SPRE1_HUMAN - dbPTM
SPRE1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPRE1_HUMAN
UniProt AC Q7Z699
Protein Name Sprouty-related, EVH1 domain-containing protein 1
Gene Name SPRED1
Organism Homo sapiens (Human).
Sequence Length 444
Subcellular Localization Cell membrane
Peripheral membrane protein . Membrane, caveola
Peripheral membrane protein . Nucleus . Localized in cholesterol-rich membrane raft/caveola fractions.
Protein Description Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity)..
Protein Sequence MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFIRGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFEDLNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDETKLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSEETATSD
------CCCCCCCCC		44.1124043423
2Acetylation------MSEETATSD
------CCCCCCCCC		44.1122814378
5Phosphorylation---MSEETATSDNDN
---CCCCCCCCCCCC		31.0520230923
7Phosphorylation-MSEETATSDNDNSY
-CCCCCCCCCCCCCC		43.9920230923
8PhosphorylationMSEETATSDNDNSYA
CCCCCCCCCCCCCCE		31.7720230923
13PhosphorylationATSDNDNSYARVRAV
CCCCCCCCCEEEEEE		24.0428985074
14PhosphorylationTSDNDNSYARVRAVV
CCCCCCCCEEEEEEE		12.5124043423
23PhosphorylationRVRAVVMTRDDSSGG
EEEEEEEECCCCCCC		21.2429759185
82PhosphorylationMLKKDLIYNKVTPTF
HHCCCCEECCCCCCE		19.07-
105PhosphorylationKFGLTFQSPADARAF
EECEEECCHHHHHHH		20.1921815630
168PhosphorylationTVVTSEPYRSSNIRP
EEECCCCCCCCCCCC		21.0527642862
176PhosphorylationRSSNIRPSPFEDLNA
CCCCCCCCCCHHHCC		32.1622199227
187PhosphorylationDLNARRVYMQSQANQ
HHCCCHHEEHHHHCC		6.3927642862
206PhosphorylationQPGLDIQSRSMEYVQ
CCCCCHHHHHHHHHH		27.0224043423
208PhosphorylationGLDIQSRSMEYVQRQ
CCCHHHHHHHHHHHH		22.6324245541
211PhosphorylationIQSRSMEYVQRQISK
HHHHHHHHHHHHHHH		8.0125884760
222PhosphorylationQISKECGSLKSQNRV
HHHHHHCCCCCCCCC		44.2623898821
224MethylationSKECGSLKSQNRVPL
HHHHCCCCCCCCCCC		52.2524129315
225PhosphorylationKECGSLKSQNRVPLK
HHHCCCCCCCCCCCC		37.6723898821
232MethylationSQNRVPLKSIRHVSF
CCCCCCCCCCCEEEE		37.45115980609
238PhosphorylationLKSIRHVSFQDEDEI
CCCCCEEEECCHHHE		15.8629255136
261PhosphorylationLIRRYADYRHPDMWK
HHHHHHCCCCCHHHC		11.5827259358
284UbiquitinationDSSIQFSKPDSKKSD
CCCCEECCCCCCCCC		54.8829967540
285UbiquitinationSSIQFSKPDSKKSDY
CCCEECCCCCCCCCC		50.3223000965
287PhosphorylationIQFSKPDSKKSDYLY
CEECCCCCCCCCCEE		50.9729507054
289UbiquitinationFSKPDSKKSDYLYSC
ECCCCCCCCCCEEEC		53.1429967540
291UbiquitinationKPDSKKSDYLYSCGD
CCCCCCCCCEEECCC		46.4623000965
292PhosphorylationPDSKKSDYLYSCGDE
CCCCCCCCEEECCCC		18.0324927040
294PhosphorylationSKKSDYLYSCGDETK
CCCCCCEEECCCCCC		8.8325884760
295PhosphorylationKKSDYLYSCGDETKL
CCCCCEEECCCCCCC		14.7226356563
301UbiquitinationYSCGDETKLSSPKDS
EECCCCCCCCCCCCC		44.3029967540
303PhosphorylationCGDETKLSSPKDSVV
CCCCCCCCCCCCCEE		46.2623186163
304PhosphorylationGDETKLSSPKDSVVF
CCCCCCCCCCCCEEE		46.5423186163
306UbiquitinationETKLSSPKDSVVFKT
CCCCCCCCCCEEEEC		65.6623000965
308PhosphorylationKLSSPKDSVVFKTQP
CCCCCCCCEEEECCC		26.7221089071
312UbiquitinationPKDSVVFKTQPSSLK
CCCCEEEECCCCCCC		34.3423000965
313PhosphorylationKDSVVFKTQPSSLKI
CCCEEEECCCCCCCC		33.9628102081
316PhosphorylationVVFKTQPSSLKIKKS
EEEECCCCCCCCCCC		38.1928102081
317PhosphorylationVFKTQPSSLKIKKSK
EEECCCCCCCCCCCC		40.1228102081
318UbiquitinationFKTQPSSLKIKKSKR
EECCCCCCCCCCCCC		8.5723000965
324UbiquitinationSLKIKKSKRRKEDGE
CCCCCCCCCCCCCCC		66.1723000965
360UbiquitinationQDAPDPIKRCIYQVS
CCCCCHHHHHHHHHH		46.7533845483
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPRE1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPRE1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPRE1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TESK1_HUMANTESK1physical
17974561
SUV91_HUMANSUV39H1physical
23455924
ZDH17_HUMANZDHHC17physical
24705354
Drug and Disease Associations
Kegg Disease
H00523 Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noona
OMIM Disease
611431Neurofibromatosis 1-like syndrome (NFLS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPRE1_HUMAN

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Related Literatures of Post-Translational Modification

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