DYH11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DYH11_HUMAN
• UniProt AC: Q96DT5
• Protein Name: Dynein heavy chain 11, axonemal
• Gene Name: DNAH11
• Organism: Homo sapiens (Human).
• Sequence Length: 4516
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme.
• Protein Description: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP..
• Protein Sequence: MAAQVAAREARDFREAPTLRLTSGAGLEAVGAVELEEEEENEEEAAARRARSFAQDARVRFLGGRLAMMLGFTEEKWSQYLESEDNRQVLGEFLESTSPACLVFSFAASGRLAASQEIPRDANHKLVFISKKITESIGVNDFSQVVLFGELPALSLGHVSAFLDEILVPVLSNKNNHKSWSCFTSQDMEYHIEVMKKKMYIFRGKMSRRTLLPIPTVAGKMDLDQNCSENKPPSNERIILHAIESVVIEWSHQIQEIIERDSVQRLLNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLKDIFLAVENALLEAQDVELYLRPLRRHIQCLQETEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRKLRPWDFQSHLVFCRFDKFLDRLIKIEDIFATTLEFEKLERLEFGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLEFDRRLGTIICEAFFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQIECGHVVLNKNMPFTSGNMKWAQQVLQRLQMFWSNFASLRYLFLGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPLVKFSAINGLLCVNFDPKLVAVLREVKYLLMLKKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLTAATTWLTWQDDCWGYIERVRAATSELEHRVERTQKNVKVIQQTMRGWARCVLPPRREHRREAAFTLEDKGDLFTKKYKLIQGDGCKIHNLVEENRKLFKANPSLDTWKIYVEFIDDIVVEGFFQAIMHDLDFFLKNTEKQLKPAPFFQAQMILLPPEIVFKPSLDREAGDGFYDLVEEMLCNSFRMSAQMNRIATHLEIKNYQNDMDNMLGLAEVRQEIMNRVVNVINKVLDFRNTLETHTYLWVDDRAEFMKHFLLYGHAVSSDEMDAHANEEIPEQPPTLEQFKEQIDIYEALYVQMSKFEDFRVFDSWFKVDMKPFKVSLLTIIKKWSWMFQEHLLRFVIDSLNELQEFIKETDSGLQRELNEGDHDGLVDIMVHLLAVRSRQRATDELFEPLKETITLLESYGQKMPEQVYIQLEELPERWETTKKIAATVRHEVSPLHNAEVTLIRKKCILFDAKQAEFRERFRHYAPLGFNAENPYTALDKANEELEALEEEMLQMQESTRLFEVALPEYKQMKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEGTVKDMTASLRAITELQSPALRDRHWHQLMKAIGVKFLINEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKFSYEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSADLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQDVSAHRAVGMYSKEKEYVPFQAECECVGHVETWLLQLEQTMQETVRHSITEAIVAYEEKPRELWIFDFPAQVALTSSQIWWTTDVGIAFSRLEEGYETALKDFHKKQISQLNTLITLLLGELPPGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSQLRHRWEDTQKHCFVNICDAQFQYFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKGLVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFRPCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMRALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVGNAGTGKSKILRTLNRTYVNMKQKPVWNDLNPKAVTTDELFGFIHHATREWKDGKIVYSYFIGLFSSILREQANLKHDGPKWIVLDGDIDPMWIESLNTVMDDNKVLTLASNERIALTPFMRLLFEIHHLRSATPATVSRAGILYVNPQDLGWNPYVASWIDRRRHQSEKANLTILFDKYVPACLDKLRTSFKTITSIPESSLVQTLCVLLECLLTPENVPSDSPKEVYEVYFVFACIWAFGGTLLQDQISDYQADFSRWWQKEMKAVKFPSQGTIFDYYVDHKTKKLLPWADKIAQFTMDPDVPLQTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASLSEDYIVSRVPFNYYTTSTALQKILEKPLEKKAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNCQYVACMNPMVGSFTINPRLQRHFTVFAFNFPSLDALNTIYGQIFSFHFQQQAFAPSILRSGPTLIQATIAFHQTMMCNFLPTAIKFHYIFNLRDLSNVFQGILFASPECLKGPLDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGIDSHMLLQQPLIYCHFADRGKDPHYMPVKDWEVLKTILTETLDNYNELNAAMHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGMVDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDSISLFMAHVHTTVNEMSTRYYQNERRHNYTTPKSFLEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQRECEADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALINYDKEHIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQELVHCKWVPFLQQKVSIPLTEGLDLISMLTDDATIAAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKYGMDLKVTHLGQKGFLNAIETALAFGDVILIENLEETIDPVLDPLLGRNTIKKGKYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKINEARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRAIEQADKVEDMQGRISILMESITHAVFLYTSQALFEKDKLTFLSQMAFQILLRKKEIDPLELDFLLRFTVEHTHLSPVDFLTSQSWSAIKAIAVMEEFRGIDRDVEGSAKQWRKWVESECPEKEKLPQEWKKKSLIQKLILLRAMRPDRMTYALRNFVEEKLGAKYVERTRLDLVKAFEESSPATPIFFILSPGVDALKDLEILGKRLGFTIDSGKFHNVSLGQGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYRVFMSAESAPTPDEHIIPQGLLENSIKITNEPPTGMLANLHAALYNFDQDTLEICSKEQEFKSILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYLEANSKVPWEDLRYLFGEIMYGGHITDDWDRKLCRVYLEEFMNPSLTEDELMLAPGFAAPPYLDYAGYHQYIEEMLPPESPALYGLHPNAEIEFLTVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQKNSNRSPYVLVCFQECERMNILIREIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWLSGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKKTKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELACPMPVIFAKATPVDRQETKQTYECPVYRTKLRGPSYIWTFRLKSEEKTAKWVLAGVALLLEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	Phosphorylation	VFISKKITESIGVND EEEECCHHHCCCCCC	32.34	22210691
136	Phosphorylation	ISKKITESIGVNDFS EECCHHHCCCCCCCC	18.91	22210691
160	Phosphorylation	ALSLGHVSAFLDEIL CCCHHHHHHHHHHHH	13.97	22210691
172	Phosphorylation	EILVPVLSNKNNHKS HHHHHHHCCCCCCCC	46.09	22210691
313	Phosphorylation	ILTTKQSSYFPTLKD HHHCCCHHCCCCHHH	28.44	25262027
314	Phosphorylation	LTTKQSSYFPTLKDI HHCCCHHCCCCHHHH	20.87	25262027
449	Ubiquitination	ASYFMGRKLRPWDFQ HHHHCCCCCCCCCCC	43.02	21906983
521	Phosphorylation	LCKLFKQSTYDPSDC HHHHHHHCCCCHHHC	29.53	-
522	Phosphorylation	CKLFKQSTYDPSDCT HHHHHHCCCCHHHCC	29.47	-
631	Phosphorylation	LNKNMPFTSGNMKWA ECCCCCCCCCCHHHH	29.83	-
632	Phosphorylation	NKNMPFTSGNMKWAQ CCCCCCCCCCHHHHH	28.66	-
755	Phosphorylation	AIFKKRNTILKYIGN HHHHHHCHHHHHHCC	31.55	-
820	Phosphorylation	IERVRAATSELEHRV HHHHHHHHHHHHHHH	23.04	-
821	Phosphorylation	ERVRAATSELEHRVE HHHHHHHHHHHHHHH	35.14	-
830	Phosphorylation	LEHRVERTQKNVKVI HHHHHHHHHHHHHHH	30.32	-
1033	Phosphorylation	KVLDFRNTLETHTYL HHHHHCHHHCCCEEE	23.01	29083192
1036	Phosphorylation	DFRNTLETHTYLWVD HHCHHHCCCEEEEEC	23.72	29083192
1038	Phosphorylation	RNTLETHTYLWVDDR CHHHCCCEEEEECCH	27.94	29083192
1039	Phosphorylation	NTLETHTYLWVDDRA HHHCCCEEEEECCHH	7.32	29083192
1119	Phosphorylation	DMKPFKVSLLTIIKK CCCCCCHHHHHHHHH	20.46	16674116
1122	Phosphorylation	PFKVSLLTIIKKWSW CCCHHHHHHHHHHHH	26.42	16674116
1203	Phosphorylation	TITLLESYGQKMPEQ HHHHHHHHCCCCCHH	17.75	-
1245	Phosphorylation	PLHNAEVTLIRKKCI CCCCCEEEEEEEEEE	14.15	-
1250	Acetylation	EVTLIRKKCILFDAK EEEEEEEEEEECCCC	19.36	19819167
1257	Acetylation	KCILFDAKQAEFRER EEEECCCCHHHHHHH	52.46	19819177
1321	Malonylation	KQMKQCRKEIKLLKG HHHHHHHHHHHHHHH	71.99	26320211
1470	Phosphorylation	EISQTWATMKFSYEV HHHHHHHHCCEEEEE	18.48	29083192
1601	Acetylation	PNLYEKLKDLQSRLS CCHHHHHHHHHHHHH	6.91	7432065
1620	Phosphorylation	ALAEYLETKRIAFPR HHHHHHHHCCCCCCC	14.30	29396449
1629	Phosphorylation	RIAFPRFYFVSSADL CCCCCCEEEECHHHH	16.66	-
1632	Phosphorylation	FPRFYFVSSADLLDI CCCEEEECHHHHHHH	32.23	22985185
1633	Phosphorylation	PRFYFVSSADLLDIL CCEEEECHHHHHHHH	5.90	22985185
1641	Phosphorylation	ADLLDILSKGAQPKQ HHHHHHHHCCCCCHH	4.65	21815630
1680	Phosphorylation	AHRAVGMYSKEKEYV HHHHCCCCCCCCCCC	30.59	25219547
1681	Phosphorylation	HRAVGMYSKEKEYVP HHHCCCCCCCCCCCC	7.73	24719451
1717	Phosphorylation	MQETVRHSITEAIVA HHHHHHHHHHHHHHH	38.15	30622161
1719	Phosphorylation	ETVRHSITEAIVAYE HHHHHHHHHHHHHCC	5.22	30622161
1725	Phosphorylation	ITEAIVAYEEKPREL HHHHHHHCCCCCCEE	34.43	30622161
1765	Phosphorylation	FSRLEEGYETALKDF HHHHHHHHHHHHHHH	39.40	20363803
1823	Phosphorylation	LISQKVVSPQAFTWL HHHCCCCCHHHHHHH	41.58	-
1828	Phosphorylation	VVSPQAFTWLSQLRH CCCHHHHHHHHHHHH	3.06	-
1831	Phosphorylation	PQAFTWLSQLRHRWE HHHHHHHHHHHHHHH	20.22	-
1900	Phosphorylation	GPAGTGKTETTKDLG CCCCCCCCCCHHHHH	16.13	19664994
1925	Phosphorylation	NCSEQMDYKSIGNIY ECCHHCCHHHHHHHH	20.54	-
2079	Phosphorylation	SVLVVAGSLKRGDKN HHHHHHCCCCCCCCC	17.99	24719451
2169	Phosphorylation	ELLAVRHSVFVVGNA HHHCCCCCEEEECCC	58.64	22817900
2221	Phosphorylation	FGFIHHATREWKDGK HHHHHHHCCCCCCCC	7.65	-
2240	Phosphorylation	YFIGLFSSILREQAN HHHHHHHHHHHHHHC	4.98	24719451
2494	Phosphorylation	TETARLRYFMELLLE CHHHHHHHHHHHHHH	19.23	25690035
2517	Phosphorylation	GNAGVGKTVFVGDTL CCCCCCCEEEECHHH	17.82	-
2523	O-linked_Glycosylation	KTVFVGDTLASLSED CEEEECHHHHHCCCC	38.83	OGP
2540	Phosphorylation	VSRVPFNYYTTSTAL CCCCCCCCCCHHHHH	2.14	24043423
2541	Phosphorylation	SRVPFNYYTTSTALQ CCCCCCCCCHHHHHH	20.29	24043423
2542	Phosphorylation	RVPFNYYTTSTALQK CCCCCCCCHHHHHHH	29.27	24043423
2543	Phosphorylation	VPFNYYTTSTALQKI CCCCCCCHHHHHHHH	5.03	24043423
2544	Phosphorylation	PFNYYTTSTALQKIL CCCCCCHHHHHHHHH	15.62	24043423
2545	Phosphorylation	FNYYTTSTALQKILE CCCCCHHHHHHHHHH	9.32	24043423
2908	Phosphorylation	TGAKNMPTVFLLTDA CCCCCCCEEEEECCH	31.75	28787133
2921	Phosphorylation	DAQVLDESFLVLIND CHHHCCHHHHHHHHH	34.67	28787133
2986	Phosphorylation	LKIILCFSPVGRTLR CHHHEEECCCCCHHH	7.23	-
3079	Phosphorylation	KSFLEQISLFKNLLK HHHHHHHHHHHHHHH	52.31	24719451
3108	Phosphorylation	NGIQKLKTTASQVGD HHHHHHHHHHHHHHH	46.58	28842319
3109	Phosphorylation	GIQKLKTTASQVGDL HHHHHHHHHHHHHHH	19.07	28842319
3111	Phosphorylation	QKLKTTASQVGDLKA HHHHHHHHHHHHHHH	46.56	28842319
3203	Phosphorylation	TLNRVNLSELKAFPN HHCCCCHHHHCCCCC	26.68	-
3352	Phosphorylation	DRNLSRLTASFEKAT HHHHHHHHHHHHHHH	32.72	-
3354	Phosphorylation	NLSRLTASFEKATAE HHHHHHHHHHHHHHH	41.87	-
3357	Methylation	RLTASFEKATAEKVR HHHHHHHHHHHHHHH	38.94	-
3359	Phosphorylation	TASFEKATAEKVRCQ HHHHHHHHHHHHHCH	21.10	-
3362	Methylation	FEKATAEKVRCQEEV HHHHHHHHHHCHHHH	11.78	-
3389	Ubiquitination	LVKELEAKKIRWGQS HHHHHHHHCCCCCCC	6.91	-
3428	Phosphorylation	VGPFTRQYRQELVHC HCHHCHHHHHHHHHC	6.47	-
3678	Acetylation	VERLEATKTTVAEIE HHHHHCCCCCHHHHH	4.25	30588213
3860	Phosphorylation	QWRKWVESECPEKEK HHHHHHHHHCCCHHH	44.94	25690035
3907	Ubiquitination	VEEKLGAKYVERTRL HHHHHCCHHHHHHHH	12.10	-
3908	Phosphorylation	EEKLGAKYVERTRLD HHHHCCHHHHHHHHH	45.32	24114839
3914	Ubiquitination	KYVERTRLDLVKAFE HHHHHHHHHHHHHHH	48.29	21906983
4341	Phosphorylation	DTWSKLAYPSTYGLA CHHHHCCCCCHHHHH	57.37	-
4345	Phosphorylation	KLAYPSTYGLAQWFN HCCCCCHHHHHHHHH	28.79	-
4396	Acetylation	IMQTMARKNEWPLDK HHHHHHHCCCCCCCC	1.45	7366469
4403	Acetylation	KNEWPLDKTRLTADV CCCCCCCCCCCEECC	50.08	7366479
4418	Phosphorylation	TKKTKEDYGHPPREG CHHCHHHHCCCCCCC	27.63	-
4498	Phosphorylation	IWTFRLKSEEKTAKW EEEEEECCCHHHHHH	3.07	28555341
4502	Phosphorylation	RLKSEEKTAKWVLAG EECCCHHHHHHHHHH	33.55	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DYH11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DYH11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DYH11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DYH11_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 244400: Kartagener syndrome (KTGS)
• 611884: Ciliary dyskinesia, primary, 7 (CILD7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.