dbPTM

SWAHC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SWAHC_HUMAN
UniProt AC	Q53LP3
Protein Name	Ankyrin repeat domain-containing protein SOWAHC
Gene Name	SOWAHC
Organism	Homo sapiens (Human).
Sequence Length	525
Subcellular Localization
Protein Description
Protein Sequence	MEGPAEWGPEAALGPEAVLRFLAERGGRALHAELVQHFRGALGGEPEQRARARAHFKELVNAVATVRVDPADGAKYVHLKKRFCEGPSEPSGDPPRIQVTAEPEAPDGPAGPEARDRLPDAAAPESLPGQGRELGEGEPPAPAHWPPLSAGARRKNSRRDVQPLPRTPAPGPSEDLELPPHGCEEADRGSSLVGATAQRPARQNLRDLVMGSSPQLKRSVCPGGSSPGSSSGGGRGRGGGDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSRSIAEEIKNLVGALDEGDGESAAGSGGGRWRLSKVLPSHLITYKLSHALEDGGDHHHHHHSAEGWVGGKAKDPGRKASGSSSGRIKPRLNKIRFRTQIVHTTPSFRDPEQPLEGRGEEGVGEERPVKGHSPFTLRPKSNVFG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Malonylation	ARARAHFKELVNAVA HHHHHHHHHHHHHHE	40.03	26320211
75	Malonylation	VDPADGAKYVHLKKR ECCCCCCEEEEEECE	54.02	26320211
76	Phosphorylation	DPADGAKYVHLKKRF CCCCCCEEEEEECEE	7.80	25884760
88	Phosphorylation	KRFCEGPSEPSGDPP CEECCCCCCCCCCCC	73.35	-
100	Phosphorylation	DPPRIQVTAEPEAPD CCCCEEEEECCCCCC	14.66	50565603
126	Phosphorylation	PDAAAPESLPGQGRE CCCCCCCCCCCCCCC	38.51	28555341
149	Phosphorylation	PAHWPPLSAGARRKN CCCCCCCCHHCCCCC	30.36	54887231
157	Phosphorylation	AGARRKNSRRDVQPL HHCCCCCCCCCCCCC	31.56	28985074
167	Phosphorylation	DVQPLPRTPAPGPSE CCCCCCCCCCCCCCC	23.12	72254051
190	Phosphorylation	CEEADRGSSLVGATA CCCCCCCCCCCHHHC	22.76	46164423
196	Phosphorylation	GSSLVGATAQRPARQ CCCCCHHHCCCHHHH	19.86	27251275
212	Phosphorylation	LRDLVMGSSPQLKRS HHHHHHCCCCCCCCC	22.28	29255136
213	Phosphorylation	RDLVMGSSPQLKRSV HHHHHCCCCCCCCCC	15.78	29255136
217	Methylation	MGSSPQLKRSVCPGG HCCCCCCCCCCCCCC	37.06	-
219	Phosphorylation	SSPQLKRSVCPGGSS CCCCCCCCCCCCCCC	26.87	23403867
225	Phosphorylation	RSVCPGGSSPGSSSG CCCCCCCCCCCCCCC	39.00	23927012
226	Phosphorylation	SVCPGGSSPGSSSGG CCCCCCCCCCCCCCC	36.23	23927012
229	Phosphorylation	PGGSSPGSSSGGGRG CCCCCCCCCCCCCCC	25.39	25159151
230	Phosphorylation	GGSSPGSSSGGGRGR CCCCCCCCCCCCCCC	38.63	25159151
231	Phosphorylation	GSSPGSSSGGGRGRG CCCCCCCCCCCCCCC	43.06	25159151
296	Ubiquitination	CEPGLLVKRDFITGF CCCCEEEECCCCCCH	46.34	22817900
338	Phosphorylation	PVNIDARTSGGYTAL CCCEECCCCCCHHHH	33.18	22210691
339	Phosphorylation	VNIDARTSGGYTALH CCEECCCCCCHHHHH	25.35	22210691
343	Phosphorylation	ARTSGGYTALHLAAM CCCCCCHHHHHHHHH	26.47	22210691
385	Phosphorylation	ASQYLSRSIAEEIKN HHHHHHHHHHHHHHH	23.83	23312004
408	Phosphorylation	DGESAAGSGGGRWRL CCCCCCCCCCCCEEC	29.54	25159151
426	Phosphorylation	LPSHLITYKLSHALE CCHHHHEEEHHHHHC	11.70	25159151
479	Phosphorylation	LNKIRFRTQIVHTTP CCCCEEEEEEEECCC	21.67	28857561
484	Phosphorylation	FRTQIVHTTPSFRDP EEEEEEECCCCCCCC	29.52	23312004
485	Phosphorylation	RTQIVHTTPSFRDPE EEEEEECCCCCCCCC	11.32	23312004
487	Phosphorylation	QIVHTTPSFRDPEQP EEEECCCCCCCCCCC	30.71	30815329
513	Phosphorylation	ERPVKGHSPFTLRPK CCCCCCCCCCCCCCC	30.31	30266825
516	Phosphorylation	VKGHSPFTLRPKSNV CCCCCCCCCCCCCCC	25.82	166222203
520	Methylation	SPFTLRPKSNVFG-- CCCCCCCCCCCCC--	48.50	-
521	Phosphorylation	PFTLRPKSNVFG--- CCCCCCCCCCCC---	40.69	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SWAHC_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SWAHC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SWAHC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SWAHC_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SWAHC_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-513, AND MASSSPECTROMETRY.	18691976 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226, AND MASSSPECTROMETRY.	16964243 [Abstract]