DCAF7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCAF7_HUMAN
• UniProt AC: P61962
• Protein Name: DDB1- and CUL4-associated factor 7
• Gene Name: DCAF7
• Organism: Homo sapiens (Human).
• Sequence Length: 342
• Subcellular Localization: Cytoplasm. Nucleus. Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.
• Protein Description: Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex..
• Protein Sequence: MSLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYNNKVQLVGLDEESSEFICRNTFDHPYPTTKLMWIPDTKGVYPDLLATSGDYLRVWRVGETETRLECLLNNNKNSDFCAPLTSFDWNEVDPYLLGTSSIDTTCTIWGLETGQVLGRVNLVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPQHHPLLRLCWNKQDPNYLATMAMDGMEVVILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTAEGEINNVQWASTQPDWIAICYNNCLEILRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLHGKRKE ------CCCCCCCCE	29.13	24719451
11	Phosphorylation	HGKRKEIYKYEAPWT CCCCCEEEEEECCEE	14.49	26074081
13	Phosphorylation	KRKEIYKYEAPWTVY CCCEEEEEECCEEEE	10.60	26074081
18	Phosphorylation	YKYEAPWTVYAMNWS EEEECCEEEEEECEE	11.54	26074081
20	Phosphorylation	YEAPWTVYAMNWSVR EECCEEEEEECEECC	7.86	26074081
25	Phosphorylation	TVYAMNWSVRPDKRF EEEEECEECCCCHHH	11.84	26074081
30	Ubiquitination	NWSVRPDKRFRLALG CEECCCCHHHHHHHH	57.00	21890473
30	Ubiquitination	NWSVRPDKRFRLALG CEECCCCHHHHHHHH	57.00	21906983
38	Phosphorylation	RFRLALGSFVEEYNN HHHHHHHHHHHHHCC	27.28	20873877
46	Ubiquitination	FVEEYNNKVQLVGLD HHHHHCCEEEEEECC	27.93	21963094
61	Glutathionylation	EESSEFICRNTFDHP HHHCCEEEECCCCCC	3.13	22555962
69	Phosphorylation	RNTFDHPYPTTKLMW ECCCCCCCCCCEEEE	15.14	21712546
71	Phosphorylation	TFDHPYPTTKLMWIP CCCCCCCCCEEEECC	30.62	21712546
73	Ubiquitination	DHPYPTTKLMWIPDT CCCCCCCEEEECCCC	38.53	21906983
80	Phosphorylation	KLMWIPDTKGVYPDL EEEECCCCCCCCHHH	25.09	21406692
81	Ubiquitination	LMWIPDTKGVYPDLL EEECCCCCCCCHHHE	54.48	21963094
84	Phosphorylation	IPDTKGVYPDLLATS CCCCCCCCHHHEEEC	10.33	20068231
94	Phosphorylation	LLATSGDYLRVWRVG HEEECCCEEEEEEEC	10.43	-
96	Methylation	ATSGDYLRVWRVGET EECCCEEEEEEECCC	21.52	115920021
103	Phosphorylation	RVWRVGETETRLECL EEEEECCCCHHHHHH	36.41	18452278
105	Phosphorylation	WRVGETETRLECLLN EEECCCCHHHHHHHC	48.23	18452278
109	S-nitrosylation	ETETRLECLLNNNKN CCCHHHHHHHCCCCC	6.57	19483679
109	S-nitrosocysteine	ETETRLECLLNNNKN CCCHHHHHHHCCCCC	6.57	-
163	Phosphorylation	LGRVNLVSGHVKTQL EEEEEECCCCCEEEE	26.75	21406692
167	Ubiquitination	NLVSGHVKTQLIAHD EECCCCCEEEEEECC	25.53	22053931
175	Ubiquitination	TQLIAHDKEVYDIAF EEEEECCHHHHEEEC	38.93	-
178	Phosphorylation	IAHDKEVYDIAFSRA EECCHHHHEEECCCC	11.61	-
184	Methylation	VYDIAFSRAGGGRDM HHEEECCCCCCCCCC	30.69	115920017
200	Phosphorylation	ASVGADGSVRMFDLR EEECCCCCEEEEECC	13.70	-
216	Phosphorylation	LEHSTIIYEDPQHHP CCCCEEEEECCCCCC	15.49	27642862
257	Phosphorylation	LDVRVPCTPVARLNN EEEECCCCCCHHHCC	18.09	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCAF7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCAF7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCAF7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYR1A_HUMAN	DYRK1A	physical	14593110
DYR1B_HUMAN	DYRK1B	physical	14593110
DYRK2_HUMAN	DYRK2	physical	14593110
M3K1_HUMAN	MAP3K1	physical	20940704
DYR1A_HUMAN	DYRK1A	physical	20940704
DYR1B_HUMAN	DYRK1B	physical	20940704
HIPK2_HUMAN	HIPK2	physical	20940704
DIAP1_HUMAN	DIAPH1	physical	16887337
DYR1A_HUMAN	DYRK1A	physical	21777625
A4_HUMAN	APP	physical	21832049
TCPB_HUMAN	CCT2	physical	25342745
TCPA_HUMAN	TCP1	physical	25342745
TCPG_HUMAN	CCT3	physical	25342745
TCPD_HUMAN	CCT4	physical	25342745
TCPE_HUMAN	CCT5	physical	25342745
TCPZ_HUMAN	CCT6A	physical	25342745
TCPH_HUMAN	CCT7	physical	25342745
TCPQ_HUMAN	CCT8	physical	25342745
DYR1A_HUMAN	DYRK1A	physical	25342745
M3K1_HUMAN	MAP3K1	physical	25342745
DYR1A_HUMAN	DYRK1A	physical	27307198
DYR1B_HUMAN	DYRK1B	physical	27307198
SWAHC_HUMAN	SOWAHC	physical	28514442
FBSL_HUMAN	FBRSL1	physical	28514442
RN169_HUMAN	RNF169	physical	28514442
DYR1B_HUMAN	DYRK1B	physical	28514442
TROAP_HUMAN	TROAP	physical	28514442
ZN703_HUMAN	ZNF703	physical	28514442
FA53C_HUMAN	FAM53C	physical	28514442
FBRS_HUMAN	FBRS	physical	28514442
AUTS2_HUMAN	AUTS2	physical	28514442
PCGF3_HUMAN	PCGF3	physical	28514442
DIAP1_HUMAN	DIAPH1	physical	28514442
SMAL1_HUMAN	SMARCAL1	physical	28514442
DYR1A_HUMAN	DYRK1A	physical	28514442
ARIP4_HUMAN	RAD54L2	physical	28514442
ZN503_HUMAN	ZNF503	physical	28514442
CSK22_HUMAN	CSNK2A2	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
ERF_HUMAN	ERF	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
FNTB_HUMAN	FNTB	physical	28514442
RYBP_HUMAN	RYBP	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
CBX6_HUMAN	CBX6	physical	28514442
ARHG8_HUMAN	NET1	physical	27173435
ENAH_HUMAN	ENAH	physical	27173435
GLCI1_HUMAN	GLCCI1	physical	27173435
DYR1A_HUMAN	DYRK1A	physical	27173435
GPBL1_HUMAN	GPBP1L1	physical	27173435
CDK17_HUMAN	CDK17	physical	27173435
LIPB1_HUMAN	PPFIBP1	physical	27173435
TXND5_HUMAN	TXNDC5	physical	27173435
FOXK1_HUMAN	FOXK1	physical	27173435
KPCI_HUMAN	PRKCI	physical	27173435
LRCH3_HUMAN	LRCH3	physical	27173435
NUMB_HUMAN	NUMB	physical	27173435
LRCH2_HUMAN	LRCH2	physical	27173435
PARD3_HUMAN	PARD3	physical	27173435
AMRA1_HUMAN	AMBRA1	physical	27173435
DOCK7_HUMAN	DOCK7	physical	27173435
CRTC3_HUMAN	CRTC3	physical	27173435
K1671_HUMAN	KIAA1671	physical	27173435
CAMP3_HUMAN	CAMSAP3	physical	27173435
DDA1_HUMAN	DDA1	physical	27173435
XRN2_HUMAN	XRN2	physical	27173435
CLAP2_HUMAN	CLASP2	physical	27173435
SKP1_HUMAN	SKP1	physical	27173435
DYL2_HUMAN	DYNLL2	physical	27173435
ANKS6_HUMAN	ANKS6	physical	27173435
CE170_HUMAN	CEP170	physical	27173435
PP1B_HUMAN	PPP1CB	physical	27173435
CB071_HUMAN	C2orf71	physical	27173435
DYL1_HUMAN	DYNLL1	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
PP1A_HUMAN	PPP1CA	physical	27173435
RAB3I_HUMAN	RAB3IP	physical	27173435
INP5E_HUMAN	INPP5E	physical	27173435
BBS12_HUMAN	BBS12	physical	27173435
CCD40_HUMAN	CCDC40	physical	27173435
CU002_HUMAN	C21orf2	physical	27173435
1433E_HUMAN	YWHAE	physical	27173435
HSF1_HUMAN	HSF1	physical	27173435
PTPC1_HUMAN	PTPDC1	physical	27173435
PLK1_HUMAN	PLK1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.