| UniProt ID | ZDH17_HUMAN | |
|---|---|---|
| UniProt AC | Q8IUH5 | |
| Protein Name | Palmitoyltransferase ZDHHC17 {ECO:0000305} | |
| Gene Name | ZDHHC17 {ECO:0000312|HGNC:HGNC:18412} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 632 | |
| Subcellular Localization |
Golgi apparatus membrane Multi-pass membrane protein . Cytoplasmic vesicle membrane Multi-pass membrane protein . Cell junction, synapse, presynaptic cell membrane Multi-pass membrane protein . Low extracellular Mg(2+) induces increase in Golgi |
|
| Protein Description | Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. [PubMed: 15603740] | |
| Protein Sequence | MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 37 | Ubiquitination | PEEIKPQSHYNHGYG HHHCCCCCCCCCCCC | 36.14 | 22505724 | |
| 39 | Phosphorylation | EIKPQSHYNHGYGEP HCCCCCCCCCCCCCC | 17.69 | 25884760 | |
| 40 | Ubiquitination | IKPQSHYNHGYGEPL CCCCCCCCCCCCCCC | 19.38 | 33845483 | |
| 43 | Phosphorylation | QSHYNHGYGEPLGRK CCCCCCCCCCCCCCC | 15.68 | 25884760 | |
| 50 | Ubiquitination | YGEPLGRKTHIDDYS CCCCCCCCCCCCCCC | 42.53 | 33845483 | |
| 56 | Phosphorylation | RKTHIDDYSTWDIVK CCCCCCCCCHHHHHH | 12.30 | 25884760 | |
| 67 | Phosphorylation | DIVKATQYGIYERCR HHHHHHHCCHHHHHH | 10.92 | - | |
| 70 | Phosphorylation | KATQYGIYERCRELV HHHHCCHHHHHHHHH | 7.92 | 25884760 | |
| 81 | Phosphorylation | RELVEAGYDVRQPDK HHHHHCCCCCCCCCC | 20.50 | 25884760 | |
| 84 | Methylation | VEAGYDVRQPDKENV HHCCCCCCCCCCCCE | 39.14 | - | |
| 97 | Ubiquitination | NVTLLHWAAINNRID CEEEEEHHHHHCCHH | 6.42 | 33845483 | |
| 105 | Phosphorylation | AINNRIDLVKYYISK HHHCCHHHHHHHHHC | 3.13 | 18083107 | |
| 107 | Ubiquitination | NNRIDLVKYYISKGA HCCHHHHHHHHHCCC | 39.37 | 33845483 | |
| 192 | Phosphorylation | MMDQNGMTPLMWAAY CCCCCCCCHHHHHHH | 18.05 | - | |
| 223 | Phosphorylation | SVNLGDKYHKNTALH EEECCCHHCCCCHHH | 23.83 | 22210691 | |
| 227 | Phosphorylation | GDKYHKNTALHWAVL CCHHCCCCHHHHHHH | 35.09 | 22210691 | |
| 256 | Ubiquitination | ANVDAQNIKGESALD CCCCHHHCCCCHHHH | 3.94 | 33845483 | |
| 257 | Ubiquitination | NVDAQNIKGESALDL CCCHHHCCCCHHHHH | 65.26 | - | |
| 260 | Phosphorylation | AQNIKGESALDLAKQ HHHCCCCHHHHHHHH | 42.68 | 22210691 | |
| 266 | Ubiquitination | ESALDLAKQRKNVWM CHHHHHHHHHCCCHH | 58.91 | 33845483 | |
| 274 | Ubiquitination | QRKNVWMINHLQEAR HHCCCHHHHHHHHHH | 1.40 | 33845483 | |
| 284 | Ubiquitination | LQEARQAKGYDNPSF HHHHHHHCCCCCHHH | 50.06 | 33845483 | |
| 286 | Phosphorylation | EARQAKGYDNPSFLR HHHHHCCCCCHHHHH | 16.31 | 25884760 | |
| 296 | Methylation | PSFLRKLKADKEFRQ HHHHHHHHCCHHHHH | 58.54 | 23644510 | |
| 299 | Methylation | LRKLKADKEFRQKVM HHHHHCCHHHHHHHH | 64.71 | 23644510 | |
| 335 | Phosphorylation | WLIKGLMYGGVWATV HHHHHHHHCHHHHHH | 18.77 | 24260401 | |
| 341 | Phosphorylation | MYGGVWATVQFLSKS HHCHHHHHHHHHHHH | 10.10 | 24260401 | |
| 346 | Phosphorylation | WATVQFLSKSFFDHS HHHHHHHHHHHCCCC | 27.78 | - | |
| 348 | Phosphorylation | TVQFLSKSFFDHSMH HHHHHHHHHCCCCHH | 27.98 | 22199227 | |
| 353 | Phosphorylation | SKSFFDHSMHSALPL HHHHCCCCHHHHHHH | 21.75 | 22199227 | |
| 356 | Phosphorylation | FFDHSMHSALPLGIY HCCCCHHHHHHHHHH | 23.90 | 22199227 | |
| 363 | Phosphorylation | SALPLGIYLATKFWM HHHHHHHHHHHHHHH | 6.62 | 22199227 | |
| 366 | Phosphorylation | PLGIYLATKFWMYVT HHHHHHHHHHHHHHH | 24.95 | 22199227 | |
| 397 | Ubiquitination | PFLANSVALFYNFGK HHHHHHHHHHHHCCC | 7.56 | 32142685 | |
| 404 | Ubiquitination | ALFYNFGKSWKSDPG HHHHHCCCCCCCCCC | 49.35 | 33845483 | |
| 407 | Ubiquitination | YNFGKSWKSDPGIIK HHCCCCCCCCCCCHH | 52.66 | 32142685 | |
| 414 | Ubiquitination | KSDPGIIKATEEQKK CCCCCCHHCCHHHHH | 47.54 | 33845483 | |
| 462 | Acetylation | VCNRCIAKFDHHCPW CCCHHHHHCCCCCCC | 31.26 | 7380607 | |
| 502 | Phosphorylation | WMIYGCISYWGLHCE HHHHHHHHHHCCCCE | 20.93 | - | |
| 503 | Phosphorylation | MIYGCISYWGLHCET HHHHHHHHHCCCCEE | 5.42 | - | |
| 629 | Phosphorylation | DQISGSGYQLV---- EECCCCCEECC---- | 10.60 | 27642862 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZDH17_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZDH17_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZDH17_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-70, AND MASSSPECTROMETRY. | |
