ICAM4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ICAM4_HUMAN
• UniProt AC: Q14773
• Protein Name: Intercellular adhesion molecule 4
• Gene Name: ICAM4
• Organism: Homo sapiens (Human).
• Sequence Length: 271
• Subcellular Localization: Isoform Long: Cell membrane; Single-pass type I membrane protein.; Isoform Short: Secreted .; Cell membrane ; Single-pass type I membrane protein .
• Protein Description: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins..
• Protein Sequence: MGSLFPLSLLFFLAAAYPGVGSALGRRTKRAQSPKGSPLAPSGTSVPFWVRMSPEFVAVQPGKSVQLNCSNSCPQPQNSSLRTPLRQGKTLRGPGWVSYQLLDVRAWSSLAHCLVTCAGKTRWATSRITAYKPPHSVILEPPVLKGRKYTLRCHVTQVFPVGYLVVTLRHGSRVIYSESLERFTGLDLANVTLTYEFAAGPRDFWQPVICHARLNLDGLVVRNSSAPITLMLAWSPAPTALASGSIAALVGILLTVGAAYLCKCLAMKSQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSLFPLSLL -----CCCCHHHHHH	26.07	24043423
8	Phosphorylation	MGSLFPLSLLFFLAA CCCCHHHHHHHHHHH	24.22	24043423
17	Phosphorylation	LFFLAAAYPGVGSAL HHHHHHHCCCHHHHH	8.87	24043423
22	Phosphorylation	AAYPGVGSALGRRTK HHCCCHHHHHHHHCC	20.22	24043423
28	Phosphorylation	GSALGRRTKRAQSPK HHHHHHHCCCCCCCC	24.42	26657352
33	Phosphorylation	RRTKRAQSPKGSPLA HHCCCCCCCCCCCCC	27.82	24825855
37	O-linked_Glycosylation	RAQSPKGSPLAPSGT CCCCCCCCCCCCCCC	23.90	OGP
42	O-linked_Glycosylation	KGSPLAPSGTSVPFW CCCCCCCCCCCCCEE	49.44	OGP
68	N-linked_Glycosylation	PGKSVQLNCSNSCPQ CCCCEEEECCCCCCC	15.30	UniProtKB CARBOHYD
78	N-linked_Glycosylation	NSCPQPQNSSLRTPL CCCCCCCCCCCCCCC	40.00	UniProtKB CARBOHYD
150	Phosphorylation	VLKGRKYTLRCHVTQ CCCCCEEEEEEEEEE	15.68	24719451
190	N-linked_Glycosylation	FTGLDLANVTLTYEF HCCCCCEEEEEEEEE	34.30	UniProtKB CARBOHYD
223	N-linked_Glycosylation	LDGLVVRNSSAPITL CCEEEEECCCCCEEE	28.80	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ICAM4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ICAM4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ICAM4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1H1_HUMAN	KRT31	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.