dbPTM

P2R3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	P2R3B_HUMAN
UniProt AC	Q9Y5P8
Protein Name	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
Gene Name	PPP2R3B
Organism	Homo sapiens (Human).
Sequence Length	575
Subcellular Localization	Nucleus .
Protein Description	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment..
Protein Sequence	MPPGKVLQPVLKMKVDELFLYWLSEASTQRMLQDCLRRIKAPGRDQPTPGDGEQPGAWPTAPLAAPRPSGLEPPGTPGPGPALPLGAASSPRNAPHVRGTRRSAGTRVVQTRKEEPLPPATSQSIPTFYFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKACGCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTRGRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPRTEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQKEQISLLRDGDSGGPELSDWEKYAAEEYDILVAEETAGEPWEDGFEAELSPVEQKLSALRSPLAQRPFFEAPSPLGAVDLYEYACGDEDLEPL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	KVLQPVLKMKVDELF CCCHHHHHCCHHHHH	36.59	-
89	Phosphorylation	ALPLGAASSPRNAPH CCCCCCCCCCCCCCC	40.10	18691976
90	Phosphorylation	LPLGAASSPRNAPHV CCCCCCCCCCCCCCC	24.13	17192257
113	Ubiquitination	TRVVQTRKEEPLPPA CEEEECCCCCCCCCC	70.58	-
147	Ubiquitination	NVDAVISKIESTFAR CHHHHHHHHHHHHHC	39.09	-
170	Ubiquitination	DDMGLVAKACGCPLY CHHHHHHHHHCCCEE	36.41	-
179	Ubiquitination	CGCPLYWKGPLFYGA HCCCEEEECCEEECC	36.77	-
184	Phosphorylation	YWKGPLFYGAGGERT EEECCEEECCCCCCC	17.47	22817900
249	Phosphorylation	VNTHPGLSFLKEASE HHHCCCHHHHHHHHH	34.15	24719451
348	Phosphorylation	RHNDHALSTKMIDRI HCCCCHHHHHHHHHH	27.11	24719451
349	Phosphorylation	HNDHALSTKMIDRIF CCCCHHHHHHHHHHH	26.02	24719451
350	Ubiquitination	NDHALSTKMIDRIFS CCCHHHHHHHHHHHH	30.40	-
357	Phosphorylation	KMIDRIFSGAVTRGR HHHHHHHHCCCCCCC	24.38	24719451
452	Ubiquitination	VKPRTEGKITLQDLK CCCCCCCCCCHHHHH	26.70	29967540
459	Ubiquitination	KITLQDLKRCKLANV CCCHHHHHHCCCCCC	65.13	29967540
483	Ubiquitination	KYLDHEQKEQISLLR HHCCHHHHHHHEEEC	48.91	29967540
510	Phosphorylation	EKYAAEEYDILVAEE HHHHHHHCCEEEEEE	10.37	28102081
518	Phosphorylation	DILVAEETAGEPWED CEEEEEECCCCCCCC	31.31	28102081
532	Phosphorylation	DGFEAELSPVEQKLS CCCCCCCCHHHHHHH	20.57	28102081
543	Phosphorylation	QKLSALRSPLAQRPF HHHHHHHCHHHCCCC	25.72	28122231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of P2R3B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of P2R3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of P2R3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TM14B_HUMAN	TMEM14B	physical	21516116

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of P2R3B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-184, AND MASSSPECTROMETRY.	18083107 [Abstract]