S22A2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S22A2_HUMAN
• UniProt AC: O15244
• Protein Name: Solute carrier family 22 member 2
• Gene Name: SLC22A2
• Organism: Homo sapiens (Human).
• Sequence Length: 555
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity..
• Protein Sequence: MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQKLDIPLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	SPGVAELSLRCGWSP CCCCEEEEEECCCCC	12.79	24719451
72	N-linked_Glycosylation	WSPAEELNYTVPGPG CCCHHHCCCCCCCCC	33.44	UniProtKB CARBOHYD
236	Phosphorylation	VGRRYRRTVGIFYQV HCHHHHHHHHHHHHH	17.68	-
241	Phosphorylation	RRTVGIFYQVAYTVG HHHHHHHHHHHHHHH	10.52	-
313	Phosphorylation	IAKKNGKSLPASLQR HHHHCCCCCCHHHHH	40.77	27174698
317	Phosphorylation	NGKSLPASLQRLRLE CCCCCCHHHHHHHHH	24.09	27174698
471	Phosphorylation	NLGVHICSSMCDIGG HHCHHHHHHCCCCCC	22.09	-
489	Phosphorylation	PFLVYRLTNIWLELP HHHHHHHHCHHHHHH	18.69	-
517	Phosphorylation	LVLLLPETKGKALPE EEHCCCCCCCCCCCH	43.06	-
544	Phosphorylation	KNKEKMIYLQVQKLD CCHHCEEEEEEEECC	6.38	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S22A2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S22A2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S22A2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUMO2_HUMAN	SUMO2	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.