| UniProt ID | MPPE1_HUMAN | |
|---|---|---|
| UniProt AC | Q53F39 | |
| Protein Name | Metallophosphoesterase 1 | |
| Gene Name | MPPE1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 396 | |
| Subcellular Localization |
Endoplasmic reticulum-Golgi intermediate compartment membrane Multi-pass membrane protein . Golgi apparatus, cis-Golgi network membrane Multi-pass membrane protein . Also localizes to endoplasmic reticulum exit site. |
|
| Protein Description | Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.. | |
| Protein Sequence | MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCYLPREDVVLIIYCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 176 | Ubiquitination | YKVERFEKVFSSERL EEEEEHHHHHCCCCC | 45.96 | - | |
| 196 | Phosphorylation | INFVMVNSVALNGDG CCEEEEEEEEECCCC | 9.43 | - | |
| 208 | Phosphorylation | GDGCGICSETEAELI CCCCCCCCHHHHHHH | 45.70 | - | |
| 276 | Ubiquitination | EERDIPFKENYDVLS HHCCCCCCCCHHHHC | 39.43 | - | |
| 289 | Ubiquitination | LSREASQKLLWWLQP HCHHHHHHHHHHHCC | 42.95 | 2189047 | |
| 289 (in isoform 2) | Ubiquitination | - | 42.95 | 21890473 | |
| 289 (in isoform 1) | Ubiquitination | - | 42.95 | 21890473 | |
| 290 (in isoform 3) | Ubiquitination | - | 3.62 | 21890473 | |
| 290 (in isoform 2) | Ubiquitination | - | 3.62 | 21890473 | |
| 290 | Ubiquitination | SREASQKLLWWLQPR CHHHHHHHHHHHCCC | 3.62 | 21890473 | |
| 333 | Phosphorylation | WRNRNNPSFIMGSIT CCCCCCCCCEEEECC | 29.54 | 27732954 | |
| 338 | Phosphorylation | NPSFIMGSITPTDYT CCCCEEEECCCCCCC | 13.10 | 27732954 | |
| 340 | Phosphorylation | SFIMGSITPTDYTLS CCEEEECCCCCCCCC | 23.10 | 27732954 | |
| 342 | Phosphorylation | IMGSITPTDYTLSKC EEEECCCCCCCCCCC | 32.75 | 27732954 | |
| 344 | Phosphorylation | GSITPTDYTLSKCYL EECCCCCCCCCCCCC | 16.44 | 27732954 | |
| 345 | Phosphorylation | SITPTDYTLSKCYLP ECCCCCCCCCCCCCC | 27.62 | 27732954 | |
| 347 | Phosphorylation | TPTDYTLSKCYLPRE CCCCCCCCCCCCCCC | 16.93 | 27732954 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MPPE1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MPPE1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MPPE1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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