ERMP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERMP1_HUMAN
• UniProt AC: Q7Z2K6
• Protein Name: Endoplasmic reticulum metallopeptidase 1 {ECO:0000250|UniProtKB:Q6UPR8, ECO:0000312|HGNC:HGNC:23703}
• Gene Name: ERMP1 {ECO:0000312|HGNC:HGNC:23703}
• Organism: Homo sapiens (Human).
• Sequence Length: 904
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures..
• Protein Sequence: MEWGSESAAVRRHRVGVERREGAAAAPPPEREARAQEPLVDGCSGGGRTRKRSPGGSGGASRGAGTGLSEVRAALGLALYLIALRTLVQLSLQQLVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLLEQIKLIEVQSNSLHKISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRDGAQHAVLANCHFDSVANSPGASDDAVSCSVMLEVLRVLSTSSEALHHAVIFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRILTDSIQRAGDNILAVLKHLATSDMLAAASKYRHGNMVFFDVLGLFVIAYPSRIGSIINYMVVMGVVLYLGKKFLQPKHKTGNYKKDFLCGLGITLISWFTSLVTVLIIAVFISLIGQSLSWYNHFYVSVCLYGTATVAKIILIHTLAKRFYYMNASAQYLGEVFFDISLFVHCCFLVTLTYQGLCSAFISAVWVAFPLLTKLCVHKDFKQHGAQGKFIAFYLLGMFIPYLYALYLIWAVFEMFTPILGRSGSEIPPDVVLASILAGCTMILSSYFINFIYLAKSTKKTMLTLTLVCAITFLLVCSGTFFPYSSNPANPKPKRVFLQHMTRTFHDLEGNAVKRDSGIWINGFDYTGISHITPHIPEINDSIRAHCEENAPLCGFPWYLPVHFLIRKNWYLPAPEVSPRNPPHFRLISKEQTPWDSIKLTFEATGPSHMSFYVRAHKGSTLSQWSLGNGTPVTSKGGDYFVFYSHGLQASAWQFWIEVQVSEEHPEGMVTVAIAAHYLSGEDKRSPQLDALKEKFPDWTFPSAWVCTYDLFVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEWGSESA -------CCCCCCHH	9.85	22223895
44	Phosphorylation	EPLVDGCSGGGRTRK CCCCCCCCCCCCCCC	46.10	25159151
49	Phosphorylation	GCSGGGRTRKRSPGG CCCCCCCCCCCCCCC	43.76	24719451
53	Phosphorylation	GGRTRKRSPGGSGGA CCCCCCCCCCCCCCC	30.82	30278072
57	Phosphorylation	RKRSPGGSGGASRGA CCCCCCCCCCCCCCC	39.71	20068231
61	Phosphorylation	PGGSGGASRGAGTGL CCCCCCCCCCCCCCH	34.22	27461979
115	Phosphorylation	DALQARDYLEHITSI CHHHHHHHHHHHHCC	14.40	-
126	Phosphorylation	ITSIGPRTTGSPENE HHCCCCCCCCCCHHH	38.35	-
132	Ubiquitination	RTTGSPENEILTVHY CCCCCCHHHHHHHHH	45.02	-
156	Ubiquitination	VQSNSLHKISVDVQR ECCCCCEEEEEEEEC	41.80	-
169	Ubiquitination	QRPTGSFSIDFLGGF ECCCCCEEEEECCCC	23.97	-
182	N-linked_Glycosylation	GFTSYYDNITNVVVK CCCCCCCCCEEEEEE	27.19	UniProtKB CARBOHYD
326	Phosphorylation	FQSGIIPSDTDFRIY HHCCCCCCCCCCEEE	42.61	-
356	Ubiquitination	NGYIYHTKYDTADRI CCEEEEEECCHHHHH	28.02	21906983
362	Methylation	TKYDTADRILTDSIQ EECCHHHHHHHHHHH	24.29	-
380	Ubiquitination	DNILAVLKHLATSDM CCHHHHHHHHHHHHH	29.94	21906983
392	Phosphorylation	SDMLAAASKYRHGNM HHHHHHHHHHHHCCE	26.03	-
393	2-Hydroxyisobutyrylation	DMLAAASKYRHGNMV HHHHHHHHHHHCCEE	41.39	-
393	Ubiquitination	DMLAAASKYRHGNMV HHHHHHHHHHHCCEE	41.39	21906983
418	Phosphorylation	AYPSRIGSIINYMVV HCHHHHHHHHHHHHH	20.23	20068231
422	Phosphorylation	RIGSIINYMVVMGVV HHHHHHHHHHHHHHH	4.85	20068231
431	Phosphorylation	VVMGVVLYLGKKFLQ HHHHHHHHHHHHHHC	11.20	20068231
704	Ubiquitination	DLEGNAVKRDSGIWI HHCCCEEECCCCEEE	48.34	21906983
704	2-Hydroxyisobutyrylation	DLEGNAVKRDSGIWI HHCCCEEECCCCEEE	48.34	-
730	N-linked_Glycosylation	TPHIPEINDSIRAHC CCCCCCCCHHHHHHH	35.00	19159218
758	Acetylation	PVHFLIRKNWYLPAP EEEHHEECCCEECCC	44.85	25825284
758	Ubiquitination	PVHFLIRKNWYLPAP EEEHHEECCCEECCC	44.85	21906983
768	Phosphorylation	YLPAPEVSPRNPPHF EECCCCCCCCCCCCE	19.24	-
780	Ubiquitination	PHFRLISKEQTPWDS CCEEEECCCCCCCCE	47.01	-
883	Ubiquitination	SPQLDALKEKFPDWT CHHHHHHHHHCCCCC	61.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERMP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERMP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERMP1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ERMP1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-730, AND MASSSPECTROMETRY.
PubMed: 19159218