2AAB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 2AAB_HUMAN
• UniProt AC: P30154
• Protein Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
• Gene Name: PPP2R1B
• Organism: Homo sapiens (Human).
• Sequence Length: 601
• Protein Description: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit..
• Protein Sequence: MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLALA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGASELGT ------CCCCCCCCC	23.43	22814378
5	Phosphorylation	---MAGASELGTGPG ---CCCCCCCCCCCC	32.22	24043423
9	Phosphorylation	AGASELGTGPGAAGG CCCCCCCCCCCCCCC	53.48	24043423
21	Phosphorylation	AGGDGDDSLYPIAVL CCCCCCCCHHHHHHH	34.25	24043423
23	Phosphorylation	GDGDDSLYPIAVLID CCCCCCHHHHHHHHH	9.13	24043423
45	Ubiquitination	QLRLNSIKKLSTIAL HHHHHHHHHHHHHHH	47.70	22053931
46	Ubiquitination	LRLNSIKKLSTIALA HHHHHHHHHHHHHHH	46.10	21890473
46	Ubiquitination	LRLNSIKKLSTIALA HHHHHHHHHHHHHHH	46.10	21890473
46	Ubiquitination	LRLNSIKKLSTIALA HHHHHHHHHHHHHHH	46.10	21890473
46	Ubiquitination	LRLNSIKKLSTIALA HHHHHHHHHHHHHHH	46.10	22053931
46 (in isoform 1)	Ubiquitination	-	46.10	21890473
46 (in isoform 2)	Ubiquitination	-	46.10	21890473
48	Phosphorylation	LNSIKKLSTIALALG HHHHHHHHHHHHHHC	27.01	27251275
49	Phosphorylation	NSIKKLSTIALALGV HHHHHHHHHHHHHCC	22.24	27251275
55	Ubiquitination	STIALALGVERTRSE HHHHHHHCCCCHHHH	17.40	27667366
59	Phosphorylation	LALGVERTRSELLPF HHHCCCCHHHHHHHH	25.66	18452278
81	Ubiquitination	EDEVLLALAEQLGNF HHHHHHHHHHHHCCC	5.63	21963094
111	Ubiquitination	PLENLATVEETVVRD CHHHHCCHHHHHHHH	5.35	21963094
119	Ubiquitination	EETVVRDKAVESLRQ HHHHHHHHHHHHHHH	43.71	21906983
119 (in isoform 1)	Ubiquitination	-	43.71	21890473
119 (in isoform 2)	Ubiquitination	-	43.71	21890473
136	Ubiquitination	QEHTPVALEAYFVPL HHCCCCHHHHHHHHH	3.83	21890473
136	Neddylation	QEHTPVALEAYFVPL HHCCCCHHHHHHHHH	3.83	32015554
136	Ubiquitination	QEHTPVALEAYFVPL HHCCCCHHHHHHHHH	3.83	23000965
140	Ubiquitination	PVALEAYFVPLVKRL CCHHHHHHHHHHHHH	6.18	22053931
142	Ubiquitination	ALEAYFVPLVKRLAS HHHHHHHHHHHHHHC	22.87	23000965
145	Ubiquitination	AYFVPLVKRLASGDW HHHHHHHHHHHCCCC	49.75	21906983
145 (in isoform 1)	Ubiquitination	-	49.75	21890473
145 (in isoform 2)	Ubiquitination	-	49.75	21890473
150	Ubiquitination	LVKRLASGDWFTSRT HHHHHHCCCCCCCCC	30.48	21987572
157	Ubiquitination	GDWFTSRTSACGLFS CCCCCCCCCCCCCHH	22.05	33845483
162	Ubiquitination	SRTSACGLFSVCYPR CCCCCCCCHHCCCCC	2.66	29967540
164	Phosphorylation	TSACGLFSVCYPRAS CCCCCCHHCCCCCCC	19.13	28152594
167	Phosphorylation	CGLFSVCYPRASNAV CCCHHCCCCCCCHHH	8.13	28152594
175	Ubiquitination	PRASNAVKAEIRQQF CCCCHHHHHHHHHHH	37.58	21906983
175 (in isoform 1)	Ubiquitination	-	37.58	21890473
175 (in isoform 2)	Ubiquitination	-	37.58	21890473
177	Ubiquitination	ASNAVKAEIRQQFRS CCHHHHHHHHHHHHH	32.74	29967540
184	Phosphorylation	EIRQQFRSLCSDDTP HHHHHHHHHCCCCCH	34.71	24719451
190	Ubiquitination	RSLCSDDTPMVRRAA HHHCCCCCHHHHHHH	20.48	24816145
192	Sulfoxidation	LCSDDTPMVRRAAAS HCCCCCHHHHHHHHH	3.88	21406390
192	Ubiquitination	LCSDDTPMVRRAAAS HCCCCCHHHHHHHHH	3.88	29967540
200	Ubiquitination	VRRAAASKLGEFAKV HHHHHHHHHHHHHHH	56.64	21890473
200	Ubiquitination	VRRAAASKLGEFAKV HHHHHHHHHHHHHHH	56.64	21890473
200	Acetylation	VRRAAASKLGEFAKV HHHHHHHHHHHHHHH	56.64	72664351
200	Neddylation	VRRAAASKLGEFAKV HHHHHHHHHHHHHHH	56.64	32015554
200	Ubiquitination	VRRAAASKLGEFAKV HHHHHHHHHHHHHHH	56.64	23000965
200 (in isoform 1)	Ubiquitination	-	56.64	21890473
200 (in isoform 2)	Ubiquitination	-	56.64	21890473
203	Ubiquitination	AAASKLGEFAKVLEL HHHHHHHHHHHHHCH	53.52	22053931
206	Ubiquitination	SKLGEFAKVLELDSV HHHHHHHHHHCHHCC	53.31	23000965
206 (in isoform 1)	Ubiquitination	-	53.31	21890473
206 (in isoform 2)	Ubiquitination	-	53.31	21890473
212	Phosphorylation	AKVLELDSVKSEIVP HHHHCHHCCHHHHHH	44.03	20068231
214	Ubiquitination	VLELDSVKSEIVPLF HHCHHCCHHHHHHHH	46.45	21906983
214 (in isoform 1)	Ubiquitination	-	46.45	21890473
214 (in isoform 2)	Ubiquitination	-	46.45	21890473
215	Phosphorylation	LELDSVKSEIVPLFT HCHHCCHHHHHHHHH	30.33	20873877
216	Ubiquitination	ELDSVKSEIVPLFTS CHHCCHHHHHHHHHH	42.14	29967540
220	Ubiquitination	VKSEIVPLFTSLASD CHHHHHHHHHHHCCC	5.18	33845483
222	Phosphorylation	SEIVPLFTSLASDEQ HHHHHHHHHHCCCCC	30.43	20873877
225	Ubiquitination	VPLFTSLASDEQDSV HHHHHHHCCCCCHHH	18.07	29967540
240	Ubiquitination	RLLAVEACVSIAQLL HHHHHHHHHHHHHHC	1.24	29967540
253	Ubiquitination	LLSQDDLETLVMPTL HCCCCCHHHCHHHHH	47.27	24816145
255	Ubiquitination	SQDDLETLVMPTLRQ CCCCHHHCHHHHHHH	1.96	29967540
267	Ubiquitination	LRQAAEDKSWRVRYM HHHHHHCCCHHHHHH	43.34	22817900
267 (in isoform 1)	Ubiquitination	-	43.34	21890473
267 (in isoform 2)	Ubiquitination	-	43.34	21890473
278	Methylation	VRYMVADRFSELQKA HHHHHHHHHHHHHHH	27.53	115488569
279	Ubiquitination	RYMVADRFSELQKAM HHHHHHHHHHHHHHH	7.38	29967540
284	Ubiquitination	DRFSELQKAMGPKIT HHHHHHHHHHCCCCC	53.62	21906983
284 (in isoform 1)	Ubiquitination	-	53.62	21890473
284 (in isoform 2)	Ubiquitination	-	53.62	21890473
289	Ubiquitination	LQKAMGPKITLNDLI HHHHHCCCCCHHHHH	42.46	29967540
289 (in isoform 2)	Ubiquitination	-	42.46	-
301	Ubiquitination	DLIPAFQNLLKDCEA HHHHHHHHHHHHCHH	40.67	21890473
301	Ubiquitination	DLIPAFQNLLKDCEA HHHHHHHHHHHHCHH	40.67	21890473
304	Ubiquitination	PAFQNLLKDCEAEVR HHHHHHHHHCHHHHH	64.60	21906983
304 (in isoform 1)	Ubiquitination	-	64.60	21890473
304 (in isoform 2)	Ubiquitination	-	64.60	21890473
317	Ubiquitination	VRAAAAHKVKELGEN HHHHHHHHHHHHHCC	50.72	24816145
319	Ubiquitination	AAAAHKVKELGENLP HHHHHHHHHHHCCCC	52.61	29967540
319 (in isoform 2)	Ubiquitination	-	52.61	-
341	Phosphorylation	IMNQILPYIKELVSD HHHCHHHHHHHHHCC	22.60	-
343	Ubiquitination	NQILPYIKELVSDTN HCHHHHHHHHHCCCH	38.87	29967540
347	Phosphorylation	PYIKELVSDTNQHVK HHHHHHHCCCHHHHH	51.87	22210691
349	Phosphorylation	IKELVSDTNQHVKSA HHHHHCCCHHHHHHH	29.31	22210691
353	Ubiquitination	VSDTNQHVKSALASV HCCCHHHHHHHHHHH	3.64	22817900
355	Phosphorylation	DTNQHVKSALASVIM CCHHHHHHHHHHHHH	27.68	20068231
357	Ubiquitination	NQHVKSALASVIMGL HHHHHHHHHHHHHHH	4.75	21890473
357	Ubiquitination	NQHVKSALASVIMGL HHHHHHHHHHHHHHH	4.75	21963094
364	Ubiquitination	LASVIMGLSTILGKE HHHHHHHHHHHHCCC	1.95	21890473
364	Ubiquitination	LASVIMGLSTILGKE HHHHHHHHHHHHCCC	1.95	21890473
370	Ubiquitination	GLSTILGKENTIEHL HHHHHHCCCCHHHHH	44.33	29967540
383	Ubiquitination	HLLPLFLAQLKDECP HHHHHHHHHHHCCCC	12.82	21890473
383	Ubiquitination	HLLPLFLAQLKDECP HHHHHHHHHHHCCCC	12.82	21890473
386	Ubiquitination	PLFLAQLKDECPDVR HHHHHHHHCCCCCCH	39.13	-
386 (in isoform 2)	Ubiquitination	-	39.13	-
402	S-nitrosylation	NIISNLDCVNEVIGI EECCCCHHHHHHHHH	3.89	22178444
402	S-palmitoylation	NIISNLDCVNEVIGI EECCCCHHHHHHHHH	3.89	29575903
412	Ubiquitination	EVIGIRQLSQSLLPA HHHHHHHHHHHHHHH	3.46	21963094
413	Phosphorylation	VIGIRQLSQSLLPAI HHHHHHHHHHHHHHH	14.91	21406692
415	Phosphorylation	GIRQLSQSLLPAIVE HHHHHHHHHHHHHHH	28.62	21406692
416	Ubiquitination	IRQLSQSLLPAIVEL HHHHHHHHHHHHHHH	5.28	22817900
420	Ubiquitination	SQSLLPAIVELAEDA HHHHHHHHHHHHHHC	2.03	21890473
420	Ubiquitination	SQSLLPAIVELAEDA HHHHHHHHHHHHHHC	2.03	21963094
427	Ubiquitination	IVELAEDAKWRVRLA HHHHHHHCCHHHHHH	12.57	23000965
428	Ubiquitination	VELAEDAKWRVRLAI HHHHHHCCHHHHHHH	48.10	21890473
428	Ubiquitination	VELAEDAKWRVRLAI HHHHHHCCHHHHHHH	48.10	22817900
428 (in isoform 1)	Ubiquitination	-	48.10	21890473
428 (in isoform 2)	Ubiquitination	-	48.10	21890473
431	Ubiquitination	AEDAKWRVRLAIIEY HHHCCHHHHHHHHHH	5.97	23000965
433	Ubiquitination	DAKWRVRLAIIEYMP HCCHHHHHHHHHHHH	3.52	29967540
435	Ubiquitination	KWRVRLAIIEYMPLL CHHHHHHHHHHHHHH	2.66	22817900
439	Ubiquitination	RLAIIEYMPLLAGQL HHHHHHHHHHHCHHH	0.91	21890473
439	Ubiquitination	RLAIIEYMPLLAGQL HHHHHHHHHHHCHHH	0.91	21963094
446	Ubiquitination	MPLLAGQLGVEFFDE HHHHCHHHCCHHCHH	8.97	21963094
451	Ubiquitination	GQLGVEFFDEKLNSL HHHCCHHCHHHHHHH	8.20	21963094
452	Ubiquitination	QLGVEFFDEKLNSLC HHCCHHCHHHHHHHH	58.40	29967540
454	Sumoylation	GVEFFDEKLNSLCMA CCHHCHHHHHHHHHH	55.61	-
475	Ubiquitination	YAIREAATNNLMKLV HHHHHHHHHHHHHHH	31.52	21963094
480	Ubiquitination	AATNNLMKLVQKFGT HHHHHHHHHHHHHCC	48.98	22817900
484	Ubiquitination	NLMKLVQKFGTEWAQ HHHHHHHHHCCHHHH	37.98	21890473
484	Ubiquitination	NLMKLVQKFGTEWAQ HHHHHHHHHCCHHHH	37.98	21963094
484 (in isoform 1)	Ubiquitination	-	37.98	21890473
484 (in isoform 2)	Ubiquitination	-	37.98	21890473
490	Ubiquitination	QKFGTEWAQNTIVPK HHHCCHHHHHCCCCE	6.11	21890473
490	Ubiquitination	QKFGTEWAQNTIVPK HHHCCHHHHHCCCCE	6.11	23000965
493	Phosphorylation	GTEWAQNTIVPKVLV CCHHHHHCCCCEEEE	15.98	30576142
494	Ubiquitination	TEWAQNTIVPKVLVM CHHHHHCCCCEEEEE	7.00	21890473
494	Ubiquitination	TEWAQNTIVPKVLVM CHHHHHCCCCEEEEE	7.00	23000965
497	Ubiquitination	AQNTIVPKVLVMAND HHHCCCCEEEEECCC	36.99	21906983
497 (in isoform 1)	Ubiquitination	-	36.99	21890473
497 (in isoform 2)	Ubiquitination	-	36.99	21890473
507	Phosphorylation	VMANDPNYLHRMTTL EECCCCCHHHHHHHH	14.85	30576142
509	Ubiquitination	ANDPNYLHRMTTLFC CCCCCHHHHHHHHHH	13.70	21890473
509	Ubiquitination	ANDPNYLHRMTTLFC CCCCCHHHHHHHHHH	13.70	23000965
513	Ubiquitination	NYLHRMTTLFCINAL CHHHHHHHHHHHHHH	14.43	21890473
513	Ubiquitination	NYLHRMTTLFCINAL CHHHHHHHHHHHHHH	14.43	23000965
514	Ubiquitination	YLHRMTTLFCINALS HHHHHHHHHHHHHHH	2.13	21963094
528	Ubiquitination	SEACGQEITTKQMLP HHHHCCCCCHHHHHH	4.57	21963094
533	Ubiquitination	QEITTKQMLPIVLKM CCCCHHHHHHHHHHH	5.25	21963094
539	Ubiquitination	QMLPIVLKMAGDQVA HHHHHHHHHCCCCCH	18.79	21963094
539 (in isoform 2)	Ubiquitination	-	18.79	-
540	Sulfoxidation	MLPIVLKMAGDQVAN HHHHHHHHCCCCCHH	4.39	21406390
554	Ubiquitination	NVRFNVAKSLQKIGP HCHHHHHHHHHHHCC	47.63	21890473
554	Ubiquitination	NVRFNVAKSLQKIGP HCHHHHHHHHHHHCC	47.63	23000965
554 (in isoform 1)	Ubiquitination	-	47.63	21890473
554 (in isoform 2)	Ubiquitination	-	47.63	21890473
558	Ubiquitination	NVAKSLQKIGPILDT HHHHHHHHHCCCCCC	55.73	21890473
558	Ubiquitination	NVAKSLQKIGPILDT HHHHHHHHHCCCCCC	55.73	23000965
558 (in isoform 1)	Ubiquitination	-	55.73	21890473
558 (in isoform 2)	Ubiquitination	-	55.73	21890473
573	Sumoylation	NALQGEVKPVLQKLG CCCCCCHHHHHHHHC	25.71	-
573	Sumoylation	NALQGEVKPVLQKLG CCCCCCHHHHHHHHC	25.71	-
573	Ubiquitination	NALQGEVKPVLQKLG CCCCCCHHHHHHHHC	25.71	21906983
573 (in isoform 1)	Ubiquitination	-	25.71	21890473
573 (in isoform 2)	Ubiquitination	-	25.71	21890473
578	Ubiquitination	EVKPVLQKLGQDEDM CHHHHHHHHCCCCCC	50.88	21963094
578 (in isoform 1)	Ubiquitination	-	50.88	21890473
578 (in isoform 2)	Ubiquitination	-	50.88	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 2AAB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 2AAB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 2AAB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP2AA_HUMAN	PPP2CA	physical	12370081
PP2AB_HUMAN	PPP2CB	physical	12370081
2ABA_HUMAN	PPP2R2A	physical	12370081
2A5A_HUMAN	PPP2R5A	physical	12370081
P2R3B_HUMAN	PPP2R3B	physical	12370081
PP2AA_HUMAN	PPP2CA	physical	17540176
RALA_HUMAN	RALA	physical	17540176
2AAA_HUMAN	PPP2R1A	physical	17540176
2ABA_HUMAN	PPP2R2A	physical	17540176
2A5G_HUMAN	PPP2R5C	physical	17540176
2A5D_HUMAN	PPP2R5D	physical	17540176
2A5E_HUMAN	PPP2R5E	physical	17540176
STRN3_HUMAN	STRN3	physical	17540176
CDK1_HUMAN	CDK1	physical	17540176
CDK4_HUMAN	CDK4	physical	17540176
HDAC1_HUMAN	HDAC1	physical	17540176
STRN_HUMAN	STRN	physical	17540176
MCM3_HUMAN	MCM3	physical	17540176
PRDX1_HUMAN	PRDX1	physical	17540176
PRDX2_HUMAN	PRDX2	physical	17540176
PARK7_HUMAN	PARK7	physical	17540176
RAB18_HUMAN	RAB18	physical	17540176
RAB7A_HUMAN	RAB7A	physical	17540176
RB11A_HUMAN	RAB11A	physical	17540176
MARH1_HUMAN	MARCH1	physical	17540176
EF2_HUMAN	EEF2	physical	17540176
ANXA5_HUMAN	ANXA5	physical	17540176
FGFR1_HUMAN	FGFR1	physical	17540176
STAT3_HUMAN	STAT3	physical	17540176
PP2AA_HUMAN	PPP2CA	physical	22939629
2ABA_HUMAN	PPP2R2A	physical	22939629
DAAF5_HUMAN	DNAAF5	physical	22863883
DAPK1_HUMAN	DAPK1	physical	21172653
UNC5B_HUMAN	UNC5B	physical	21172653
2A5D_HUMAN	PPP2R5D	physical	23555304
2A5E_HUMAN	PPP2R5E	physical	23555304
RORG_HUMAN	RORC	physical	23555304
2AAB_HUMAN	PPP2R1B	physical	23555304
CLOCK_HUMAN	CLOCK	physical	23555304
PDCD4_HUMAN	PDCD4	physical	26344197
2A5E_HUMAN	PPP2R5E	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
2AAA_HUMAN	PPP2R1A	physical	26496610
DCAF1_HUMAN	VPRBP	physical	26281983

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.