TM14B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM14B_HUMAN
• UniProt AC: Q9NUH8
• Protein Name: Transmembrane protein 14B
• Gene Name: TMEM14B
• Organism: Homo sapiens (Human).
• Sequence Length: 114
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions..
• Protein Sequence: MEKPLFPLVPLHWFGFGYTALVVSGGIVGYVKTGSVPSLAAGLLFGSLAGLGAYQLYQDPRNVWGFLAATSVTFVGVMGMRSYYYGKFMPVGLIAGASLLMAAKVGVRMLMTSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Phosphorylation	MGMRSYYYGKFMPVG CCCCHHHCCCCCCHH	12.95	-
87	Ubiquitination	MRSYYYGKFMPVGLI CCHHHCCCCCCHHHH	23.51	-
98	Phosphorylation	VGLIAGASLLMAAKV HHHHHHHHHHHHHHH	22.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM14B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM14B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM14B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCALD_HUMAN	NCALD	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.