EXT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXT1_HUMAN
• UniProt AC: Q16394
• Protein Name: Exostosin-1
• Gene Name: EXT1
• Organism: Homo sapiens (Human).
• Sequence Length: 746
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . The EXT1/EXT2 complex is localized in the Golgi apparatus.
• Protein Description: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. [PubMed: 22660413]
• Protein Sequence: MQAKKRYFILLSAGSCLALLFYFGGLQFRASRSHSRREEHSGRNGLHHPSPDHFWPRFPDALRPFVPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQKGEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQSLHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVVLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVVVIEGESKVMSSRFLPYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIERL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Methylation	YFGGLQFRASRSHSR HHCCCCEEECCCCCC	20.77	-
89	N-linked_Glycosylation	PRQKRDANSSIYKGK HHHCCCCCCCCCCCC	40.35	UniProtKB CARBOHYD
123	Ubiquitination	VYVYPQQKGEKIAES EEEEECCCCHHHHHH	64.88	29967540
130	Phosphorylation	KGEKIAESYQNILAA CCHHHHHHHHHHHHH	24.01	26670566
131	Phosphorylation	GEKIAESYQNILAAI CHHHHHHHHHHHHHH	9.33	18491316
141	Phosphorylation	ILAAIEGSRFYTSDP HHHHHHCCCCCCCCH	13.36	24888630
238	Phosphorylation	DVSIPLFSKDHPRTG EEEEEEECCCCCCCC	44.87	24719451
330	N-linked_Glycosylation	DYREMLHNATFCLVP CHHHHHHHCEEEEEC	36.39	UniProtKB CARBOHYD
344	Phosphorylation	PRGRRLGSFRFLEAL CCCCCCCHHHHHHHH	20.17	24719451
532	O-linked_Glycosylation	AKHRWPATAVPVVVI CCCCCCCCEECEEEE	24.90	OGP
617	Phosphorylation	SKWTNDYSMVLTGAA CCCCCCCEEHHHHHH	12.79	21712546
621	Phosphorylation	NDYSMVLTGAAIYHK CCCEEHHHHHHHHHH	17.23	29507054
626	Phosphorylation	VLTGAAIYHKYYHYL HHHHHHHHHHHHHHH	6.37	29507054

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNTF_HUMAN	CNTF	physical	17353931
OSTF1_HUMAN	OSTF1	physical	17353931
EXT1_HUMAN	EXT1	physical	10679296
EXT2_HUMAN	EXT2	physical	10679296
TRAP1_HUMAN	TRAP1	physical	10545594

Drug and Disease Associations

• Kegg Disease
• H00122: Multiple exostoses
• H00493: Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker ty
• OMIM Disease
• 133700: Hereditary multiple exostoses 1 (EXT1)
• 150230: Tricho-rhino-phalangeal syndrome 2 (TRPS2)
• 215300: Chondrosarcoma (CHDSA)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.