DTX3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DTX3_HUMAN
• UniProt AC: Q8N9I9
• Protein Name: Probable E3 ubiquitin-protein ligase DTX3
• Gene Name: DTX3
• Organism: Homo sapiens (Human).
• Sequence Length: 347
• Subcellular Localization: Cytoplasm .
• Protein Description: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity..
• Protein Sequence: MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
183	Phosphorylation	TLEKCRHSFCEGCIT HHHHHHHHHHHHHHH	16.55	27251275
197	Acetylation	TRALQVKKACPMCGR HHHHHHHHHCCCCCC	57.26	30588313

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DTX3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DTX3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DTX3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYFB_HUMAN	FARSB	physical	26186194
NARFL_HUMAN	NARFL	physical	26186194
NDUF5_HUMAN	NDUFAF5	physical	26186194
CHFR_HUMAN	CHFR	physical	26186194
ITSN1_HUMAN	ITSN1	physical	26186194
MK09_HUMAN	MAPK9	physical	26186194
NMD3_HUMAN	NMD3	physical	26186194
NDUS6_HUMAN	NDUFS6	physical	26186194
RN114_HUMAN	RNF114	physical	26186194
CHFR_HUMAN	CHFR	physical	28514442
NARFL_HUMAN	NARFL	physical	28514442
NMD3_HUMAN	NMD3	physical	28514442
ITSN1_HUMAN	ITSN1	physical	28514442
MK09_HUMAN	MAPK9	physical	28514442
NDUS6_HUMAN	NDUFS6	physical	28514442
RN114_HUMAN	RNF114	physical	28514442
GUAD_HUMAN	GDA	physical	28514442
NDUF5_HUMAN	NDUFAF5	physical	28514442
SYFB_HUMAN	FARSB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.