| UniProt ID | CPNS2_HUMAN | |
|---|---|---|
| UniProt AC | Q96L46 | |
| Protein Name | Calpain small subunit 2 | |
| Gene Name | CAPNS2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 248 | |
| Subcellular Localization | Cytoplasm. Cell membrane. Translocates to the plasma membrane upon calcium binding.. | |
| Protein Description | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.. | |
| Protein Sequence | MFLAKALLEGADRGLGEALGGLFGGGGQRREGGGRNIGGIVGGIVNFISEAAAAQYTPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MFLAKALL -------CHHHHHHH | 5.84 | - | |
| 86 | Phosphorylation | RRFRQQFTQLAGPDM HHHHHHHHHHHCCCC | 20.52 | 32142685 | |
| 98 | Phosphorylation | PDMEVGATDLMNILN CCCCCCHHHHHHHHH | 24.60 | 29978859 | |
| 136 | Phosphorylation | SVMDSDTTGKLGFEE HHHCCCCCCCCCHHH | 36.99 | - | |
| 145 | Ubiquitination | KLGFEEFKYLWNNIK CCCHHHHHHHHHHHH | 42.59 | - | |
| 159 | Acetylation | KKWQCVYKQYDRDHS HHHHHEEEECCCCCC | 23.22 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CPNS2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CPNS2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CPNS2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| ACTA_HUMAN | ACTA2 | physical | 26186194 | |
| CPNS1_HUMAN | CAPNS1 | physical | 26186194 | |
| CAN1_HUMAN | CAPN1 | physical | 26186194 | |
| ICAL_HUMAN | CAST | physical | 26186194 | |
| LIX1L_HUMAN | LIX1L | physical | 26186194 | |
| LIX1L_HUMAN | LIX1L | physical | 28514442 | |
| ICAL_HUMAN | CAST | physical | 28514442 | |
| ACTA_HUMAN | ACTA2 | physical | 28514442 | |
| CPNS1_HUMAN | CAPNS1 | physical | 28514442 | |
| ACTBL_HUMAN | ACTBL2 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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