dbPTM

EP15R_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EP15R_HUMAN
UniProt AC	Q9UBC2
Protein Name	Epidermal growth factor receptor substrate 15-like 1
Gene Name	EPS15L1
Organism	Homo sapiens (Human).
Sequence Length	864
Subcellular Localization	Cell membrane Peripheral membrane protein. Nucleus. Membrane, coated pit. Localized to plasma membrane coated pits..
Protein Description	Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2..
Protein Sequence	MAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGTLDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALPPKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQPLGADSGDPFQSKKGFGDPFSGKDPFVPSSAAKPSKASASGFADFTSVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAPLIPLS ------CCCCCCCHH	20.14	19413330
9	Phosphorylation	AAPLIPLSQQIPTGN CCCCCCHHHCCCCCC	18.06	29083192
14	Phosphorylation	PLSQQIPTGNSLYES CHHHCCCCCCCHHHH	51.10	28348404
17	Phosphorylation	QQIPTGNSLYESYYK HCCCCCCCHHHHHHC	33.40	28348404
19	Phosphorylation	IPTGNSLYESYYKQV CCCCCCHHHHHHCCC	11.58	28348404
21	Phosphorylation	TGNSLYESYYKQVDP CCCCHHHHHHCCCCH	21.87	25627689
22	Phosphorylation	GNSLYESYYKQVDPA CCCHHHHHHCCCCHH	11.62	25627689
30	Phosphorylation	YKQVDPAYTGRVGAS HCCCCHHHCCCCCHH	18.34	25147952
46	Phosphorylation	AALFLKKSGLSDIIL HHHHHHHCCCCHHHH	43.30	30266825
46 (in isoform 2)	Phosphorylation	-	43.30	27251275
49	Phosphorylation	FLKKSGLSDIILGKI HHHHCCCCHHHHHHH	30.23	30266825
49 (in isoform 2)	Phosphorylation	-	30.23	27251275
74	Phosphorylation	FLDKQGFYVALRLVA CCCCCCHHHHHHHHH	7.52	28152594
90	Phosphorylation	AQSGHEVTLSNLNLS HHCCCEEEEECCCCC	22.83	26074081
92	Phosphorylation	SGHEVTLSNLNLSMP CCCEEEEECCCCCCC	29.88	26074081
97	Phosphorylation	TLSNLNLSMPPPKFH EEECCCCCCCCCCCC	28.33	26074081
106	Phosphorylation	PPPKFHDTSSPLMVT CCCCCCCCCCCEEEC	23.64	22167270
106 (in isoform 2)	Phosphorylation	-	23.64	27251275
107	Phosphorylation	PPKFHDTSSPLMVTP CCCCCCCCCCEEECC	35.70	22167270
108	Phosphorylation	PKFHDTSSPLMVTPP CCCCCCCCCEEECCC	24.93	22167270
108 (in isoform 2)	Phosphorylation	-	24.93	27251275
113	Phosphorylation	TSSPLMVTPPSAEAH CCCCEEECCCCCHHE	18.60	25159151
113 (in isoform 2)	Phosphorylation	-	18.60	27251275
116	Phosphorylation	PLMVTPPSAEAHWAV CEEECCCCCHHEEEE	39.69	25159151
146	Phosphorylation	LPINGLLSGDKVKPV CCCCCCCCCCCCCCC	50.41	25867546
171	Phosphorylation	LGRVWDLSDIDKDGH HHCCCCHHHCCCCCC	30.01	-
202	Phosphorylation	LEKEPVPSALPPSLI HHHCCCCCCCCHHHC	42.55	28509920
207	Phosphorylation	VPSALPPSLIPPSKR CCCCCCHHHCCCCCC	36.67	28509920
212	Phosphorylation	PPSLIPPSKRKKTVF CHHHCCCCCCCCCCC	39.47	28509920
217	Phosphorylation	PPSKRKKTVFPGAVP CCCCCCCCCCCCCEE	30.34	23927012
229	Phosphorylation	AVPVLPASPPPKDSL CEEECCCCCCCCCCC	35.68	29255136
229 (in isoform 2)	Phosphorylation	-	35.68	27251275
235	Phosphorylation	ASPPPKDSLRSTPSH CCCCCCCCCCCCCCC	31.63	30278072
238	Phosphorylation	PPKDSLRSTPSHGSV CCCCCCCCCCCCCCC	50.38	25159151
239	Phosphorylation	PKDSLRSTPSHGSVS CCCCCCCCCCCCCCC	23.52	23927012
241	Phosphorylation	DSLRSTPSHGSVSSL CCCCCCCCCCCCCCC	40.34	25159151
241 (in isoform 2)	Phosphorylation	-	40.34	27251275
244	Phosphorylation	RSTPSHGSVSSLNST CCCCCCCCCCCCCCC	17.25	25159151
244 (in isoform 2)	Phosphorylation	-	17.25	27251275
246	Phosphorylation	TPSHGSVSSLNSTGS CCCCCCCCCCCCCCC	30.70	23927012
246 (in isoform 2)	Phosphorylation	-	30.70	27251275
247	Phosphorylation	PSHGSVSSLNSTGSL CCCCCCCCCCCCCCC	29.43	23927012
247 (in isoform 2)	Phosphorylation	-	29.43	27251275
250	Phosphorylation	GSVSSLNSTGSLSPK CCCCCCCCCCCCCCC	39.16	25159151
250 (in isoform 2)	Phosphorylation	-	39.16	27251275
251	Phosphorylation	SVSSLNSTGSLSPKH CCCCCCCCCCCCCCC	29.71	23927012
253	Phosphorylation	SSLNSTGSLSPKHSL CCCCCCCCCCCCCCC	26.26	22167270
253 (in isoform 2)	Phosphorylation	-	26.26	27251275
255	Phosphorylation	LNSTGSLSPKHSLKQ CCCCCCCCCCCCCCC	33.33	22167270
255 (in isoform 2)	Phosphorylation	-	33.33	27251275
259	Phosphorylation	GSLSPKHSLKQTQPT CCCCCCCCCCCCCCC	43.31	23401153
261	Ubiquitination	LSPKHSLKQTQPTVN CCCCCCCCCCCCCEE	55.07	-
263	Phosphorylation	PKHSLKQTQPTVNWV CCCCCCCCCCCEEEE	34.62	28857561
293	Phosphorylation	TDLDLDGYVSGQEVK CCCCCCCCCCHHHHH	7.36	25147952
295	Phosphorylation	LDLDGYVSGQEVKEI CCCCCCCCHHHHHHH	26.69	27251275
355	Phosphorylation	IDPPQVLSPDMVPPS CCCCCCCCCCCCCCH	21.72	25159151
362	Phosphorylation	SPDMVPPSERGTPGP CCCCCCCHHCCCCCC	33.58	25159151
362 (in isoform 2)	Phosphorylation	-	33.58	27251275
366	Phosphorylation	VPPSERGTPGPDSSG CCCHHCCCCCCCCCC	31.15	19664994
366 (in isoform 2)	Phosphorylation	-	31.15	27251275
371	Phosphorylation	RGTPGPDSSGSLGSG CCCCCCCCCCCCCCC	39.47	29255136
372	Phosphorylation	GTPGPDSSGSLGSGE CCCCCCCCCCCCCCC	39.52	29255136
374	Phosphorylation	PGPDSSGSLGSGEFT CCCCCCCCCCCCCCC	31.35	29255136
374 (in isoform 2)	Phosphorylation	-	31.35	27251275
377	Phosphorylation	DSSGSLGSGEFTGVK CCCCCCCCCCCCCCC	40.20	29255136
377 (in isoform 2)	Phosphorylation	-	40.20	27251275
381	Phosphorylation	SLGSGEFTGVKELDD CCCCCCCCCCCCHHH	36.44	29255136
384	Ubiquitination	SGEFTGVKELDDISQ CCCCCCCCCHHHHHH	54.63	-
390	Phosphorylation	VKELDDISQEIAQLQ CCCHHHHHHHHHHHH	28.84	25159151
390 (in isoform 2)	Phosphorylation	-	28.84	27251275
400	Ubiquitination	IAQLQREKYSLEQDI HHHHHHHHHCHHHHH	42.18	-
401	Phosphorylation	AQLQREKYSLEQDIR HHHHHHHHCHHHHHH	17.46	29214152
401 (in isoform 2)	Phosphorylation	-	17.46	27642862
402	Phosphorylation	QLQREKYSLEQDIRE HHHHHHHCHHHHHHH	36.18	25159151
402 (in isoform 2)	Phosphorylation	-	36.18	27251275
417	Ubiquitination	KEEAIRQKTSEVQEL HHHHHHHHHHHHHHH	44.14	-
418	Phosphorylation	EEAIRQKTSEVQELQ HHHHHHHHHHHHHHH	23.06	-
432	Phosphorylation	QNDLDRETSSLQELE HHHHHHHHHHHHHHH	25.22	26657352
433	Phosphorylation	NDLDRETSSLQELEA HHHHHHHHHHHHHHH	25.05	25850435
434	Phosphorylation	DLDRETSSLQELEAQ HHHHHHHHHHHHHHH	41.30	25849741
434 (in isoform 2)	Phosphorylation	-	41.30	27251275
462	Sulfoxidation	QKAKLRDMLSDVRQK HHHHHHHHHHHHHHH	2.89	21406390
478	Phosphorylation	QDETQMISSLKTQIQ HHHHHHHHHHHHHHH	25.03	24719451
482	Phosphorylation	QMISSLKTQIQSQES HHHHHHHHHHHHHHH	35.88	21601212
486	Phosphorylation	SLKTQIQSQESDLKS HHHHHHHHHHHHHHH	37.23	25159151
486 (in isoform 2)	Phosphorylation	-	37.23	27251275
489	Phosphorylation	TQIQSQESDLKSQED HHHHHHHHHHHHHHH	40.38	22817901
492	Ubiquitination	QSQESDLKSQEDDLN HHHHHHHHHHHHHHH	55.90	21890473
492 (in isoform 2)	Ubiquitination	-	55.90	-
518	Phosphorylation	EETQLEQSIQAGRVQ HHHHHHHHHHHCCHH	13.80	28555341
528	Phosphorylation	AGRVQLETIIKSLKS HCCHHHHHHHHHHHC	36.27	20068231
531	Ubiquitination	VQLETIIKSLKSTQD HHHHHHHHHHHCCHH	45.98	21890473
531	Ubiquitination	VQLETIIKSLKSTQD HHHHHHHHHHHCCHH	45.98	21890473
531	Ubiquitination	VQLETIIKSLKSTQD HHHHHHHHHHHCCHH	45.98	21890473
531	Ubiquitination	VQLETIIKSLKSTQD HHHHHHHHHHHCCHH	45.98	21890473
531 (in isoform 2)	Ubiquitination	-	45.98	-
534	Ubiquitination	ETIIKSLKSTQDEIN HHHHHHHHCCHHHHH	59.56	21906983
534 (in isoform 2)	Ubiquitination	-	59.56	-
546	Acetylation	EINQARSKLSQLHES HHHHHHHHHHHHHHH	46.75	25953088
546	Ubiquitination	EINQARSKLSQLHES HHHHHHHHHHHHHHH	46.75	-
546 (in isoform 2)	Ubiquitination	-	46.75	-
548	Phosphorylation	NQARSKLSQLHESRQ HHHHHHHHHHHHHHH	34.14	29214152
553	Phosphorylation	KLSQLHESRQEAHRS HHHHHHHHHHHHHHH	28.63	28555341
560	Phosphorylation	SRQEAHRSLEQYDQV HHHHHHHHHHHHHHH	26.79	25159151
560 (in isoform 2)	Phosphorylation	-	26.79	27642862
564	Phosphorylation	AHRSLEQYDQVLDGA HHHHHHHHHHHHHHC	10.04	28176443
564 (in isoform 2)	Phosphorylation	-	10.04	27642862
575	Phosphorylation	LDGAHGASLTDLANL HHHCCCCCHHHHHHH	36.07	25159151
575 (in isoform 2)	Phosphorylation	-	36.07	27642862
577	Phosphorylation	GAHGASLTDLANLSE HCCCCCHHHHHHHHH	26.86	25159151
583	Phosphorylation	LTDLANLSEGVSLAE HHHHHHHHHCCCHHH	31.92	28450419
583 (in isoform 2)	Phosphorylation	-	31.92	27251275
587	Phosphorylation	ANLSEGVSLAERGSF HHHHHCCCHHHHCCC	32.49	25627689
593	Phosphorylation	VSLAERGSFGAMDDP CCHHHHCCCCCCCCC	27.08	23401153
593 (in isoform 2)	Phosphorylation	-	27.08	27251275
593 (in isoform 4)	Phosphorylation	-	27.08	27251275
597	Sulfoxidation	ERGSFGAMDDPFKNK HHCCCCCCCCCCCCC	6.50	21406390
602	Ubiquitination	GAMDDPFKNKALLFS CCCCCCCCCCEEEEC	64.03	21890473
602	Ubiquitination	GAMDDPFKNKALLFS CCCCCCCCCCEEEEC	64.03	21890473
602	Ubiquitination	GAMDDPFKNKALLFS CCCCCCCCCCEEEEC	64.03	21890473
604	Ubiquitination	MDDPFKNKALLFSNN CCCCCCCCEEEECCC	40.79	21890473
604	Ubiquitination	MDDPFKNKALLFSNN CCCCCCCCEEEECCC	40.79	21890473
604	Ubiquitination	MDDPFKNKALLFSNN CCCCCCCCEEEECCC	40.79	21890473
604 (in isoform 2)	Ubiquitination	-	40.79	-
609	Phosphorylation	KNKALLFSNNTQELH CCCEEEECCCCCCCC	29.19	26074081
612	Phosphorylation	ALLFSNNTQELHPDP EEEECCCCCCCCCCC	27.89	22199227
612 (in isoform 2)	Phosphorylation	-	27.89	27251275
627	Ubiquitination	FQTEDPFKSDPFKGA CCCCCCCCCCCCCCC	60.38	21890473
627 (in isoform 2)	Ubiquitination	-	60.38	-
628	Phosphorylation	QTEDPFKSDPFKGAD CCCCCCCCCCCCCCC	51.39	25159151
628 (in isoform 2)	Phosphorylation	-	51.39	27251275
632	Ubiquitination	PFKSDPFKGADPFKG CCCCCCCCCCCCCCC	59.59	21890473
632	Ubiquitination	PFKSDPFKGADPFKG CCCCCCCCCCCCCCC	59.59	21890473
632	Ubiquitination	PFKSDPFKGADPFKG CCCCCCCCCCCCCCC	59.59	21890473
632 (in isoform 2)	Ubiquitination	-	59.59	-
638	Ubiquitination	FKGADPFKGDPFQND CCCCCCCCCCCCCCC	68.72	21890473
638	Ubiquitination	FKGADPFKGDPFQND CCCCCCCCCCCCCCC	68.72	21890473
638	Ubiquitination	FKGADPFKGDPFQND CCCCCCCCCCCCCCC	68.72	21890473
652	Phosphorylation	DPFAEQQTTSTDPFG CCCHHCCCCCCCCCC	23.55	28348404
653	Phosphorylation	PFAEQQTTSTDPFGG CCHHCCCCCCCCCCC	25.87	28348404
654	Phosphorylation	FAEQQTTSTDPFGGD CHHCCCCCCCCCCCC	33.91	28348404
655	Phosphorylation	AEQQTTSTDPFGGDP HHCCCCCCCCCCCCC	45.67	28348404
664	Ubiquitination	PFGGDPFKESDPFRG CCCCCCCCCCCCCCC	62.79	21906983
666	Phosphorylation	GGDPFKESDPFRGSA CCCCCCCCCCCCCCC	51.69	23663014
672	Phosphorylation	ESDPFRGSATDDFFK CCCCCCCCCCHHHHH	24.60	25159151
672 (in isoform 2)	Phosphorylation	-	24.60	27251275
674	Phosphorylation	DPFRGSATDDFFKKQ CCCCCCCCHHHHHHH	37.49	23663014
679	Ubiquitination	SATDDFFKKQTKNDP CCCHHHHHHHHCCCC	43.92	21890473
679	Ubiquitination	SATDDFFKKQTKNDP CCCHHHHHHHHCCCC	43.92	21890473
679 (in isoform 2)	Ubiquitination	-	43.92	-
680	Ubiquitination	ATDDFFKKQTKNDPF CCHHHHHHHHCCCCC	59.03	-
680 (in isoform 2)	Ubiquitination	-	59.03	-
683	Ubiquitination	DFFKKQTKNDPFTSD HHHHHHHCCCCCCCC	57.78	21890473
683	Ubiquitination	DFFKKQTKNDPFTSD HHHHHHHCCCCCCCC	57.78	21890473
683 (in isoform 2)	Ubiquitination	-	57.78	-
688	Phosphorylation	QTKNDPFTSDPFTKN HHCCCCCCCCCCCCC	37.29	28348404
689	Phosphorylation	TKNDPFTSDPFTKNP HCCCCCCCCCCCCCC	43.60	28348404
689 (in isoform 2)	Phosphorylation	-	43.60	27251275
694	Ubiquitination	FTSDPFTKNPSLPSK CCCCCCCCCCCCCCC	68.21	21890473
694 (in isoform 2)	Ubiquitination	-	68.21	-
697	Phosphorylation	DPFTKNPSLPSKLDP CCCCCCCCCCCCCCC	63.41	25849741
697 (in isoform 2)	Phosphorylation	-	63.41	27251275
700	Phosphorylation	TKNPSLPSKLDPFES CCCCCCCCCCCCCCC	51.66	30576142
701	Ubiquitination	KNPSLPSKLDPFESS CCCCCCCCCCCCCCC	55.77	21890473
701	Ubiquitination	KNPSLPSKLDPFESS CCCCCCCCCCCCCCC	55.77	21890473
701	Ubiquitination	KNPSLPSKLDPFESS CCCCCCCCCCCCCCC	55.77	21890473
701 (in isoform 2)	Ubiquitination	-	55.77	-
707	Phosphorylation	SKLDPFESSDPFSSS CCCCCCCCCCCCCCC	40.18	25159151
707 (in isoform 2)	Phosphorylation	-	40.18	27251275
708	Phosphorylation	KLDPFESSDPFSSSS CCCCCCCCCCCCCCC	41.95	25159151
712	Phosphorylation	FESSDPFSSSSVSSK CCCCCCCCCCCCCCC	34.40	28450419
713	Phosphorylation	ESSDPFSSSSVSSKG CCCCCCCCCCCCCCC	27.32	30108239
714	Phosphorylation	SSDPFSSSSVSSKGS CCCCCCCCCCCCCCC	33.29	25159151
714 (in isoform 2)	Phosphorylation	-	33.29	27251275
715	Phosphorylation	SDPFSSSSVSSKGSD CCCCCCCCCCCCCCC	28.15	28450419
717	Phosphorylation	PFSSSSVSSKGSDPF CCCCCCCCCCCCCCC	28.42	30278072
717 (in isoform 2)	Phosphorylation	-	28.42	27251275
718	Phosphorylation	FSSSSVSSKGSDPFG CCCCCCCCCCCCCCC	38.59	30108239
719	Ubiquitination	SSSSVSSKGSDPFGT CCCCCCCCCCCCCCC	55.73	-
732	Phosphorylation	GTLDPFGSGSFNSAE CCCCCCCCCCCCCCC	31.48	26657352
734	Phosphorylation	LDPFGSGSFNSAEGF CCCCCCCCCCCCCCC	23.97	28270605
734 (in isoform 2)	Phosphorylation	-	23.97	27251275
737	Phosphorylation	FGSGSFNSAEGFADF CCCCCCCCCCCCCCH	26.20	28270605
745	Phosphorylation	AEGFADFSQMSKPPP CCCCCCHHHCCCCCC	26.06	28270605
748	Phosphorylation	FADFSQMSKPPPSGP CCCHHHCCCCCCCCC	34.08	28270605
772	Phosphorylation	FSDDPFKSKQDTPAL CCCCCCCCCCCCCCC	35.61	23312004
776	Phosphorylation	PFKSKQDTPALPPKK CCCCCCCCCCCCCCC	14.15	28348404
782	Acetylation	DTPALPPKKPAPPRP CCCCCCCCCCCCCCC	70.24	7674313
783	Acetylation	TPALPPKKPAPPRPK CCCCCCCCCCCCCCC	52.78	7674325
793	Phosphorylation	PPRPKPPSGKSTPVS CCCCCCCCCCCCCHH	68.34	30278072
793 (in isoform 2)	Phosphorylation	-	68.34	27251275
796	Phosphorylation	PKPPSGKSTPVSQLG CCCCCCCCCCHHHCC	41.28	30206219
796 (in isoform 2)	Phosphorylation	-	41.28	27251275
797	Phosphorylation	KPPSGKSTPVSQLGS CCCCCCCCCHHHCCC	31.06	21082442
800	Phosphorylation	SGKSTPVSQLGSADF CCCCCCHHHCCCCCC	22.38	22199227
804	Phosphorylation	TPVSQLGSADFPEAP CCHHHCCCCCCCCCC	33.00	28464451
821	Phosphorylation	FQPLGADSGDPFQSK CCCCCCCCCCCCCCC	44.56	26074081
827	Phosphorylation	DSGDPFQSKKGFGDP CCCCCCCCCCCCCCC	36.39	26074081
828	Ubiquitination	SGDPFQSKKGFGDPF CCCCCCCCCCCCCCC	46.24	21890473
828	Ubiquitination	SGDPFQSKKGFGDPF CCCCCCCCCCCCCCC	46.24	21890473
828 (in isoform 2)	Ubiquitination	-	46.24	-
829	Ubiquitination	GDPFQSKKGFGDPFS CCCCCCCCCCCCCCC	65.79	21890473
829	Ubiquitination	GDPFQSKKGFGDPFS CCCCCCCCCCCCCCC	65.79	21890473
829 (in isoform 2)	Ubiquitination	-	65.79	-
838	Ubiquitination	FGDPFSGKDPFVPSS CCCCCCCCCCCCCCH	62.11	21890473
838	Ubiquitination	FGDPFSGKDPFVPSS CCCCCCCCCCCCCCH	62.11	21890473
838 (in isoform 2)	Ubiquitination	-	62.11	-
844	Phosphorylation	GKDPFVPSSAAKPSK CCCCCCCCHHCCCCC	27.57	28555341
845	Phosphorylation	KDPFVPSSAAKPSKA CCCCCCCHHCCCCCC	26.61	25159151
848	Ubiquitination	FVPSSAAKPSKASAS CCCCHHCCCCCCCCC	49.92	21890473
848	Ubiquitination	FVPSSAAKPSKASAS CCCCHHCCCCCCCCC	49.92	21890473
848 (in isoform 2)	Ubiquitination	-	49.92	-
851	Ubiquitination	SSAAKPSKASASGFA CHHCCCCCCCCCCCC	55.69	-
851 (in isoform 2)	Ubiquitination	-	55.69	-
853 (in isoform 2)	Phosphorylation	-	27.06	27251275
855 (in isoform 2)	Phosphorylation	-	31.76	27251275
861 (in isoform 2)	Phosphorylation	-	28.85	27251275
862 (in isoform 2)	Phosphorylation	-	21.98	27251275
904	Ubiquitination	----------------------------------------------- -----------------------------------------------		21890473
904 (in isoform 2)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EP15R_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EP15R_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EP15R_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AGFG1_HUMAN	AGFG1	genetic	10613896
UBQL1_HUMAN	UBQLN1	physical	16159959
BIRC6_HUMAN	BIRC6	physical	22863883
CND3_HUMAN	NCAPG	physical	22863883
PRP4_HUMAN	PRPF4	physical	22863883
ZZEF1_HUMAN	ZZEF1	physical	22863883
AGFG2_HUMAN	AGFG2	genetic	10613896
DCAF7_HUMAN	DCAF7	physical	27173435
UBP15_HUMAN	USP15	physical	27173435
JIP4_HUMAN	SPAG9	physical	27173435
MCM2_HUMAN	MCM2	physical	27173435
MCM4_HUMAN	MCM4	physical	27173435
MCM6_HUMAN	MCM6	physical	27173435
NS1BP_HUMAN	IVNS1ABP	physical	27173435
SMC1A_HUMAN	SMC1A	physical	27173435
GAPD1_HUMAN	GAPVD1	physical	27173435
ANK3_HUMAN	ANK3	physical	27173435
SBNO1_HUMAN	SBNO1	physical	27173435
SMC3_HUMAN	SMC3	physical	27173435
CD11A_HUMAN	CDK11A	physical	27173435
SOX4_HUMAN	SOX4	physical	27173435
HSF1_HUMAN	HSF1	physical	27173435
PLK1_HUMAN	PLK1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EP15R_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-229; SER-238 AND SER-255, AND MASSSPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244; SER-255; SER-560;THR-577 AND THR-797, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-229; SER-238 AND SER-255, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-366; SER-371 ANDSER-374, AND MASS SPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108 AND SER-793, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241; SER-244 ANDSER-255, AND MASS SPECTROMETRY.	15144186 [Abstract]