosphorylation | SHKRKRSSGSFCYCH CCCCCCCCCCCEEEC | 42.35 | 28450419 | |
| 58 | Phosphorylation | KRKRSSGSFCYCHPD CCCCCCCCCEEECCC | 17.68 | 28450419 | |
| 61 | Phosphorylation | RSSGSFCYCHPDSET CCCCCCEEECCCCCC | 7.56 | 28450419 | |
| 66 | Phosphorylation | FCYCHPDSETDEDEE CEEECCCCCCCCCCC | 47.01 | 28450419 | |
| 68 | Phosphorylation | YCHPDSETDEDEEEG EECCCCCCCCCCCCC | 48.95 | 28450419 | |
| 84 | Phosphorylation | EQQRLLNTPRRKKLK HHHHHHCCHHHHHCC | 20.38 | 22210691 | |
| 217 | Phosphorylation | VKTVCGYYTSAGTYG CEEEEEEECCCCCCC | 4.58 | - | |
| 219 | Phosphorylation | TVCGYYTSAGTYGLD EEEEEECCCCCCCHH | 14.47 | - | |
| 276 | Phosphorylation | MQVEMDIYTALKKWM EEEEHHHHHHHHHHH | 5.02 | - | |
| 277 | Phosphorylation | QVEMDIYTALKKWMF EEEHHHHHHHHHHHH | 26.33 | - | |
| 296 | Ubiquitination | PSWNGSLKQLLTETD CCCCCCHHHHHHHHC | 40.37 | - | |
| 302 | Phosphorylation | LKQLLTETDVWFSKQ HHHHHHHHCCCCCCC | 30.53 | 24260401 | |
| 308 | Ubiquitination | ETDVWFSKQRKDFEG HHCCCCCCCCCCCCC | 44.65 | - | |
| 387 | Ubiquitination | VGPQEINKEELEGNS CCCCCCCHHHHCCCC | 59.22 | - | |
| 493 | Phosphorylation | QVVMNLDSRLLIFPL HEEECCCHHHHHHHH | 28.17 | 29978859 | |
| 501 | Phosphorylation | RLLIFPLYICCNFLY HHHHHHHHHHHHHHE | 7.67 | 29978859 | |
| 508 | Phosphorylation | YICCNFLYISPEKKN HHHHHHHEECCCCCC | 8.67 | 29978859 | |
| 510 | Phosphorylation | CCNFLYISPEKKN-- HHHHHEECCCCCC-- | 17.28 | 29978859 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GMCL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GMCL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GMCL1_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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