TTC19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTC19_HUMAN
• UniProt AC: Q6DKK2
• Protein Name: Tetratricopeptide repeat protein 19, mitochondrial
• Gene Name: TTC19
• Organism: Homo sapiens (Human).
• Sequence Length: 380
• Subcellular Localization: Mitochondrion inner membrane .
• Protein Description: Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. [PubMed: 21278747]
• Protein Sequence: MFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPLLAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEISVQHIREELAELSKKSRPLTNSVKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MFRLLSWSLGRGFLR CCCHHHHHHHHHHHH	19.98	24719451
101	Ubiquitination	AEIIQLLKRAKLSIM HHHHHHHHHHCCCCC	59.92	-
132	2-Hydroxyisobutyrylation	LAYQTDNKKAITYTY HHHHCCCCCEEEEEH	46.52	-
132	Ubiquitination	LAYQTDNKKAITYTY HHHHCCCCCEEEEEH	46.52	-
162	Phosphorylation	AEQLFKATMSYLLGG HHHHHHHHHHHHHCC	13.77	25599653
165	Phosphorylation	LFKATMSYLLGGGMK HHHHHHHHHHCCCCC	8.63	25599653
224	Sulfoxidation	KELAEDIMSVEEKAN HHHHHHHHCHHHHHC	5.93	21406390
225	Phosphorylation	ELAEDIMSVEEKANT HHHHHHHCHHHHHCH	27.06	-
250	Phosphorylation	CARYLLFSKQPSQAQ HHHHHHHCCCHHHHH	30.28	24719451
251	Ubiquitination	ARYLLFSKQPSQAQR HHHHHHCCCHHHHHH	59.92	21890473
251	Ubiquitination	ARYLLFSKQPSQAQR HHHHHHCCCHHHHHH	59.92	21890473
262	Ubiquitination	QAQRMYEKALQISEE HHHHHHHHHHHHHHH	36.59	-
346	Ubiquitination	EIYQEALKQAKLKKD HHHHHHHHHCCCCCC	56.08	-
346	Acetylation	EIYQEALKQAKLKKD HHHHHHHHHCCCCCC	56.08	25953088
352	Ubiquitination	LKQAKLKKDEISVQH HHHCCCCCCCCCHHH	71.65	-
352	2-Hydroxyisobutyrylation	LKQAKLKKDEISVQH HHHCCCCCCCCCHHH	71.65	-
370	Ubiquitination	ELAELSKKSRPLTNS HHHHHHHHCCCCCCC	48.60	-
371	Phosphorylation	LAELSKKSRPLTNSV HHHHHHHCCCCCCCC	42.75	21406692
372	Ubiquitination	AELSKKSRPLTNSVK HHHHHHCCCCCCCCC	38.84	21890473
372	Ubiquitination	AELSKKSRPLTNSVK HHHHHHCCCCCCCCC	38.84	21890473
372	Ubiquitination	AELSKKSRPLTNSVK HHHHHHCCCCCCCCC	38.84	21890473
372	Ubiquitination	AELSKKSRPLTNSVK HHHHHHCCCCCCCCC	38.84	21890473
375	Phosphorylation	SKKSRPLTNSVKL-- HHHCCCCCCCCCC--	28.29	21406692
377	Phosphorylation	KSRPLTNSVKL---- HCCCCCCCCCC----	18.52	21406692
383	Ubiquitination	NSVKL---------- CCCCC----------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTC19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTC19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTC19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPRE1_HUMAN	SPRED1	physical	21900206
HPS6_HUMAN	HPS6	physical	21900206
UBA1_HUMAN	UBA1	physical	21900206
4ET_HUMAN	EIF4ENIF1	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
LMBL3_HUMAN	L3MBTL3	physical	25416956
IHO1_HUMAN	CCDC36	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.