| UniProt ID | PTPC1_HUMAN | |
|---|---|---|
| UniProt AC | A2A3K4 | |
| Protein Name | Protein tyrosine phosphatase domain-containing protein 1 | |
| Gene Name | PTPDC1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 754 | |
| Subcellular Localization | ||
| Protein Description | May play roles in cilia formation and/or maintenance.. | |
| Protein Sequence | MAAGVLPQNEQPYSTLVNNSECVANMKGNLERPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTPLRNIFSCCDPKAHAVTLPQYLIRQRHLLHGYEARLLKHVPKIIHLVCKLLLDLAENRPVMMKDVSEGPGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGMIFSNEQQFDPLWKRRNVECLQPLTHLKRRLSYSDSDLKRAENLLEQGETPQTVPAQILVGHKPRQQKLISHCYIPQSPEPDLHKEALVRSTLSFWSQSKFGGLEGLKDNGSPIFHGRIIPKEAQQSGAFSADVSGSHSPGEPVSPSFANVHKDPNPAHQQVSHCQCKTHGVGSPGSVRQNSRTPRSPLDCGSSPKAQFLVEHETQDSKDLSEAASHSALQSELSAEARRILAAKALANLNESVEKEELKRKVEMWQKELNSRDGAWERICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRRADAAEALFLLEKGQHQTILCVLHCIVNLQTIPVDVEEAFLAHAIKAFTKVNFDSENGPTVYNTLKKIFKHTLEEKRKMTKDGPKPGL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 (in isoform 2) | Phosphorylation | - | 32.32 | 30631047 | |
| 26 (in isoform 2) | Phosphorylation | - | 4.19 | 30624053 | |
| 27 (in isoform 2) | Phosphorylation | - | 44.44 | 30624053 | |
| 34 | Phosphorylation | KGNLERPTPKYTKVG CCCCCCCCCCCCHHH | 38.34 | 25159151 | |
| 112 | Phosphorylation | HIIDQFLSHGIKTII HHHHHHHHCCCHHEE | 22.43 | 29396449 | |
| 374 | Ubiquitination | QQFDPLWKRRNVECL HHCCHHHHHCCCHHH | 49.52 | - | |
| 392 | Phosphorylation | THLKRRLSYSDSDLK HHHHHHHCCCHHHHH | 22.30 | 23927012 | |
| 393 | Phosphorylation | HLKRRLSYSDSDLKR HHHHHHCCCHHHHHH | 22.53 | 23927012 | |
| 394 | Phosphorylation | LKRRLSYSDSDLKRA HHHHHCCCHHHHHHH | 27.54 | 29255136 | |
| 396 | Phosphorylation | RRLSYSDSDLKRAEN HHHCCCHHHHHHHHH | 38.61 | 29255136 | |
| 410 | Phosphorylation | NLLEQGETPQTVPAQ HHHHCCCCCCCCCCE | 27.76 | 25850435 | |
| 413 | Phosphorylation | EQGETPQTVPAQILV HCCCCCCCCCCEEEC | 29.66 | 29255136 | |
| 423 | Ubiquitination | AQILVGHKPRQQKLI CEEECCCCHHCCHHH | 35.65 | - | |
| 431 | Phosphorylation | PRQQKLISHCYIPQS HHCCHHHHCCCCCCC | 20.24 | 23186163 | |
| 434 | Phosphorylation | QKLISHCYIPQSPEP CHHHHCCCCCCCCCC | 15.37 | 23186163 | |
| 438 | Phosphorylation | SHCYIPQSPEPDLHK HCCCCCCCCCCCCCH | 26.35 | 25159151 | |
| 444 | Phosphorylation | QSPEPDLHKEALVRS CCCCCCCCHHHHHHH | 33.03 | 24719451 | |
| 446 | Phosphorylation | PEPDLHKEALVRSTL CCCCCCHHHHHHHHH | 36.17 | 24719451 | |
| 448 | Phosphorylation | PDLHKEALVRSTLSF CCCCHHHHHHHHHHH | 3.27 | 27251275 | |
| 457 | Phosphorylation | RSTLSFWSQSKFGGL HHHHHHHHHCCCCCC | 23.67 | 25159151 | |
| 468 | Ubiquitination | FGGLEGLKDNGSPIF CCCCCCCCCCCCCCC | 61.06 | - | |
| 472 | Phosphorylation | EGLKDNGSPIFHGRI CCCCCCCCCCCCCEE | 22.52 | 25159151 | |
| 490 | Phosphorylation | EAQQSGAFSADVSGS HHHHCCCCEEECCCC | 7.64 | 24719451 | |
| 492 | Phosphorylation | QQSGAFSADVSGSHS HHCCCCEEECCCCCC | 18.12 | 27251275 | |
| 505 | Phosphorylation | HSPGEPVSPSFANVH CCCCCCCCHHHCCCC | 26.07 | 25849741 | |
| 529 | Phosphorylation | VSHCQCKTHGVGSPG CCCCEEECCCCCCCC | 31.33 | 27251275 | |
| 534 | Phosphorylation | CKTHGVGSPGSVRQN EECCCCCCCCCCCCC | 24.55 | 23403867 | |
| 537 | Phosphorylation | HGVGSPGSVRQNSRT CCCCCCCCCCCCCCC | 19.94 | 28985074 | |
| 544 | Phosphorylation | SVRQNSRTPRSPLDC CCCCCCCCCCCCCCC | 23.91 | 26552605 | |
| 547 | Phosphorylation | QNSRTPRSPLDCGSS CCCCCCCCCCCCCCC | 30.90 | 25850435 | |
| 553 | Phosphorylation | RSPLDCGSSPKAQFL CCCCCCCCCCCHHEE | 50.20 | 25159151 | |
| 554 | Phosphorylation | SPLDCGSSPKAQFLV CCCCCCCCCCHHEEE | 18.72 | 28985074 | |
| 556 | Ubiquitination | LDCGSSPKAQFLVEH CCCCCCCCHHEEEEE | 57.69 | - | |
| 585 | Phosphorylation | SALQSELSAEARRIL HHHHHHHHHHHHHHH | 21.73 | 24719451 | |
| 586 | Phosphorylation | ALQSELSAEARRILA HHHHHHHHHHHHHHH | 27.39 | 24719451 | |
| 588 | Phosphorylation | QSELSAEARRILAAK HHHHHHHHHHHHHHH | 13.03 | 27251275 | |
| 595 | Ubiquitination | ARRILAAKALANLNE HHHHHHHHHHHCCCH | 38.02 | - | |
| 599 | Phosphorylation | LAAKALANLNESVEK HHHHHHHCCCHHHCH | 44.22 | 24719451 | |
| 601 | Phosphorylation | AKALANLNESVEKEE HHHHHCCCHHHCHHH | 39.03 | 27251275 | |
| 606 | Ubiquitination | NLNESVEKEELKRKV CCCHHHCHHHHHHHH | 55.09 | - | |
| 716 | Ubiquitination | HAIKAFTKVNFDSEN HHHHHHHCCCCCCCC | 28.82 | - | |
| 730 | Phosphorylation | NGPTVYNTLKKIFKH CCCCHHHHHHHHHHH | 23.44 | - | |
| 732 | Ubiquitination | PTVYNTLKKIFKHTL CCHHHHHHHHHHHHH | 41.61 | - | |
| 746 | Phosphorylation | LEEKRKMTKDGPKPG HHHHHHHCCCCCCCC | 29.08 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PTPC1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PTPC1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PTPC1_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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