EXT2_HUMAN - dbPTM
EXT2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EXT2_HUMAN
UniProt AC Q93063
Protein Name Exostosin-2
Gene Name EXT2
Organism Homo sapiens (Human).
Sequence Length 718
Subcellular Localization Endoplasmic reticulum membrane
Single-pass type II membrane protein . Golgi apparatus membrane
Single-pass type II membrane protein . The EXT1/EXT2 complex is localized in the Golgi apparatus.
Protein Description Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. [PubMed: 22660413]
Protein Sequence MCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
75PhosphorylationVVRLPADSPIPERGD
EEEECCCCCCCCCCC		27.17-
101UbiquitinationYRCGFNPKNKIKVYI
EECCCCCCCCEEEEE		72.48-
112UbiquitinationKVYIYALKKYVDDFG
EEEEEEHHHHHHHHC		33.61-
113UbiquitinationVYIYALKKYVDDFGV
EEEEEHHHHHHHHCC		51.89-
114PhosphorylationYIYALKKYVDDFGVS
EEEEHHHHHHHHCCC		13.9228509920
168UbiquitinationNQNTLRIKETAQAMA
CCCCHHHHHHHHHHH		42.4521906983
168 (in isoform 2)Ubiquitination-42.45-
168 (in isoform 1)Ubiquitination-42.4521890473
181 (in isoform 2)Ubiquitination-37.7121890473
245 (in isoform 1)Ubiquitination-69.3521890473
245UbiquitinationAEVDLPEKGPGPRQY
EECCCCCCCCCHHHE		69.3521906983
245 (in isoform 2)Ubiquitination-69.35-
258 (in isoform 2)Ubiquitination-29.8921890473
275 (in isoform 1)Ubiquitination-32.6921890473
275UbiquitinationDLEALQVKHGESVLV
HHHHHHCCCCCEEEE		32.6921906983
285UbiquitinationESVLVLDKCTNLSEG
CEEEEEECCCCCCCC		38.51-
288 (in isoform 2)Ubiquitination-51.5521890473
288N-linked_GlycosylationLVLDKCTNLSEGVLS
EEEECCCCCCCCHHH		51.55UniProtKB CARBOHYD
369UbiquitinationSVVVPEEKMSDVYSI
EEECCHHHHHHHHHH		41.8821906983
369 (in isoform 2)Ubiquitination-41.88-
369 (in isoform 1)Ubiquitination-41.8821890473
375PhosphorylationEKMSDVYSILQSIPQ
HHHHHHHHHHHHCCH		19.3726074081
379PhosphorylationDVYSILQSIPQRQIE
HHHHHHHHCCHHHHH		32.5626074081
382 (in isoform 2)Ubiquitination-48.5221890473
402PhosphorylationFWEAYFQSIKAIALA
HHHHHHHHHHHHHHH		19.0224719451
478UbiquitinationRVITEVSKVPSLSKL
HHHHHHHCCCCHHHE		64.4421906983
478 (in isoform 1)Ubiquitination-64.4421890473
484UbiquitinationSKVPSLSKLLVVWNN
HCCCCHHHEEEEEEC		51.6521906983
484 (in isoform 1)Ubiquitination-51.6521890473
488 (in isoform 2)Ubiquitination-4.58-
491 (in isoform 2)Ubiquitination-30.9621890473
494UbiquitinationVVWNNQNKNPPEDSL
EEEECCCCCCCCCCC		62.1521906983
494 (in isoform 1)Ubiquitination-62.1521890473
497 (in isoform 2)Ubiquitination-68.3821890473
504 (in isoform 2)Ubiquitination-31.40-
504UbiquitinationPEDSLWPKIRVPLKV
CCCCCCCCCCCCCEE		31.40-
507 (in isoform 2)Ubiquitination-8.0921890473
510UbiquitinationPKIRVPLKVVRTAEN
CCCCCCCEEEECCCH		32.39-
518 (in isoform 1)Ubiquitination-44.8121890473
518UbiquitinationVVRTAENKLSNRFFP
EEECCCHHHHCCCCC		44.8121906983
531 (in isoform 2)Ubiquitination-34.6021890473
579UbiquitinationLWDHEMNKWKYESEW
EEECCCCCCEECCCC		43.69-
581UbiquitinationDHEMNKWKYESEWTN
ECCCCCCEECCCCCH		40.52-
637N-linked_GlycosylationAMNFLVANVTGKAVI
HHHHHEEECCCCEEE		25.14UniProtKB CARBOHYD
645UbiquitinationVTGKAVIKVTPRKKF
CCCCEEEEECCCCCC		33.19-
653UbiquitinationVTPRKKFKCPECTAI
ECCCCCCCCCCCCEE		58.73-
679UbiquitinationERSECINKFASVFGT
CHHHHHHHHHHHHCC		23.54-
686O-linked_GlycosylationKFASVFGTMPLKVVE
HHHHHHCCCCEEEEE		12.26OGP
690UbiquitinationVFGTMPLKVVEHRAD
HHCCCCEEEEEECCC		38.062189047
690 (in isoform 1)Ubiquitination-38.0621890473
700UbiquitinationEHRADPVLYKDDFPE
EECCCCCCCCCCCHH		5.5321890473
702UbiquitinationRADPVLYKDDFPEKL
CCCCCCCCCCCHHHH		46.81-
708UbiquitinationYKDDFPEKLKSFPNI
CCCCCHHHHHCCCCC		62.54-
710UbiquitinationDDFPEKLKSFPNIGS
CCCHHHHHCCCCCCC		62.21-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EXT2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EXT2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EXT2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STK16_HUMANSTK16physical
17353931
SYUG_HUMANSNCGphysical
17353931
HYOU1_HUMANHYOU1physical
17353931
CNTF_HUMANCNTFphysical
17353931
ELOC_HUMANTCEB1physical
17353931
RS29_HUMANRPS29physical
17353931
CRUM1_HUMANCRB1physical
17353931
CLC2L_HUMANCLEC2Lphysical
17353931
EXT2_HUMANEXT2physical
10679296
GALT5_HUMANGALNT5physical
10545594
TRAP1_HUMANTRAP1physical
10545594
S22A2_HUMANSLC22A2physical
21988832
INVS_HUMANINVSphysical
28514442
TTC19_HUMANTTC19physical
28514442
RBFA_HUMANRBFAphysical
28514442
EXT1_HUMANEXT1physical
28514442
AFAP1_HUMANAFAP1physical
28514442
ATE1_HUMANATE1physical
28514442
CUX1_HUMANCUX1physical
28514442
CASP_HUMANCUX1physical
28514442
UBP30_HUMANUSP30physical
28514442
NOP9_HUMANNOP9physical
28514442
DPB1_HUMANHLA-DPB1physical
28514442
Drug and Disease Associations
Kegg Disease
H00122 Multiple exostoses
H00493 Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker ty
OMIM Disease
133701Hereditary multiple exostoses 2 (EXT2)
601224Potocki-Shaffer syndrome (POSHS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EXT2_HUMAN

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Related Literatures of Post-Translational Modification

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