| UniProt ID | IHO1_HUMAN | |
|---|---|---|
| UniProt AC | Q8IYA8 | |
| Protein Name | Interactor of HORMAD1 protein 1 {ECO:0000303|PubMed:27723721} | |
| Gene Name | CCDC36 {ECO:0000312|HGNC:HGNC:27945} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 594 | |
| Subcellular Localization | Chromosome . Specifically localizes to unsynapsed chromosomal regions during meiosis. | |
| Protein Description | Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.. | |
| Protein Sequence | MNFNVWNIKEMLSIPSGSGNKKSSNWNNNQNDYSSLSDSQFLFGSQFCPENSETLSAPLDFGAHLRHSKQSQQNYLEGEPSIFTKYQTKPQLFGGDIKDGGLFPPPLSVGKSKGLLEQFEEKKKRAKDKCDSETLYNFVSNVRESILRLQTSVEKSEDHLSSRSQSILDSLETVAKTLQETIQAQNDLVFEAVQDKGNMEQAILEMKKRFEARQGEFIEMKSNLKHLEVLVAQQSQEFQQLCEQLGQLNVPSVLAELKRLISVPPVKDSASQTSPPLAQSLNLTRQEKYTSEKPVLWQAQALPAAWNPGMGSLQPGEFDVWGEGAKNDDLQEEAALPAFGSHERNRHVKDKVVQTNCKNWAVTKTGAKNHGSSVPGHKIPSDRDLVSQGASQLTSLEINFSTSIKNACQKYQAQSMFLCDPREHLVIKQKDGTVEMRGKDKKQQPRKAHRAHRGRLIASKQKQIPIQTCKFNSKYQSPQPAISVPQSPFLGQQEPRAQPLHLQCPRSPRKPVCPILGGTVMPNKTVRAVQGRLLQLSRCSSQDNWLLSSSSQGDHQMSWFSDLNLGCSETPLCKEAGKNLLYDLGFDSSDDDGF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | O-linked_Glycosylation | MLSIPSGSGNKKSSN HHCCCCCCCCCCCCC | 30379171 | ||
| 22 | Ubiquitination | PSGSGNKKSSNWNNN CCCCCCCCCCCCCCC | - | ||
| 34 | O-linked_Glycosylation | NNNQNDYSSLSDSQF CCCCCCCCCCCHHHH | 30379171 | ||
| 68 | Phosphorylation | FGAHLRHSKQSQQNY HHHHHHCCHHHHCHH | 23898821 | ||
| 71 | Phosphorylation | HLRHSKQSQQNYLEG HHHCCHHHHCHHHCC | 23898821 | ||
| 75 | Phosphorylation | SKQSQQNYLEGEPSI CHHHHCHHHCCCCCH | 23898821 | ||
| 81 | Phosphorylation | NYLEGEPSIFTKYQT HHHCCCCCHHHCCCC | 23898821 | ||
| 84 | Phosphorylation | EGEPSIFTKYQTKPQ CCCCCHHHCCCCCCC | 23898821 | ||
| 123 | Ubiquitination | LEQFEEKKKRAKDKC HHHHHHHHHHHHHCC | - | ||
| 373 | Phosphorylation | GAKNHGSSVPGHKIP CCCCCCCCCCCCCCC | 19413330 | ||
| 588 | Phosphorylation | LYDLGFDSSDDDGF- HHHCCCCCCCCCCC- | - | ||
| 589 | Phosphorylation | YDLGFDSSDDDGF-- HHCCCCCCCCCCC-- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IHO1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IHO1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IHO1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZGPAT_HUMAN | ZGPAT | physical | 21516116 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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