MARH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MARH1_HUMAN
• UniProt AC: Q8TCQ1
• Protein Name: E3 ubiquitin-protein ligase MARCH1
• Gene Name: 1-Mar
• Organism: Homo sapiens (Human).
• Sequence Length: 289
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Early endos
• Protein Description: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system..
• Protein Sequence: MLGWCEAIARNPHRIPNNTRTPEISGDLADASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20 (in isoform 2)	Phosphorylation	-	50.86	22985185
21 (in isoform 2)	Phosphorylation	-	24.20	22985185
45	Phosphorylation	NEKSPGRSASRSSNI CCCCCCCCCCCCCCC	36.19	20068231
47	Phosphorylation	KSPGRSASRSSNISK CCCCCCCCCCCCCCC	33.66	20068231
49	Phosphorylation	PGRSASRSSNISKAS CCCCCCCCCCCCCCC	25.82	20068231
50	Phosphorylation	GRSASRSSNISKASS CCCCCCCCCCCCCCC	36.75	30576142
53	Phosphorylation	ASRSSNISKASSPTT CCCCCCCCCCCCCCC	26.81	20068231
56	Phosphorylation	SSNISKASSPTTGTA CCCCCCCCCCCCCCC	40.36	23403867
57	Phosphorylation	SNISKASSPTTGTAP CCCCCCCCCCCCCCC	31.00	23403867
59	Phosphorylation	ISKASSPTTGTAPRS CCCCCCCCCCCCCCC	39.54	23403867
60	Phosphorylation	SKASSPTTGTAPRSQ CCCCCCCCCCCCCCC	35.60	20068231
62	Phosphorylation	ASSPTTGTAPRSQSR CCCCCCCCCCCCCCC	31.25	29449344
66	Phosphorylation	TTGTAPRSQSRLSVC CCCCCCCCCCCCEEC	31.30	30377224
68	Phosphorylation	GTAPRSQSRLSVCPS CCCCCCCCCCEECCC	36.11	30377224
71	Phosphorylation	PRSQSRLSVCPSTQD CCCCCCCEECCCCCC	22.14	24719451
158	O-linked_Glycosylation	ERRKIFCSVTFHVIA HHHHHHHHHHHHHHH	17.28	29351928
160	Phosphorylation	RKIFCSVTFHVIAIT HHHHHHHHHHHHHHH	7.54	-
160	O-linked_Glycosylation	RKIFCSVTFHVIAIT HHHHHHHHHHHHHHH	7.54	29351928
271	Phosphorylation	VVVPVPQTGANSLPS EEEECCCCCCCCCCC	31.99	23532336
275	Phosphorylation	VPQTGANSLPSAEGG CCCCCCCCCCCCCCC	40.92	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MARH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MARH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MARH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2B1F_HUMAN	HLA-DRB1	physical	23264739
2B13_HUMAN	HLA-DRB1	physical	23264739
2B1G_HUMAN	HLA-DRB1	physical	23264739
DRA_HUMAN	HLA-DRA	physical	23264739
TFR1_HUMAN	TFRC	physical	23606747
UBE2H_HUMAN	UBE2H	physical	14722266
UB2R1_HUMAN	CDC34	physical	14722266
UB2D1_HUMAN	UBE2D1	physical	14722266
INSR_HUMAN	INSR	physical	27577745

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.