TESK1_HUMAN - dbPTM
TESK1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TESK1_HUMAN
UniProt AC Q15569
Protein Name Dual specificity testis-specific protein kinase 1
Gene Name TESK1
Organism Homo sapiens (Human).
Sequence Length 626
Subcellular Localization
Protein Description Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)..
Protein Sequence MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLFLPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVTTPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECEGSSPEPEPPGPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHSLPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGARS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37MethylationGGGPGRGRPSSYRAL
CCCCCCCCCHHHHHH		26.94115386611
69PhosphorylationKIGAGFFSEVYKVRH
HHCCCCCCEEEEEEE		24.72-
179UbiquitinationFHRDLTSKNCLVRRE
CCCCCCCCCCEEEEH		46.58-
212UbiquitinationVYREGARKEPLAVVG
CCCCCCCCCCEEEEC		64.25-
220PhosphorylationEPLAVVGSPYWMAPE
CCEEEECCCCCCCHH		11.8210207045
338MethylationHNQGSVARGGPSATL
CCCCCCCCCCCCCCC		48.7458860115
342PhosphorylationSVARGGPSATLPRPD
CCCCCCCCCCCCCCC		36.8424719451
344PhosphorylationARGGPSATLPRPDPR
CCCCCCCCCCCCCCC		41.4524719451
353PhosphorylationPRPDPRLSRSRSDLF
CCCCCCCCCCCCCCC		29.5023090842
355PhosphorylationPDPRLSRSRSDLFLP
CCCCCCCCCCCCCCC		32.5328857561
357PhosphorylationPRLSRSRSDLFLPPS
CCCCCCCCCCCCCCC		39.6528857561
364PhosphorylationSDLFLPPSPESPPNW
CCCCCCCCCCCCCCC		39.0823090842
367PhosphorylationFLPPSPESPPNWGDN
CCCCCCCCCCCCCCC		49.3823090842
376PhosphorylationPNWGDNLTRVNPFSL
CCCCCCCCCCCCCCC		38.5323090842
391AcetylationREDLRGGKIKLLDTP
CHHHCCCCEEECCCC		39.2211791385
393AcetylationDLRGGKIKLLDTPSK
HHCCCCEEECCCCCC		46.6211791397
399PhosphorylationIKLLDTPSKPVLPLV
EEECCCCCCCCCCCC		52.2430001349
400AcetylationKLLDTPSKPVLPLVP
EECCCCCCCCCCCCC		40.1111791409
437PhosphorylationTPARRCRSLPSSPEL
CCCCCCCCCCCCCCC		48.5430266825
440PhosphorylationRRCRSLPSSPELPRR
CCCCCCCCCCCCCHH		64.9130266825
441PhosphorylationRCRSLPSSPELPRRM
CCCCCCCCCCCCHHH		22.0622617229
507PhosphorylationSSASQPWSPRSGPVL
CCCCCCCCCCCCCCC		19.6724719451
540PhosphorylationPWNRAQHSLPRAAAL
CCHHHHCCCCCHHHH		28.1730266825
553PhosphorylationALERTEPSPPPSAPR
HHHCCCCCCCCCCCC		43.7528985074
603PhosphorylationNLNCEAGSLLCHRGH
CCCCCCCCEECCCCC		25.8023312004
616PhosphorylationGHHAKPPTPSLQLPG
CCCCCCCCCCCCCCC		33.7524719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TESK1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TESK1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TESK1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
1433B_HUMANYWHABphysical
11555644
SPY4_HUMANSPRY4physical
12027893
TYY1_HUMANYY1physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TESK1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437 AND SER-441, ANDMASS SPECTROMETRY.

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