dbPTM

ITSN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ITSN1_HUMAN
UniProt AC	Q15811
Protein Name	Intersectin-1
Gene Name	ITSN1
Organism	Homo sapiens (Human).
Sequence Length	1721
Subcellular Localization	Endomembrane system. Cell junction, synapse, synaptosome. Cell projection, lamellipodium. Membrane, clathrin-coated pit. Colocalizes with SGIP1 at the plasma membrane in structures corresponding most probably to clathrin-coated pits.
Protein Description	Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1..
Protein Sequence	MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	RMDQVEFSIAMKLIK CCCHHHHHHHHHHHH	8.91	18767875
182	Phosphorylation	PAATLPKSSSFSRSG CCCCCCCCCCCCCCC	29.31	26074081
183	Phosphorylation	AATLPKSSSFSRSGP CCCCCCCCCCCCCCC	41.34	26074081
184	Phosphorylation	ATLPKSSSFSRSGPG CCCCCCCCCCCCCCC	34.04	26074081
186	Phosphorylation	LPKSSSFSRSGPGSQ CCCCCCCCCCCCCCH	27.73	26074081
188	Phosphorylation	KSSSFSRSGPGSQLN CCCCCCCCCCCCHHH	48.41	26074081
192	Phosphorylation	FSRSGPGSQLNTKLQ CCCCCCCCHHHHHHH	34.33	26074081
203	Phosphorylation	TKLQKAQSFDVASVP HHHHHCCCCCCCCCC	28.42	25159151
208	Phosphorylation	AQSFDVASVPPVAEW CCCCCCCCCCCHHHC	34.70	25106551
220	Phosphorylation	AEWAVPQSSRLKYRQ HHCCCCCHHHHHHHH	16.03	-
221	Phosphorylation	EWAVPQSSRLKYRQL HCCCCCHHHHHHHHH	36.06	-
231	Phosphorylation	KYRQLFNSHDKTMSG HHHHHHHCCCCCCCC	26.23	28842319
247	Phosphorylation	LTGPQARTILMQSSL CCCHHHHHHHHHCCC	22.83	22210691
252	Phosphorylation	ARTILMQSSLPQAQL HHHHHHHCCCCHHHH	21.63	22210691
253	Phosphorylation	RTILMQSSLPQAQLA HHHHHHCCCCHHHHH	27.46	22210691
275	Phosphorylation	IDQDGKLTAEEFILA CCCCCCCCHHHHHHH	35.19	22468782
291	Phosphorylation	HLIDVAMSGQPLPPV HHHHHHHCCCCCCCC	25.25	22468782
313	Phosphorylation	PSFRRVRSGSGISVI CCCCCCCCCCCEEEE	34.16	29255136
315	Phosphorylation	FRRVRSGSGISVISS CCCCCCCCCEEEEEC	33.91	29255136
318	Phosphorylation	VRSGSGISVISSTSV CCCCCCEEEEECCCC	19.54	23927012
321	Phosphorylation	GSGISVISSTSVDQR CCCEEEEECCCCCCC	25.96	24702127
322	Phosphorylation	SGISVISSTSVDQRL CCEEEEECCCCCCCC	17.36	24702127
323	Phosphorylation	GISVISSTSVDQRLP CEEEEECCCCCCCCC	26.44	24702127
324	Phosphorylation	ISVISSTSVDQRLPE EEEEECCCCCCCCCC	26.16	23403867
345	Ubiquitination	EQQQLEKKLPVTFED HHHHHHHHCCCCCCH	48.96	-
353	Ubiquitination	LPVTFEDKKRENFER CCCCCCHHHHHHCCC	46.67	-
354	Ubiquitination	PVTFEDKKRENFERG CCCCCHHHHHHCCCC	76.81	-
472	Acetylation	QEDIVVLKAKKKTLE HHCEEEEEECCCEEE	46.69	20167786
475	Acetylation	IVVLKAKKKTLEFEL EEEEEECCCEEEEEH	56.71	130715
476	Ubiquitination	VVLKAKKKTLEFELE EEEEECCCEEEEEHH	58.60	-
477	Phosphorylation	VLKAKKKTLEFELEA EEEECCCEEEEEHHH	40.16	23403867
495	Acetylation	KKHQLEGKLQDIRCR CCHHHHHHHHHHHHH	33.33	19608861
545	Acetylation	LGRLIPEKQILNDQL HHHHCCHHHHHHHHH	36.97	23954790
559	Phosphorylation	LKQVQQNSLHRDSLV HHHHHHCCCCHHHHH	22.63	21955146
564	Phosphorylation	QNSLHRDSLVTLKRA HCCCCHHHHHHHHHH	25.37	23403867
567	Phosphorylation	LHRDSLVTLKRALEA CCHHHHHHHHHHHHH	31.67	29514088
608	Ubiquitination	DIFNNQLKELREIHN HHHHHHHHHHHHHHC	44.96	-
624	Phosphorylation	QQLQKQKSMEAERLK HHHHHHHHHHHHHHH	21.25	26657352
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
658 (in isoform 1)	Ubiquitination	-	49.98	21890473
658 (in isoform 2)	Ubiquitination	-	49.98	21890473
658 (in isoform 3)	Ubiquitination	-	49.98	21890473
658 (in isoform 4)	Ubiquitination	-	49.98	21890473
658	Ubiquitination	RRAQERDKQWLEHVQ HHHHHHHHHHHHHHH	49.98	21890473
675	Ubiquitination	DEHQRPRKLHEEEKL CCCCCCCHHHHHHHH	57.80	-
687	Phosphorylation	EKLKREESVKKKDGE HHHHHHHHHHHCCCH	34.19	30576142
704	Ubiquitination	GKQEAQDKLGRLFHQ HHHHHHHHHHHHHHH	40.54	-
717	Ubiquitination	HQHQEPAKPAVQAPW HHCCCCCCCCCCCCC	44.20	-
729	Ubiquitination	APWSTAEKGPLTISA CCCCCCCCCCEEEEC	64.46	-
735	Phosphorylation	EKGPLTISAQENVKV CCCCEEEECCCCEEE	20.75	25159151
819	Phosphorylation	PVKPVTDSTSAPAPK CCCCCCCCCCCCCCC	18.20	26074081
820	Phosphorylation	VKPVTDSTSAPAPKL CCCCCCCCCCCCCCE	31.55	26074081
821	Phosphorylation	KPVTDSTSAPAPKLA CCCCCCCCCCCCCEE	35.89	26074081
826	Ubiquitination	STSAPAPKLALRETP CCCCCCCCEECCCCC	48.80	-
832	Phosphorylation	PKLALRETPAPLAVT CCEECCCCCCCEEEE	20.51	26074081
839	Phosphorylation	TPAPLAVTSSEPSTT CCCCEEEECCCCCCC	22.41	29978859
840	Phosphorylation	PAPLAVTSSEPSTTP CCCEEEECCCCCCCC	26.55	29978859
841	Phosphorylation	APLAVTSSEPSTTPN CCEEEECCCCCCCCC	44.13	26074081
844	Phosphorylation	AVTSSEPSTTPNNWA EEECCCCCCCCCCCC	40.64	26074081
845	Phosphorylation	VTSSEPSTTPNNWAD EECCCCCCCCCCCCC	57.92	26074081
846	Phosphorylation	TSSEPSTTPNNWADF ECCCCCCCCCCCCCC	28.49	26074081
854	Phosphorylation	PNNWADFSSTWPTST CCCCCCCCCCCCCCC	27.66	29978859
855	Phosphorylation	NNWADFSSTWPTSTN CCCCCCCCCCCCCCC	34.19	29978859
856	Phosphorylation	NWADFSSTWPTSTNE CCCCCCCCCCCCCCC	33.98	29978859
859	Phosphorylation	DFSSTWPTSTNEKPE CCCCCCCCCCCCCCC	39.48	29978859
860	Phosphorylation	FSSTWPTSTNEKPET CCCCCCCCCCCCCCC	25.75	29978859
861	Phosphorylation	SSTWPTSTNEKPETD CCCCCCCCCCCCCCC	50.29	29978859
891	Phosphorylation	AGQLRQRSAFTPATA CCCCCCCCCCCCCCC	21.28	26846344
894	Phosphorylation	LRQRSAFTPATATGS CCCCCCCCCCCCCCC	16.25	26846344
897	Phosphorylation	RSAFTPATATGSSPS CCCCCCCCCCCCCCC	26.42	26846344
899	Phosphorylation	AFTPATATGSSPSPV CCCCCCCCCCCCCCC	32.99	26846344
901	Phosphorylation	TPATATGSSPSPVLG CCCCCCCCCCCCCCC	34.42	29255136
902	Phosphorylation	PATATGSSPSPVLGQ CCCCCCCCCCCCCCC	30.64	29255136
904	Phosphorylation	TATGSSPSPVLGQGE CCCCCCCCCCCCCCC	29.59	19664994
922	Phosphorylation	GLQAQALYPWRAKKD CCCCEECCCCCCCCC	12.08	-
964	Phosphorylation	QKGWFPKSYVKLISG CCCCCCHHHEEECCC	35.08	29083192
965	Phosphorylation	KGWFPKSYVKLISGP CCCCCHHHEEECCCC	14.02	29083192
970	Phosphorylation	KSYVKLISGPIRKST HHHEEECCCCCCCCC	49.29	20068231
976	Phosphorylation	ISGPIRKSTSMDSGS CCCCCCCCCCCCCCC	18.83	25159151
977	Phosphorylation	SGPIRKSTSMDSGSS CCCCCCCCCCCCCCC	30.98	25159151
978	Phosphorylation	GPIRKSTSMDSGSSE CCCCCCCCCCCCCCC	27.90	28355574
981	Phosphorylation	RKSTSMDSGSSESPA CCCCCCCCCCCCCCH	31.75	21712546
983	Phosphorylation	STSMDSGSSESPASL CCCCCCCCCCCCHHH	34.58	29255136
984	Phosphorylation	TSMDSGSSESPASLK CCCCCCCCCCCHHHH	45.69	29255136
986	Phosphorylation	MDSGSSESPASLKRV CCCCCCCCCHHHHHH	27.93	29255136
989	Phosphorylation	GSSESPASLKRVASP CCCCCCHHHHHHCCC	37.50	29255136
995	Phosphorylation	ASLKRVASPAAKPVV HHHHHHCCCCCCCCC	16.53	26657352
1040	Phosphorylation	KKDGDWWTGTVGDKA ECCCCEEEEEECCCC	20.79	26091039
1042	Phosphorylation	DGDWWTGTVGDKAGV CCCEEEEEECCCCCC	17.59	26091039
1052	Phosphorylation	DKAGVFPSNYVRLKD CCCCCCCCCCEEEEC	29.36	26091039
1054	Phosphorylation	AGVFPSNYVRLKDSE CCCCCCCCEEEECCC	7.41	23822953
1069	Phosphorylation	GSGTAGKTGSLGKKP CCCCCCCCCCCCCCH	30.96	22210691
1071	Phosphorylation	GTAGKTGSLGKKPEI CCCCCCCCCCCCHHH	38.90	28464451
1084	Phosphorylation	EIAQVIASYTATGPE HHHHHHHHHCCCCHH	16.34	28857561
1088	Phosphorylation	VIASYTATGPEQLTL HHHHHCCCCHHHEEE	45.53	28464451
1132	Phosphorylation	IGWFPANYVKLLSPG EEEEEHHHEEEECCC	10.89	23822953
1137	Phosphorylation	ANYVKLLSPGTSKIT HHHEEEECCCCCCCC	31.55	28555341
1140	Phosphorylation	VKLLSPGTSKITPTE EEEECCCCCCCCCCC	30.17	23403867
1141	Phosphorylation	KLLSPGTSKITPTEP EEECCCCCCCCCCCC	28.16	23403867
1144	Phosphorylation	SPGTSKITPTEPPKS CCCCCCCCCCCCCHH	28.09	25159151
1146	Phosphorylation	GTSKITPTEPPKSTA CCCCCCCCCCCHHHH	53.10	23403867
1206	Phosphorylation	GQVGLFPSNYVKLTT CEEEECCCCCEEEEC	33.20	25627689
1208	Phosphorylation	VGLFPSNYVKLTTDM EEECCCCCEEEECCC	11.87	25159151
1303	Ubiquitination	LKALRVRKKMSGEKM HHHHHHHHHCCCCCC	50.39	-
1383	Phosphorylation	LKPMQRVTRYPLIIK CHHHHHHCCHHHHHH	27.03	-
1466	Phosphorylation	GPRKFLHSGKLYKAK CHHHHHHCCCEEECC	39.51	26437602
1501	Phosphorylation	KPLGSSGTDKVFSPK CCCCCCCCCCCCCCC	34.30	-
1506	Phosphorylation	SGTDKVFSPKSNLQY CCCCCCCCCCCCCCE	34.11	24719451
1550	Phosphorylation	SHIDRVYTLRAESIN EEECEEEEEECHHHC	13.60	24719451
1560	Phosphorylation	AESINERTAWVQKIK CHHHCHHHHHHHHHH	20.77	20068231
1645	Phosphorylation	TLNPKWNSNCQFFIR HCCCCCCCCCEEEEE	37.56	-
1670	Phosphorylation	VFERDQFSPDDFLGR EEECCCCCCCCCCCC	23.06	24076635

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ITCH	Q96J02	PMID:29851086

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ITSN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ITSN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMRC2_HUMAN	SMARCC2	physical	16169070
RM20_HUMAN	MRPL20	physical	16169070
SNX5_HUMAN	SNX5	physical	16169070
EF1A1_HUMAN	EEF1A1	physical	16169070
KIF5A_HUMAN	KIF5A	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
SNP25_HUMAN	SNAP25	physical	10373452
SNP23_HUMAN	SNAP23	physical	10373452
EPHB2_HUMAN	EPHB2	physical	12389031
CDC42_HUMAN	CDC42	physical	11584276
WASL_HUMAN	WASL	physical	11584276
CDC42_HUMAN	CDC42	physical	12006984
AP2B1_HUMAN	AP2B1	physical	18654987
ASAP2_HUMAN	ASAP2	physical	18654987
CBL_HUMAN	CBL	physical	18654987
BCAP_HUMAN	PIK3AP1	physical	18654987
PFD5_HUMAN	PFDN5	physical	18654987
SF3B4_HUMAN	SF3B4	physical	18654987
CCNO_HUMAN	CCNO	physical	18654987
WBP11_HUMAN	WBP11	physical	18654987
EPN2_HUMAN	EPN2	physical	22558309
PICAL_HUMAN	PICALM	physical	22558309
FNBP4_HUMAN	FNBP4	physical	22558309
FOG2_HUMAN	ZFPM2	physical	22558309
AGFG1_HUMAN	AGFG1	physical	22558309
RFIP2_HUMAN	RAB11FIP2	physical	22558309
DAB2_HUMAN	DAB2	physical	22558309
AGFG2_HUMAN	AGFG2	physical	22558309
CLIP2_HUMAN	CLIP2	physical	22558309
EP15R_HUMAN	EPS15L1	physical	22558309
GOGA5_HUMAN	GOLGA5	physical	22558309
ITSN1_HUMAN	ITSN1	physical	22558309
PEPL_HUMAN	PPL	physical	22558309
P85A_HUMAN	PIK3R1	physical	22558309
LIPA2_HUMAN	PPFIA2	physical	22558309
CYH1_HUMAN	CYTH1	physical	22558309
BRE1B_HUMAN	RNF40	physical	22558309
SPDLY_HUMAN	SPDL1	physical	22558309
CLH1_HUMAN	CLTC	physical	22558309
EPS15_HUMAN	EPS15	physical	22558309
KI16B_HUMAN	KIF16B	physical	22558309
ARFP2_HUMAN	ARFIP2	physical	22558309
DESM_HUMAN	DES	physical	22558309
FNBP1_HUMAN	FNBP1	physical	22558309
GCC1_HUMAN	GCC1	physical	22558309
HIP1_HUMAN	HIP1	physical	22558309
MTUS2_HUMAN	MTUS2	physical	22558309
CE85L_HUMAN	CEP85L	physical	22558309
PACN3_HUMAN	PACSIN3	physical	22558309
PDC6I_HUMAN	PDCD6IP	physical	22558309
PREX1_HUMAN	PREX1	physical	22558309
RABE1_HUMAN	RABEP1	physical	22558309
RAI14_HUMAN	RAI14	physical	22558309
SCOC_HUMAN	SCOC	physical	22558309
TRIM8_HUMAN	TRIM8	physical	22558309
P3C2B_HUMAN	PIK3C2B	physical	22558309
GARE2_HUMAN	GAREML	physical	22558309
SPY2_HUMAN	SPRY2	physical	22558309
DLGP1_HUMAN	DLGAP1	physical	22558309
SYNJ2_HUMAN	SYNJ2	physical	22558309
AP2B1_HUMAN	AP2B1	physical	22558309
FCSD2_HUMAN	FCHSD2	physical	22558309
PICAL_MOUSE	Picalm	physical	22558309
EPN2_MOUSE	Epn2	physical	22558309
AGFG2_MOUSE	Agfg2	physical	22558309
AGFG1_MOUSE	Agfg1	physical	22558309
EP15R_MOUSE	Eps15l1	physical	22558309
AMOL1_MOUSE	Amotl1	physical	22558309
BECN1_MOUSE	Becn1	physical	22558309
HM20A_MOUSE	Hmg20a	physical	22558309
K2C1_MOUSE	Krt1	physical	22558309
K2C71_MOUSE	Krt71	physical	22558309
K2C79_MOUSE	Krt79	physical	22558309
PEPL_MOUSE	Ppl	physical	22558309
SWP70_MOUSE	Swap70	physical	22558309
SYNCI_MOUSE	Sync	physical	22558309
DLGP2_MOUSE	Dlgap2	physical	22558309
PLVAP_MOUSE	Plvap	physical	22558309
SPY2_MOUSE	Spry2	physical	22558309
P53_MOUSE	Trp53	physical	22558309
ITSN2_HUMAN	ITSN2	physical	22558309
RAB5A_HUMAN	RAB5A	physical	22558309
ARF6_HUMAN	ARF6	physical	22558309
PDE4D_HUMAN	PDE4D	physical	22558309
DISC1_HUMAN	DISC1	physical	22558309
SH3K1_HUMAN	SH3KBP1	physical	19166927
ITSN1_HUMAN	ITSN1	physical	21712076
CBL_HUMAN	CBL	physical	21712076
REPS1_HUMAN	REPS1	physical	20946875
SYNJ1_HUMAN	SYNJ1	physical	18539136
WASP_HUMAN	WAS	physical	18539136
SOS1_HUMAN	SOS1	physical	18539136
CBL_HUMAN	CBL	physical	18539136
CBLB_HUMAN	CBLB	physical	18539136
EPS15_HUMAN	EPS15	physical	10064583
SOS1_HUMAN	SOS1	physical	15824104
WASP_HUMAN	WAS	physical	15824104
TTC37_HUMAN	TTC37	physical	22939629
SKIV2_HUMAN	SKIV2L	physical	22939629
SETD3_HUMAN	SETD3	physical	22939629
RNH2A_HUMAN	RNASEH2A	physical	22939629
EPS15_HUMAN	EPS15	physical	26344197
EP15R_HUMAN	EPS15L1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ITSN1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-495, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315; SER-902; SER-904;SER-978 AND SER-986, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-904, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-559, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-904, AND MASSSPECTROMETRY.	15302935 [Abstract]